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WO2001036478A3 - Methods and compositions relating to bactericidal/permeability increasing factor-like polypeptides and polynucleotides - Google Patents

Methods and compositions relating to bactericidal/permeability increasing factor-like polypeptides and polynucleotides

Info

Publication number
WO2001036478A3
WO2001036478A3 PCT/US2000/031878 US0031878W WO0136478A3 WO 2001036478 A3 WO2001036478 A3 WO 2001036478A3 US 0031878 W US0031878 W US 0031878W WO 0136478 A3 WO0136478 A3 WO 0136478A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
polynucleotides
polypeptides
proteins
novel
bactericidal
Prior art date
Application number
PCT/US2000/031878
Other languages
French (fr)
Other versions
WO2001036478A2 (en )
Inventor
David G Ballinger
Julio J Mulero
Xiaohong Qian
Nancy K Mize
Dana A Haley
Bryan J Boyle
Original Assignee
Hyseq Inc
David G Ballinger
Julio J Mulero
Xiaohong Qian
Nancy K Mize
Dana A Haley
Bryan J Boyle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4742Bactericidal/Permeability-increasing protein [BPI]
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2123/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2299/00Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • Y02A90/26

Abstract

The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides and polynucleotides of the invention comprise amino acid and nucleic acid sequences of novel bactericidal/permeability increasing-like gene and gene products.
PCT/US2000/031878 1999-11-19 2000-11-20 Methods and compositions relating to bactericidal/permeability increasing factor-like polypeptides and polynucleotides WO2001036478A3 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US44337099 true 1999-11-19 1999-11-19
US09/443,370 1999-11-19
US09484597 US6129473A (en) 2000-01-18 2000-01-18 Pen or the like with dual illuminating ends
US09/484,597 2000-01-18
US18392200 true 2000-02-22 2000-02-22
US60/183,922 2000-02-22
US19340000 true 2000-03-29 2000-03-29
US60/193,400 2000-03-29

Publications (2)

Publication Number Publication Date
WO2001036478A2 true WO2001036478A2 (en) 2001-05-25
WO2001036478A3 true true WO2001036478A3 (en) 2002-10-31

Family

ID=27497581

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/031878 WO2001036478A3 (en) 1999-11-19 2000-11-20 Methods and compositions relating to bactericidal/permeability increasing factor-like polypeptides and polynucleotides

Country Status (1)

Country Link
WO (1) WO2001036478A3 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1263957A2 (en) * 2000-04-05 2002-12-11 MERCK PATENT GmbH Human lipid binding protein 1
CA2406087A1 (en) * 2000-04-18 2001-10-25 Merck Patent Gesellschaft Mit Beschraenkter Haftung New lipid binding protein 2
JP2004500833A (en) * 2000-04-18 2004-01-15 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトングMerck Patent Gesellschaft mit beschraenkter Haftung New lipid-binding protein 3
US20050192221A1 (en) * 2003-12-04 2005-09-01 Mccray Paul B.Jr. Methods and compositions related to plunc polypeptides
US7951781B2 (en) 2006-11-02 2011-05-31 University Of Iowa Research Foundation Methods and compositions related to PLUNC surfactant polypeptides

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992003535A1 (en) * 1990-08-13 1992-03-05 Incyte Pharmaceuticals, Inc. Recombinant bpi proteins, uses of bpi proteins, and methods of preparing same
WO1993005797A1 (en) * 1991-09-27 1993-04-01 Incyte Pharmaceuticals, Inc. Compositions comprising a bactericidal/permeability increasing protein and a lipid carrier, methods of making same, and uses thereof
WO1995000641A1 (en) * 1993-06-17 1995-01-05 Xoma Corporation Lipopolysaccharide binding protein derivatives
WO1995001428A1 (en) * 1993-07-02 1995-01-12 Incyte Pharmaceuticals, Inc. Glycosylated and non-glycosylated bactericidal/permeability increasing proteins, and methods for producing same
WO1995005393A2 (en) * 1993-08-18 1995-02-23 Morphosys Gesellschaft Für Proteinoptimierung Mbh Lipopolysaccharide-binding and neutralizing peptides
WO1998058961A1 (en) * 1997-06-20 1998-12-30 Xoma Corporation Bactericidal/permeability-increasing protein: crystallization, x-ray diffraction, three-dimensional structure determination, rational drug design and molecular modeling of related proteins
WO1999006440A1 (en) * 1997-07-31 1999-02-11 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Novel synthetic peptides with antimicrobial and endotoxin neutralizing properties for management of the sepsis syndrome

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992003535A1 (en) * 1990-08-13 1992-03-05 Incyte Pharmaceuticals, Inc. Recombinant bpi proteins, uses of bpi proteins, and methods of preparing same
WO1993005797A1 (en) * 1991-09-27 1993-04-01 Incyte Pharmaceuticals, Inc. Compositions comprising a bactericidal/permeability increasing protein and a lipid carrier, methods of making same, and uses thereof
WO1995000641A1 (en) * 1993-06-17 1995-01-05 Xoma Corporation Lipopolysaccharide binding protein derivatives
WO1995001428A1 (en) * 1993-07-02 1995-01-12 Incyte Pharmaceuticals, Inc. Glycosylated and non-glycosylated bactericidal/permeability increasing proteins, and methods for producing same
WO1995005393A2 (en) * 1993-08-18 1995-02-23 Morphosys Gesellschaft Für Proteinoptimierung Mbh Lipopolysaccharide-binding and neutralizing peptides
WO1998058961A1 (en) * 1997-06-20 1998-12-30 Xoma Corporation Bactericidal/permeability-increasing protein: crystallization, x-ray diffraction, three-dimensional structure determination, rational drug design and molecular modeling of related proteins
WO1999006440A1 (en) * 1997-07-31 1999-02-11 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Novel synthetic peptides with antimicrobial and endotoxin neutralizing properties for management of the sepsis syndrome

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BEAMER L J ET AL: "Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution.", SCIENCE. UNITED STATES 20 JUN 1997, vol. 276, no. 5320, 20 June 1997 (1997-06-20), pages 1861 - 1864, XP002203252, ISSN: 0036-8075 *
M. G. CLAROS ET AL.: "TopPred II: an improved software for membrane protein structure predictions.", CABIOS COMPUTER APPLICATIONS IN THE BIOSCIENCES., vol. 10, no. 6, December 1994 (1994-12-01), IRL PRESS,OXFORD., GB, pages 685 - 686, XP002203253, ISSN: 0266-7061 *

Also Published As

Publication number Publication date Type
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