WO2004037817A1 - Composes de n-oxyde - Google Patents
Composes de n-oxyde Download PDFInfo
- Publication number
- WO2004037817A1 WO2004037817A1 PCT/JP2003/013591 JP0313591W WO2004037817A1 WO 2004037817 A1 WO2004037817 A1 WO 2004037817A1 JP 0313591 W JP0313591 W JP 0313591W WO 2004037817 A1 WO2004037817 A1 WO 2004037817A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- substituent
- alkyl
- ylthio
- oxopiperidine
- dichlorobenzyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003275632A AU2003275632A1 (en) | 2002-10-25 | 2003-10-24 | N-oxide compounds |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002311960 | 2002-10-25 | ||
JP2002-311960 | 2002-10-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004037817A1 true WO2004037817A1 (fr) | 2004-05-06 |
Family
ID=32171104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2003/013591 WO2004037817A1 (fr) | 2002-10-25 | 2003-10-24 | Composes de n-oxyde |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2003275632A1 (fr) |
WO (1) | WO2004037817A1 (fr) |
Cited By (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007102768A1 (fr) * | 2006-03-07 | 2007-09-13 | Astrazeneca Ab | Dérivés de pipéridine, leur procédé de synthèse, leur emploi en tant qu'agents thérapeutiques et les compositions pharmaceutiques les incluant |
WO2007102767A1 (fr) * | 2006-03-07 | 2007-09-13 | Astrazeneca Ab | Dérivés de pipéridine, leur procédé de synthèse, leur emploi en tant qu'agents thérapeutiques et les compositions pharmaceutiques les incluant |
US7456193B2 (en) | 2002-10-23 | 2008-11-25 | Sanofi-Aventis | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics |
US7709468B2 (en) | 2005-09-02 | 2010-05-04 | Abbott Laboratories | Imidazo based heterocycles |
US7897776B2 (en) | 2007-04-23 | 2011-03-01 | Salutria Pharmaceuticals Llc | Sulfonamide containing compounds for treatment of inflammatory disorders |
US8044206B2 (en) | 2003-03-07 | 2011-10-25 | Astellas Pharma Inc. | Nitrogen—containing heterocyclic derivatives having 2,6-disubstituted styryl |
US8252829B2 (en) | 2009-06-05 | 2012-08-28 | Link Medicine Corporation | Aminopyrrolidinone derivatives and uses thereof |
US8569343B2 (en) | 2007-03-12 | 2013-10-29 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US8673920B2 (en) | 2009-05-06 | 2014-03-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US8952166B2 (en) | 2012-07-26 | 2015-02-10 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US8999991B2 (en) | 2011-10-25 | 2015-04-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US8999990B2 (en) | 2011-10-25 | 2015-04-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9045445B2 (en) | 2010-06-04 | 2015-06-02 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
US9056859B2 (en) | 2010-10-29 | 2015-06-16 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9062070B2 (en) | 2011-08-19 | 2015-06-23 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9073882B2 (en) | 2010-10-27 | 2015-07-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9108947B2 (en) | 2011-10-31 | 2015-08-18 | Merck Sharp & Dohme Corp. | Inhibitors of the Renal Outer Medullary Potassium channel |
US9139585B2 (en) | 2011-10-31 | 2015-09-22 | Merck Sharp & Dohme Corp. | Inhibitors of the Renal Outer Medullary Potassium channel |
US9206199B2 (en) | 2011-12-16 | 2015-12-08 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9493474B2 (en) | 2011-10-31 | 2016-11-15 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9527830B2 (en) | 2011-09-16 | 2016-12-27 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9573961B2 (en) | 2012-12-19 | 2017-02-21 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9604998B2 (en) | 2013-02-18 | 2017-03-28 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9751881B2 (en) | 2013-07-31 | 2017-09-05 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9765074B2 (en) | 2013-03-15 | 2017-09-19 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9777002B2 (en) | 2012-11-29 | 2017-10-03 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US10160751B2 (en) | 2015-02-12 | 2018-12-25 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US10208048B2 (en) | 2015-04-28 | 2019-02-19 | Janssen Sciences Ireland Uc | RSV antiviral pyrazolo- and triazolo-pyrimidine compounds |
US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
WO2021040519A1 (fr) * | 2019-08-26 | 2021-03-04 | Stichting Vumc | Inhibition de la sécrétion mycobactérienne de type vii |
US11339165B2 (en) | 2017-11-29 | 2022-05-24 | Janssen Sciences Ireland Unlimited Company | Pyrazolopyrimidines having activity against the respiratory syncytial virus (RSV) |
US11491157B2 (en) | 2018-01-31 | 2022-11-08 | Janssen Sciences Ireland Unlimited Company Co Cork, IE | Cycloalkyl substituted pyrazolopyrimidines having activity against RSV |
US11708369B2 (en) | 2018-04-23 | 2023-07-25 | Janssen Sciences Ireland Unlimited Company | Heteroaromatic compounds having activity against RSV |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000006085A2 (fr) * | 1998-07-28 | 2000-02-10 | Smithkline Beecham Corporation | Composes et procedes |
WO2000068203A1 (fr) * | 1999-05-07 | 2000-11-16 | Takeda Chemical Industries, Ltd. | Composes cycliques et leurs utilisations |
WO2001014333A1 (fr) * | 1999-08-24 | 2001-03-01 | Astrazeneca Uk Limited | Composes de piperidine substitues utiles comme modulateurs de l'activite de recepteurs de chimiokine |
GB2373186A (en) * | 2001-02-23 | 2002-09-18 | Astrazeneca Ab | Pharmaceutical combinations of a CCR3 antagonist and a compound which is usefulreatment of asthma, allergic disease or inflammation |
-
2003
- 2003-10-24 WO PCT/JP2003/013591 patent/WO2004037817A1/fr not_active Application Discontinuation
- 2003-10-24 AU AU2003275632A patent/AU2003275632A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000006085A2 (fr) * | 1998-07-28 | 2000-02-10 | Smithkline Beecham Corporation | Composes et procedes |
WO2000068203A1 (fr) * | 1999-05-07 | 2000-11-16 | Takeda Chemical Industries, Ltd. | Composes cycliques et leurs utilisations |
WO2001014333A1 (fr) * | 1999-08-24 | 2001-03-01 | Astrazeneca Uk Limited | Composes de piperidine substitues utiles comme modulateurs de l'activite de recepteurs de chimiokine |
GB2373186A (en) * | 2001-02-23 | 2002-09-18 | Astrazeneca Ab | Pharmaceutical combinations of a CCR3 antagonist and a compound which is usefulreatment of asthma, allergic disease or inflammation |
Cited By (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7456193B2 (en) | 2002-10-23 | 2008-11-25 | Sanofi-Aventis | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics |
US8044206B2 (en) | 2003-03-07 | 2011-10-25 | Astellas Pharma Inc. | Nitrogen—containing heterocyclic derivatives having 2,6-disubstituted styryl |
US7709468B2 (en) | 2005-09-02 | 2010-05-04 | Abbott Laboratories | Imidazo based heterocycles |
WO2007102767A1 (fr) * | 2006-03-07 | 2007-09-13 | Astrazeneca Ab | Dérivés de pipéridine, leur procédé de synthèse, leur emploi en tant qu'agents thérapeutiques et les compositions pharmaceutiques les incluant |
WO2007102768A1 (fr) * | 2006-03-07 | 2007-09-13 | Astrazeneca Ab | Dérivés de pipéridine, leur procédé de synthèse, leur emploi en tant qu'agents thérapeutiques et les compositions pharmaceutiques les incluant |
US10307416B2 (en) | 2007-03-12 | 2019-06-04 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US10143690B2 (en) | 2007-03-12 | 2018-12-04 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US8569343B2 (en) | 2007-03-12 | 2013-10-29 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US9233168B2 (en) | 2007-03-12 | 2016-01-12 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US8946285B2 (en) | 2007-03-12 | 2015-02-03 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
US8952032B2 (en) | 2007-03-12 | 2015-02-10 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US9827239B2 (en) | 2007-03-12 | 2017-11-28 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US9512135B2 (en) | 2007-03-12 | 2016-12-06 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US9233167B2 (en) | 2007-03-12 | 2016-01-12 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US9458166B2 (en) | 2007-03-12 | 2016-10-04 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US7897776B2 (en) | 2007-04-23 | 2011-03-01 | Salutria Pharmaceuticals Llc | Sulfonamide containing compounds for treatment of inflammatory disorders |
US9018211B2 (en) | 2009-05-06 | 2015-04-28 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US8673920B2 (en) | 2009-05-06 | 2014-03-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US8252829B2 (en) | 2009-06-05 | 2012-08-28 | Link Medicine Corporation | Aminopyrrolidinone derivatives and uses thereof |
US9045445B2 (en) | 2010-06-04 | 2015-06-02 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
US9073882B2 (en) | 2010-10-27 | 2015-07-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9056859B2 (en) | 2010-10-29 | 2015-06-16 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9062070B2 (en) | 2011-08-19 | 2015-06-23 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9527830B2 (en) | 2011-09-16 | 2016-12-27 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US8999990B2 (en) | 2011-10-25 | 2015-04-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US8999991B2 (en) | 2011-10-25 | 2015-04-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9139585B2 (en) | 2011-10-31 | 2015-09-22 | Merck Sharp & Dohme Corp. | Inhibitors of the Renal Outer Medullary Potassium channel |
US9108947B2 (en) | 2011-10-31 | 2015-08-18 | Merck Sharp & Dohme Corp. | Inhibitors of the Renal Outer Medullary Potassium channel |
US9493474B2 (en) | 2011-10-31 | 2016-11-15 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9206199B2 (en) | 2011-12-16 | 2015-12-08 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US8952166B2 (en) | 2012-07-26 | 2015-02-10 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9206198B2 (en) | 2012-07-26 | 2015-12-08 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9777002B2 (en) | 2012-11-29 | 2017-10-03 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9573961B2 (en) | 2012-12-19 | 2017-02-21 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9604998B2 (en) | 2013-02-18 | 2017-03-28 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9765074B2 (en) | 2013-03-15 | 2017-09-19 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9751881B2 (en) | 2013-07-31 | 2017-09-05 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US10160751B2 (en) | 2015-02-12 | 2018-12-25 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US10208048B2 (en) | 2015-04-28 | 2019-02-19 | Janssen Sciences Ireland Uc | RSV antiviral pyrazolo- and triazolo-pyrimidine compounds |
US10611769B2 (en) | 2015-04-28 | 2020-04-07 | Janssen Sciences Ireland Unlimited Company | RSV antiviral pyrazolo- and triazolo-pyrimidine compounds |
US11084826B2 (en) | 2015-04-28 | 2021-08-10 | Janssen Sciences Ireland Unlimited Company | RSV antiviral pyrazolo- and triazolo-pyrimidine compounds |
US11339165B2 (en) | 2017-11-29 | 2022-05-24 | Janssen Sciences Ireland Unlimited Company | Pyrazolopyrimidines having activity against the respiratory syncytial virus (RSV) |
US11491157B2 (en) | 2018-01-31 | 2022-11-08 | Janssen Sciences Ireland Unlimited Company Co Cork, IE | Cycloalkyl substituted pyrazolopyrimidines having activity against RSV |
US11708369B2 (en) | 2018-04-23 | 2023-07-25 | Janssen Sciences Ireland Unlimited Company | Heteroaromatic compounds having activity against RSV |
WO2021040519A1 (fr) * | 2019-08-26 | 2021-03-04 | Stichting Vumc | Inhibition de la sécrétion mycobactérienne de type vii |
Also Published As
Publication number | Publication date |
---|---|
AU2003275632A1 (en) | 2004-05-13 |
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