WO2004069989A3 - Novel purified phosphodiesterase polypeptides - Google Patents

Novel purified phosphodiesterase polypeptides Download PDF

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Publication number
WO2004069989A3
WO2004069989A3 PCT/CA2004/000167 CA2004000167W WO2004069989A3 WO 2004069989 A3 WO2004069989 A3 WO 2004069989A3 CA 2004000167 W CA2004000167 W CA 2004000167W WO 2004069989 A3 WO2004069989 A3 WO 2004069989A3
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WO
WIPO (PCT)
Prior art keywords
polypeptides
novel purified
phosphodiesterase polypeptides
purified phosphodiesterase
novel
Prior art date
Application number
PCT/CA2004/000167
Other languages
French (fr)
Other versions
WO2004069989A2 (en
Inventor
John D Mendlein
James Guohua Pan
Akil Dharamsi
Megan Domagala
Daniel Mamelak
Merry-Lynn Mcdonald
Peixiang Wang
Original Assignee
Affinium Pharm Inc
John D Mendlein
James Guohua Pan
Akil Dharamsi
Megan Domagala
Daniel Mamelak
Merry-Lynn Mcdonald
Peixiang Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharm Inc, John D Mendlein, James Guohua Pan, Akil Dharamsi, Megan Domagala, Daniel Mamelak, Merry-Lynn Mcdonald, Peixiang Wang filed Critical Affinium Pharm Inc
Publication of WO2004069989A2 publication Critical patent/WO2004069989A2/en
Publication of WO2004069989A3 publication Critical patent/WO2004069989A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The present invention relates to novel compositions of phosphodiesterase polypeptides. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NOs: 2, 11, and/or 38, and fragments thereof. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
PCT/CA2004/000167 2003-02-07 2004-02-09 Novel purified phosphodiesterase polypeptides WO2004069989A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US44601903P 2003-02-07 2003-02-07
US60/446,019 2003-02-07
US45228203P 2003-03-05 2003-03-05
US60/452,282 2003-03-05
US49279903P 2003-08-06 2003-08-06
US60/492,799 2003-08-06

Publications (2)

Publication Number Publication Date
WO2004069989A2 WO2004069989A2 (en) 2004-08-19
WO2004069989A3 true WO2004069989A3 (en) 2005-06-09

Family

ID=32854301

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2004/000167 WO2004069989A2 (en) 2003-02-07 2004-02-09 Novel purified phosphodiesterase polypeptides

Country Status (1)

Country Link
WO (1) WO2004069989A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005103241A1 (en) * 2004-04-26 2005-11-03 Pfizer Products Inc. Crystal structure of 3', 5'-cyclic nucleotide phosphodiesterase 9a (pde9a) and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005414A1 (en) * 1998-07-21 2000-02-03 Rutgers, The State University Linking gene sequence to gene function by three dimensional (3d) protein structure determination
WO2002026954A2 (en) * 2000-09-28 2002-04-04 Warner-Lambert Company Llc Truncated phosphodiesterase-7 polypeptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005414A1 (en) * 1998-07-21 2000-02-03 Rutgers, The State University Linking gene sequence to gene function by three dimensional (3d) protein structure determination
WO2002026954A2 (en) * 2000-09-28 2002-04-04 Warner-Lambert Company Llc Truncated phosphodiesterase-7 polypeptides

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 4 October 2004 (2004-10-04), XP002299080, retrieved from EBI Database accession no. AAE24531 *
DATABASE EMBL [online] 4 October 2004 (2004-10-04), XP002299081, retrieved from EBI Database accession no. AAE24532 *
DATABASE UNIPROT 15 July 1998 (1998-07-15), XP002299082, retrieved from EBI Database accession no. Q13946 *
MICHAELI TAMAR ET AL: "Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 268, no. 17, 1993, pages 12925 - 12932, XP002167301, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2004069989A2 (en) 2004-08-19

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