WO2004105951A1 - Systeme porte-echantillons modulaire - Google Patents

Systeme porte-echantillons modulaire Download PDF

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Publication number
WO2004105951A1
WO2004105951A1 PCT/EP2004/005678 EP2004005678W WO2004105951A1 WO 2004105951 A1 WO2004105951 A1 WO 2004105951A1 EP 2004005678 W EP2004005678 W EP 2004005678W WO 2004105951 A1 WO2004105951 A1 WO 2004105951A1
Authority
WO
WIPO (PCT)
Prior art keywords
modules
module
sample holder
holder system
modular
Prior art date
Application number
PCT/EP2004/005678
Other languages
German (de)
English (en)
Inventor
Uwe Vietze
Alexander Cross
Original Assignee
Hte Aktiengesellschaft The High Throughput Experimentation Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2003124397 external-priority patent/DE10324397A1/de
Priority claimed from DE2003133545 external-priority patent/DE10333545A1/de
Application filed by Hte Aktiengesellschaft The High Throughput Experimentation Company filed Critical Hte Aktiengesellschaft The High Throughput Experimentation Company
Publication of WO2004105951A1 publication Critical patent/WO2004105951A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50855—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using modular assemblies of strips or of individual wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
    • B01J2219/0031—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks the racks or blocks being mounted in stacked arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00319—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks the blocks being mounted in stacked arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/023—Adapting objects or devices to another adapted for different sizes of tubes, tips or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Definitions

  • the present invention relates to a modular sample holder system which has at least three modules and is suitable for use in analysis devices. It also relates to a method for populating these modules.
  • the present invention is in the technical field of high throughput materials research, particularly high throughput catalyst research. It is known that the use of such high-throughput methods can significantly increase the efficiency or effectiveness in finding new materials for specific purposes. It is among other things important, already when preparing an analysis of the corresponding materials, e.g. B. in the preparation of an analysis of heterogeneous catalysts to significantly increase the speed in the preparation and execution of the analysis, the preparation of the samples for analysis due to the risk of contamination of the samples to be analyzed among themselves, is of particular importance. For example, when preparing z. B. heterogeneous catalysts for a subsequent catalyst screening, it is advantageous to the sample preparation steps such. B. Transfer of the samples into the form necessary for the analysis, to be carried out in simple separate steps, the individual sample holders preferably being equipped with samples separately from one another.
  • Previously known sample holder systems are either specifically adapted to certain analysis devices or are predefined by them with defined dimensions, or are designed in such a way that contamination of the individual samples with one another, in particular during sample loading, cannot be avoided.
  • the present invention was therefore based on the object of providing a device and a method which make it possible to prepare samples for analysis as efficiently as possible and avoid contamination of the samples with one another and thus the parallelized characterization of e.g. B. to make heterogeneous catalysts more flexible and to accelerate them significantly or to enable them in the first place.
  • the present invention thus relates to a modular sample holder system which has at least the following components: (a) at least one first module which is suitable for receiving at least one sample;
  • first modules of a modular sample holder system the first modules being equipped separately from one another with at least one sample, and contamination between the first modules being avoided.
  • the term “module” describes a three-dimensional object that has at least one section.
  • the module can be constructed from one or more materials and can be solid or hollow. It can have any suitable geometric shape. It preferably has two mutually parallel surfaces. An example of such a module is a cuboid or cylinder. However, a large number of similar geometries are also conceivable.
  • the modules can, for example, have an oval, round or polygonal outline with straight or curved connections between the corner points of the polygon. A round or equilateral is preferred polygonal module shape, preferably all first or all second or all third modules have the same geometry.
  • the modules are preferably made from a solid material (which in turn can be constructed from one or more starting materials).
  • the modules can be disc-shaped, for example.
  • Plastics such as PP (polypropylene), PE (polyethylene), PVC (polyvinyl chloride), acrylic glass, Kapton and Teflon;
  • Metals or metal alloys such as brass, aluminum and stainless steel, such as those according to DIN 1.4401, DIN 1.4435, DIN 1.4541, DIN 1.4571, DIN 1.4573, DIN 1.4575, DIN 2.4360 / 2.4366, DIN 2.4615 / 2.4617, DIN 2.4800 / 2.4810, DIN 2.4816, DIN 2.4851, DIN 2.4856, DIN 2.4858, DIN 1.4767, DIN 1.4401, DIN 2.4610, DIN 1.4765, DIN 1.4847, DIN 1.4301 as well as glasses, ceramics, graphite, carbon fiber, quartz glass, oxidic or
  • “Sections” in the context of the present invention are defined locations on or in the modules, such as cavities, which can always be found again due to their coordinates (three-dimensional coordinate system). These locations or sections are suitable for receiving samples in the first modules, for receiving first modules in the second modules and for receiving second modules in the third modules.
  • sample denotes a single defined unit, which is located in the respective separate sections of the modules and which can consist of one or more components or materials.
  • the sample can be produced both outside and inside the first modules, it also being conceivable for partial or pre-production to be carried out outside the first modules in combination with completion of the samples carried out in the first modules, in particular from the point of view that a sample can also be composed of melter components.
  • non gasfb substances such as solids (such as powder or monolithic solids, granules, beads, tablets and other shaped articles), liquids, sols, gels, waxy substances or substance mixtures, dispersions , Emulsions and suspensions, particularly preferably solids.
  • these can be molecular and non-molecular chemical compounds or formulations, or mixtures or materials, the term “non-molecular” defining substances that can be varied or changed continuously, in contrast to "molecular” substances, the structural characteristics of which can only be changed by varying discrete states, for example by varying a substitution pattern.
  • composition of the respective samples comprises both the stoichiometric and the substance and element composition of the materials to be tested, which can vary from material to material. It is therefore possible according to the invention to produce or test material libraries which consist of materials which are identical in terms of their element composition, but the stoichiometric composition of the elements making up the material differs between the individual materials; it is also possible that the material library is made up of materials that differ in their element composition; Of course, it is also possible for the individual materials to differ in their stoichiometric and elemental composition.
  • the material library is constructed from samples which are identical in terms of their element composition and stoichiometric composition, but differ in terms of their physical or chemical or physico-chemical properties as a result of a treatment step.
  • element used here refers to elements of the periodic table of the elements.
  • substrate here means materials, components or precursor components which lead to a material.
  • the samples e.g. heterogeneous or heterogenized catalysts, luminophores, thermoelectric, piezoelectric, semiconducting, electro-optical, superconducting or magnetic substances or mixtures of two or more of these substances, in particular intermetallic compounds, oxides, oxide mixtures, mixed oxides, ionic or covalent compounds of metals and / or non-metals, metal alloys, ceramics, organometallic compounds and composite materials, dielectrics, thermoelectrics, magnetoresistive and magneto-optical materials, organic compounds, enzymes and enzyme mixtures, active pharmaceutical ingredients, substances for feed and feed supplements, substances for food and nutritional supplements and cosmetics and mixtures of two or more oxides can be varied as desired. It is also possible that a variety of catalysts, which are largely similar but differ in their elements in at least one element, can be used to test all catalyst variants using a suitable different element composition.
  • the samples in the material library can be the same or different from one another, the latter being preferred.
  • the at least one second module of the modular sample holding system can have at least two first modules or record, the first modules having the same or different shapes and the same or different materials.
  • the at least one first module of the modular sample holding system preferably has at least one or more sections on one side for receiving one or more samples, the sections in the individual first modules having the same or different shapes.
  • the at least one first module of the modular sample holding system is designed such that it completely encloses the at least one sample.
  • the modular sample holder system can be equipped in such a way that in each individual section there are one or more samples which are the same or different from one another and where there is one sample per section, the samples in the respective sections are the same or different from one another.
  • the modular sample holder system preferably has a number of sections for sample collection in the range from 4 to 1536.
  • the at least one first module is, for example, cuboid, the individual side lengths being in the range from 0.5 mm to 300 mm.
  • the at least one first module is preferably cube-shaped and preferably has an edge length in the range from 10 mm to 30 mm, in particular an edge length of 19 mm.
  • Another embodiment of the modular sample holder system is characterized in that the first, second and third modules have several layers.
  • devices in particular for sample treatment, can be integrated into the layers of the modular sample holding system.
  • devices for sample treatment are understood to mean, for example, devices for heating (for example heating elements) and cooling (for example cooling elements) of the modules or the samples or means for supplying and / or removing fluids.
  • the means for supplying and / or discharging preferably fluid media are preferably implemented through tubular openings or channels, such as, for example, tube and capillary systems or bores, or through porous layers.
  • the means for supply and / or discharge preferably have an angle to the longitudinal plane of the module, which is preferably 90 °. Furthermore, there is the possibility of arranging the supply and discharge lines at an angle to one another and also in different planes, an angle of 90 ° being preferred for this purpose when the supply and discharge lines are arranged in one plane.
  • channel here preferably describes a connection, running through a module, in the present case, for example, a plate or disk, of two openings present on the body surface, which, for example, allows a fluid to pass through the module.
  • the channel can have any geometry. It can have a cross-sectional area that is variable over the length of the channel or, preferably, a constant channel cross-sectional area.
  • the channel cross section can, for example, have an oval, round or polygonal outline with straight or curved connections between the corner points of the polygon. A round or equilateral polygonal cross section is preferred. All channels in the module preferably have the same geometry (cross section and length) and run parallel to one another.
  • the means for supplying and / or discharging the fluid media can also have a membrane.
  • Membranes are preferably to be understood as permeable or semi-permeable closures or regions of a closure, which in principle can be provided with a closure or locking device for opening and closing the membrane.
  • the membrane can also be a pore membrane, the pore membrane having pores with a defined texture for uniform pressure distribution of the fluid media.
  • a “pore membrane” is understood to mean a membrane with preferably a pore system.
  • the pore system can be ordered and / or disordered, directed and / or undirected.
  • pores there are no restrictions with regard to the dimensions and the number of pores insofar as they are suitable for supplying and / or discharging preferably fluid media. Furthermore, they should preferably have a permeability to radiation, for example high-energy electromagnetic radiation such as magnetic fields, light, UV-VIS, XRD and microwaves, and heat radiation.
  • high-energy electromagnetic radiation such as magnetic fields, light, UV-VIS, XRD and microwaves, and heat radiation.
  • the pores preferably have a diameter of 1 to 500 ⁇ m, particularly preferably 5 to 30 ⁇ m and preferably a length of 1 to 1000 ⁇ m, particularly preferably 50 to 200 ⁇ m.
  • the pore diameter and the pore length must be adjusted accordingly.
  • the number of pores per inlet and / or outlet is preferably 1 to 1000, particularly preferably 3 to 20 pores.
  • the pore radius distribution is preferably monomodal. However, multimodal and / or hierarchically organized pore systems can also be implemented.
  • the pores are preferably arranged in parallel and preferably in the direction of the fluid flow. The pores can also be arranged non-straight and connected to interconnectable pore systems.
  • Such pore systems cause a uniform fluid distribution over all sections, which, for. B. compared to binary and quaternary trees, good scalability and higher parallelization can be achieved.
  • all production processes known to the person skilled in the art and suitable for producing the pores described above are suitable as production processes for pores.
  • Examples include: lithographic processes, etching processes, LIGA processes, laser ablation processes, drilling processes, milling processes, eroding processes, lapping processes (such as ultrasonic vibratory lapping), ECM processes, screen printing processes, lithographic electroplating, embossing processes, punching processes, etc.
  • Suitable pore membranes can also be produced by crystallization processes and / or ceramic processes as well as sintering processes and template-based processes.
  • Examples of such pore membranes are: foam ceramics, zeolite membranes, sintered metal frits, glass frits, inorganic porous filter media and many others.
  • the devices for sample treatment of the modular sample holder system described above can also be located outside the first, second and third modules.
  • a further preferred embodiment of the modular sample holding system is characterized in that the first, second and third modules are designed to be self-centering, so that they are predetermined when they are assembled Take positions exactly. This can be ensured, for example, by the respective geometric shapes of the modules.
  • the positions of the individual first, second and third modules within the modular sample holder system as well as the positions and composition of the samples can furthermore be stored by means of a barcode which is attached to the sample holder system.
  • the bar code or bar code which is preferably part of the modules, consists of thick and thin bars or pixels (eg dots or other shapes) arranged according to a specific law of education (code type) and the "white" gaps in between. Bars, dots and / or other shapes or the “gaps” in between can also be provided in the form of recesses in the respective carrier material of the bar code.
  • code type a specific law of education
  • Bars, dots and / or other shapes or the “gaps” in between can also be provided in the form of recesses in the respective carrier material of the bar code.
  • one-dimensional and / or two-dimensional code types such as, for. B.
  • the quality of identification is determined, among other things, by the width and the width ratio (cheap 1: 3) of the thin and thick bars or gaps, their thickness tolerance, the degree of blackening and the edge sharpness of the bars.
  • Identification can also be done by mechanically scanning a shape and / or embossing.
  • the barcode can in principle be attached to the modules by all application or insertion methods known to the person skilled in the art, the respective method being sufficiently resistant to the barcode
  • reaction conditions z. B. high temperature and reactive gas
  • Suitable application and application methods are, for example: adhesive processes, print (printing) processes, engraving processes, lithographic processes, etching processes, LIGA processes, laser ablation processes, drilling processes, milling processes, eroding processes, lapping processes (such as ultrasonic vibratory lapping), ECM processes , Screen printing, etc.
  • a barcode is preferably stuck onto the modules for identification.
  • the method according to the invention for equipping first modules of the modular sample holding system can additionally have the following steps in the assembly as well as alternatively:
  • the assembly of the first modules of the modular sample holder system can be carried out in parallel and / or sequentially, preferably in an automated manner.
  • the modular sample holder system according to the invention is preferably used in analysis devices for combinatorial characterization of the samples with regard to performance properties.
  • "Performance properties" are measurable properties, preferably those of the first or second order, of the samples of a material library, which are recorded within an automated characterization (analysis) with suitable sensors.
  • first-order properties are understood to be as far as possible those properties which are obtained with the aid of physical characterization methods, such as X-ray diffraction, LEED structure elucidation, EDX, X-ray fluorescence analysis; X-ray photoelectron spectroscopy, Auger spectroscopy.
  • physical characterization methods such as X-ray diffraction, LEED structure elucidation, EDX, X-ray fluorescence analysis; X-ray photoelectron spectroscopy, Auger spectroscopy.
  • first-order properties are: atomic distance, element composition, etc.
  • Second-order properties are understood to mean those property values that can be obtained using physicochemical characterization methods, e.g. Nitrogen adsorption (surface dimensions (BET)); TPD (binding strengths of absorbates on surfaces or selective chemisorption - sizes of the surfaces of active centers) are accessible.
  • BET surface dimensions
  • TPD binding strengths of absorbates on surfaces or selective chemisorption - sizes of the surfaces of active centers
  • property expression denotes physical, chemical or physico-chemical states of the individual materials within the material library; examples include: oxidation state, crystallinity, etc.
  • the characterization of the samples for at least one performance property is preferably carried out by a separate analysis station within the analysis.
  • the analysis stations can also be combined. It is also conceivable that a separate analysis device is used for each property to be checked.
  • analysis is to be understood to mean all analysis techniques for characterizing materials within a material library in order to determine their characteristics.
  • thermography examples include: infrared thermography, infrared thermography in combination with mass spectroscopy, mass spectroscopy, GC, LC, HPLC, micro-GC, dispersive FTIR spectroscopy, microwave spectroscopy, Raman spectroscopy, MIR, UV, UV-VIS, NMR, ESR, GC-MS, infrared thermography / Raman spectroscopy, infrared thermography / dispersive FTIR spectroscopy, color detection with chemical indicator / MS, color detection with chemical indicator / GCMS, color detection with chemical indicator / dispersive FTIR spectroscopy , photoacoustic analysis, electronic or electrochemical sensors, tomographic NMR and ESR methods, optical microscopy, scanning electron microscopy, TEM (transmission electron microscopy), SEM (scanning electron microscopy), AFM (atomic force microscopy), STM (scanning tunnel microscopy), X-ray diffractometry and X-ray fluorescence
  • the analysis of the samples for performance properties can be carried out in parallel or sequentially.
  • a device for characterizing materials in at least one sample which has a modular sample holding system.
  • a plurality of first modules are inserted or preferably inserted into a second module after they have been equipped with samples.
  • a second module is preferably inserted or applied in the third module.
  • the insertion or application from one module to another module can be carried out by all connection or joining techniques known to the person skilled in the art, detachable connection or joining techniques being preferred.
  • interlocking connections such as, for example, pin connections, bolt connections, wedge connections, feather key and disc spring connections, tongue and groove connections
  • screw connections spring connections
  • permanent and / or not Permanent adhesive for example with pressure sensitive adhesives, contact adhesives, dispersion adhesives, hot melt adhesives, PVC plastisol, epoxy resin, phenolic resin, polyurethane, silicone resin, cyanoacrylate, diacrylic acid ester
  • magnetic connections permanent magnetic connections, electromagnetic connections
  • the preferably a second module is preferably connected to the third module in a form-fitting manner.
  • first, second and third modules of a modular sample holder system which is characterized in that a plurality of first modules are connected to at least one second module and this second module to at least one third module by means of at least one connection technology.
  • connection technology is selected from the group: form-fit connections, screw connections, spring connections, adhesive connections and magnetic connections.
  • La shows a schematic illustration of first modules in a side view
  • Fig. Lb is a schematic representation of a second module in a side view
  • Fig. Lc is a schematic representation of a cross section of a third module in a side view
  • FIG. 2 shows a schematic representation of a second module with first modules arranged thereon with a square outer contour and one section per first module
  • FIG. 3 shows a schematic illustration of a second module with first modules arranged thereon with a rectangular outer contour and six sections per first module;
  • FIG. 4 shows a schematic representation of a second module with first modules arranged thereon, which are combined from square first modules with one section each and rectangular first modules with three or six sections each;
  • 5 shows a schematic representation of a second module with four first modules arranged thereon, each with a 21 ⁇ 14 matrix of sections; 6 shows a schematic illustration of a second module with honeycomb-shaped first modules arranged thereon.
  • FIG. 1 a shows an embodiment of first modules 100, which in turn each have a section 110 for receiving one or more samples.
  • the first modules 100 shown in FIG. 1 a are cuboid, each first module 100 having a cylindrical section 110 which is introduced into the first module 100 like a bore.
  • FIG. 1b shows an embodiment of a second module 200 which has a section 210 for receiving first modules 100.
  • the second module 200 shown in FIG. 1b is cuboid, the section 210 forming a cuboid recess in the second module 200, which is designed in such a way that it can accommodate a certain number of first modules 100.
  • the depth 220 of the section 210 preferably corresponds to 1/2 to 2/3 of the height 120 of a first module 100.
  • An embodiment is also possible in which the height 120 of a first module 100 1/2 to 2/3 of the depth 220 of the Section 210 corresponds.
  • FIG. 1 c shows an embodiment of a third module 300, which has a section 310 for receiving second modules 200.
  • the third module 300 is preferably designed such that it is suitable for inclusion in an analysis device.
  • the third module 300 has a cuboid section 310, the dimensions of which preferably correspond to the external dimensions of, for example, a second module 200.
  • the third module 300 has a stop 330, wherein the position fixation of the second module 200 within the section 310 can also be ensured by other suitable means.
  • the actual fixing of the second module 200 within the section 310 is preferably carried out with a spring 320. In principle there is also the possibility that more Other second modules 200 are received by the section 310 of the third module 300.
  • the modules 100, 200, 300 are preferably joined together without additional clamping means, a corresponding tolerance in the external dimensions of the modules 100, 200, 300 ensuring that the respective outer shapes of the modules can be easily joined to one another.
  • FIG. 2 shows a possible combination of twenty-four first modules 100 with a square outer contour, each first module 100 having a cylindrical section 110.
  • the first modules 100 are inserted in the form of a 6 ⁇ 4 matrix in the section 210 of a second module 200.
  • FIG. 3 shows a further possible combination of first modules 100.
  • first modules 100 there are four first modules 100, each with six cylindrical sections 110, which are inserted into section 210 of a second module 200.
  • first modules 100 shown in FIG. 4 represents a combination of the possible combinations from FIGS. 2 and 3, the shape and number of sections 110 additionally being varied.
  • twelve first modules 100 with a square outer contour and one section 110 per first module 100 were combined with two first modules 100 with a rectangular outer contour and three or six sections 110 per first module 100 in a section 210 of a second module 200 .
  • Six of the twelve first modules 100 with a square outer contour have cylindrical sections 110 and six cuboid, preferably cube-shaped sections 110.
  • the three sections 110 of a rectangular first module 100 are cuboid, the six sections 110 of the further rectangular first module 100 are cylindrical.
  • each first module 100, 294 having cylindrical sections 110 in the form of a 21 ⁇ 14 matrix.
  • the four first modules 100 are inserted adjacent to one another in the section 210 of a second module 200.
  • each of the first modules 100 has a cylindrical section 110.
  • thirty-two first modules 100 are inserted in the section 210 of a second module 200.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

L'invention concerne un système porte-échantillons modulaire qui comprend au moins les composants suivants : (a) au moins un premier module qui est conçu pour recevoir un échantillon ; (b) au moins un second module qui est conçu pour recevoir au moins un premier module ; et (c) au moins un troisième module qui est conçu pour recevoir au moins un second module.
PCT/EP2004/005678 2003-05-28 2004-05-26 Systeme porte-echantillons modulaire WO2004105951A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10324397.6 2003-05-28
DE2003124397 DE10324397A1 (de) 2003-05-28 2003-05-28 Modulares Probenhalterungssystem
DE10333545.5 2003-07-23
DE2003133545 DE10333545A1 (de) 2003-07-23 2003-07-23 Modulares Probenhalterungssystem

Publications (1)

Publication Number Publication Date
WO2004105951A1 true WO2004105951A1 (fr) 2004-12-09

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