WO2004052454A1 - Enveloppe surmoulee pour un dispositif medical modulaire implantable - Google Patents

Enveloppe surmoulee pour un dispositif medical modulaire implantable Download PDF

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Publication number
WO2004052454A1
WO2004052454A1 PCT/US2003/038928 US0338928W WO2004052454A1 WO 2004052454 A1 WO2004052454 A1 WO 2004052454A1 US 0338928 W US0338928 W US 0338928W WO 2004052454 A1 WO2004052454 A1 WO 2004052454A1
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WO
WIPO (PCT)
Prior art keywords
implantable medical
medical device
overmold
modules
modular
Prior art date
Application number
PCT/US2003/038928
Other languages
English (en)
Other versions
WO2004052454B1 (fr
Inventor
Ruchika Singhal
Darren A. Janzig
Carl D. Wahlstrand
Robert M. Skime
Paulette C. Olson
Original Assignee
Medtronic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic, Inc. filed Critical Medtronic, Inc.
Priority to EP03796790A priority Critical patent/EP1578498A1/fr
Priority to AU2003297725A priority patent/AU2003297725A1/en
Publication of WO2004052454A1 publication Critical patent/WO2004052454A1/fr
Publication of WO2004052454B1 publication Critical patent/WO2004052454B1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/375—Constructional arrangements, e.g. casings
    • A61N1/37514—Brain implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/375—Constructional arrangements, e.g. casings
    • A61N1/37518—Anchoring of the implants, e.g. fixation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/375—Constructional arrangements, e.g. casings
    • A61N1/3752—Details of casing-lead connections
    • A61N1/3754—Feedthroughs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/375—Constructional arrangements, e.g. casings
    • A61N1/3758—Packaging of the components within the casing

Definitions

  • the invention relates to medical devices, and more particularly, to implantable medical devices that deliver therapy to and/or monitor a patient.
  • implantable medical devices may include a variety of electrical and/or mechanical components.
  • an IMD includes a rigid housing that houses all of its components, which are generally fragile, to protect the components from forces to which they would otherwise be exposed when implanted within the human body.
  • IMD housings are typically hermetically sealed.
  • Many IMD housings are fabricated from Titanium because of its desirable rigidity and biocompatibility.
  • the size and shape of an IMD housing is dependant on the sizes and shapes of the components of the IMD.
  • Large components common to most IMDs include a battery, a telemetry coil, and a hybrid circuit that includes digital circuits, e.g., integrated circuit chips and/or a microprocessor, and analog circuit components.
  • Attempts have been made to reduce the size of the IMD housing by reducing the size of these components, changing the shape of these components, and organizing these components within the IMD housing to avoid empty space within the housing.
  • the size, shape and rigidity of IMD housings still greatly limits the locations within the human body where an IMD can be practically implanted.
  • an IMD is typically implanted within the abdomen, upper pectoral region, or subclavicular region of a patient.
  • Leads or catheters must be used in order to deliver therapy or monitor a physiological parameter at a location of the body other than where the IMD is implanted.
  • Implantation and positioning of leads and catheters can be difficult and time- consuming from the perspective of a surgeon, particularly where the IMD is located a significant distance from the treatment or monitoring site.
  • the increased surgical time, increased surgical trauma, and increased amount of implanted material associated with the use of leads and catheters can increase the risk to the patient of complications associated with the implantation of an IMD.
  • IMDs that are used to treat or monitor the brain are implanted some distance away from the brain, e.g., within the subclavicular region of patients.
  • DBS deep brain stimulation
  • the long leads that connect the implantable medical device to electrodes implanted within the brain require tunneling under the scalp and the skin of the neck, thereby requiring increased surgery and a prolonged amount of time under general anesthesia during the implant procedure.
  • tunneling the leads under the scalp and skin of the neck requires an additional surgical procedure under general anesthesia.
  • the lengthy tract along the leads is more susceptible to infection, and the leads can erode the overlying scalp, forcing removal so that the scalp can heal.
  • the long leads running under the scalp and through the neck are more susceptible to fracture due to torsional and other forces caused by normal head and neck movements.
  • the invention relates to an overmold for a modular implantable medical device.
  • Various functional components of a modular implantable medical device are separated into interconnected modules.
  • This distributed architecture for the implantable medical device may permit the device footprint to be distributed over a larger area while making a profile of the device smaller.
  • the multiple modules and the flexible interconnections between the modules may permit the overall shape of the implantable medical device to be formed to better match the body location into which it is to be implanted.
  • An overmold integrates the modules of a modular implantable medical device into a structure.
  • the overmold is flexible, e.g., allows intermodule motion, and provides a biocompatible interface between the component modules and the patient.
  • the edge of the overmold forms a sloped interface that provides a slope from the top of the implantable medical device to a body surface, such as the cranium.
  • the sloped interface may be defined by an angle, which may be greater than 90 degrees, and is preferably approximately equal to 135 degrees.
  • the overmold may be preformed to a concave shape to better conform to a body surface, such as the cranium.
  • the overmold may incorporate one or more motion reduction elements to restrict intermodule motion to certain directions or ranges in order to protect the structural integrity of interconnections between the modules.
  • the overmold can include elastomeric materials, such as silicone, and/or non-elastomeric materials such as polysulfone and polyurethane. Further, the overmold may include one or more components. For example, a first component may comprise an elastomeric material and at least partially encapsulates each of the modules, while a second component comprises a non-elastomeric material that surrounds, e.g., is lo ⁇ ated proximate to sides of one or more modules. The first component may provide biocompatibility, flexibility and a desired form factor for the modular implantable medical device.
  • the second component may, for example, provide structural integrity for the modular implantable medical device, e.g., restrict intermodule motion, hold the one or more modules within the first component, and provide through-holes for secure attachment of the modular implantable medical device to a surface within the patient, such as the cranium.
  • the invention is directed to an implantable medical device that includes a plurality of interconnected modules. Each of the modules comprises a housing. The implantable medical device further comprises an overmold that at least partially encapsulates each of the housings.
  • FIGS. 1A and IB are conceptual diagrams illustrating a modular implantable medical device implanted in a patient according to an example embodiment of the present invention.
  • FIG. 2 is a schematic diagram illustrating a modular implantable medical device according to another embodiment of the present invention.
  • FIGS. 3A-3F are schematic diagrams illustrating various arrangements of modules within a modular implantable medical device according to various embodiments of the present invention.
  • FIGS. 4A-4C are schematic diagrams illustrating the construction of an overmold of a modular implantable medical device according to the present invention.
  • FIGS. 5A-5B are schematic diagrams illustrating the interaction of components of an overmold according to the present invention.
  • FIG. 6 is a schematic diagram illustrating the degrees of motion present in a modular implantable medical device.
  • FIG. 7 is a schematic diagram illustrating motion reduction within various degrees of motion within a modular implantable medical device.
  • FIG. 8A-C are schematic diagrams illustrating example embodiments of modular implantable medical devices having lead management features.
  • FIG. 9 is a schematic diagram illustrating an example embodiment of a modular implantable medical device having an access loop for removal.
  • FIG. 10 is a schematic diagram illustrating a perspective view of an example embodiment of a modular implantable medical device having a triangular module arrangement.
  • FIG. 11 is a schematic diagram illustrating a perspective view of an example embodiment of a modular implantable medical device having an inline module arrangement.
  • FIG. 12 is a schematic diagram illustrating side view of a modular implantable medical device having an inline module arrangement.
  • FIG. 13 is a schematic diagram illustrating an exploded view of a modular implantable medical device having a triangular module arrangement.
  • FIG. 14 is a flowchart illustrating a method of constructing an implantable medical device with an overmold according to the present invention.
  • FIGS. 1A and IB are conceptual diagrams illustrating a modular implantable medical device 101 implanted within a patient 100.
  • modular implantable medical device 101 may be implanted at locations for which implantation of conventional implantable medical devices has been deemed undesirable, thus permitting the implantable medical device 101 to be implanted near a monitoring and/or therapy delivery location.
  • modular implantable medical device 101 is implanted under the scalp of the patient 100 in order to locate the device 101 close to the location to which therapy is to be delivered via leads 102, i.e., the brain of patient 100.
  • Modular implantable medical device 101 may deliver stimulation to the brain of patient 100 to, for example, provide deep brain stimulation (DBS) therapy, or to stimulate the cortex of the brain. Cortical stimulation may involve stimulation of the motor cortex. Modular implantable medical device 101 may be used to treat any nervous system disorder including, but not limited to, epilepsy, pain, psychological disorders including mood and anxiety disorders, movement disorders (MVD), such as, but not limited to, essential tremor, Parkinson's disease, and neurodegenerative disorders.
  • DBS deep brain stimulation
  • MMD movement disorders
  • modular implantable medical device 101 is not limited to delivery of stimulation to the brain of patient 100, and may be employed with leads 102 deployed anywhere in the head or neck including, for example, leads deployed on or near the surface of the skull, leads deployed beneath the skull such as near or on the dura mater, leads placed adjacent cranial or other nerves in the neck or head, or leads placed directly on the surface of the brain.
  • modular implantable medical device 101 is not limited to implantation under the scalp of patient 100. Indeed, modular implantable medical device 101 may be implanted anywhere within patient 100. For example, modular implantable medical device 101 can be implanted within the neck of patient 100, and deliver stimulation to the vagus nerve or the cervical region of the spinal cord.
  • Modular implantable medical device 101 may alternatively be implanted within a pectoral region or the abdomen of patient 100 to act as a diaphragmatic pacer , or to provide any of the monitoring and therapy delivery functions known in the art to be associated with cardiac pacemakers. Further, modular implantable medical device 101 may be implanted in the upper buttock region and deliver spinal cord, urological or gastrological stimulation therapy, or may be configured to be implanted within the periphery, e.g., limbs, of patient 100 for delivery of stimulation to the muscles and/or peripheral nervous system of patient 100.
  • Modular implantable medical device 101 may enable implantation at some of these example locations for which implantation of conventional implantable medical devices is generally deemed undesirable.
  • Modular implantable medical device 101 is not limited to embodiments that deliver stimulation.
  • modular implantable medical device 101 may additionally or alternatively monitor one or more physiological parameters and/or the activity of patient 100, and may include sensors for these purposes.
  • modular implantable medical device 101 may operate in an open loop mode (also referred to as non- responsive operation), or in a closed loop mode (also referred to as responsive).
  • Modular implantable medical device 101 may also provide warnings based on the monitoring.
  • Shorter leads 102 may advantageously improve the accuracy of such sensors by reducing noise attributable to leads 102. Shorter leads 102 may also advantageously reduce the negative affects of imaging techniques such as magnetic resonance imaging "MRI" on a person implanted with implantable medical device 101.
  • MRI magnetic resonance imaging
  • Additional alternate embodiments for implantable medical devices implemented according to principles of the present invention may also include non-electrical based therapies such as targeted introduction of fluids and similar therapeutic materials using pumps and reservoirs of material.
  • non-electrical based therapies such as targeted introduction of fluids and similar therapeutic materials using pumps and reservoirs of material.
  • FIG. 2 is a schematic diagram illustrating a modular implantable medical device 201 according to another embodiment of the present invention.
  • implantable medical device 201 is arranged in a triangular configuration.
  • Modular implantable medical device 201 includes three modules: a control module 210, a power source module 211, and a recharge module 212. Each of modules 210-212 includes a respective housing.
  • Modular implantable medical device 201 also contains a set of lead connection modules 213 that permits external leads 102 (FIGS. 1A and IB) to be connected to control module 210 as needed.
  • the distribution of functional components of modular implantable medical device 201 into modules permits modular implantable medical device 201 to possess a thin profile by spreading the components over a larger surface area.
  • Control module 210 includes control electronics for controlling the monitoring and/or therapy delivery functions of modular implantable medical device 201, such as a microprocessor, and may include therapy delivery circuitry.
  • Power source module 211 includes a power source that provides energy to control module 210, which in some embodiments is a rechargeable power source such as a rechargeable battery and/or capacitor.
  • Recharge module 212 includes a recharge coil for inductively receiving energy to recharge a rechargeable power source within power source module 211.
  • one or modules may be coupled by coupling modules (not shown).
  • a coupling module may be flexible, and may include a lumen to carry a conductor or a fluid between modules of a modular implantable medical device.
  • a coupling module is made of a flexible material such as silicone or a flexible polymer.
  • a coupling module is hermetic and made of substantially less flexible material, such as titanium or stainless steel, and the flexibility of a coupling module is provided by the configuration and/or construction the coupling module.
  • a coupling module may be flexible in a plurality of directions to provide modules of a modular implantable medical device with multiple degrees of freedom of motion with respect to each other.
  • a coupling module provides at least three degrees of motion, and the degrees of motion provided include rotational motion.
  • modules 210, 211 and 212, additional or alternative modules for a modular implantable medical device, the interconnection of modules within a modular implantable medical device, and lead connection modules 213 may be found in commonly assigned U.S. Patent Application entitled “MODULAR IMPLANTABLE MEDICAL DEVICE.” assigned Attorney Docket No.: 1023-318US01/P-10891.00; commonly assigned U.S. Patent Application entitled “COUPLING MODULES OF A DISTRIBUTED MODULAR IMPLANTABLE MEDICAL DEVICE.” assigned Attorney Docket No.: 1023- 333US01/P-11796.00; and commonly assigned U.S. Patent Application entitled “LEAD INTERCONNECT MODULE OF A MODULAR IMPLANTABLE MEDICAL DEVICE,” assigned Attorney Docket No.: 1023-334US01/P-11799.00.
  • modular implantable medical device 201 includes an overmold 214.
  • Overmold 214 at least partially encapsulates modules 210-212. Further, as will be described in greater detail below, lead connection modules 213 may be formed in overmold 214. Overmold integrates modules 210-212 into a structure. Overmold 214 may provide a flexible structure that permits the device 501 to conform to a variety of implant locations.
  • overmold 214 may be curved to match the shape of the location within a patient in which the device is being implanted. For example, implantation of modular implantable medical device 201 under the scalp of a patient may be accomplished if overmold 214 is concave to substantially conform to the shape of the cranium of the patient. Concavity of modular implantable medical devices is described in greater detail in a commonly-assigned U.S. Patent Application entitled “CONCAVITY OF AN IMPLANTABLE MEDICAL DEVICE.” assigned Attorney Docket No.: 1023-336US01/ -11800.00. Any number of shapes may be used to match a particular implantable medical device 201 to an implantation location for a device.
  • Overmold 214 may comprise a solid biocompatible elastomeric material that is soft and flexible such as silicone.
  • overmold 214 comprises two or more materials, and two or more components.
  • overmold may comprise one or more elastomeric components formed of an elastomeric material, such as silicone, and one or more non-elastomeric components formed of a non-elastomeric material, such as polysulfone, or a polyurethane such as Tecothane®, which is commercially available from Hermedics Polymer Products, Wilmington, MA.
  • the one or more elastomeric components may provide the overall shape and flexibility of modular implantable medical device 201, while the non-elastomeric components may provide structural integrity for modular implantable medical device 201, restrict intermodule motion within modular implantable medical device 201 to certain ranges, and form a part of the lead interconnection modules 213. Further detail regarding reduction of intermodule motion within modular implantable medical devices may be found in a commonly-assigned U.S. Patent Application entitled "REDUCING RELATIVE INTERMODULE MOTION IN A DISTRIBUTED MODULAR IMPLANTABLE MEDICAL DEVICE.” assigned Attorney Docket No.: 1023-33 lUSOl/P-11797.00.
  • FIGS. 3A-3F are schematic diagrams illustrating various arrangements of multiple modules within a modular implantable medical device 301 according to various embodiments of the present invention.
  • modular implantable medical device 301 has three modules as discussed above in reference to FIG. 2: a control module 210, a power source module 211, and a recharge module 212.
  • These modules may be arranged into a variety of configurations, including those illustrated, as long as any required interconnections needed between the modules, e.g., coupling modules, may be routed within the device.
  • the various embodiments include triangular configurations, in such as those shown in FIGS. 3A-C, and inline configurations, such as those shown in FIGS. 3D-F.
  • the set of lead connection devices 313 may be located in various locations within the device as well.
  • an overmold 322 at least partially encapsulates each of modules 210, 211 and 212.
  • at least one of the modules of modular IMD 301 is located outside of overmold 322.
  • Module 212 located outside of overmold may, as shown in FIG. 3D, be tethered to overmold 322, allowing module 212 to be freely positioned some significant distance from overmold 322. Additional details relating to configurations of modules within a modular implantable medical devices and tethering of modules of an implantable medical device may be found in a U.S. Patent Application entitled "MODULAR IMPLANTABLE MEDICAL DEVICE.” assigned Attorney Docket No.: 1023- 318US01/P-10891.00.
  • FIGS. 4A-4C are schematic diagrams illustrating an overmold 422 of a modular implantable medical device 401.
  • FIG. 4A illustrates that the modular implantable medical device 401 comprises a set of modules 410-412, and a set of motion reduction elements 421 within overmold 422, such as motion reduction fibers connecting modules 410 and 411.
  • Modules 410 and 411 are also coupled by a coupling module 423.
  • overmold 422 and coupling module 423 are flexible, overmold 422 and coupling module 423 may not provide sufficient motion reduction for the modules 410-412. Specifically, excessive relative motion between modules 410 and 411 may compromise the structural integrity of coupling module 424, which may lead to failure of modular implantable medical device 401.
  • Motion reduction elements 421 are used to provide sufficient structural integrity to the device 401 once implanted into the patient 100 by restricting relative motion between modules 410 and 411 to certain directions or within certain ranges. Additional details regarding motion reduction elements 421 are described in co-pending and commonly assigned U.S. Patent Application entitled "REDUCING RELATIVE INTER-MOLDULE MOTION IN A MODULAR IMPLANTABLE MEDICAL DEVICE,” assigned Attorney Docket No.: 1023-331US01 / P-l 1797.00.
  • FIG. 4B illustrates that the overmold 422 may include two or more components, each component made of a different material.
  • the overmold 422 includes an elastomeric component 430 and a non- elastomeric component 431.
  • the non-elastomeric component 431 is typically shaped to surround at least one of modules 410-412, i.e., is located proximate to sides of at least one of modules 410-412.
  • a plurality of individual non-elastomeric components 431 surround respective modules 410-412.
  • a non-elastomeric component 431 surrounds a plurality of modules 410-412 to integrate the surrounded modules in a common, semi-rigid structure.
  • the one or more non-elastomeric components 431 may be used to contain one or more modules within elastomeric component 430.
  • the one or more non-elastomeric components 431 may be formed to hold modules 410-412 within respective positions within elastomeric component 430.
  • Elastomeric component 430 may, as shown in FIG. 4B, at least partially encapsulate each of modules 410-412 and provide an desired form factor for a modular implantable medical device.
  • non-elastomeric elements 431 are fitted into an elastomeric component 430 to form the overmold 422 before the electronic modules 410-412 are inserted into respective locations within overmold 422 where they will be contained by non-elastomeric elements 431.
  • overmold 422 provides a number of functions in including attaching to modules and other elements to provide a smooth interface surface for the device as it interacts with the patient, and protecting electrical connections and feed thru wires needed to connect modules to external leads.
  • Overmold 422 may be constructed from a durometric specific material to provide a clinically desirable device.
  • a material used to construct the overmold 422 may possess a thermal conductivity characteristic to either act as a heat sink if needed to dissipate heat from modules 410-412, or a material to act as an insulator to shield the patient 100 from any excess heat from modules 410-412. Because the implantable medical device 401 may be constructed from a large number of modules to perform a desired task, the materials selected for used in constructing the overmold 422 may vary as needed by each embodiment.
  • the device 401 may be fabricated by integrating components 431 and 432 to form the overmold 422, constructing the modules 410-412 and their respective connection modules 423, and constructing any motion reduction elements 421. Once all of these components are fabricated, the motion restriction elements 421 may be combined with the overmold 422, and the interconnected modules 410-412 may be inserted into the overmold 422 into respective positions where they are contained by components 431.
  • FIG. 4C illustrates that the overmold 422 provides sloped interface 441 between the modules within the device 401 and the patient's body components.
  • the sloped interface 441 provides a smooth transition between the body and the device modules 410-412. Protrusions are known to cause possible stress points for tissue that is located over implanted devices, which can, for example, lead to skin erosion in the case of a device implanted under the scalp. As such, the sloped interface 441 attempts to minimize the transition from the modules 410-412 and the edge of the device 401 to eliminate these points of stress.
  • An angle of interface 442 from the patient's body and the sloped interface 441 is greater than 90 degrees. Angle 442 may be between 120 and 150 degrees, is preferably between 130 and 140 degrees, and is most preferably approximately 135 degrees.
  • FIGS. 5A-5B are schematic diagrams illustrating the interaction of components of an implantable medical device that are part of an overmold .
  • FIG. 5A provides a side cross-sectional view of an overmold 522 that includes an elestomeric component 530 and a non-elastomeric component 531 that interfaces with a control module 610.
  • the non-elastomeric component 531 is shaped to mate with and surround the module 510, and may provide motion reduction for the module.
  • the non-elastomeric component 531 may be mechanically connected to at least one other module of a modular implantable medical device, e.g., to non-elastomeric components that surround other modules of an implantable medical device, by a motion reduction element 521.
  • the overmold 522 encapsulates a plurality of modules in this embodiment, and each of the modules may be surrounded by a non-elastomeric component 531 that is connected to other non-elastomeric components by motion reduction elements 521.
  • a through hole 551 may be located through overmold 522, e.g., through elastomeric component 530 and non-elastomeric component 531, to provide an attachment point for the implantable medical device.
  • the implantable medical device may be secured in place using bone screws or similar attachment devices that secure the device to the patient.
  • Such through holes 551 permit the device to be mechanically attached to the patient once the device is positioned at a desired location.
  • elastomeric component 530 is shown as completely encapsulating the modules and components within FIG. 5.
  • elastomeric component 530 may merely surround the module 510 but not cover the top of the module. Such an arrangement may render the profile of the overall device smaller.
  • a surface across the overmold and the electronics module 510 may minimize transition discontinuities to minimize profile changes that may interact with a patient after implantation.
  • one or both components 530 and 531 cover a top of module 510, or fully encapsulate module 510.
  • FIG. 5B illustrates a top view of the overmold 522 having an elastomeric component 530 that covers a non-elastomeric component 531 that surrounds the control module 510.
  • the through hole 551 used as an attachment point is shown as part of the non-elastomeric component 531 that is covered by the elastomeric component 530.
  • the shape of the non-elastomeric component 531 and control module 510 are shown as being rectangular in this embodiment. However, one skilled in the art will recognize that any shape for the non-elastomeric component 531 and control module 510 may be used without deviating from the spirit and scope of the present invention.
  • non-elastomeric component 531 need not be the same as that the shape of the component that it surrounds.
  • the modules may be restrained within the overmold 522 using many restraint mechanisms known in the arts including attachment elements, adhesives, snap rings, and similar elements.
  • overmold 522 may be constructed from two different materials, a softer, more flexible elastomeric component 530 and one or more harder, more rigid non-elastomeric components 531, one skilled in the art may recognize that an overmold 522 may include a single component made of either class of material to provide the surface smoothing, module integration, and structural module restraint features described herein.
  • the overmold 522 may include several additional features unrelated to the above functions regarding the restraint and interconnection of multiple modules.
  • radio-opaque markers 561 and 562 maybe imbedded within the overmold 522 to assist in determining an exact location of an implantable medical device within a patient. These radio-opaque markers 561 and 562 typically possess a non-symetrical shape to permit registration and orientation of the device 501 from imaging of the markers. These radio-opaque markers may be constructed using barium and similar materials that permit such imaging. A telemetry and/or recharge coil may be embedded directly within the overmold 522. Therapeutic agents, such as anti-infection and anti-inflammatory agents may be impregnated within the overmold 522 to assist in complications that may arise from implantation and use of the implanted medical device.
  • FIG. 6 is a schematic diagram illustrating degrees of intermodular motion that may be present in modular implantable medical device.
  • motion between the two modules may include pitch motion 601, yaw motion 602, and roll motion 603.
  • one or more of these three degrees of motion may be limited to prevent mechanical failures of interconnections between the modules during use of a modular implantable medical device.
  • modules of a modular implantable medical device may be connected by connector modules, which may be compromised by excessive intermodule motion.
  • Such interconnect members are described in greater detail in commonly assigned U.S. Patent Application entitled “REDUCING RELATIVE INTERMODULE MOTION IN A DISTRIBUTED MODULAR IMPLANTABLE MEDICAL DEVICE,” assigned Attorney Docket No.: 1023-331US01/P-11797.00.
  • FIG: 7 is a schematic diagram illustrating motion reduction within various degrees of motion within a modular implantable medical device.
  • a connector module 721 may be used between the modules 701-702 to connect elements within these module 701-702.
  • Motion reduction elements 722 and 723 may be used to reduce inter-modular motion, and in some cases, to limit inter-modular motion to a range of motion.
  • Motion reduction elements 722 and 723 may be formed as part of non- elastomeric components 531 of an overmold 522 associated with each of modules 701 and 702. As shown in FIG. 7, motion reduction elements 722 and 723 allow free inter-modular motion within one of the degrees within a range.
  • one non-elastomeric component includes one or more motion reduction elements 722.
  • two non-elastomeric components 531 include motion reduction elements 722 and 723, respectively, which interact to reduce inter-modular motion.
  • a modular implantable medical device may include any number of motion reduction elements, which may take any of a variety of shapes. In some embodiments, motion reduction elements may be used in all axes to maximize the amount of motion reduction provided.
  • the implantable medical device having multiple modules typically requires sufficient motion reduction to prevent undue mechanical stresses on interconnection connection member 721 between the modules 701-702 that may not be provided by a flexible overmold 522.
  • FIG. 8A is a block diagram illustrating an example embodiment of a modular implantable medical device 801 having a tethered lead interconnect site 861 according to the present invention.
  • An overmold 822 of implantable medical device 801 at least partially encapsulates and connects a plurality of modules 810- 812 while not encapsulating lead connection modules 813 that are part of tethered lead interconnect site 861.
  • the implantation of device 801 would not require the insertion of external leads into the overmold 822.
  • the external leads may be located a distance away from the device 801. Such an arrangement may assist in the management of the external leads as they are placed within the patient and routed to a device implantation location. Further, location of leads and connection site 861 away from overmold 822 may make it less likely that the leads will be damaged during a surgical explant procedure.
  • overmold 822 may possess mechanical structures such as grooves 832, an externally attached pouch 833, or an integrated containment cavity 834 to contain and/or route the external leads away from the implantable medical device 801 in an efficient manner.
  • the external leads may possess a minimum length to provide a particular electrical characteristic for the implantable medical device 801. This minimum length may be greater than a distance needed by a particular patient for some implantation locations.
  • the overmold may be spread over an area surrounding the modular device, the overmold may cover holes in the cranium formed to allow external leads to access the brain. Additional structures, including one or more cap structures 835 that secures a lead as it passes through the hole in the cranium may be an integral part of the overmold connector module 822.
  • FIG. 9 is a block diagram illustrating an example embodiment of a modular implantable medical device 901 having an access loop 971 for removal according to the present invention.
  • Access loop 971 may be mechanically coupled to, or formed as a part of overmold connector module 922. This access loop 971 may be used to assist in the removal of the implantable medical device 901 at a point in time when the device 901 is no longer needed by the patient, or at a point in time when a particular device 901 needs to be replaced.
  • the device 901 may be encapsulated within the patient 100 with scar tissue fibers such that physical effort will be required to remove the device 901 from its implantation location.
  • This access loop 971 provides a clinician a removal assist structure to physically manipulate the implantable medical device 901 during its removal.
  • This access loop 971 may also be useful during implantation of the device 901 as well as it provides a handle to manipulate the device 901 without handing the overmold 922 and its related modules.
  • One skilled in the art will recognize that alternate embodiments for the access loop that may include removal handles, a strip cord and a reinforced opening within the overmold connector module to provide a mechanism to grasp the device to assist in removal.
  • FIG. 10 is a schematic diagram illustrating an example embodiment of a modular implantable medical device 1001 having a triangular module arrangement according to the present invention.
  • a triangular arrangement of modules is shown with a overmold 1022 that at least partially encapsulates all of the modules.
  • Lead interconnection modules 1013 are located between the modules at a common location.
  • Overmold 1022 provides a slope interface 1041.
  • FIG. 11 is a schematic diagram illustrating an example embodiment of a modular implantable medical device 1101 having an inline module arrangement according to the present invention.
  • an inline arrangement of modules is shown with an overmold 1122 that at least partially encapsulates all of the modules.
  • a lead interconnection module 1113 is located on one side of the overmold 1122.
  • Overmold 1122 provides a slope interface 1141.
  • FIG. 12 is a schematic diagram illustrating side view of a multi-module implantable medical device having an inline module arrangement according to the present invention.
  • the side view of the device 1201 shows an underside of the device 1202 that possess a curved shape to permit implantation at a location having a curved body structure.
  • FIG. 13 is a schematic diagram illustrating an exploded view of a modular implantable medical device 1301 having a triangular module arrangement according to the present invention.
  • yet another triangular arrangement of modules is shown with an overmold 1322 at least partially encapsulating all of the modules.
  • a slope interface element 1341 is shown surrounding the overmold 1322.
  • the slope interface element 1341 is shown as a separate physical structure, such as a flexible band, an o-ring, removable flexible flange, or a tapered outer contour element that surrounds the overmold 1322, rather than a tapered portion of overmold 1322.
  • Slope interface element 1341 provides a desired sloped interface between the edge of the implantable medical device and the patient.
  • the shape and contour of slope interface element 1341 may be modified at the time of implantation to obtain a desired shape, or slope interface elements 1341 may be selected at the time of implantation from a variety of slope interface elements to provide a desired slope interface for a particular patient.
  • FIG. 14 is a flowchart illustrating a method of constructing an implantable medical device with an overmold according to the present invention.
  • An implantable medical device 401 may be fabricated by constructing the overmold 422 (1401) from a first and second component.
  • overmold 422 may comprise two or more materials, and two or more components.
  • overmold may comprise one or more elastomeric components formed of an elastomeric material, such as silicone, and one or more non-elastomeric components formed of a non-elastomeric material.
  • the modules 410-412 with their respective connector modules 423 are constructed (1402).
  • any motion reduction elements 421 included in the device 401 are constructed.
  • the motion restriction elements 421 may be combined with the overmold 422 (1403) and the interconnected modules 410-412 may be inserted (1404) into the overmold 422. From the combination of these components, the device 401 is formed.
  • an implantable medical device comprises a single housing and an overmold that at least partially encapsulates the housing. It is to be understood that other embodiments may be utilized and operational changes may be made without departing from the scope of the present invention as recited in the attached claims.

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  • Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Electrotherapy Devices (AREA)
  • Prostheses (AREA)
  • Surgical Instruments (AREA)

Abstract

La présente invention a trait à un dispositif médical modulaire implantable (101, 201, 301, 401, 801, 901, 1001, 1101, 1201, 1301) permettant d'obtenir des dispositifs médicaux implantables de plus petite dimension pour une meilleure adaptation dans des sites du corps humain. Un dispositif modulaire implantable répartit les divers éléments fonctionnels du dispositif médical implantable en un ensemble de modules interconnectés (201-212, 410-412, 510, 701-702, 810). Cette architecture distribuée d'un dispositif médical modulaire implantable permet de répartir l'encombrement du dispositif sur une plus grande surface tout en lui procurant une plus petite dimension, et permet une meilleure adaptation de la forme globale du dispositif médical implantable au site corporel dans lequel il est destiné à être implanté. Une enveloppe surmoulée (214, 322, 422, 522, 822, 922, 1022, 1122, 1222, 1322) incorpore les modules d'un dispositif médical modulaire implantable en une structure unique. Dans certains modes de réalisation, l'enveloppe surmoulée est flexible et fournit une interface biocompatible entre les modules d'éléments et le patient, tout en limitant le mouvement potentiellement endommageant entre modules.
PCT/US2003/038928 2002-12-09 2003-12-09 Enveloppe surmoulee pour un dispositif medical modulaire implantable WO2004052454A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP03796790A EP1578498A1 (fr) 2002-12-09 2003-12-09 Enveloppe surmoulee pour un dispositif medical modulaire implantable
AU2003297725A AU2003297725A1 (en) 2002-12-09 2003-12-09 Overmold for a modular implantable medical device

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US43185402P 2002-12-09 2002-12-09
US60/431,854 2002-12-09
US47126203P 2003-05-16 2003-05-16
US60/471,262 2003-05-16
US50394503P 2003-09-20 2003-09-20
US50394603P 2003-09-20 2003-09-20
US60/503,945 2003-09-20
US60/503,946 2003-09-20
US50785703P 2003-10-01 2003-10-01
US60/507,857 2003-10-01

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WO2004052454A1 true WO2004052454A1 (fr) 2004-06-24
WO2004052454B1 WO2004052454B1 (fr) 2004-08-19

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Application Number Title Priority Date Filing Date
PCT/US2003/038928 WO2004052454A1 (fr) 2002-12-09 2003-12-09 Enveloppe surmoulee pour un dispositif medical modulaire implantable
PCT/US2003/038940 WO2004052457A1 (fr) 2002-12-09 2003-12-09 Module de connexion de fil de dispositif medical implantable modulaire
PCT/US2003/038982 WO2004052459A1 (fr) 2002-12-09 2003-12-09 Concavite d'un dispositif medical implantable
PCT/US2003/038926 WO2004052452A1 (fr) 2002-12-09 2003-12-09 Reduction de mouvement relatif entre modules dans un dispositif medical modulaire implantable
PCT/US2003/038927 WO2004052453A1 (fr) 2002-12-09 2003-12-09 Dispositif medical implantable a profil bas
PCT/US2003/038939 WO2004052456A1 (fr) 2002-12-09 2003-12-09 Dispositif medical implantable modulaire
PCT/US2003/038938 WO2004052455A1 (fr) 2002-12-09 2003-12-09 Module de couplage d'un dispositif medical implantable
PCT/US2003/038981 WO2004052458A1 (fr) 2002-12-09 2003-12-09 Dispositif medical implantable modulaire

Family Applications After (7)

Application Number Title Priority Date Filing Date
PCT/US2003/038940 WO2004052457A1 (fr) 2002-12-09 2003-12-09 Module de connexion de fil de dispositif medical implantable modulaire
PCT/US2003/038982 WO2004052459A1 (fr) 2002-12-09 2003-12-09 Concavite d'un dispositif medical implantable
PCT/US2003/038926 WO2004052452A1 (fr) 2002-12-09 2003-12-09 Reduction de mouvement relatif entre modules dans un dispositif medical modulaire implantable
PCT/US2003/038927 WO2004052453A1 (fr) 2002-12-09 2003-12-09 Dispositif medical implantable a profil bas
PCT/US2003/038939 WO2004052456A1 (fr) 2002-12-09 2003-12-09 Dispositif medical implantable modulaire
PCT/US2003/038938 WO2004052455A1 (fr) 2002-12-09 2003-12-09 Module de couplage d'un dispositif medical implantable
PCT/US2003/038981 WO2004052458A1 (fr) 2002-12-09 2003-12-09 Dispositif medical implantable modulaire

Country Status (6)

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US (11) US8397732B2 (fr)
EP (8) EP1578499A1 (fr)
AT (3) ATE468883T1 (fr)
AU (8) AU2003294596A1 (fr)
DE (3) DE60332764D1 (fr)
WO (8) WO2004052454A1 (fr)

Families Citing this family (344)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8177762B2 (en) 1998-12-07 2012-05-15 C. R. Bard, Inc. Septum including at least one identifiable feature, access ports including same, and related methods
US7346391B1 (en) * 1999-10-12 2008-03-18 Flint Hills Scientific Llc Cerebral or organ interface system
US7660621B2 (en) 2000-04-07 2010-02-09 Medtronic, Inc. Medical device introducer
US9655705B1 (en) * 2000-09-29 2017-05-23 Precision Medical Devices, Inc. Body canal contacting means for body fluid flow control methods and devices
US7288085B2 (en) * 2001-04-10 2007-10-30 Medtronic, Inc. Permanent magnet solenoid pump for an implantable therapeutic substance delivery device
US7130675B2 (en) * 2002-06-28 2006-10-31 Tristan Technologies, Inc. High-resolution magnetoencephalography system and method
US7704260B2 (en) 2002-09-17 2010-04-27 Medtronic, Inc. Low profile instrument immobilizer
EP1578499A1 (fr) 2002-12-09 2005-09-28 Medtronic, Inc. Dispositif medical implantable modulaire
US7596408B2 (en) * 2002-12-09 2009-09-29 Medtronic, Inc. Implantable medical device with anti-infection agent
AU2003901867A0 (en) * 2003-04-17 2003-05-08 Cochlear Limited Osseointegration fixation system for an implant
US8811643B2 (en) * 2003-05-08 2014-08-19 Advanced Bionics Integrated cochlear implant headpiece
US7599508B1 (en) 2003-05-08 2009-10-06 Advanced Bionics, Llc Listening device cap
US8270647B2 (en) * 2003-05-08 2012-09-18 Advanced Bionics, Llc Modular speech processor headpiece
US7263401B2 (en) 2003-05-16 2007-08-28 Medtronic, Inc. Implantable medical device with a nonhermetic battery
US20050004637A1 (en) * 2003-05-16 2005-01-06 Ruchika Singhal Explantation of implantable medical device
US7317947B2 (en) * 2003-05-16 2008-01-08 Medtronic, Inc. Headset recharger for cranially implantable medical devices
US20050003268A1 (en) * 2003-05-16 2005-01-06 Scott Erik R. Battery housing configuration
US7617007B2 (en) 2003-06-04 2009-11-10 Synecor Llc Method and apparatus for retaining medical implants within body vessels
US8239045B2 (en) 2003-06-04 2012-08-07 Synecor Llc Device and method for retaining a medical device within a vessel
EP1633434B1 (fr) 2003-06-04 2014-11-19 Synecor Systeme electrophysiologiques intravasculaires
US7082336B2 (en) * 2003-06-04 2006-07-25 Synecor, Llc Implantable intravascular device for defibrillation and/or pacing
US7840270B2 (en) 2003-07-23 2010-11-23 Synapse Biomedical, Inc. System and method for conditioning a diaphragm of a patient
US20050102006A1 (en) * 2003-09-25 2005-05-12 Whitehurst Todd K. Skull-mounted electrical stimulation system
US7225032B2 (en) * 2003-10-02 2007-05-29 Medtronic Inc. External power source, charger and system for an implantable medical device having thermal characteristics and method therefore
US20050075696A1 (en) 2003-10-02 2005-04-07 Medtronic, Inc. Inductively rechargeable external energy source, charger, system and method for a transcutaneous inductive charger for an implantable medical device
US9278208B1 (en) 2003-10-20 2016-03-08 University Of Central Florida Research Foundation, Inc. Spatial-temporal deep brain stimulation methods and systems
US8024049B1 (en) * 2003-10-20 2011-09-20 University Of Central Florida Research Foundation, Inc. Spatial-temporal deep brain stimulation methods and systems
US7747335B2 (en) 2003-12-12 2010-06-29 Synecor Llc Implantable medical device having pre-implant exoskeleton
US7769461B2 (en) * 2003-12-19 2010-08-03 Boston Scientific Neuromodulation Corporation Skull-mounted electrical stimulation system and method for treating patients
WO2005090370A1 (fr) * 2004-02-05 2005-09-29 The Regents Of The University Of California Agents pharmacologiquement actifs contenant des phosphonates esterifies, et leurs procedes d'utilisation
US7580756B2 (en) * 2004-02-13 2009-08-25 Medtronic, Inc. Methods and apparatus for securing a therapy delivery device within a burr hole
US7596399B2 (en) * 2004-04-29 2009-09-29 Medtronic, Inc Implantation of implantable medical device
US20050245984A1 (en) * 2004-04-30 2005-11-03 Medtronic, Inc. Implantable medical device with lubricious material
US8862235B1 (en) * 2005-07-01 2014-10-14 Alfred E. Mann Foundation For Scientific Research Brain implant device
US20060009814A1 (en) * 2004-07-07 2006-01-12 Alfred E. Mann Foundation For Scientific Research Brian implant device
US8105714B2 (en) 2004-10-29 2012-01-31 Medtronic, Inc. Lithium-ion battery
US8980453B2 (en) 2008-04-30 2015-03-17 Medtronic, Inc. Formation process for lithium-ion batteries
US7682745B2 (en) 2004-10-29 2010-03-23 Medtronic, Inc. Medical device having lithium-ion battery
ATE499714T1 (de) * 2004-10-29 2011-03-15 Medtronic Inc Verfahren zum aufladen einer lithiumionenbatterie
US9065145B2 (en) 2004-10-29 2015-06-23 Medtronic, Inc. Lithium-ion battery
US7927742B2 (en) 2004-10-29 2011-04-19 Medtronic, Inc. Negative-limited lithium-ion battery
US7807299B2 (en) 2004-10-29 2010-10-05 Medtronic, Inc. Lithium-ion battery
US7879495B2 (en) 2004-10-29 2011-02-01 Medtronic, Inc. Medical device having lithium-ion battery
US20080044728A1 (en) * 2004-10-29 2008-02-21 Medtronic, Inc. Lithium-ion battery
US7641992B2 (en) 2004-10-29 2010-01-05 Medtronic, Inc. Medical device having lithium-ion battery
CN101048898B (zh) 2004-10-29 2012-02-01 麦德托尼克公司 锂离子电池及医疗装置
US7662509B2 (en) 2004-10-29 2010-02-16 Medtronic, Inc. Lithium-ion battery
US9077022B2 (en) 2004-10-29 2015-07-07 Medtronic, Inc. Lithium-ion battery
US7642013B2 (en) 2004-10-29 2010-01-05 Medtronic, Inc. Medical device having lithium-ion battery
WO2006052765A2 (fr) 2004-11-04 2006-05-18 Smith & Nephew, Inc. Dispositif de mesure de cycles et de charge
US20070239230A1 (en) * 2004-12-17 2007-10-11 Medtronic, Inc. System and method for regulating cardiac triggered therapy to the brain
WO2006066099A1 (fr) * 2004-12-17 2006-06-22 Medtronic, Inc. Systeme et methode pour reguler une therapie a declenchement cardio-pulmonaire, administree au cerveau
US8112148B2 (en) 2004-12-17 2012-02-07 Medtronic, Inc. System and method for monitoring cardiac signal activity in patients with nervous system disorders
US8108038B2 (en) * 2004-12-17 2012-01-31 Medtronic, Inc. System and method for segmenting a cardiac signal based on brain activity
US8485979B2 (en) 2004-12-17 2013-07-16 Medtronic, Inc. System and method for monitoring or treating nervous system disorders
US8108046B2 (en) * 2004-12-17 2012-01-31 Medtronic, Inc. System and method for using cardiac events to trigger therapy for treating nervous system disorders
US8112153B2 (en) 2004-12-17 2012-02-07 Medtronic, Inc. System and method for monitoring or treating nervous system disorders
US8209019B2 (en) * 2004-12-17 2012-06-26 Medtronic, Inc. System and method for utilizing brain state information to modulate cardiac therapy
US8209009B2 (en) 2004-12-17 2012-06-26 Medtronic, Inc. System and method for segmenting a cardiac signal based on brain stimulation
US8214035B2 (en) * 2004-12-17 2012-07-03 Medtronic, Inc. System and method for utilizing brain state information to modulate cardiac therapy
US7376466B2 (en) * 2005-01-26 2008-05-20 Boston Scientific Neuromodulation Corporation Casings for implantable stimulators and methods of making the same
US7657316B2 (en) * 2005-02-25 2010-02-02 Boston Scientific Neuromodulation Corporation Methods and systems for stimulating a motor cortex of the brain to treat a medical condition
EP1858565B1 (fr) 2005-03-04 2021-08-11 C.R. Bard, Inc. Systemes et procedes d'identification d'orifice d'acces
US7947022B2 (en) 2005-03-04 2011-05-24 C. R. Bard, Inc. Access port identification systems and methods
US9474888B2 (en) 2005-03-04 2016-10-25 C. R. Bard, Inc. Implantable access port including a sandwiched radiopaque insert
US8029482B2 (en) 2005-03-04 2011-10-04 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
US7363082B2 (en) * 2005-03-24 2008-04-22 Synecor Llc Flexible hermetic enclosure for implantable medical devices
US7593538B2 (en) * 2005-03-28 2009-09-22 Starkey Laboratories, Inc. Antennas for hearing aids
EP3173121B8 (fr) 2005-04-27 2021-03-24 C.R. Bard Inc. Appareils de perfuseur avec septum
WO2006116613A1 (fr) 2005-04-27 2006-11-02 C.R. Bard, Inc. Appareils de perfusion
US10307581B2 (en) 2005-04-27 2019-06-04 C. R. Bard, Inc. Reinforced septum for an implantable medical device
US7684864B2 (en) * 2005-04-28 2010-03-23 Medtronic, Inc. Subcutaneous cardioverter-defibrillator
US7673528B2 (en) * 2005-05-12 2010-03-09 Euisik Yoon Flexible modular sensor systems
US8391990B2 (en) 2005-05-18 2013-03-05 Cardiac Pacemakers, Inc. Modular antitachyarrhythmia therapy system
EP1904173B8 (fr) * 2005-06-09 2016-06-08 Medtronic, Inc. Dispositif medical implantable comportant des electrodes sur de multiples surfaces de boitier
US8620435B2 (en) 2005-06-09 2013-12-31 Medtronic, Inc. Combination therapy including peripheral nerve field stimulation
US7815667B2 (en) * 2005-07-21 2010-10-19 Pyles Stephen T Power source for an implantable medical device
EP1924211B1 (fr) 2005-08-23 2019-12-18 Smith & Nephew, Inc. Implant orthopedique telemetrique
US9050005B2 (en) 2005-08-25 2015-06-09 Synapse Biomedical, Inc. Method and apparatus for transgastric neurostimulation
US20070225773A1 (en) * 2005-09-28 2007-09-27 Yang Shen Implantable transcranial pulse generator having a collapsible portion
US20070123923A1 (en) * 2005-11-30 2007-05-31 Lindstrom Curtis C Implantable medical device minimizing rotation and dislocation
US20070142696A1 (en) 2005-12-08 2007-06-21 Ventrassist Pty Ltd Implantable medical devices
JP2009519769A (ja) * 2005-12-15 2009-05-21 カーディアック ペースメイカーズ， インコーポレイテッド 埋込可能型装置用小形電源用の方法と装置
US9616223B2 (en) * 2005-12-30 2017-04-11 Medtronic, Inc. Media-exposed interconnects for transducers
US9849216B2 (en) 2006-03-03 2017-12-26 Smith & Nephew, Inc. Systems and methods for delivering a medicament
US8676323B2 (en) 2006-03-09 2014-03-18 Synapse Biomedical, Inc. Ventilatory assist system and methods to improve respiratory function
US20070265673A1 (en) * 2006-04-03 2007-11-15 Terrance Ransbury Flexible interconnect assembly for implantable medical devices
DE102006018851A1 (de) * 2006-04-22 2007-10-25 Biotronik Crm Patent Ag Aktives medizinisches Geräteimplantat mit mindestens zwei diagnostischen und/oder therapeutischen Funktionen
US9084901B2 (en) 2006-04-28 2015-07-21 Medtronic, Inc. Cranial implant
US7856272B2 (en) * 2006-04-28 2010-12-21 Flint Hills Scientific, L.L.C. Implantable interface for a medical device system
US8121667B2 (en) * 2006-05-12 2012-02-21 Koninklijke Philips Electronics N.V. Interfaced base unit and display system for an MRI magnet room
US20080097153A1 (en) * 2006-08-24 2008-04-24 Ignagni Anthony R Method and apparatus for grasping an abdominal wall
US7899537B1 (en) * 2006-10-27 2011-03-01 Pacesetter, Inc. Pericardial cardioverter defibrillator
US7894915B1 (en) 2006-10-27 2011-02-22 Pacesetter, Inc. Implantable medical device
US8401648B2 (en) * 2006-10-31 2013-03-19 Medtronic, Inc. Housing for implantable medical device
US9265912B2 (en) 2006-11-08 2016-02-23 C. R. Bard, Inc. Indicia informative of characteristics of insertable medical devices
US9642986B2 (en) 2006-11-08 2017-05-09 C. R. Bard, Inc. Resource information key for an insertable medical device
US8311633B2 (en) * 2006-12-04 2012-11-13 Synecor Llc Intravascular implantable device having superior anchoring arrangement
US20080147168A1 (en) * 2006-12-04 2008-06-19 Terrance Ransbury Intravascular implantable device having detachable tether arrangement
CN101657230B (zh) * 2006-12-15 2014-01-29 纳索菲力克斯有限公司 复苏设备和复苏方法
US9079016B2 (en) 2007-02-05 2015-07-14 Synapse Biomedical, Inc. Removable intramuscular electrode
US9445720B2 (en) 2007-02-23 2016-09-20 Smith & Nephew, Inc. Processing sensed accelerometer data for determination of bone healing
AT505042B1 (de) * 2007-03-21 2009-11-15 Med El Elektromed Geraete Gmbh System zur elektrostimulation
US8469908B2 (en) * 2007-04-06 2013-06-25 Wilson T. Asfora Analgesic implant device and system
US8512264B1 (en) 2007-04-06 2013-08-20 Wilson T. Asfora Analgesic implant device and system
US9554721B1 (en) * 2007-04-23 2017-01-31 Neurowave Systems Inc. Seizure detector, brain dysfunction monitor and method
US9399130B2 (en) 2007-04-25 2016-07-26 Medtronic, Inc. Cannula configured to deliver test stimulation
US9561053B2 (en) 2007-04-25 2017-02-07 Medtronic, Inc. Implant tool to facilitate medical device implantation
US8000788B2 (en) 2007-04-27 2011-08-16 Medtronic, Inc. Implantable medical device for treating neurological conditions including ECG sensing
US9820671B2 (en) 2007-05-17 2017-11-21 Synapse Biomedical, Inc. Devices and methods for assessing motor point electromyogram as a biomarker
CA2692142C (fr) 2007-06-20 2016-07-26 Medical Components, Inc. Orifice d'acces veineux avec indices moules et/ou radio-opaques
WO2009012395A1 (fr) 2007-07-19 2009-01-22 Innovative Medical Devices, Llc Ensemble orifice d'accès veineux avec indices discernables par rayons x
EP3311877A1 (fr) 2007-07-19 2018-04-25 Medical Components, Inc. Ensemble d'orifice d'accès veineux avec des inscriptions lisibles aux rayons x
US9592377B2 (en) 2007-07-27 2017-03-14 Second Sight Medical Products, Inc. Implantable device for the brain
US8060218B2 (en) * 2007-08-02 2011-11-15 Synecor, Llc Inductive element for intravascular implantable devices
US9757554B2 (en) 2007-08-23 2017-09-12 Bioness Inc. System for transmitting electrical current to a bodily tissue
US8738137B2 (en) * 2007-08-23 2014-05-27 Bioness Inc. System for transmitting electrical current to a bodily tissue
CA2697381A1 (fr) * 2007-08-23 2009-02-26 Bioness, Inc. Systeme pour transmettre un courant electrique a un tissu corporel
CA2698686A1 (fr) 2007-09-06 2009-03-12 Smith & Nephew, Inc. Systeme et procede pour communiquer avec un implant telemetrique
US20090082827A1 (en) * 2007-09-26 2009-03-26 Cardiac Pacemakers, Inc. Hinged anchors for wireless pacing electrodes
US20100198103A1 (en) * 2007-10-09 2010-08-05 Imthera Medical, Inc. System and method for neural stimulation
US8428726B2 (en) 2007-10-30 2013-04-23 Synapse Biomedical, Inc. Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system
US8478412B2 (en) 2007-10-30 2013-07-02 Synapse Biomedical, Inc. Method of improving sleep disordered breathing
US9248280B2 (en) * 2007-11-02 2016-02-02 Boston Scientific Neuromodulation Corporation Closed-loop feedback for steering stimulation energy within tissue
US20090118804A1 (en) * 2007-11-05 2009-05-07 Advanced Bionics Corporation Method of mounting minimally invasive plug electrodes within cranium of patient
US9579496B2 (en) 2007-11-07 2017-02-28 C. R. Bard, Inc. Radiopaque and septum-based indicators for a multi-lumen implantable port
US8165694B2 (en) * 2008-01-29 2012-04-24 Boston Scientific Neuromodulation Corporation Thermal management of implantable medical devices
US8024045B2 (en) * 2008-02-08 2011-09-20 Intelect Medical, Inc. Multi-functional burr hole assembly
US20090216324A1 (en) * 2008-02-22 2009-08-27 Leigh Charles R A Malleable implantable medical device
JP2009225935A (ja) * 2008-03-21 2009-10-08 Nitto Denko Corp 体液採取用回路基板およびバイオセンサ
US20090281623A1 (en) * 2008-05-12 2009-11-12 Medtronic, Inc. Customization of implantable medical devices
US20090312835A1 (en) * 2008-06-17 2009-12-17 Greatbatch Ltd. Dielectric fluid filled active implantable medical devices
WO2009154456A1 (fr) * 2008-06-18 2009-12-23 Kerphos B.V. Système électronique flexible produisant un signal de stimulation pour le corps humain
NL2001698C2 (en) 2008-06-18 2009-12-22 Nasophlex B V Cardioverter / defibrillator.
NL2001697C2 (en) 2008-06-18 2009-12-22 Nasophlex B V Nose stimulator for producing a stimulation signal to a nose.
NL2001694C2 (en) * 2008-06-18 2009-12-22 Nasophlex B V Ear stimulator for producing a stimulation signal to an ear.
EP3173125B1 (fr) 2008-07-30 2019-03-27 Ecole Polytechnique Fédérale de Lausanne Appareil de stimulation optimisée d'une cible neurologique
US8335551B2 (en) * 2008-09-29 2012-12-18 Chong Il Lee Method and means for connecting a large number of electrodes to a measuring device
US9492210B2 (en) 2008-10-15 2016-11-15 Smith & Nephew, Inc. Composite internal fixators
US9192769B2 (en) 2008-10-31 2015-11-24 Medtronic, Inc. Shunt-current reduction techniques for an implantable therapy system
US8560060B2 (en) 2008-10-31 2013-10-15 Medtronic, Inc. Isolation of sensing and stimulation circuitry
US9393432B2 (en) 2008-10-31 2016-07-19 Medtronic, Inc. Non-hermetic direct current interconnect
WO2010051486A1 (fr) * 2008-10-31 2010-05-06 Medtronic, Inc. Boîtier de réduction du courant dérivé pour système thérapeutique implantable
US8498698B2 (en) * 2008-10-31 2013-07-30 Medtronic, Inc. Isolation of sensing and stimulation circuitry
BRPI0919890B8 (pt) 2008-10-31 2019-09-24 Bard Inc C R orifício de acesso para prover acesso subcutâneo a um paciente, e, orifício de acesso injetável de força
AU2009315316B2 (en) 2008-11-12 2015-11-05 Ecole Polytechnique Federale De Lausanne Microfabricated neurostimulation device
US8932271B2 (en) 2008-11-13 2015-01-13 C. R. Bard, Inc. Implantable medical devices including septum-based indicators
US11890443B2 (en) 2008-11-13 2024-02-06 C. R. Bard, Inc. Implantable medical devices including septum-based indicators
US9522081B2 (en) 2008-12-02 2016-12-20 University Of Washington Methods and devices for brain cooling for treatment and/or prevention of epileptic seizures
US8591562B2 (en) * 2008-12-02 2013-11-26 University Of Washington Methods and devices for brain cooling for treatment and prevention of acquired epilepsy
US8321028B1 (en) * 2008-12-02 2012-11-27 Advanced Bionics Impact resistant implantable antenna coil assembly
US8737658B2 (en) 2008-12-19 2014-05-27 Starkey Laboratories, Inc. Three dimensional substrate for hearing assistance devices
US8494197B2 (en) * 2008-12-19 2013-07-23 Starkey Laboratories, Inc. Antennas for custom fit hearing assistance devices
US10142747B2 (en) 2008-12-19 2018-11-27 Starkey Laboratories, Inc. Three dimensional substrate for hearing assistance devices
US8699733B2 (en) 2008-12-19 2014-04-15 Starkey Laboratories, Inc. Parallel antennas for standard fit hearing assistance devices
US8565457B2 (en) 2008-12-19 2013-10-22 Starkey Laboratories, Inc. Antennas for standard fit hearing assistance devices
US8704124B2 (en) 2009-01-29 2014-04-22 Smith & Nephew, Inc. Low temperature encapsulate welding
EP2258442A1 (fr) * 2009-06-03 2010-12-08 Greatbatch Ltd. Dispositifs médicaux implantables actifs remplis de fluides diélectriques
US20110004288A1 (en) * 2009-06-12 2011-01-06 Terrance Ransbury Intravascular implantable device having integrated anchor mechanism
WO2010144916A2 (fr) * 2009-06-12 2010-12-16 Innerpulse, Inc. Procédés et systèmes pour des dispositifs implantables intravasculaires anti-thrombotiques
WO2011005847A1 (fr) 2009-07-07 2011-01-13 C. R. Bard, Inc. Traverse interne extensible pour un dispositif médical
US10286218B2 (en) 2009-07-31 2019-05-14 Medtronic, Inc. Connector enclosure assemblies of medical devices including an angled lead passageway
EP2501294B1 (fr) 2009-11-17 2018-08-15 C.R. Bard, Inc. Orifice d'accès surmoulé comprenant des caractéristiques d'ancrage et d'identification
CA3026948C (fr) 2009-12-01 2022-07-12 Ecole Polytechnique Federale De Lausanne Dispositif de neurostimulation microfabrique et ses procedes de fabrication et d'utilisation
US8744568B2 (en) * 2009-12-22 2014-06-03 Boston Scientific Scimed, Inc. Medical device with electroactive polymer powered by photovoltaic cell
WO2011091071A2 (fr) * 2010-01-20 2011-07-28 The Regents Of The University Of California Système, dispositifs, et procédés destinés à l'implantation crânienne d'un dispositif de neuromodulation
US8527065B2 (en) * 2010-02-11 2013-09-03 Biotronik Se & Co. Kg Electrode device for active medical implant
EP2552536B1 (fr) 2010-04-01 2016-06-08 Ecole Polytechnique Fédérale de Lausanne (EPFL) Dispositif d'interaction avec un tissu neurologique
US9216297B2 (en) 2010-04-05 2015-12-22 Medtronic, Inc. Flexible recharge coil techniques
US8594806B2 (en) 2010-04-30 2013-11-26 Cyberonics, Inc. Recharging and communication lead for an implantable device
CA2820598A1 (fr) * 2010-12-09 2012-06-14 Heartware, Inc. Unite de commande et source d'energie pour pompe a sang implantable
CN103282080B (zh) 2010-12-28 2016-05-18 美敦力公司 包括金属连接件封壳的医疗装置
USD682416S1 (en) 2010-12-30 2013-05-14 C. R. Bard, Inc. Implantable access port
USD676955S1 (en) 2010-12-30 2013-02-26 C. R. Bard, Inc. Implantable access port
EP2667936B1 (fr) 2011-01-26 2017-08-23 Medtronic, Inc. Dispositifs médicaux implantables et ensembles boîtiers de connecteurs associés utilisant des conducteurs couplés électriquement à des broches de traversée
FR2970874B1 (fr) * 2011-01-27 2013-03-01 Pierre Sabin Dispositif percutane permanent de connexion electrique et procede de fabrication
US8515540B2 (en) 2011-02-24 2013-08-20 Cochlear Limited Feedthrough having a non-linear conductor
EP3586908A1 (fr) 2011-04-04 2020-01-01 Micron Devices LLC Electrode de dérivation implantable pour stimulation des tissus neuraux, dotée de communication sans fil
US9901268B2 (en) 2011-04-13 2018-02-27 Branchpoint Technologies, Inc. Sensor, circuitry, and method for wireless intracranial pressure monitoring
US9287580B2 (en) 2011-07-27 2016-03-15 Medtronic, Inc. Battery with auxiliary electrode
CA2848998A1 (fr) 2011-09-15 2013-03-21 Stimwave Technologies Incorporated Module relais pour implant
US9950179B2 (en) * 2011-10-28 2018-04-24 Medtronic, Inc. Medical devices for trial stimulation
USD751200S1 (en) 2011-12-08 2016-03-08 Heartware, Inc. Controller for implantable blood pump
US20130149560A1 (en) 2011-12-09 2013-06-13 Medtronic, Inc. Auxiliary electrode for lithium-ion battery
US20150018728A1 (en) 2012-01-26 2015-01-15 Bluewind Medical Ltd. Wireless neurostimulators
US9981137B2 (en) 2012-01-27 2018-05-29 Nuvectra Corporation Heat dispersion for implantable medical devices
US9630231B2 (en) 2012-01-27 2017-04-25 Nuvectra Corporation Superplastic forming for titanium implant enclosures
US9283397B2 (en) * 2012-01-31 2016-03-15 Christopher C. Stancer Charge control for high voltage therapy energy storage component
US9630018B2 (en) 2012-01-31 2017-04-25 Medtronic, Inc. Charge control for high voltage therapy energy storage component
EP2626109A1 (fr) * 2012-02-08 2013-08-14 Sapiens Steering Brain Stimulation B.V. Système de sonde pour applications cérébrales
US9510953B2 (en) 2012-03-16 2016-12-06 Vertebral Technologies, Inc. Modular segmented disc nucleus implant
US9681836B2 (en) 2012-04-23 2017-06-20 Cyberonics, Inc. Methods, systems and apparatuses for detecting seizure and non-seizure states
JP6529179B2 (ja) 2012-07-26 2019-06-12 ニクソア エス．アー． アンテナを含むインプラント型睡眠時無呼吸処置デバイス
US9343923B2 (en) 2012-08-23 2016-05-17 Cyberonics, Inc. Implantable medical device with backscatter signal based communication
WO2014039925A2 (fr) 2012-09-07 2014-03-13 Yale University Système de refroidissement du cerveau
US9935498B2 (en) 2012-09-25 2018-04-03 Cyberonics, Inc. Communication efficiency with an implantable medical device using a circulator and a backscatter signal
CA2892439C (fr) 2012-11-21 2021-10-12 Newpace Ltd. Dispositif cardiaque sous-cutane injectable en chaine
WO2014087337A1 (fr) 2012-12-06 2014-06-12 Bluewind Medical Ltd. Pose de neurostimulateurs implantables
US20140163626A1 (en) * 2012-12-12 2014-06-12 Grahame Walling Implantable device migration control
FR2999441B1 (fr) * 2012-12-14 2016-01-01 Commissariat Energie Atomique Boitier hermetique, en particulier pour l'encapsulation d'un dispositif medical implantable.
US9254393B2 (en) 2012-12-26 2016-02-09 Micron Devices Llc Wearable antenna assembly
US8849408B1 (en) 2013-01-04 2014-09-30 University Of Central Florida Research Foundation, Inc. Methods for electronic directionality of deep-brain stimulation
EP2968953B1 (fr) * 2013-03-12 2018-10-17 Cardiac Pacemakers, Inc. Dispositif médical implantable et son ensemble
US9887574B2 (en) 2013-03-15 2018-02-06 Globus Medical, Inc. Spinal cord stimulator system
US9878170B2 (en) 2013-03-15 2018-01-30 Globus Medical, Inc. Spinal cord stimulator system
US9439686B2 (en) 2013-03-15 2016-09-13 Warsaw Orthopedic, Inc. Spinal correction system and method
US9872997B2 (en) 2013-03-15 2018-01-23 Globus Medical, Inc. Spinal cord stimulator system
EP2968959B1 (fr) * 2013-03-15 2017-09-20 Medtronic, Inc. Dispositif implantable ayant raccord pour dérivation interne
US9440076B2 (en) 2013-03-15 2016-09-13 Globus Medical, Inc. Spinal cord stimulator system
EP2994191A1 (fr) * 2013-05-10 2016-03-16 Advanced Bionics AG Implants cochléaires à profil mince
WO2015004673A1 (fr) * 2013-07-11 2015-01-15 Newpace Ltd. Batterie et intégration de composants électroniques dans un dispositif médical implantable
US10610693B2 (en) * 2013-07-11 2020-04-07 Newpace Ltd. Battery and electronics integration in a flexible implantable medical device
US20150038948A1 (en) * 2013-07-31 2015-02-05 G-Tech Electronic Research & Development, LLC Apparatus and use of a neurochemisrty regulator device insertable in the cranium for the treatment of cerebral cortical disorders
US9042991B2 (en) 2013-08-14 2015-05-26 Syntilla Medical LLC Implantable head mounted neurostimulation system for head pain
USD751201S1 (en) 2013-08-26 2016-03-08 Heartware, Inc. Handheld controller
US9333366B2 (en) 2013-09-05 2016-05-10 Boston Scientific Neuromodulation Corporation Construction for an implantable medical device having a battery affixed to the case
US10960215B2 (en) 2013-10-23 2021-03-30 Nuxcel, Inc. Low profile head-located neurostimulator and method of fabrication
WO2015081027A1 (fr) 2013-11-29 2015-06-04 The Johns Hopkins University Guides de coupe pouvant être suivis spécifiques à un patient
AU2015204701B2 (en) 2014-01-10 2018-03-15 Cardiac Pacemakers, Inc. Systems and methods for detecting cardiac arrhythmias
ES2661718T3 (es) 2014-01-10 2018-04-03 Cardiac Pacemakers, Inc. Métodos y sistemas para mejorar la comunicación entre dispositivos médicos
US9901269B2 (en) 2014-04-17 2018-02-27 Branchpoint Technologies, Inc. Wireless intracranial monitoring system
US9848789B2 (en) 2014-04-17 2017-12-26 Branchpoint Technologies, Inc. Wireless intracranial monitoring system
EP3476430B1 (fr) 2014-05-16 2020-07-01 Aleva Neurotherapeutics SA Dispositif d'interaction avec un tissu neurologique
US11311718B2 (en) 2014-05-16 2022-04-26 Aleva Neurotherapeutics Sa Device for interacting with neurological tissue and methods of making and using the same
US9474894B2 (en) 2014-08-27 2016-10-25 Aleva Neurotherapeutics Deep brain stimulation lead
US9403011B2 (en) 2014-08-27 2016-08-02 Aleva Neurotherapeutics Leadless neurostimulator
EP3185952B1 (fr) 2014-08-28 2018-07-25 Cardiac Pacemakers, Inc. Système implantable pour le suivi du rythme cardiaque et un procédé associé pour déclencher une période de suppression par un second dispositif
CN107106832B (zh) * 2014-09-08 2020-10-27 纽佩斯公司 柔性可充电植入式皮下医疗装置结构及组装方法
US10603175B2 (en) 2014-11-24 2020-03-31 The Johns Hopkins University Cutting machine for resizing raw implants during surgery
EP3226968B1 (fr) 2014-12-01 2018-12-26 Cardiac Pacemakers, Inc. Dispositif médical implantable comprenant des composants de circuits empilés
US9579511B2 (en) * 2014-12-15 2017-02-28 Medtronic, Inc. Medical device with surface mounted lead connector
CN107206240B (zh) 2015-02-06 2021-01-22 心脏起搏器股份公司 用于治疗心律不齐的系统和方法
WO2016126968A1 (fr) 2015-02-06 2016-08-11 Cardiac Pacemakers, Inc. Systèmes et procédés pour l'administration sécurisée d'une thérapie par stimulation électrique
WO2016130477A2 (fr) 2015-02-09 2016-08-18 Cardiac Pacemakers, Inc. Dispositif médical implantable comportant une étiquette d'identification radio-opaque
EP3265172B1 (fr) 2015-03-04 2018-12-19 Cardiac Pacemakers, Inc. Systèmes de traitement d'arythmies cardiaques
US10050700B2 (en) 2015-03-18 2018-08-14 Cardiac Pacemakers, Inc. Communications in a medical device system with temporal optimization
EP3270768B1 (fr) 2015-03-18 2023-12-13 Cardiac Pacemakers, Inc. Communications dans un système de dispositif médical avec une évaluation de qualité de liaison
US10232169B2 (en) 2015-07-23 2019-03-19 Boston Scientific Neuromodulation Corporation Burr hole plugs for electrical stimulation systems and methods of making and using
EP3337558A1 (fr) 2015-08-20 2018-06-27 Cardiac Pacemakers, Inc. Systèmes et procédés de communication entre des dispositifs médicaux
US10357159B2 (en) 2015-08-20 2019-07-23 Cardiac Pacemakers, Inc Systems and methods for communication between medical devices
US9968787B2 (en) 2015-08-27 2018-05-15 Cardiac Pacemakers, Inc. Spatial configuration of a motion sensor in an implantable medical device
US9956414B2 (en) 2015-08-27 2018-05-01 Cardiac Pacemakers, Inc. Temporal configuration of a motion sensor in an implantable medical device
US9770597B2 (en) * 2015-08-27 2017-09-26 Precision Medical Devices, Inc. Telemetry port for implanted medical device
US10159842B2 (en) 2015-08-28 2018-12-25 Cardiac Pacemakers, Inc. System and method for detecting tamponade
US10226631B2 (en) 2015-08-28 2019-03-12 Cardiac Pacemakers, Inc. Systems and methods for infarct detection
CN108136189B (zh) 2015-08-28 2021-10-15 心脏起搏器股份公司 用于行为响应信号检测和治疗递送的系统
US11058541B2 (en) 2015-09-04 2021-07-13 The Johns Hopkins University Low-profile intercranial device
US10092760B2 (en) 2015-09-11 2018-10-09 Cardiac Pacemakers, Inc. Arrhythmia detection and confirmation
EP3359251B1 (fr) 2015-10-08 2019-08-07 Cardiac Pacemakers, Inc. Ajustement des fréquences de stimulation dans un dispositif médical implantable
US10105540B2 (en) 2015-11-09 2018-10-23 Bluewind Medical Ltd. Optimization of application of current
EP4252833A3 (fr) 2015-11-17 2023-11-15 Inspire Medical Systems, Inc. Dispositif de traitement par microstimulation pour les troubles respiratoires du sommeil (sdb)
US10576292B2 (en) 2015-11-29 2020-03-03 Boston Scientific Neuromodulation Corporation Skull-mounted deep brain stimulator
JP6608063B2 (ja) 2015-12-17 2019-11-20 カーディアック ペースメイカーズ， インコーポレイテッド 植込み型医療装置
US10905886B2 (en) 2015-12-28 2021-02-02 Cardiac Pacemakers, Inc. Implantable medical device for deployment across the atrioventricular septum
WO2017127548A1 (fr) 2016-01-19 2017-07-27 Cardiac Pacemakers, Inc. Dispositifs permettant de recharger sans fil une batterie rechargeable d'un dispositif médical implantable
EP3411111A1 (fr) 2016-02-02 2018-12-12 Aleva Neurotherapeutics SA Traitement de maladies auto-immunes par stimulation cérébrale profonde
EP3411113B1 (fr) 2016-02-04 2019-11-27 Cardiac Pacemakers, Inc. Système de pose avec capteur de force pour dispositif cardiaque sans fil
WO2017173275A1 (fr) 2016-03-31 2017-10-05 Cardiac Pacemakers, Inc. Dispositif médical implantable à batterie rechargeable
US10668294B2 (en) 2016-05-10 2020-06-02 Cardiac Pacemakers, Inc. Leadless cardiac pacemaker configured for over the wire delivery
US10328272B2 (en) 2016-05-10 2019-06-25 Cardiac Pacemakers, Inc. Retrievability for implantable medical devices
JP6764956B2 (ja) 2016-06-27 2020-10-07 カーディアック ペースメイカーズ， インコーポレイテッド 再同期ペーシング管理に皮下で感知されたｐ波を使用する心臓治療法システム
US10232168B2 (en) 2016-06-27 2019-03-19 Ecole Polytechnique Federale De Lausanne (Epfl) System for active skull replacement for brain interface and method of using the same
US11207527B2 (en) 2016-07-06 2021-12-28 Cardiac Pacemakers, Inc. Method and system for determining an atrial contraction timing fiducial in a leadless cardiac pacemaker system
US10426962B2 (en) 2016-07-07 2019-10-01 Cardiac Pacemakers, Inc. Leadless pacemaker using pressure measurements for pacing capture verification
CN109475743B (zh) 2016-07-20 2022-09-02 心脏起搏器股份公司 在无引线心脏起搏器系统中利用心房收缩定时基准的系统
US10238871B2 (en) 2016-08-02 2019-03-26 Cochlear Limited Implantable medical device arrangements
WO2018035343A1 (fr) 2016-08-19 2018-02-22 Cardiac Pacemakers, Inc. Dispositif médical implantable trans-septal
CN109641129B (zh) 2016-08-24 2023-06-30 心脏起搏器股份公司 使用融合促进进行定时管理的心脏再同步
CN109640809B (zh) 2016-08-24 2021-08-17 心脏起搏器股份公司 使用p波到起搏定时的集成式多装置心脏再同步治疗
US10912648B2 (en) 2016-08-30 2021-02-09 Longeviti Neuro Solutions Llc Method for manufacturing a low-profile intercranial device and the low-profile intercranial device manufactured thereby
EP3515553B1 (fr) 2016-09-21 2020-08-26 Cardiac Pacemakers, Inc. Dispositif de stimulation sans fil muni d'un boîtier qui abrite des composants interne du dispositif de stimulation sans fil et fonctionne comme boîtier de batterie et borne d'une batterie interne
US10758737B2 (en) 2016-09-21 2020-09-01 Cardiac Pacemakers, Inc. Using sensor data from an intracardially implanted medical device to influence operation of an extracardially implantable cardioverter
US10994145B2 (en) 2016-09-21 2021-05-04 Cardiac Pacemakers, Inc. Implantable cardiac monitor
CN109922860B (zh) 2016-10-27 2023-07-04 心脏起搏器股份公司 具有集成传感器的可植入医疗装置递送系统
EP3532161B1 (fr) 2016-10-27 2023-08-30 Cardiac Pacemakers, Inc. Dispositif médical implantable à capteur de pression
US10413733B2 (en) 2016-10-27 2019-09-17 Cardiac Pacemakers, Inc. Implantable medical device with gyroscope
WO2018081275A1 (fr) 2016-10-27 2018-05-03 Cardiac Pacemakers, Inc. Thérapie de resynchronisation cardiaque à dispositifs multiples avec des améliorations de synchronisation
WO2018081237A1 (fr) 2016-10-27 2018-05-03 Cardiac Pacemakers, Inc. Utilisation d'un dispositif séparé pour gérer l'énergie d'impulsion de stimulation d'un stimulateur cardiaque
WO2018081133A1 (fr) 2016-10-27 2018-05-03 Cardiac Pacemakers, Inc. Dispositif médical implantable présentant un canal d'écoute à réglage de rendement
US10434317B2 (en) 2016-10-31 2019-10-08 Cardiac Pacemakers, Inc. Systems and methods for activity level pacing
CN109890456B (zh) 2016-10-31 2023-06-13 心脏起搏器股份公司 用于活动水平起搏的系统
WO2018089311A1 (fr) 2016-11-08 2018-05-17 Cardiac Pacemakers, Inc Dispositif médical implantable pour déploiement auriculaire
EP3538213B1 (fr) 2016-11-09 2023-04-12 Cardiac Pacemakers, Inc. Systèmes et dispositifs pour régler des paramètres d'impulsion de stimulation cardiaque pour un dispositif de stimulation cardiaque
WO2018093605A1 (fr) 2016-11-21 2018-05-24 Cardiac Pacemakers, Inc. Stimulateur cardiaque sans fil fournissant une thérapie de resynchronisation cardiaque
US10881869B2 (en) 2016-11-21 2021-01-05 Cardiac Pacemakers, Inc. Wireless re-charge of an implantable medical device
US10881863B2 (en) 2016-11-21 2021-01-05 Cardiac Pacemakers, Inc. Leadless cardiac pacemaker with multimode communication
US10639486B2 (en) 2016-11-21 2020-05-05 Cardiac Pacemakers, Inc. Implantable medical device with recharge coil
WO2018094342A1 (fr) 2016-11-21 2018-05-24 Cardiac Pacemakers, Inc Dispositif médical implantable comportant un boîtier magnétiquement perméable et une bobine inductive placée autour du boîtier
US10124178B2 (en) 2016-11-23 2018-11-13 Bluewind Medical Ltd. Implant and delivery tool therefor
US11207532B2 (en) 2017-01-04 2021-12-28 Cardiac Pacemakers, Inc. Dynamic sensing updates using postural input in a multiple device cardiac rhythm management system
US11478643B2 (en) 2017-01-10 2022-10-25 Inspire Medical Systems, Inc. Power element for an implantable medical device
US10029107B1 (en) 2017-01-26 2018-07-24 Cardiac Pacemakers, Inc. Leadless device with overmolded components
EP3573706A1 (fr) 2017-01-26 2019-12-04 Cardiac Pacemakers, Inc. Communication de dispositif intracorporel avec transmission de message redondante
CN110198759B (zh) 2017-01-26 2023-08-11 心脏起搏器股份公司 具有可拆卸固定件的无引线可植入装置
US10758734B2 (en) * 2017-02-28 2020-09-01 Boston Scientific Neuromodulation Corporation Implantable medical device with a silicone housing
US10821288B2 (en) 2017-04-03 2020-11-03 Cardiac Pacemakers, Inc. Cardiac pacemaker with pacing pulse energy adjustment based on sensed heart rate
US10905872B2 (en) 2017-04-03 2021-02-02 Cardiac Pacemakers, Inc. Implantable medical device with a movable electrode biased toward an extended position
US20180353764A1 (en) 2017-06-13 2018-12-13 Bluewind Medical Ltd. Antenna configuration
EP3668592B1 (fr) 2017-08-18 2021-11-17 Cardiac Pacemakers, Inc. Dispositif médical implantable avec capteur de pression
WO2019036568A1 (fr) 2017-08-18 2019-02-21 Cardiac Pacemakers, Inc. Dispositif médical implantable comprenant un concentrateur de flux et une bobine de réception disposée autour du concentrateur de flux
US10994147B2 (en) * 2017-08-31 2021-05-04 Medtronic, Inc. Implantable medical device structures
US10646254B2 (en) * 2017-09-06 2020-05-12 Medtronic, Inc. Shifting burr cap assembly
EP3684465B1 (fr) 2017-09-20 2021-07-14 Cardiac Pacemakers, Inc. Dispositif médical implantable avec modes de fonctionnement multiples
US11185703B2 (en) 2017-11-07 2021-11-30 Cardiac Pacemakers, Inc. Leadless cardiac pacemaker for bundle of his pacing
EP3710105B1 (fr) * 2017-11-13 2023-10-04 Boston Scientific Neuromodulation Corporation Systèmes de fabrication et d'utilisation d'un module de commande à profil bas pour un système de stimulation électrique
WO2019108545A1 (fr) 2017-12-01 2019-06-06 Cardiac Pacemakers, Inc. Procédés et systèmes pour détecter des repères de synchronisation de contraction auriculaire pendant un remplissage ventriculaire à partir d'un stimulateur cardiaque sans fil implanté de manière ventriculaire
CN111417432B (zh) 2017-12-01 2024-04-30 心脏起搏器股份公司 具有复归行为的无引线心脏起搏器
CN111432874A (zh) 2017-12-01 2020-07-17 心脏起搏器股份公司 从心室植入的无引线心脏起搏器检测搜索窗口内心房收缩定时基准的方法和系统
WO2019108482A1 (fr) 2017-12-01 2019-06-06 Cardiac Pacemakers, Inc. Procédés et systèmes pour détecter des repères de synchronisation de contraction auriculaire et pour déterminer un intervalle cardiaque à partir d'un stimulateur cardiaque sans fil implanté de manière ventriculaire
US10554069B2 (en) * 2017-12-15 2020-02-04 Medtronic, Inc. Medical device temperature estimation
CN111556773A (zh) 2018-01-04 2020-08-18 心脏起搏器股份公司 无逐搏通信的双腔起搏
US11529523B2 (en) 2018-01-04 2022-12-20 Cardiac Pacemakers, Inc. Handheld bridge device for providing a communication bridge between an implanted medical device and a smartphone
US11589992B2 (en) 2018-01-09 2023-02-28 Longeviti Neuro Solutions Llc Universal low-profile intercranial assembly
WO2019143574A1 (fr) * 2018-01-16 2019-07-25 Boston Scientific Neuromodulation Corporation Système de stimulation électrique avec une batterie au boîtier neutre et module de commande pour un tel système
US10702692B2 (en) 2018-03-02 2020-07-07 Aleva Neurotherapeutics Neurostimulation device
US11058870B2 (en) 2018-03-09 2021-07-13 Boston Scientific Neuromodulation Corporation Burr hole plugs for electrical stimulation systems and methods of making and using
US11992686B2 (en) * 2018-03-16 2024-05-28 The Regents Of The University Of California Flexible spinal cord stimulators for pain and trauma management through neuromodulation
EP3765142B1 (fr) 2018-03-16 2022-05-04 Boston Scientific Neuromodulation Corporation Kit pour fixer des bouchons de trou de trépan pour des systèmes de stimulation
WO2019183386A1 (fr) 2018-03-21 2019-09-26 Medtronic, Inc. Structures de dispositif médical implantable comprenant une bobine de recharge et/ou de télémétrie
WO2019183514A1 (fr) 2018-03-23 2019-09-26 Medtronic, Inc. Thérapie cardiaque du ventricule vers l'atrium (vfa) pour la tachycardie
US11400296B2 (en) 2018-03-23 2022-08-02 Medtronic, Inc. AV synchronous VfA cardiac therapy
EP3768377B1 (fr) 2018-03-23 2023-11-22 Medtronic, Inc. Thérapie de resynchronisation cardiaque vfa
US11253708B2 (en) 2018-05-24 2022-02-22 Medtronic, Inc. Machined features of enclosures for implantable medical devices
WO2020065582A1 (fr) 2018-09-26 2020-04-02 Medtronic, Inc. Capture dans une thérapie cardiaque du ventricule à partir de l'oreillette
US11951313B2 (en) 2018-11-17 2024-04-09 Medtronic, Inc. VFA delivery systems and methods
US11247059B2 (en) 2018-11-20 2022-02-15 Pacesetter, Inc. Biostimulator having flexible circuit assembly
CN113164201A (zh) 2018-11-21 2021-07-23 伯恩森斯韦伯斯特(以色列)有限责任公司 具有堆叠式电路组件的消融导管
US20200222703A1 (en) * 2019-01-10 2020-07-16 Stimwave Technologies Incorporated Wireless implantable pulse generators
US11471683B2 (en) 2019-01-29 2022-10-18 Synapse Biomedical, Inc. Systems and methods for treating sleep apnea using neuromodulation
US11058882B2 (en) 2019-02-11 2021-07-13 Medtronic, Inc. Implantable medical devices having circuitry located adjacent to header-related structures
US11679265B2 (en) 2019-02-14 2023-06-20 Medtronic, Inc. Lead-in-lead systems and methods for cardiac therapy
US11697025B2 (en) 2019-03-29 2023-07-11 Medtronic, Inc. Cardiac conduction system capture
US11213676B2 (en) 2019-04-01 2022-01-04 Medtronic, Inc. Delivery systems for VfA cardiac therapy
WO2020205843A1 (fr) * 2019-04-01 2020-10-08 Boston Scientific Neuromodulation Corporation Systèmes et procédés de fabrication et d'utilisation d'un module de commande peu encombrant pour un système de stimulation électrique
US20200338325A1 (en) * 2019-04-29 2020-10-29 Cognos Theraeutics Inc Method and apparatus for a long-term, fully implantable mri compatible drug pump
US11357992B2 (en) 2019-05-03 2022-06-14 Boston Scientific Neuromodulation Corporation Connector assembly for an electrical stimulation system and methods of making and using
US11712188B2 (en) 2019-05-07 2023-08-01 Medtronic, Inc. Posterior left bundle branch engagement
US11305127B2 (en) 2019-08-26 2022-04-19 Medtronic Inc. VfA delivery and implant region detection
US11813466B2 (en) 2020-01-27 2023-11-14 Medtronic, Inc. Atrioventricular nodal stimulation
US11911168B2 (en) 2020-04-03 2024-02-27 Medtronic, Inc. Cardiac conduction system therapy benefit determination
US11813464B2 (en) 2020-07-31 2023-11-14 Medtronic, Inc. Cardiac conduction system evaluation
US11400299B1 (en) 2021-09-14 2022-08-02 Rainbow Medical Ltd. Flexible antenna for stimulator
WO2023049145A1 (fr) * 2021-09-22 2023-03-30 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Composants électroniques crâniens implantables
WO2023152131A1 (fr) * 2022-02-11 2023-08-17 Biotronik Se & Co. Kg Dispositif médical implantable actif comprenant un élément de liaison de type film

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5645586A (en) * 1994-07-08 1997-07-08 Ventritex, Inc. Conforming implantable defibrillator
US6269266B1 (en) * 1998-08-20 2001-07-31 Implex Aktiengesellschaft Hearing Technology Power supply module for an implantable device
US6308101B1 (en) * 1998-07-31 2001-10-23 Advanced Bionics Corporation Fully implantable cochlear implant system
US6358281B1 (en) * 1999-11-29 2002-03-19 Epic Biosonics Inc. Totally implantable cochlear prosthesis
US6480743B1 (en) * 2000-04-05 2002-11-12 Neuropace, Inc. System and method for adaptive brain stimulation

Family Cites Families (232)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US656503A (en) * 1900-04-28 1900-08-21 American Dredging Company Hydraulic dredging apparatus.
US3310051A (en) * 1963-12-10 1967-03-21 Rudolf R Schulte Surgical reservoir for implantation beneath the skin
FR1516654A (fr) * 1966-03-25 1968-03-08 Chirana Zd Y Zdravotnickej Tec Cardio-stimulateur implantable
DE1589587A1 (de) 1966-03-25 1970-04-30 Chirana Zd Y Zdravotnickej Ech Implantabiler Kardiostimulator
US3522811A (en) 1969-02-13 1970-08-04 Medtronic Inc Implantable nerve stimulator and method of use
DE2053728C3 (de) 1969-11-03 1980-03-06 Devices Ltd., Welwyn Garden City, Hertfordshire (Ver. Koenigreich) Implantierbare elektrische Vorrichtung und Verfahren zur Herstellung dieser Vorrichtung
US3724467A (en) * 1971-04-23 1973-04-03 Avery Labor Inc Electrode implant for the neuro-stimulation of the spinal cord
US3720874A (en) 1971-11-08 1973-03-13 Motorola Inc Dipole antenna arrangement for radio with separate speaker-microphone assembly
US3888260A (en) 1972-06-28 1975-06-10 Univ Johns Hopkins Rechargeable demand inhibited cardiac pacer and tissue stimulator
US3913587A (en) 1973-12-10 1975-10-21 Dow Corning Implantable extendable member
DE2415385A1 (de) 1974-03-29 1975-10-02 Siemens Ag Herzschrittmacher
US3926198A (en) 1974-06-10 1975-12-16 Arco Med Prod Co Cardiac pacer
US4040412A (en) 1974-08-09 1977-08-09 Sato Takuya R Bioelectrodes
US4010760A (en) 1975-05-23 1977-03-08 Medtronic, Inc. Coupling assembly for implantable electromedical devices
US4006748A (en) * 1976-01-29 1977-02-08 Pacestter Systems, Inc. Implantable unipolar pacemaker with improved outer electrode plate
US4013081A (en) * 1976-04-19 1977-03-22 Arco Medical Products Company Pediatric cardiac pacer system
US4256115A (en) 1976-12-20 1981-03-17 American Technology, Inc. Leadless cardiac pacer
US4094321A (en) 1977-02-07 1978-06-13 Rudolph Muto Shallow, dome-shaped pacer with bottom storage means for catheter
US4266552A (en) * 1979-11-13 1981-05-12 Medtronic, Inc. Lead anchoring bobbin
US4328813A (en) * 1980-10-20 1982-05-11 Medtronic, Inc. Brain lead anchoring system
DE3107128C2 (de) * 1981-02-26 1984-07-05 Heinze, Roland, Dipl.-Ing., 8000 München Regelschaltung zur Anpassung der Stimulationsfrequenz eines Herzschrittmachers an die Belastung eines Patienten
US4408607A (en) 1981-04-13 1983-10-11 Empi, Inc. Capacitive energy source and circuitry for powering medical apparatus
US4399819A (en) 1981-12-21 1983-08-23 Telectronics Pty. Ltd. Heart pacer mechanical construction
US4499907A (en) * 1982-11-15 1985-02-19 Medtronic, Inc. Energy limiting cardioversion lead
US4503860A (en) 1983-03-31 1985-03-12 Bio-Scan, Inc. Electroencephalography electrode assembly
US4616655A (en) 1984-01-20 1986-10-14 Cordis Corporation Implantable pulse generator having a single printed circuit board and a chip carrier
US4574780A (en) 1984-11-13 1986-03-11 Manders Ernest K Tissue expander and method
US4934368A (en) * 1988-01-21 1990-06-19 Myo/Kinetics Systems, Inc. Multi-electrode neurological stimulation apparatus
US5251127A (en) 1988-02-01 1993-10-05 Faro Medical Technologies Inc. Computer-aided surgery apparatus
US4911178A (en) * 1988-06-02 1990-03-27 Neal Carol A Pacemaker wire dressing
US4972846A (en) 1989-01-31 1990-11-27 W. L. Gore & Associates, Inc. Patch electrodes for use with defibrillators
US4969899A (en) 1989-03-08 1990-11-13 Cox-Uphoff International Inflatable implant
DE3918086C1 (fr) 1989-06-02 1990-09-27 Hortmann Gmbh, 7449 Neckartenzlingen, De
US4928696A (en) * 1989-07-26 1990-05-29 Mindcenter Corporation Electrode-supporting headset
US5396813A (en) 1989-08-31 1995-03-14 Nikkiso Company Limited Gas passage shifting device
US5271397A (en) 1989-09-08 1993-12-21 Cochlear Pty. Ltd. Multi-peak speech processor
US5085644A (en) * 1990-04-02 1992-02-04 Pudenz-Schulte Medical Research Corporation Sterilizable medication infusion device with dose recharge restriction
US5218959A (en) 1990-10-03 1993-06-15 Fenster Harold A Body implantable electrical signal generator with redundant lead retainer and surgical procedure
US5116345A (en) 1990-11-28 1992-05-26 Ohio Medical Instrument Co., Inc. Stereotactically implanting an intracranial device
US5207218A (en) * 1991-02-27 1993-05-04 Medtronic, Inc. Implantable pulse generator
JPH04338450A (ja) * 1991-05-15 1992-11-25 Sharp Corp 血圧計用カフ装置
US5954757A (en) * 1991-05-17 1999-09-21 Gray; Noel Desmond Heart pacemaker
US5368832A (en) * 1991-06-07 1994-11-29 Occidental Chemical Corporation Zero discharge process for manufacturing of phosphorous acid and hypophosphorous acid
US5243977A (en) * 1991-06-26 1993-09-14 Trabucco Hector O Pacemaker
US5144946A (en) 1991-08-05 1992-09-08 Siemens Pacesetter, Inc. Combined pacemaker substrate and electrical interconnect and method of assembly
EP0534782A1 (fr) 1991-09-26 1993-03-31 Medtronic, Inc. Boîtier de dispositif médical implantable
US5220929A (en) * 1991-10-02 1993-06-22 Ventritex, Inc. Bio-compatible boot for implantable medical device
US5314453A (en) * 1991-12-06 1994-05-24 Spinal Cord Society Position sensitive power transfer antenna
US5197332A (en) * 1992-02-19 1993-03-30 Calmed Technology, Inc. Headset hearing tester and hearing aid programmer
US5603318A (en) 1992-04-21 1997-02-18 University Of Utah Research Foundation Apparatus and method for photogrammetric surgical localization
US5324312A (en) * 1992-05-06 1994-06-28 Medtronic, Inc. Tool-less threaded connector assembly
US5676651A (en) 1992-08-06 1997-10-14 Electric Boat Corporation Surgically implantable pump arrangement and method for pumping body fluids
US5252090A (en) 1992-09-30 1993-10-12 Telectronics Pacing Systems, Inc. Self-locking implantable stimulating lead connector
US5284161A (en) * 1992-11-12 1994-02-08 Karell Manuel L Snopper-the snoring stopper anti-snoring mouth device
US5314451A (en) * 1993-01-15 1994-05-24 Medtronic, Inc. Replaceable battery for implantable medical device
US5531787A (en) 1993-01-25 1996-07-02 Lesinski; S. George Implantable auditory system with micromachined microsensor and microactuator
US5477855A (en) 1993-07-16 1995-12-26 Alfred E. Mann Foundation For Scientific Research Shield for conductors of an implantable device
USH1465H (en) * 1993-09-08 1995-07-04 Medtronic, Inc. Implantable lead infection barrier
US5411537A (en) 1993-10-29 1995-05-02 Intermedics, Inc. Rechargeable biomedical battery powered devices with recharging and control system therefor
US5573551A (en) 1993-11-01 1996-11-12 Intermedics, Inc. Implantable medical device with detachable battery or electronic circuit
US5411538A (en) * 1993-11-01 1995-05-02 Intermedics, Inc. Implantable medical device with detachable battery or electronic circuit
US5431695A (en) 1993-11-23 1995-07-11 Medtronic, Inc. Pacemaker
US5489225A (en) * 1993-12-16 1996-02-06 Ventritex, Inc. Electrical terminal with a collet grip for a defibrillator
US5843093A (en) * 1994-02-09 1998-12-01 University Of Iowa Research Foundation Stereotactic electrode assembly
US5800535A (en) 1994-02-09 1998-09-01 The University Of Iowa Research Foundation Wireless prosthetic electrode for the brain
US5697975A (en) 1994-02-09 1997-12-16 The University Of Iowa Research Foundation Human cerebral cortex neural prosthetic for tinnitus
US5419977A (en) 1994-03-09 1995-05-30 Medtronic, Inc. Electrochemical device having operatively combined capacitor
US5571148A (en) 1994-08-10 1996-11-05 Loeb; Gerald E. Implantable multichannel stimulator
US5458997A (en) 1994-08-19 1995-10-17 Medtronic, Inc. Rebalancing of lithium/silver vandium oxide (Li/SVO) cells for improved performance
CA2131777A1 (fr) * 1994-09-09 1996-03-10 Allen Shkuratoff Dispositif electrique scelle avec borne et orifice de remplissage monopiece
US5480416A (en) * 1994-09-22 1996-01-02 Intermedics, Inc. Cardiac pacemaker with universal coating
CA2204789C (fr) 1994-11-10 2002-11-12 Paul Ashton Dispositif implantable et rechargeable a diffusion controlee pour l'administration de medicaments directement dans une partie interne du corps
US5562715A (en) 1994-12-01 1996-10-08 Czura; John J. Cardiac pulse generator
US5613935A (en) * 1994-12-16 1997-03-25 Jarvik; Robert High reliability cardiac assist system
US5678559A (en) 1995-01-23 1997-10-21 Drakulic; Budimir S. Eeg system
US5554194A (en) 1995-06-07 1996-09-10 United States Surgical Corporation Modular surgical implant
US5638832A (en) * 1995-06-07 1997-06-17 Interval Research Corporation Programmable subcutaneous visible implant
US20020169485A1 (en) 1995-10-16 2002-11-14 Neuropace, Inc. Differential neurostimulation therapy driven by physiological context
US6944501B1 (en) 2000-04-05 2005-09-13 Neurospace, Inc. Neurostimulator involving stimulation strategies and process for using it
US6558686B1 (en) 1995-11-08 2003-05-06 Baylor College Of Medicine Method of coating medical devices with a combination of antiseptics and antiseptic coating therefor
US5792067A (en) 1995-11-21 1998-08-11 Karell; Manuel L. Apparatus and method for mitigating sleep and other disorders through electromuscular stimulation
US5873899A (en) * 1996-01-16 1999-02-23 Pacesetter Inc. Implantable medical device having compliant support for internal components
WO1997029802A2 (fr) * 1996-02-20 1997-08-21 Advanced Bionics Corporation Microstimulateur implantable ameliore et systemes d'utilisation associes
US5674260A (en) * 1996-02-23 1997-10-07 Pacesetter, Inc. Apparatus and method for mounting an activity sensor or other component within a pacemaker using a contoured hybrid lid
SE9601154D0 (sv) * 1996-03-26 1996-03-26 Pacesetter Ab Aktivt implantat
US5895414A (en) * 1996-04-19 1999-04-20 Sanchez-Zambrano; Sergio Pacemaker housing
DE19622669A1 (de) 1996-06-05 1997-12-11 Implex Gmbh Implantierbare Einheit
US5741313A (en) * 1996-09-09 1998-04-21 Pacesetter, Inc. Implantable medical device with a reduced volumetric configuration and improved shock stabilization
US5814095A (en) 1996-09-18 1998-09-29 Implex Gmbh Spezialhorgerate Implantable microphone and implantable hearing aids utilizing same
US5830137A (en) 1996-11-18 1998-11-03 University Of South Florida Green light pulse oximeter
CN1248979A (zh) * 1997-01-14 2000-03-29 Dsm有限公司 烯烃聚合的方法
US5876424A (en) * 1997-01-23 1999-03-02 Cardiac Pacemakers, Inc. Ultra-thin hermetic enclosure for implantable medical devices
US5749911A (en) 1997-01-24 1998-05-12 Cardiac Pacemakers, Inc. Implantable tissue stimulator incorporating deposited multilayer capacitor
US5991664A (en) 1997-03-09 1999-11-23 Cochlear Limited Compact inductive arrangement for medical implant data and power transfer
US5776169A (en) * 1997-04-28 1998-07-07 Sulzer Intermedics Inc. Implantable cardiac stimulator for minimally invasive implantation
FR2765486B1 (fr) 1997-07-03 1999-10-01 Ela Medical Sa Systeme d'immobilisation mecanique d'un connecteur de sonde dans un connecteur de generateur de dispositif medical implantable actif, notamment pour un stimulateur cardiaque, defibrillateur et/ou cardioverteur
US6205358B1 (en) * 1997-08-01 2001-03-20 Medtronic, Inc. Method of making ultrasonically welded, staked of swaged components in an implantable medical device
US5871514A (en) 1997-08-01 1999-02-16 Medtronic, Inc. Attachment apparatus for an implantable medical device employing ultrasonic energy
US6067474A (en) * 1997-08-01 2000-05-23 Advanced Bionics Corporation Implantable device with improved battery recharging and powering configuration
US6248080B1 (en) * 1997-09-03 2001-06-19 Medtronic, Inc. Intracranial monitoring and therapy delivery control device, system and method
US6516808B2 (en) * 1997-09-12 2003-02-11 Alfred E. Mann Foundation For Scientific Research Hermetic feedthrough for an implantable device
WO1999017585A1 (fr) 1997-09-29 1999-04-08 Cochlear Limited Appareil et procede d'alarme publique pour implants cochleaires
US5843150A (en) 1997-10-08 1998-12-01 Medtronic, Inc. System and method for providing electrical and/or fluid treatment within a patient's brain
US5941906A (en) 1997-10-15 1999-08-24 Medtronic, Inc. Implantable, modular tissue stimulator
US6016449A (en) * 1997-10-27 2000-01-18 Neuropace, Inc. System for treatment of neurological disorders
US6354299B1 (en) * 1997-10-27 2002-03-12 Neuropace, Inc. Implantable device for patient communication
US6230049B1 (en) 1999-08-13 2001-05-08 Neuro Pace, Inc. Integrated system for EEG monitoring and electrical stimulation with a multiplicity of electrodes
US6427086B1 (en) 1997-10-27 2002-07-30 Neuropace, Inc. Means and method for the intracranial placement of a neurostimulator
US6459936B2 (en) 1997-10-27 2002-10-01 Neuropace, Inc. Methods for responsively treating neurological disorders
US6597954B1 (en) * 1997-10-27 2003-07-22 Neuropace, Inc. System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes
US6647296B2 (en) 1997-10-27 2003-11-11 Neuropace, Inc. Implantable apparatus for treating neurological disorders
US6248126B1 (en) * 1998-01-12 2001-06-19 The Johns Hopkins University Technique for using heat flow management to treat brain disorders
US5954751A (en) * 1998-01-15 1999-09-21 Intermedics Inc. Implantable defibrillator with stacked transistor subassemblies
US5958088A (en) 1998-03-04 1999-09-28 Duracell, Inc. Prismatic cell construction
US6016593A (en) 1998-04-10 2000-01-25 Kyrstein Investments Ltd. Electric drive system for planer mill infeed and outfeed rolls
US6266556B1 (en) 1998-04-27 2001-07-24 Beth Israel Deaconess Medical Center, Inc. Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation
US6044304A (en) * 1998-04-29 2000-03-28 Medtronic, Inc. Burr ring with integral lead/catheter fixation device
US6421566B1 (en) 1998-04-30 2002-07-16 Medtronic, Inc. Selective dorsal column stimulation in SCS, using conditioning pulses
US5938689A (en) 1998-05-01 1999-08-17 Neuropace, Inc. Electrode configuration for a brain neuropacemaker
US6006124A (en) 1998-05-01 1999-12-21 Neuropace, Inc. Means and method for the placement of brain electrodes
DE19827898C1 (de) 1998-06-23 1999-11-11 Hans Leysieffer Verfahren und Vorrichtung zur Versorgung eines teil- oder vollimplantierten aktiven Gerätes mit elektrischer Energie
DE19829637C2 (de) * 1998-07-02 2000-10-19 Implex Hear Tech Ag Medizinisches Implantat
US6091979A (en) * 1998-07-07 2000-07-18 Children's Medical Center Corporation Subdural electrode arrays for monitoring cortical electrical activity
US6272382B1 (en) 1998-07-31 2001-08-07 Advanced Bionics Corporation Fully implantable cochlear implant system
US6366813B1 (en) 1998-08-05 2002-04-02 Dilorenzo Daniel J. Apparatus and method for closed-loop intracranical stimulation for optimal control of neurological disease
DE19837913C2 (de) 1998-08-20 2000-09-28 Implex Hear Tech Ag Implantierbare Vorrichtung mit einer eine Empfangsspule aufweisenden Ladestromeinspeiseanordnung
US6299980B1 (en) * 1998-09-29 2001-10-09 Medtronic Ave, Inc. One step lubricious coating
US7062330B1 (en) * 1998-10-26 2006-06-13 Boveja Birinder R Electrical stimulation adjunct (Add-ON) therapy for urinary incontinence and urological disorders using implanted lead stimulus-receiver and an external pulse generator
US6283997B1 (en) 1998-11-13 2001-09-04 The Trustees Of Princeton University Controlled architecture ceramic composites by stereolithography
US6436422B1 (en) 1998-11-23 2002-08-20 Agion Technologies L.L.C. Antibiotic hydrophilic polymer coating
US6052623A (en) * 1998-11-30 2000-04-18 Medtronic, Inc. Feedthrough assembly for implantable medical devices and methods for providing same
WO2000040295A1 (fr) * 1999-01-06 2000-07-13 Ball Semiconductor, Inc. Neuro-stimulateur implantable
US6106464A (en) 1999-02-22 2000-08-22 Vanderbilt University Apparatus and method for bone surface-based registration of physical space with tomographic images and for guiding an instrument relative to anatomical sites in the image
US6168580B1 (en) * 1999-03-26 2001-01-02 Iontophoretics Corporation Antimicrobial device and methods for long-term catheters
US6324428B1 (en) 1999-03-30 2001-11-27 Pacesetter, Inc. Implantable medical device having an improved electronic assembly for increasing packaging density and enhancing component protection
US6259951B1 (en) * 1999-05-14 2001-07-10 Advanced Bionics Corporation Implantable cochlear stimulator system incorporating combination electrode/transducer
US6233488B1 (en) 1999-06-25 2001-05-15 Carl A. Hess Spinal cord stimulation as a treatment for addiction to nicotine and other chemical substances
US6516227B1 (en) * 1999-07-27 2003-02-04 Advanced Bionics Corporation Rechargeable spinal cord stimulator system
US6327502B1 (en) 1999-08-16 2001-12-04 Pacesetter Ab Implantable stimulator housing with electrode connector
US6241032B1 (en) * 1999-09-07 2001-06-05 Thomas E. Falgout, Sr. One-way drill string clutch
US6560486B1 (en) * 1999-10-12 2003-05-06 Ivan Osorio Bi-directional cerebral interface system
US6445956B1 (en) 1999-10-18 2002-09-03 Abiomed, Inc. Implantable medical device
US6882881B1 (en) * 1999-10-19 2005-04-19 The Johns Hopkins University Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders
AU2621601A (en) 1999-11-03 2001-05-14 Case Western Reserve University System and method for producing a three-dimensional model
US6324433B1 (en) 2000-01-20 2001-11-27 Electrocare Technologies, Llc Electrode-lead coupling skull mounted port assembly
US6356792B1 (en) 2000-01-20 2002-03-12 Electro Core Technologies, Llc Skull mounted electrode lead securing assembly
US6920359B2 (en) * 2000-02-15 2005-07-19 Advanced Bionics Corporation Deep brain stimulation system for the treatment of Parkinson's Disease or other disorders
US6627337B2 (en) 2000-02-16 2003-09-30 Wilson Greatbatch Ltd. Conversion of low rate energy into high rate energy by parallel discharging
DE60112109D1 (de) 2000-03-24 2005-08-25 Cymbet Corp Gehäuse für die anordnung und anordnungen mit integrierter batterie
DE10015421C2 (de) * 2000-03-28 2002-07-04 Implex Ag Hearing Technology I Teil- oder vollimplantierbares Hörsystem
US6478776B1 (en) * 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
US6772026B2 (en) 2000-04-05 2004-08-03 Therics, Inc. System and method for rapidly customizing design, manufacture and/or selection of biomedical devices
US6466822B1 (en) 2000-04-05 2002-10-15 Neuropace, Inc. Multimodal neurostimulator and process of using it
DE10018361C2 (de) * 2000-04-13 2002-10-10 Cochlear Ltd Mindestens teilimplantierbares Cochlea-Implantat-System zur Rehabilitation einer Hörstörung
DE10018360C2 (de) * 2000-04-13 2002-10-10 Cochlear Ltd Mindestens teilimplantierbares System zur Rehabilitation einer Hörstörung
US6490486B1 (en) 2000-04-27 2002-12-03 Pacesetter, Inc. Implantable cardiac stimulation device and method that monitors displacement of an implanted lead
US6610067B2 (en) 2000-05-01 2003-08-26 Arthrosurface, Incorporated System and method for joint resurface repair
US6517476B1 (en) * 2000-05-30 2003-02-11 Otologics Llc Connector for implantable hearing aid
AU2001268857A1 (en) * 2000-05-30 2001-12-11 Genesis Group Inc. A fuel cell incorporating a modified ion exchange membrane
US6505077B1 (en) * 2000-06-19 2003-01-07 Medtronic, Inc. Implantable medical device with external recharging coil electrical connection
US6782292B2 (en) 2000-06-20 2004-08-24 Advanced Bionics Corporation System and method for treatment of mood and/or anxiety disorders by electrical brain stimulation and/or drug infusion
JP2002017652A (ja) * 2000-06-30 2002-01-22 Olympus Optical Co Ltd 内視鏡装置
CA2411782A1 (fr) * 2000-06-30 2002-01-17 Cochlear Limited Implant cochleaire
US7756584B2 (en) 2000-07-13 2010-07-13 Advanced Neuromodulation Systems, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7010351B2 (en) * 2000-07-13 2006-03-07 Northstar Neuroscience, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US20030125786A1 (en) 2000-07-13 2003-07-03 Gliner Bradford Evan Methods and apparatus for effectuating a lasting change in a neural-function of a patient
DE10041727C2 (de) * 2000-08-25 2003-04-10 Cochlear Ltd Implantierbares hermetisch dichtes Gehäuse für eine implantierbare medizinische Vorrichtung
DE10041726C1 (de) * 2000-08-25 2002-05-23 Implex Ag Hearing Technology I Implantierbares Hörsystem mit Mitteln zur Messung der Ankopplungsqualität
DE10041728A1 (de) * 2000-08-25 2002-03-21 Implex Hear Tech Ag Implantierbare medizinische Vorrichtung mit einem hermetisch dichten Gehäuse
GB2370509A (en) * 2000-08-29 2002-07-03 Don Edward Casey Subcutaneously implanted photovoltaic power supply
US7120495B2 (en) * 2000-09-18 2006-10-10 Cameron Health, Inc. Flexible subcutaneous implantable cardioverter-defibrillator
US6788974B2 (en) * 2000-09-18 2004-09-07 Cameron Health, Inc. Radian curve shaped implantable cardioverter-defibrillator canister
US6950705B2 (en) 2000-09-18 2005-09-27 Cameron Health, Inc. Canister designs for implantable cardioverter-defibrillators
US7194309B2 (en) 2000-09-18 2007-03-20 Cameron Health, Inc. Packaging technology for non-transvenous cardioverter/defibrillator devices
US7039465B2 (en) 2000-09-18 2006-05-02 Cameron Health, Inc. Ceramics and/or other material insulated shell for active and non-active S-ICD can
US6405079B1 (en) * 2000-09-22 2002-06-11 Mehdi M. Ansarinia Stimulation method for the dural venous sinuses and adjacent dura for treatment of medical conditions
US6498951B1 (en) 2000-10-13 2002-12-24 Medtronic, Inc. Implantable medical device employing integral housing for a formable flat battery
US6567703B1 (en) * 2000-11-08 2003-05-20 Medtronic, Inc. Implantable medical device incorporating miniaturized circuit module
US6618623B1 (en) 2000-11-28 2003-09-09 Neuropace, Inc. Ferrule for cranial implant
US7033326B1 (en) 2000-12-29 2006-04-25 Advanced Bionics Corporation Systems and methods of implanting a lead for brain stimulation
US7630750B2 (en) 2001-02-05 2009-12-08 The Research Foundation For The State University Of New York Computer aided treatment planning
US7069081B2 (en) 2001-02-08 2006-06-27 Wilson Greatbatch Ltd. One piece header assembly for an implantable medical device
US20020116029A1 (en) * 2001-02-20 2002-08-22 Victor Miller MRI-compatible pacemaker with power carrying photonic catheter and isolated pulse generating electronics providing VOO functionality
US6726678B1 (en) * 2001-02-22 2004-04-27 Isurgical, Llc Implantable reservoir and system for delivery of a therapeutic agent
US7299096B2 (en) 2001-03-08 2007-11-20 Northstar Neuroscience, Inc. System and method for treating Parkinson's Disease and other movement disorders
US6622046B2 (en) 2001-05-07 2003-09-16 Medtronic, Inc. Subcutaneous sensing feedthrough/electrode assembly
US6810285B2 (en) * 2001-06-28 2004-10-26 Neuropace, Inc. Seizure sensing and detection using an implantable device
US6671544B2 (en) 2001-06-28 2003-12-30 Medtronic, Inc. Low impedance implantable extension for a neurological electrical stimulator
US6977124B2 (en) * 2001-07-19 2005-12-20 Wilson Greatbatch Technologies, Inc. Contoured casing for an electrochemical cell
EP1277494B1 (fr) * 2001-07-19 2010-03-10 Greatbatch Ltd. Boîtier galbé pour un dispositif médical implantable
US6456256B1 (en) 2001-08-03 2002-09-24 Cardiac Pacemakers, Inc. Circumferential antenna for an implantable medical device
US6721602B2 (en) * 2001-08-21 2004-04-13 Medtronic, Inc. Implantable medical device assembly and manufacturing method
US6626680B2 (en) * 2001-08-24 2003-09-30 Wilson Greatbatch Ltd. Wire bonding surface
US7070881B2 (en) 2001-10-18 2006-07-04 Quallion Llc Electrical battery assembly and method of manufacture
US6788976B2 (en) * 2001-11-02 2004-09-07 Lockheed Martin Corporation Movement timing simulator
US6894456B2 (en) * 2001-11-07 2005-05-17 Quallion Llc Implantable medical power module
US20030109903A1 (en) * 2001-12-12 2003-06-12 Epic Biosonics Inc. Low profile subcutaneous enclosure
US20030120320A1 (en) 2001-12-20 2003-06-26 Medtronic,Inc. Implantable medical device having a housing or component case with an insulating material formed thereon, and methods of making same
US6963780B2 (en) 2002-01-31 2005-11-08 Medtronic, Inc. Implantable medical device including a surface-mount terminal array
US7110819B1 (en) 2002-03-05 2006-09-19 Pacesetter, Inc. Implantable medical device having a protected connection header
US7206627B2 (en) 2002-03-06 2007-04-17 Z-Kat, Inc. System and method for intra-operative haptic planning of a medical procedure
WO2003090022A2 (fr) 2002-04-16 2003-10-30 Noble Philip C Methodes d'apprentissage par informatique pour des interventions chirurgicales
US6968234B2 (en) 2002-04-25 2005-11-22 Medtronic, Inc. Implantable medical device having biologically active polymeric casing
US20030228042A1 (en) 2002-06-06 2003-12-11 Usha Sinha Method and system for preparation of customized imaging atlas and registration with patient images
AU2002950755A0 (en) * 2002-08-09 2002-09-12 Cochlear Limited Fixation system for a cochlear implant
US6994933B1 (en) * 2002-09-16 2006-02-07 Oak Ridge Micro-Energy, Inc. Long life thin film battery and method therefor
US20050075679A1 (en) * 2002-09-30 2005-04-07 Gliner Bradford E. Methods and apparatuses for treating neurological disorders by electrically stimulating cells implanted in the nervous system
US6931284B2 (en) * 2002-10-25 2005-08-16 Medtronic, Inc. Implantable medical device with air core antenna assembly
WO2004043536A1 (fr) 2002-11-12 2004-05-27 Neuropace, Inc. Systeme de stimulation adaptative du cerveau
US7302298B2 (en) * 2002-11-27 2007-11-27 Northstar Neuroscience, Inc Methods and systems employing intracranial electrodes for neurostimulation and/or electroencephalography
US7596408B2 (en) * 2002-12-09 2009-09-29 Medtronic, Inc. Implantable medical device with anti-infection agent
AU2003297761A1 (en) * 2002-12-09 2004-06-30 Northstar Neuroscience, Inc. Methods for treating neurological language disorders
EP1578499A1 (fr) * 2002-12-09 2005-09-28 Medtronic, Inc. Dispositif medical implantable modulaire
US20040186528A1 (en) 2003-03-20 2004-09-23 Medtronic, Inc. Subcutaneous implantable medical devices with anti-microbial agents for chronic release
US7167760B2 (en) 2003-04-28 2007-01-23 Vanderbilt University Apparatus and methods of optimal placement of deep brain stimulator
US7263401B2 (en) 2003-05-16 2007-08-28 Medtronic, Inc. Implantable medical device with a nonhermetic battery
US20050003268A1 (en) * 2003-05-16 2005-01-06 Scott Erik R. Battery housing configuration
US20050004637A1 (en) 2003-05-16 2005-01-06 Ruchika Singhal Explantation of implantable medical device
US7317947B2 (en) * 2003-05-16 2008-01-08 Medtronic, Inc. Headset recharger for cranially implantable medical devices
US7454251B2 (en) 2003-05-29 2008-11-18 The Cleveland Clinic Foundation Excess lead retaining and management devices and methods of using same
EP1638459A2 (fr) 2003-06-11 2006-03-29 Case Western Reserve University Conception assistee par ordinateur d'implants du squelette
CA2534363A1 (fr) * 2003-08-01 2005-02-10 Brad Fowler Appareil et procedes permettant d'appliquer une stimulation neurale a un patient
WO2005051479A2 (fr) 2003-11-20 2005-06-09 Advanced Neuromodulation Systems, Inc. Systeme de stimulation electrique et methode de traitement des acouphenes
JP4408708B2 (ja) * 2004-01-14 2010-02-03 株式会社島精機製作所 ニットパンツの編成方法、ニットパンツ、および横編機にパンツを編成させるための編成プログラム
US7107097B2 (en) 2004-01-14 2006-09-12 Northstar Neuroscience, Inc. Articulated neural electrode assembly
US20060004422A1 (en) 2004-03-11 2006-01-05 Dirk De Ridder Electrical stimulation system and method for stimulating tissue in the brain to treat a neurological condition
US7283856B2 (en) 2004-04-09 2007-10-16 Neuro Pace, Inc. Implantable lead system with seed electrodes
US7596399B2 (en) 2004-04-29 2009-09-29 Medtronic, Inc Implantation of implantable medical device
US20050245984A1 (en) 2004-04-30 2005-11-03 Medtronic, Inc. Implantable medical device with lubricious material
US7783359B2 (en) 2005-01-05 2010-08-24 Boston Scientific Neuromodulation Corporation Devices and methods using an implantable pulse generator for brain stimulation
US9084901B2 (en) 2006-04-28 2015-07-21 Medtronic, Inc. Cranial implant
US9393432B2 (en) * 2008-10-31 2016-07-19 Medtronic, Inc. Non-hermetic direct current interconnect

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5645586A (en) * 1994-07-08 1997-07-08 Ventritex, Inc. Conforming implantable defibrillator
US6308101B1 (en) * 1998-07-31 2001-10-23 Advanced Bionics Corporation Fully implantable cochlear implant system
US6269266B1 (en) * 1998-08-20 2001-07-31 Implex Aktiengesellschaft Hearing Technology Power supply module for an implantable device
US6358281B1 (en) * 1999-11-29 2002-03-19 Epic Biosonics Inc. Totally implantable cochlear prosthesis
US6480743B1 (en) * 2000-04-05 2002-11-12 Neuropace, Inc. System and method for adaptive brain stimulation

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US7848817B2 (en) 2010-12-07
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WO2004052457B1 (fr) 2004-08-26
US20070185539A1 (en) 2007-08-09
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US20110054563A1 (en) 2011-03-03
US7392089B2 (en) 2008-06-24
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US8666497B2 (en) 2014-03-04
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DE60332764D1 (de) 2010-07-08
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US20040176816A1 (en) 2004-09-09
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US20040176817A1 (en) 2004-09-09
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US20040172090A1 (en) 2004-09-02
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US8397732B2 (en) 2013-03-19
US20040176815A1 (en) 2004-09-09
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US8457744B2 (en) 2013-06-04
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US7212864B2 (en) 2007-05-01
US20040176814A1 (en) 2004-09-09
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US20040176673A1 (en) 2004-09-09
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US20040176818A1 (en) 2004-09-09
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US20040176819A1 (en) 2004-09-09

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