WO2004089415A3 - Therapie combinatoire utilisant un inhibiteur de 11$g(b)-hydroxysteroide deshydrogenase de type 1 et agoniste du recepteur de glucocorticoides pour minimiser les effets secondaires associes a la therapie a base d'agoniste du recepteur de glucocorticoides - Google Patents

Therapie combinatoire utilisant un inhibiteur de 11$g(b)-hydroxysteroide deshydrogenase de type 1 et agoniste du recepteur de glucocorticoides pour minimiser les effets secondaires associes a la therapie a base d'agoniste du recepteur de glucocorticoides Download PDF

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WO2004089415A3
WO2004089415A3 PCT/DK2004/000248 DK2004000248W WO2004089415A3 WO 2004089415 A3 WO2004089415 A3 WO 2004089415A3 DK 2004000248 W DK2004000248 W DK 2004000248W WO 2004089415 A3 WO2004089415 A3 WO 2004089415A3
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WIPO (PCT)
Prior art keywords
receptor agonist
inhibitor
hydroxysteroid dehydrogenase
glucocorticoid receptor
combinations
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PCT/DK2004/000248
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English (en)
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WO2004089415A2 (fr
Inventor
Gita Camilla Tejlgaard Kampen
Henrik Sune Andersen
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Novo Nordisk As
Gita Camilla Tejlgaard Kampen
Henrik Sune Andersen
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Publication date
Application filed by Novo Nordisk As, Gita Camilla Tejlgaard Kampen, Henrik Sune Andersen filed Critical Novo Nordisk As
Priority to EP04725890A priority Critical patent/EP1615667A2/fr
Priority to JP2006504351A priority patent/JP2006522744A/ja
Publication of WO2004089415A2 publication Critical patent/WO2004089415A2/fr
Publication of WO2004089415A3 publication Critical patent/WO2004089415A3/fr
Priority to US11/246,814 priority patent/US20060094699A1/en
Priority to US12/491,659 priority patent/US20090264412A1/en

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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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Abstract

L'invention concerne une thérapie combinatoire comprenant l'administration d'un inhibiteur de 11β-hydroxystéroïde déshydrogénase de type 1 et d'un agoniste du récepteur de glucocorticoïdes destinée au traitement de certaines formes de cancer, de maladies et de troubles dont l'inflammation est une composante, et permettant de minimiser les effets secondaires associés à la thérapie à base d'agoniste du récepteur de glucocorticoïdes.
PCT/DK2004/000248 2003-04-11 2004-04-06 Therapie combinatoire utilisant un inhibiteur de 11$g(b)-hydroxysteroide deshydrogenase de type 1 et agoniste du recepteur de glucocorticoides pour minimiser les effets secondaires associes a la therapie a base d'agoniste du recepteur de glucocorticoides WO2004089415A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP04725890A EP1615667A2 (fr) 2003-04-11 2004-04-06 Therapie combinatoire utilisant un inhibiteur de 11beta-hydroxysteroide deshydrogenase de type 1 et agoniste du recepteur de glucocorticoides
JP2006504351A JP2006522744A (ja) 2003-04-11 2004-04-06 グルココルチコイド受容体アゴニスト療法に伴う副作用を最小化するための、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤およびグルココルチコイド受容体アゴニストを使用する併用療法
US11/246,814 US20060094699A1 (en) 2003-04-11 2005-10-07 Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy
US12/491,659 US20090264412A1 (en) 2003-04-11 2009-06-25 Combination Therapy Using An 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor And A Glucocorticoid Receptor Agonist To Minimize The Side Effects Associated With Glucocorticoid Receptor Agonist Therapy

Applications Claiming Priority (58)

Application Number Priority Date Filing Date Title
DKPA200300566 2003-04-11
DKPA200300571 2003-04-11
DKPA200300568 2003-04-11
DKPA200300566 2003-04-11
DKPA200300565 2003-04-11
DKPA200300565 2003-04-11
DKPA200300568 2003-04-11
DKPA200300569 2003-04-11
DKPA200300569 2003-04-11
DKPA200300570 2003-04-11
DKPA200300571 2003-04-11
DKPA200300570 2003-04-11
US46780003P 2003-05-02 2003-05-02
US46736203P 2003-05-02 2003-05-02
US46744303P 2003-05-02 2003-05-02
US46745303P 2003-05-02 2003-05-02
US46736303P 2003-05-02 2003-05-02
US46728403P 2003-05-02 2003-05-02
US60/467,443 2003-05-02
US60/467,362 2003-05-02
US60/467,453 2003-05-02
US60/467,800 2003-05-02
US60/467,284 2003-05-02
US60/467,363 2003-05-02
DKPA200300778 2003-05-22
DKPA200300776 2003-05-22
DKPA200300776 2003-05-22
DKPA20030778 2003-05-22
US47515703P 2003-06-02 2003-06-02
US47519503P 2003-06-02 2003-06-02
US60/475,195 2003-06-02
US60/475,157 2003-06-02
DKPA200300972 2003-06-27
DKPA200300972 2003-06-27
DKPA200300990 2003-06-30
DKPA200300989 2003-06-30
DKPA200300988 2003-06-30
DKPA200300990 2003-06-30
DKPA200300988 2003-06-30
DKPA200300989 2003-06-30
DKPA200300998 2003-07-02
DKPA200300998 2003-07-02
US48609403P 2003-07-10 2003-07-10
US48609703P 2003-07-10 2003-07-10
US48609803P 2003-07-10 2003-07-10
US48607803P 2003-07-10 2003-07-10
US48609503P 2003-07-10 2003-07-10
US60/486,078 2003-07-10
US60/486,094 2003-07-10
US60/486,097 2003-07-10
US60/486,095 2003-07-10
US60/486,098 2003-07-10
DKPA200301910 2003-12-22
DKPA200301910 2003-12-22
DKPA200400009 2004-01-06
DKPA200400009 2004-01-06
US53709904P 2004-01-16 2004-01-16
US60/537,099 2004-01-16

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/246,814 Continuation US20060094699A1 (en) 2003-04-11 2005-10-07 Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy

Publications (2)

Publication Number Publication Date
WO2004089415A2 WO2004089415A2 (fr) 2004-10-21
WO2004089415A3 true WO2004089415A3 (fr) 2005-03-10

Family

ID=33163367

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2004/000248 WO2004089415A2 (fr) 2003-04-11 2004-04-06 Therapie combinatoire utilisant un inhibiteur de 11$g(b)-hydroxysteroide deshydrogenase de type 1 et agoniste du recepteur de glucocorticoides pour minimiser les effets secondaires associes a la therapie a base d'agoniste du recepteur de glucocorticoides

Country Status (3)

Country Link
EP (1) EP1615667A2 (fr)
JP (1) JP2006522744A (fr)
WO (1) WO2004089415A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
US8927549B2 (en) 2008-11-21 2015-01-06 High Point Pharmaceuticals, Llc Adamantyl benzamide derivatives
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9402831B2 (en) 2011-11-14 2016-08-02 Synta Pharmaceutical Corp. Combination therapy of HSP90 inhibitors with BRAF inhibitors

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04009329A (es) 2002-03-26 2005-01-25 Boehringer Ingelheim Pharma Mimeticos de glucocorticoides, metodos para su preparacion, composiciones farmaceuticas y usos de los mismos.
ATE467616T1 (de) * 2003-04-11 2010-05-15 High Point Pharmaceuticals Llc Verbindungen mit aktivität an der 11beta- hydroxasteroiddehydrogenase
SE0301232D0 (sv) * 2003-04-25 2003-04-25 Astrazeneca Ab Novel use
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7563905B2 (en) 2004-03-12 2009-07-21 Wyeth Triazole derivatives and method of using the same to treat HIV infections
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
CA2565630C (fr) 2004-05-07 2013-05-28 Janssen Pharmaceutica N.V. Utilisation de derives de pyrrolidin-2-one et de piperidin-2-one comme inhibiteurs de la 11-beta-hydroxysteroide deshydrogenase
EP1778652A2 (fr) * 2004-08-20 2007-05-02 EntreMed, Inc. Compositions et procedes comportant des antagonistes de recepteur active par la proteinase
DE602005017159D1 (de) 2004-08-30 2009-11-26 Janssen Pharmaceutica Nv Oxysteroid-dehydrogenase-inhibitoren
JP5208505B2 (ja) 2004-08-30 2013-06-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ １１−ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのｎ−２アダマンタニル−２−フェノキシ−アセトアミド誘導体
WO2006024628A1 (fr) 2004-08-30 2006-03-09 Janssen Pharmaceutica N.V. Derives de lactame tricyclique utilises en tant qu'inhibiteurs de 11-beta-hydroxysteroide deshydrogenase
US20090036484A1 (en) * 2004-10-29 2009-02-05 Astrazeneca Ab Use of Unsaturated Quionoline or Naphtalene Derivatives as Medicaments
JP4954083B2 (ja) 2004-11-18 2012-06-13 シンタ ファーマスーティカルズ コーポレイション Ｈｓｐ９０活性を調節するトリアゾール化合物
US7741361B2 (en) 2004-12-27 2010-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
BRPI0610459A2 (pt) 2005-04-05 2010-06-22 Hoffmann La Roche composto, processo para a sua preparação, composições farmacêuticas que o compreendem, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por inibidores de deidrogenase de hidroxiesteróides-11b e utilização do composto
CA2610172A1 (fr) * 2005-06-08 2006-12-14 Japan Tobacco Inc. Compose heterocyclique
EP2314574A1 (fr) * 2005-06-17 2011-04-27 Apogee Biothechnology Corporation Inhibiteurs de la sphingosine kinase
CA2618628C (fr) 2005-08-18 2014-11-18 Synta Pharmaceuticals Corp. Derives de triazole modulant l'activite de hsp90
US7622492B2 (en) 2005-08-31 2009-11-24 Hoffmann-La Roche Inc. Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase
TW200734313A (en) * 2006-01-17 2007-09-16 Astrazeneca Ab Piperazines and piperidines as mGluR5 potentiators
WO2007082808A2 (fr) 2006-01-18 2007-07-26 F. Hoffmann-La Roche Ag Thiazoles en tant qu'inhibiteurs de 11 beta-hsd1
DK1999114T3 (en) 2006-03-22 2015-08-03 Hoffmann La Roche Pyrazoles AS 11-BETA-HSD-1
EP1998760A2 (fr) * 2006-03-30 2008-12-10 James E. Summerton Compositions outils oncologiques et procédés d'utilisation pour détecter et traiter des tumeurs
US8034834B2 (en) 2006-05-25 2011-10-11 Synta Pharmaceuticals Corp. Method for treating proliferative disorders with HSP90 inhibitors
EP2038262B1 (fr) 2006-05-25 2014-11-12 Synta Pharmaceuticals Corp. Composés de triazole qui modulent l'activité de la hsp90
US8115005B2 (en) 2006-08-04 2012-02-14 Decode Genetics Ehf. Pyrazolylphenyl and pyrrolylphenyl inhibitors of LTA4H for treating inflammation
TW200823215A (en) 2006-08-04 2008-06-01 Merz Pharma Gmbh & Amp Co Kgaa Pyrazolopyrimidines, a process for their preparation and the use as a medicine
US7727978B2 (en) 2006-08-24 2010-06-01 Bristol-Myers Squibb Company Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
EP2086970B1 (fr) 2006-08-24 2014-02-26 Novartis AG Dérivés de 2-(pyrazin-2-yl)-thiazole et de 2-(1h pyrazol-3-yl)-thiazole et composés similaires en tant qu' inhibiteurs de stearoyl-coa desaturase (scd) pour le traitement de maladies metaboliques, cardiovasculaires et d'autres maladies
WO2008029168A2 (fr) * 2006-09-08 2008-03-13 Summit Corporation Plc Traitement de la dystrophie musculaire de duchenne
JP5351025B2 (ja) 2006-09-22 2013-11-27 ノバルティス アーゲー ヘテロ環式有機化合物
RU2470040C2 (ru) * 2006-10-17 2012-12-20 Ратджерс, Те Стейт Юниверсити Оф Нью Джерси N-замещенные мономеры и полимеры
WO2008070507A2 (fr) 2006-12-06 2008-06-12 Boehringer Ingelheim International Gmbh Substances mimétiques de glucocorticoïde, procédés de préparation de celles-ci, compositions pharmaceutiques et utilisations de celles-ci
BRPI0720452A2 (pt) 2006-12-20 2014-01-14 Novartis Ag Compostos orgânicos
EA016951B1 (ru) 2007-02-23 2012-08-30 ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи N-АДАМАНТИЛБЕНЗАМИДЫ В КАЧЕСТВЕ ИНГИБИТОРОВ 11-β-ГИДРОКСИСТЕРОИДДЕГИДРОГЕНАЗЫ
EP2125704A1 (fr) 2007-02-23 2009-12-02 High Point Pharmaceuticals, LLC N-adamantyl benzamides utilisés en tant qu'inhibiteurs de la 11-bêta-hydroxystéroïde déshydrogénase
US20110003852A1 (en) 2007-02-23 2011-01-06 Soren Ebdrup N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
WO2008121126A1 (fr) * 2007-03-30 2008-10-09 Summerton James E Molécules non-peptidiques pour la détection et le traitement des tumeurs
CA2681582C (fr) 2007-03-30 2015-07-14 Amgen Inc. Procedes de traitement de troubles intestinaux
WO2008134035A1 (fr) * 2007-04-27 2008-11-06 Panacos Pharmaceuticals, Inc. DÉRIVÉS D'AMIDE PYRIMIDINE ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-α] À SUBSTITUTION ALPHA
CA2693457C (fr) 2007-07-17 2012-10-23 F. Hoffmann-La Roche Ag Inhibiteurs de 11b-hydroxysteroide deshydrogenase
CA2694224A1 (fr) * 2007-07-25 2009-01-29 Boehringer Ingelheim International Gmbh Mimetiques de glucocorticoides, leurs procedes de production, compositions pharmaceutiques et utilisations associees
US8119658B2 (en) 2007-10-01 2012-02-21 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
FR2929851B1 (fr) * 2008-04-09 2012-11-30 Centre Nat Rech Scient Molecules inhibant une voie metabolique impliquant la proteine tyrosine kinase syk et procede d'identification de ces molecules
AU2009256289A1 (en) 2008-06-06 2009-12-10 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
CN103965200B (zh) 2008-09-22 2016-06-08 阵列生物制药公司 作为trk激酶抑制剂的取代的咪唑并[1,2-b]哒嗪化合物
US8536185B2 (en) * 2008-09-22 2013-09-17 Cayman Chemical Company, Incorporated Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases
MX2011004258A (es) 2008-10-22 2011-06-01 Merck Sharp & Dohme Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos.
LT3372605T (lt) 2008-10-22 2022-02-10 Array Biopharma, Inc. Pakeistieji pirazolo[1,5-a]pirimidino junginiai, kaip trk kinazės inhibitoriai
CA2741672A1 (fr) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Nouveaux agents antidiabetiques utiles avec des derives de benzimidazole cycliques
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
US9062076B2 (en) * 2009-10-22 2015-06-23 Fibrotech Therapeutics Pty Ltd Fused ring analogues of anti-fibrotic agents
CA2786314A1 (fr) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Nouveaux derives benzimidazole cycliques utiles comme agents antidiabetiques
EP2560640A1 (fr) 2010-04-19 2013-02-27 Synta Pharmaceuticals Corp. Thérapie anticancéreuse à l'aide d'une combinaison d'un composé inhibiteur de hsp90 et d'un inhibiteur d'egfr
KR102132405B1 (ko) 2010-05-20 2020-07-09 어레이 바이오파마 인크. Trk 키나제 저해제로서의 매크로시클릭 화합물
AU2011202542A1 (en) * 2010-07-14 2012-02-02 Indian Institute Of Science Benzothiophene carboxamide compounds, composition and applications thereof
FR2962649A1 (fr) 2010-07-19 2012-01-20 Conservatoire Nat Arts Et Metiers Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide
WO2012015715A1 (fr) 2010-07-27 2012-02-02 High Point Pharmaceuticals, Llc Dérivés de thiazol-2-ylamine substitués, compositions pharmaceutiques et procédés d'utilisation en tant que modulateurs de 11-bêta-hsd1
KR101668514B1 (ko) 2011-02-25 2016-10-21 머크 샤프 앤드 돔 코포레이션 항당뇨병제로서 유용한 신규 시클릭 아자벤즈이미다졸 유도체
CA2853799A1 (fr) 2011-11-02 2013-05-10 Synta Pharmaceuticals Corp. Therapie anticancereuse utilisant une combinaison d'inhibiteurs de hsp 90 et d'inhibiteurs de topoisomerase i
CA2853806C (fr) 2011-11-02 2020-07-14 Synta Pharmaceuticals Corp. Polytherapie d'inhibiteurs de hsp 90 avec des agents contenant du platine
JO3407B1 (ar) * 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
JP2015525782A (ja) 2012-08-02 2015-09-07 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 抗糖尿病性三環式化合物
US10092574B2 (en) 2012-09-26 2018-10-09 Valorisation-Recherche, Limited Partnership Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
RU2015140066A (ru) 2013-02-22 2017-03-30 Мерк Шарп И Доум Корп. Противодиабетические бициклические соединения
BR112015021886A2 (pt) 2013-03-13 2017-07-18 Unilever Nv composição de fotoproteção para cuidados pessoais, método de aumentar a proteção e método para diminuir a produção de sebo na pele
CN105377374B (zh) 2013-03-13 2019-05-28 荷兰联合利华有限公司 具有三环癸烷甲酰胺类化合物的化妆品组合物
CN105007885B (zh) 2013-03-13 2018-06-26 荷兰联合利华有限公司 个人护理组合物中某些芳香组分的延长递送
US9650375B2 (en) 2013-03-14 2017-05-16 Merck Sharp & Dohme Corp. Indole derivatives useful as anti-diabetic agents
CN103420931B (zh) * 2013-05-02 2015-07-08 范国煌 调节巨噬细胞极化并抗糖尿病的五环化合物及其应用
GB201317363D0 (en) 2013-10-01 2013-11-13 Eisai Ltd Novel compounds
WO2015051496A1 (fr) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Composés tricycliques antidiabétiques
CA2930085C (fr) 2013-12-09 2021-11-02 Unilever Plc Procede de fabrication d'adamantanamides
US9381171B2 (en) 2013-12-19 2016-07-05 Samsung Electronics Co., Ltd. Composition including dapsone for preventing or treating side effect of steroid in subject and use of the composition
MX2016015062A (es) 2014-05-23 2017-02-27 Hoffmann La Roche Compuestos de 5-cloro-2-difluorometoxifenil pirazolopirimidina los cuales son inhibidores de janus cinasas (jak).
KR102529578B1 (ko) 2014-08-29 2023-05-09 (주)아모레퍼시픽 신규 아다만탄 유도체 화합물
UY36390A (es) * 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
JP2017538678A (ja) 2014-11-05 2017-12-28 フレクサス・バイオサイエンシーズ・インコーポレイテッドＦｌｅｘｕｓ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． 免疫調節剤
RS64122B1 (sr) 2014-11-16 2023-05-31 Array Biopharma Inc Kristalni oblik (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroksipirolidin-1-karboksamid hidrogensulfata
BR112018008357A2 (pt) 2015-10-26 2018-11-27 Array Biopharma Inc mutações de ponto em câncer resistente a inibidor de trk e métodos relacionados às mesmas
CA3010615C (fr) 2016-01-14 2024-02-20 Beth Israel Deaconess Medical Center, Inc. Modulateurs de mastocytes et leurs utilisations
AU2017246554B2 (en) 2016-04-04 2022-08-18 Loxo Oncology, Inc. Liquid formulations of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
HRP20230704T1 (hr) 2016-05-18 2023-10-27 Loxo Oncology, Inc. Priprava (s)-n-(5-((r)-2-(2,5-difluorfenil)pirolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroksipirolidin-1-karboksamida
JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
WO2018086531A1 (fr) * 2016-11-08 2018-05-17 正大天晴药业集团股份有限公司 Composé de sulfonamides en tant qu'inhibiteur d'adnccc
EP3548035A4 (fr) 2016-11-30 2020-07-22 Case Western Reserve University Combinaisons d'inhibiteurs de 15-pgdh avec des corcostéroïdes et/ou des inhibiteurs du tnf et leurs utilisations
WO2018106518A1 (fr) 2016-12-06 2018-06-14 Merck Sharp & Dohme Corp. Composés hétérocycliques antidiabétiques
US10968232B2 (en) 2016-12-20 2021-04-06 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
WO2018145080A1 (fr) * 2017-02-06 2018-08-09 Case Western Reserve University Compositions et procédés de modulation de l'activité de la déshydrogénase à chaîne courte
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
CN110891568A (zh) 2017-04-07 2020-03-17 凯斯西储大学 用于治疗冠状动脉病症的短链脱氢酶活性的抑制剂
CR20190520A (es) 2017-05-22 2020-01-21 Hoffmann La Roche Composiciones y compuestos terapéuticos y métodos para utilizarlos
JP2022516057A (ja) 2018-12-31 2022-02-24 バイオメア フュージョン，エルエルシー メニン－ｍｌｌ相互作用の不可逆的阻害剤
CA3125353A1 (fr) 2018-12-31 2020-07-09 Biomea Fusion, Llc Inhibiteurs de l'interaction menine-mll
US20220288033A1 (en) * 2019-09-04 2022-09-15 Agency For Science, Technology And Research Heterocyclic compounds as modulators of beta-catenin / tcf4 interaction
EP4055011A1 (fr) * 2019-11-05 2022-09-14 Dermira, Inc Antagonists de mrgprx2 et leurs utilisations
EP4387972A1 (fr) 2021-08-20 2024-06-26 Biomea Fusion, Inc. Formes cristallines de n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidine-6-yl]phényl]-4-[[3(r)-[(1-oxo-2-propène-1-yl)amino]-1-pipéridinyl]méthyl]-2-pyridinecarboxamide, un inhibiteur irréversible de ménine-mll pour le traitement du cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072084A2 (fr) * 2001-03-08 2002-09-19 Sterix Limited Utilisation
WO2002076435A2 (fr) * 2001-03-23 2002-10-03 The University Of Edinburgh Modulation d'un profile lipidique

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089471A2 (fr) * 2003-04-11 2004-10-21 Novo Nordisk A/S Utilisation pharmaceutique de pyrazolo[1,5-a]pyrimidines substituees

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072084A2 (fr) * 2001-03-08 2002-09-19 Sterix Limited Utilisation
WO2002076435A2 (fr) * 2001-03-23 2002-10-03 The University Of Edinburgh Modulation d'un profile lipidique

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8927549B2 (en) 2008-11-21 2015-01-06 High Point Pharmaceuticals, Llc Adamantyl benzamide derivatives
US9402831B2 (en) 2011-11-14 2016-08-02 Synta Pharmaceutical Corp. Combination therapy of HSP90 inhibitors with BRAF inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK

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