WO2004081165A3 - Novel purified dihydrodipicolinate synthase polypeptides and structures thereof - Google Patents

Novel purified dihydrodipicolinate synthase polypeptides and structures thereof Download PDF

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Publication number
WO2004081165A3
WO2004081165A3 PCT/CA2004/000359 CA2004000359W WO2004081165A3 WO 2004081165 A3 WO2004081165 A3 WO 2004081165A3 CA 2004000359 W CA2004000359 W CA 2004000359W WO 2004081165 A3 WO2004081165 A3 WO 2004081165A3
Authority
WO
WIPO (PCT)
Prior art keywords
structures
dihydrodipicolinate synthase
synthase polypeptides
novel purified
polypeptides
Prior art date
Application number
PCT/CA2004/000359
Other languages
French (fr)
Other versions
WO2004081165A2 (en
Inventor
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Rosanne Thalakada
Kathleen Nethery
Simon Houston
Kristina Buzadzija
Matthew Tai
Bryan Beattie
Original Assignee
Affinium Pharm Inc
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Rosanne Thalakada
Kathleen Nethery
Simon Houston
Kristina Buzadzija
Matthew Tai
Bryan Beattie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharm Inc, Aled Edwards, Akil Dharamsi, Masoud Vedadi, Rosanne Thalakada, Kathleen Nethery, Simon Houston, Kristina Buzadzija, Matthew Tai, Bryan Beattie filed Critical Affinium Pharm Inc
Publication of WO2004081165A2 publication Critical patent/WO2004081165A2/en
Publication of WO2004081165A3 publication Critical patent/WO2004081165A3/en
Priority to US11/224,753 priority Critical patent/US20070048814A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Abstract

The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO:4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
PCT/CA2004/000359 2003-03-12 2004-03-12 Novel purified dihydrodipicolinate synthase polypeptides and structures thereof WO2004081165A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/224,753 US20070048814A1 (en) 2004-03-12 2005-09-12 Novel Purified dihydrodipicolinate synthase polypeptides and structures thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45411803P 2003-03-12 2003-03-12
US60/454,118 2003-03-12

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/224,753 Continuation-In-Part US20070048814A1 (en) 2004-03-12 2005-09-12 Novel Purified dihydrodipicolinate synthase polypeptides and structures thereof

Publications (2)

Publication Number Publication Date
WO2004081165A2 WO2004081165A2 (en) 2004-09-23
WO2004081165A3 true WO2004081165A3 (en) 2004-12-16

Family

ID=32990866

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2004/000359 WO2004081165A2 (en) 2003-03-12 2004-03-12 Novel purified dihydrodipicolinate synthase polypeptides and structures thereof

Country Status (1)

Country Link
WO (1) WO2004081165A2 (en)

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BLICKLING STEFAN ET AL: "Reaction mechanism of Escherichia coli dihydrodipicolinate synthase investigated by X-ray crystallography and NMR spectroscopy", BIOCHEMISTRY, vol. 36, no. 1, 1997, pages 24 - 33, XP002299036, ISSN: 0006-2960 *
DATABASE EMBL 1 November 1995 (1995-11-01), FLEISCHMANN ET AL.: "Hemophilus influenzae Dihydropicolinate synthase", XP002299037, retrieved from EBI Database accession no. P43797 *
LABER B ET AL: "ESCHERICHIA COLI DIHYDRODIPICOLINATE SYNTHASE IDENTIFICATION OF THE ACTIVE SITE AND CRYSTALLIZATION", BIOCHEMICAL JOURNAL, THE BIOCHEMICAL SOCIETY, LONDON, GB, vol. 288, no. 2, 1992, pages 691 - 695, XP009035909, ISSN: 0264-6021 *
MIRWALDT CHRISTIAN ET AL: "The Crystal Structure of Dihydrodipicolinate Synthase from Escherichia coli at 2.5 A Resolution", JOURNAL OF MOLECULAR BIOLOGY, vol. 246, no. 1, 1995, pages 227 - 239, XP002299035, ISSN: 0022-2836 *

Also Published As

Publication number Publication date
WO2004081165A2 (en) 2004-09-23

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