WO2003095604A3 - Purified peptide deformylase from streptococcus pneumoniae - Google Patents

Purified peptide deformylase from streptococcus pneumoniae Download PDF

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Publication number
WO2003095604A3
WO2003095604A3 PCT/CA2003/000654 CA0300654W WO03095604A3 WO 2003095604 A3 WO2003095604 A3 WO 2003095604A3 CA 0300654 W CA0300654 W CA 0300654W WO 03095604 A3 WO03095604 A3 WO 03095604A3
Authority
WO
WIPO (PCT)
Prior art keywords
streptococcus pneumoniae
purified peptide
peptide deformylase
provides
deformylase
Prior art date
Application number
PCT/CA2003/000654
Other languages
French (fr)
Other versions
WO2003095604A2 (en
Inventor
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Ivy Ng
Simon Houston
Francois Vallee
Matthew Kimber
Donald Awrey
Bryan Beattie
Original Assignee
Affinium Pharm Inc
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Ivy Ng
Simon Houston
Francois Vallee
Matthew Kimber
Donald Awrey
Bryan Beattie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharm Inc, Aled Edwards, Akil Dharamsi, Masoud Vedadi, Ivy Ng, Simon Houston, Francois Vallee, Matthew Kimber, Donald Awrey, Bryan Beattie filed Critical Affinium Pharm Inc
Priority to AU2003229423A priority Critical patent/AU2003229423A1/en
Publication of WO2003095604A2 publication Critical patent/WO2003095604A2/en
Publication of WO2003095604A3 publication Critical patent/WO2003095604A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified peptide deformylase from Streptococcus Pneumoniae comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
PCT/CA2003/000654 2002-05-09 2003-05-09 Purified peptide deformylase from streptococcus pneumoniae WO2003095604A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003229423A AU2003229423A1 (en) 2002-05-09 2003-05-09 Purified peptide deformylase from streptococcus pneumoniae

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37897702P 2002-05-09 2002-05-09
US60/378,977 2002-05-09

Publications (2)

Publication Number Publication Date
WO2003095604A2 WO2003095604A2 (en) 2003-11-20
WO2003095604A3 true WO2003095604A3 (en) 2004-06-24

Family

ID=29420462

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2003/000654 WO2003095604A2 (en) 2002-05-09 2003-05-09 Purified peptide deformylase from streptococcus pneumoniae

Country Status (2)

Country Link
AU (1) AU2003229423A1 (en)
WO (1) WO2003095604A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1683521A1 (en) * 2005-01-21 2006-07-26 Centre National De La Recherche Scientifique (Cnrs) Peptide deformylase inhibitors, their use, and pharmaceutical compositions containing the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0863152A2 (en) * 1997-02-10 1998-09-09 Smithkline Beecham Corporation Streptococcus pneumoniae Def1 protein

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0863152A2 (en) * 1997-02-10 1998-09-09 Smithkline Beecham Corporation Streptococcus pneumoniae Def1 protein

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
APFEL C M ET AL: "Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 45, no. 4, 2001, pages 1058 - 1064, XP002263508 *
GROCHE DIETER ET AL: "Isolation and crystallization of functionally competent Escherichia coli peptide deformylase forms containing either iron or nickel in the active site", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 246, no. 2, 19 May 1998 (1998-05-19), pages 342 - 346, XP002209218, ISSN: 0006-291X *
KARAS M ET AL: "LASER DESORPTION IONIZATION OF PROTEINS WITH MOLECULAR MASSES EXCEEDING 10 000 DALTONS", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 60, 1988, pages 2299 - 2301, XP001024784, ISSN: 0003-2700 *
MARGOLIS P ET AL: "Resistance of Streptococcus pneumoniae to Deformylase Inhibitors is due to mutations in defB", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 45, no. 9, 2001, pages 2432 - 2435, XP002263507 *

Also Published As

Publication number Publication date
AU2003229423A8 (en) 2003-11-11
AU2003229423A1 (en) 2003-11-11
WO2003095604A2 (en) 2003-11-20

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