WO2004070488A1 - Dispositif microfluidique - Google Patents

Dispositif microfluidique Download PDF

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Publication number
WO2004070488A1
WO2004070488A1 PCT/EP2004/001116 EP2004001116W WO2004070488A1 WO 2004070488 A1 WO2004070488 A1 WO 2004070488A1 EP 2004001116 W EP2004001116 W EP 2004001116W WO 2004070488 A1 WO2004070488 A1 WO 2004070488A1
Authority
WO
WIPO (PCT)
Prior art keywords
values
sensors
microfluidic device
variables
microfluidic
Prior art date
Application number
PCT/EP2004/001116
Other languages
German (de)
English (en)
Inventor
Herbert Grieb
Astrid Lohf
Original Assignee
Siemens Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Aktiengesellschaft filed Critical Siemens Aktiengesellschaft
Publication of WO2004070488A1 publication Critical patent/WO2004070488A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/05—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects
    • G01F1/34—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by measuring pressure or differential pressure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F25/00—Testing or calibration of apparatus for measuring volume, volume flow or liquid level or for metering by volume
    • G01F25/10—Testing or calibration of apparatus for measuring volume, volume flow or liquid level or for metering by volume of flowmeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
    • G01N3/56—Investigating resistance to wear or abrasion
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D7/00—Control of flow
    • G05D7/06—Control of flow characterised by the use of electric means
    • G05D7/0617—Control of flow characterised by the use of electric means specially adapted for fluid materials
    • G05D7/0629—Control of flow characterised by the use of electric means specially adapted for fluid materials characterised by the type of regulator means
    • G05D7/0694—Control of flow characterised by the use of electric means specially adapted for fluid materials characterised by the type of regulator means by action on throttling means or flow sources of very small size, e.g. microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00867—Microreactors placed in series, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00871—Modular assembly
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00959—Flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00963—Pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00986—Microprocessor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/146—Employing pressure sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/024—Storing results with means integrated into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Fluid Mechanics (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automation & Control Theory (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Chemistry (AREA)
  • Testing Of Devices, Machine Parts, Or Other Structures Thereof (AREA)

Abstract

L'invention vise à surveiller l'usure d'un dispositif microfluidique comportant des canaux fluidiques (7). A cet effet, il est prévu d'allouer auxdits canaux, des détecteurs (9) pour détecter des grandeurs significatives en ce qui concerne le débit. Un dispositif (13) mémorise les valeurs des grandeurs détectées et un dispositif de comparaison (14) compare les valeurs des grandeurs détectées, à des valeurs antérieures d'ores et déjà mémorisées. Un dispositif d'évaluation (15) produit un message, si l'écart entre les valeurs comparées les unes aux autres dépasse une grandeur prédéfinie.
PCT/EP2004/001116 2003-02-07 2004-02-06 Dispositif microfluidique WO2004070488A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10305102.3 2003-02-07
DE10305102A DE10305102A1 (de) 2003-02-07 2003-02-07 Mikrofluidik-Einrichtung

Publications (1)

Publication Number Publication Date
WO2004070488A1 true WO2004070488A1 (fr) 2004-08-19

Family

ID=32747625

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/001116 WO2004070488A1 (fr) 2003-02-07 2004-02-06 Dispositif microfluidique

Country Status (2)

Country Link
DE (1) DE10305102A1 (fr)
WO (1) WO2004070488A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007037669A1 (de) * 2006-09-29 2008-04-24 Hitachi, Ltd. Vorrichtung zur chemischen Synthese
WO2009101434A3 (fr) * 2008-02-14 2010-05-06 Compactgtl Plc Module de réaction catalytique
EP3237212A4 (fr) * 2015-04-30 2018-09-19 Hewlett-Packard Development Company, L.P. Étalonnage de capteur de débit à base d'éjection de gouttes

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005013915A1 (de) * 2005-03-24 2006-09-28 Siemens Ag Verfahrenstechnische, insbesondere mikroverfahrenstechnische Anlage
SG140513A1 (en) * 2006-09-05 2008-03-28 Yokogawa Electric Corp A method to evaluate a performance of a control valve and a system thereof
DE102014221499A1 (de) 2014-10-23 2016-04-28 Robert Bosch Gmbh Verfahren und Vorrichtung zum Testen eines mikrofluidischen Systems

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707796A (en) * 1983-10-19 1987-11-17 Calabro Salvatore R Reliability and maintainability indicator
WO2000062919A1 (fr) * 1999-04-16 2000-10-26 Norbert Schwesinger Microsysteme chimique modulaire
WO2001036085A1 (fr) * 1999-11-15 2001-05-25 Siemens Aktiengesellschaft Systeme pour le traitement automatise de fluides pourvu de modules de processus interchangeables juxtaposables
WO2001050095A1 (fr) * 1999-12-29 2001-07-12 Schlumberger Industries, S.A. Procede et dispositif de detection d'un dysfonctionnement pour un debitmetre a ultrasons
US6302130B1 (en) * 1998-08-24 2001-10-16 Fujikin Incorporated Method and apparatus for detection of orifice clogging in pressure-type flow rate controllers
WO2002090894A1 (fr) * 2001-05-09 2002-11-14 Rosemount Inc. Systeme de diagnostic d'ecoulement

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707796A (en) * 1983-10-19 1987-11-17 Calabro Salvatore R Reliability and maintainability indicator
US6302130B1 (en) * 1998-08-24 2001-10-16 Fujikin Incorporated Method and apparatus for detection of orifice clogging in pressure-type flow rate controllers
WO2000062919A1 (fr) * 1999-04-16 2000-10-26 Norbert Schwesinger Microsysteme chimique modulaire
WO2001036085A1 (fr) * 1999-11-15 2001-05-25 Siemens Aktiengesellschaft Systeme pour le traitement automatise de fluides pourvu de modules de processus interchangeables juxtaposables
WO2001050095A1 (fr) * 1999-12-29 2001-07-12 Schlumberger Industries, S.A. Procede et dispositif de detection d'un dysfonctionnement pour un debitmetre a ultrasons
WO2002090894A1 (fr) * 2001-05-09 2002-11-14 Rosemount Inc. Systeme de diagnostic d'ecoulement

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007037669A1 (de) * 2006-09-29 2008-04-24 Hitachi, Ltd. Vorrichtung zur chemischen Synthese
WO2009101434A3 (fr) * 2008-02-14 2010-05-06 Compactgtl Plc Module de réaction catalytique
EA019000B1 (ru) * 2008-02-14 2013-12-30 КОМПАКТДЖТЛ ПиЭлСи Каталитический реакционный модуль
EP3237212A4 (fr) * 2015-04-30 2018-09-19 Hewlett-Packard Development Company, L.P. Étalonnage de capteur de débit à base d'éjection de gouttes
US10495507B2 (en) 2015-04-30 2019-12-03 Hewlett-Packard Development Company, L.P. Drop ejection based flow sensor calibration

Also Published As

Publication number Publication date
DE10305102A1 (de) 2004-08-26

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