WO2004089889A2 - Verfahren zur herstellung von riboflavin der modifikation b/c in granulatform - Google Patents
Verfahren zur herstellung von riboflavin der modifikation b/c in granulatform Download PDFInfo
- Publication number
- WO2004089889A2 WO2004089889A2 PCT/EP2004/003689 EP2004003689W WO2004089889A2 WO 2004089889 A2 WO2004089889 A2 WO 2004089889A2 EP 2004003689 W EP2004003689 W EP 2004003689W WO 2004089889 A2 WO2004089889 A2 WO 2004089889A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- riboflavin
- fluidized bed
- range
- precipitation
- temperature
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/12—Heterocyclic compounds containing pteridine ring systems containing pteridine ring systems condensed with carbocyclic rings or ring systems
- C07D475/14—Benz [g] pteridines, e.g. riboflavin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
Definitions
- EP-A 0457075 describes a process for the production of free-flowing, non-dusting and binder-free riboflavin spray granules or microgranules from pure riboflavin.
- An aqueous or water-containing suspension of pure, finely divided riboflavin is spray-dried in a fluidized bed, subjected to single-substance atomization drying or disc atomization drying.
- the riboflavin that can be produced by the process steps according to the invention is obtained in the form of agglomerates. These have a high density and a smooth surface and are distinguished, above all in view of the processing which is usually still necessary, by considerable advantages over conventional spherical riboflavin crystals.
- the conventional crystals sometimes have a spiky surface (see EP-A 0995749) and are not very stable to shear. This property, which is unfavorable for the process control, favors the growth of needle-shaped crystals and poor process stability and poor filtration and handling properties.
- the riboflavin suspension is subjected to fluidized-bed spray granulation to dry it.
- the suspension is sprayed continuously or discontinuously into a fluidized bed of dry reaction product in the fluidized bed spray granulation used according to the invention.
- the drying device is provided with devices which allow a specific particle size fraction to be obtained and the granulation process to be maintained (cf. K. Kroll, drying technology, Volume II, "Dryer and drying process", Springer, Berlin, 1978, 221-223).
- the aqueous or water-containing suspension of finely divided riboflavin is continuously sprayed into a fluidized bed.
- the rate of spraying is adjusted so that the fluidized bed has a temperature corresponding to the desired degree of drying. It is determined by the difference between the inlet and outlet temperatures of the fluidizing gas blown into the dryer. If the process is carried out continuously, fine particle riboflavin in the fluidized bed is assumed only when the fluidized bed dryer is started up for the first time. Then you get a dry product with an almost constant particle size distribution. From this, a certain part of the desired particle size fractions is advantageously taken continuously or intermittently.
- the particle fraction in the particle size range from approximately 50 to approximately 450 ⁇ m is discharged as a product of value and the fine particles and / or the fine particles obtained by grinding larger particles are continuously returned to the fluidized bed in order to maintain the granulation processes.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Glanulating (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/552,137 US7329748B2 (en) | 2003-04-11 | 2004-04-07 | Method for the production of riboflavin of modification b/c in granular form |
EP04726106A EP1615927A2 (de) | 2003-04-11 | 2004-04-07 | Verfahren zur herstellung von riboflavin der modifikation b/c in granulatform |
CA002521633A CA2521633A1 (en) | 2003-04-11 | 2004-04-07 | Method for the production of riboflavin of modification b/c in granular form |
JP2006505032A JP2006522763A (ja) | 2003-04-11 | 2004-04-07 | 顆粒形態のb/c変態型リボフラビンの調製方法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2003117051 DE10317051A1 (de) | 2003-04-11 | 2003-04-11 | Verfahren zur Herstellung von Riboflavin der Modifikation B/C in Granulatform |
DE10317051.0 | 2003-04-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004089889A2 true WO2004089889A2 (de) | 2004-10-21 |
WO2004089889A3 WO2004089889A3 (de) | 2005-06-02 |
Family
ID=33016306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2004/003689 WO2004089889A2 (de) | 2003-04-11 | 2004-04-07 | Verfahren zur herstellung von riboflavin der modifikation b/c in granulatform |
Country Status (8)
Country | Link |
---|---|
US (1) | US7329748B2 (de) |
EP (1) | EP1615927A2 (de) |
JP (1) | JP2006522763A (de) |
KR (1) | KR20060006028A (de) |
CN (1) | CN100334087C (de) |
CA (1) | CA2521633A1 (de) |
DE (1) | DE10317051A1 (de) |
WO (1) | WO2004089889A2 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104961740B (zh) * | 2015-06-02 | 2016-04-27 | 湖北广济药业股份有限公司 | 一种含核黄素的固体制剂及其制备方法 |
CN113929683A (zh) * | 2021-11-15 | 2022-01-14 | 天津大学 | 一种提高核黄素晶体堆密度和流动性的方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0307767A1 (de) * | 1987-09-18 | 1989-03-22 | F. Hoffmann-La Roche Ag | Neue Form des Riboflavins |
EP0457075A2 (de) * | 1990-05-04 | 1991-11-21 | BASF Aktiengesellschaft | Verfahren zur Herstellung von rieselfähigen, nichtstaubenden bindemittelfreien Riboflavinsprühgranulaten oder -mikrogranulaten aus reinem Riboflavin |
EP0730034A1 (de) * | 1995-03-03 | 1996-09-04 | F. Hoffmann-La Roche Ag | Reinigung von Riboflavin |
EP0995749A1 (de) * | 1998-10-19 | 2000-04-26 | F. Hoffmann-La Roche Ag | Reinigungs- und Kristallisationsverfahren für Riboflavin |
EP1048668A2 (de) * | 1999-04-30 | 2000-11-02 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von Riboflavinsprühgranulaten |
-
2003
- 2003-04-11 DE DE2003117051 patent/DE10317051A1/de not_active Withdrawn
-
2004
- 2004-04-07 EP EP04726106A patent/EP1615927A2/de not_active Withdrawn
- 2004-04-07 WO PCT/EP2004/003689 patent/WO2004089889A2/de not_active Application Discontinuation
- 2004-04-07 KR KR1020057019236A patent/KR20060006028A/ko not_active Application Discontinuation
- 2004-04-07 JP JP2006505032A patent/JP2006522763A/ja not_active Withdrawn
- 2004-04-07 CA CA002521633A patent/CA2521633A1/en not_active Abandoned
- 2004-04-07 CN CNB2004800097641A patent/CN100334087C/zh not_active Expired - Fee Related
- 2004-04-07 US US10/552,137 patent/US7329748B2/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0307767A1 (de) * | 1987-09-18 | 1989-03-22 | F. Hoffmann-La Roche Ag | Neue Form des Riboflavins |
EP0457075A2 (de) * | 1990-05-04 | 1991-11-21 | BASF Aktiengesellschaft | Verfahren zur Herstellung von rieselfähigen, nichtstaubenden bindemittelfreien Riboflavinsprühgranulaten oder -mikrogranulaten aus reinem Riboflavin |
EP0730034A1 (de) * | 1995-03-03 | 1996-09-04 | F. Hoffmann-La Roche Ag | Reinigung von Riboflavin |
EP0995749A1 (de) * | 1998-10-19 | 2000-04-26 | F. Hoffmann-La Roche Ag | Reinigungs- und Kristallisationsverfahren für Riboflavin |
EP1048668A2 (de) * | 1999-04-30 | 2000-11-02 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von Riboflavinsprühgranulaten |
Also Published As
Publication number | Publication date |
---|---|
CA2521633A1 (en) | 2004-10-21 |
CN100334087C (zh) | 2007-08-29 |
US7329748B2 (en) | 2008-02-12 |
KR20060006028A (ko) | 2006-01-18 |
CN1774438A (zh) | 2006-05-17 |
US20060258664A1 (en) | 2006-11-16 |
WO2004089889A3 (de) | 2005-06-02 |
EP1615927A2 (de) | 2006-01-18 |
JP2006522763A (ja) | 2006-10-05 |
DE10317051A1 (de) | 2004-10-21 |
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