WO2004099245A1 - Interferon-$g(y) stabilise - Google Patents

Interferon-$g(y) stabilise Download PDF

Info

Publication number
WO2004099245A1
WO2004099245A1 PCT/EP2004/004677 EP2004004677W WO2004099245A1 WO 2004099245 A1 WO2004099245 A1 WO 2004099245A1 EP 2004004677 W EP2004004677 W EP 2004004677W WO 2004099245 A1 WO2004099245 A1 WO 2004099245A1
Authority
WO
WIPO (PCT)
Prior art keywords
interferon
amino acid
polyethylene glycol
homologous
cysteine
Prior art date
Application number
PCT/EP2004/004677
Other languages
German (de)
English (en)
Inventor
Herwig Brunner
Hayssam Zakaria
Bernd Otto
Tobias Thomas
Florian Battermann
Marco Kresin
Andreas Busche
Christian Schmalz
Original Assignee
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. filed Critical Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
Publication of WO2004099245A1 publication Critical patent/WO2004099245A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne un interféron-Ω stabilisé. L'interféron-Ω selon l'invention est modifié sur un ou plusieurs de ses acides aminés comportant des groupes latéraux thiol ou amino, au moyen de polyéthylène glycol. Les acides aminés cystéine, asparagine, glutamine, lysine, arginine et/ou histidine sont particulièrement adaptés à une telle modification.
PCT/EP2004/004677 2003-05-05 2004-05-03 Interferon-$g(y) stabilise WO2004099245A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10320223 2003-05-05
DE10320223.4 2003-05-05

Publications (1)

Publication Number Publication Date
WO2004099245A1 true WO2004099245A1 (fr) 2004-11-18

Family

ID=33426684

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/004677 WO2004099245A1 (fr) 2003-05-05 2004-05-03 Interferon-$g(y) stabilise

Country Status (1)

Country Link
WO (1) WO2004099245A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA020220B1 (ru) * 2011-12-21 2014-09-30 Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") Ковалентный конъюгат полиэтиленгликоля с полипептидом, имеющим активность интерферона-гамма

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991001758A1 (fr) * 1989-08-07 1991-02-21 Debiopharm S.A. Derives polymeres de subtances medicamenteuses biologiquement actifs
US5567422A (en) * 1993-02-02 1996-10-22 Enzon, Inc. Azlactone activated polyalkylene oxides conjugated to biologically active nucleophiles
WO1999003887A1 (fr) * 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derives d'hormone de croissance et proteines associees
WO2001036001A2 (fr) * 1999-11-12 2001-05-25 Maxygen Holdings Ltd Conjugues d'interferon gamma

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991001758A1 (fr) * 1989-08-07 1991-02-21 Debiopharm S.A. Derives polymeres de subtances medicamenteuses biologiquement actifs
US5567422A (en) * 1993-02-02 1996-10-22 Enzon, Inc. Azlactone activated polyalkylene oxides conjugated to biologically active nucleophiles
WO1999003887A1 (fr) * 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derives d'hormone de croissance et proteines associees
WO2001036001A2 (fr) * 1999-11-12 2001-05-25 Maxygen Holdings Ltd Conjugues d'interferon gamma

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TANG WEI ET AL: "Studies on the PEGylation of protein at a specific site: sulfhydryl-PEGylation of 97 Cys-IFN-.gamma", 1997, STN CAPLUS, XP002937792 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA020220B1 (ru) * 2011-12-21 2014-09-30 Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") Ковалентный конъюгат полиэтиленгликоля с полипептидом, имеющим активность интерферона-гамма

Similar Documents

Publication Publication Date Title
DE69935345T3 (de) Methoden und zusammensetzungen zur prävention und behandlung der anämie
EP1161452B1 (fr) Dimeres d'insuline pontes de maniere covalente
DE69034179T2 (de) Expressionssysteme für ein amidierendes Enzym
DE60224415T2 (de) Pegyliertes und diglykosyliertes erythropoietin
DE69722397T2 (de) Insulin-derivate und ihre verwendung
DE69736712T2 (de) Verfahren zur milderung von neuropatischen schmerz mit prosaposin verwandten peptiden
DE60117919T2 (de) Fusionsprotein mit verbesserter in vivo erythropoietinwirkung
EP0769020B1 (fr) Nouvelles proteines mutantes de l'il-4 humaine utilisees comme antagonistes ou agonistes partiels de l'interleukine humaine 4
DE69635675T2 (de) Verkürzter aus einer gliazelllinie gewonnener neurotropher faktor
DD268976A5 (de) Verfahren zur Herstellung von Humaninsulinanaloga
DE102008003566A1 (de) Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
Kostyo et al. Biosynthetic 20-kilodalton methionyl-human growth hormone has diabetogenic and insulin-like activities.
DE69434909T2 (de) Herstellung von humaninsulin
DE60019147T2 (de) Fibrinolytisch wirksames polypeptid
DE3104949A1 (de) Verfahren zur herstellung von threonin(pfeil hoch)b(pfeil hoch)(pfeil hoch)3(pfeil hoch)(pfeil hoch)0(pfeil hoch)-estern menschlichen insulins sowie threonin(pfeil hoch)b(pfeil hoch)(pfeil hoch)3(pfeil hoch)(pfeil hoch)0(pfeil hoch)-ester menschlichen insulins
Gottschall et al. Interleukin-1 beta is more potent than interleukin-1 alpha in supressing follicle-stimulating hormone-induced differentiation of ovarian granulosa cells
EP1084248B1 (fr) Nouveaux analogues de l'insuline presentant un pouvoir de liaison accru avec le zinc
EP0427162A1 (fr) Nouveaux dérivés de l'insuline, leur préparation, leur usage et une composition pharmaceutique les contenant
DE4036856C1 (fr)
DE69636052T2 (de) Mpl-liganden analoga
DE3536939A1 (de) Biologisch aktive derivate des human-(gamma)-interferons, ihre herstellung und arzneimittel, die solche derivate enthalten
EP0089007B1 (fr) Procédé de transformation d'analogues de préproinsulines en insulines
WO2004099245A1 (fr) Interferon-$g(y) stabilise
EP0110294B1 (fr) Agent pour traitement d'ostéoporose
EP0447468B1 (fr) Proteines d'ancrod, leur production et utilisation

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase