WO2004024891A3 - MBMs AS MODIFIERS OF BRANCHING MORPHOGENESIS AND METHODS OF USE - Google Patents

MBMs AS MODIFIERS OF BRANCHING MORPHOGENESIS AND METHODS OF USE Download PDF

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Publication number
WO2004024891A3
WO2004024891A3 PCT/US2003/029089 US0329089W WO2004024891A3 WO 2004024891 A3 WO2004024891 A3 WO 2004024891A3 US 0329089 W US0329089 W US 0329089W WO 2004024891 A3 WO2004024891 A3 WO 2004024891A3
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WO
WIPO (PCT)
Prior art keywords
branching morphogenesis
methods
mbms
modifiers
mbm
Prior art date
Application number
PCT/US2003/029089
Other languages
French (fr)
Other versions
WO2004024891A2 (en
Inventor
Felix D Karim
Linda N Keyes
Gregory D Plowman
Kim Lickteig
Bing Hai
Joanne I Adamkewicz
Original Assignee
Exelixis Inc
Felix D Karim
Linda N Keyes
Gregory D Plowman
Kim Lickteig
Bing Hai
Joanne I Adamkewicz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Felix D Karim, Linda N Keyes, Gregory D Plowman, Kim Lickteig, Bing Hai, Joanne I Adamkewicz filed Critical Exelixis Inc
Priority to AU2003272449A priority Critical patent/AU2003272449A1/en
Publication of WO2004024891A2 publication Critical patent/WO2004024891A2/en
Publication of WO2004024891A3 publication Critical patent/WO2004024891A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity

Abstract

Human MBM genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MBM are provided.
PCT/US2003/029089 2002-09-16 2003-09-15 MBMs AS MODIFIERS OF BRANCHING MORPHOGENESIS AND METHODS OF USE WO2004024891A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003272449A AU2003272449A1 (en) 2002-09-16 2003-09-15 MBMs AS MODIFIERS OF BRANCHING MORPHOGENESIS AND METHODS OF USE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41115402P 2002-09-16 2002-09-16
US60/411,154 2002-09-16

Publications (2)

Publication Number Publication Date
WO2004024891A2 WO2004024891A2 (en) 2004-03-25
WO2004024891A3 true WO2004024891A3 (en) 2004-08-19

Family

ID=31994245

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/029089 WO2004024891A2 (en) 2002-09-16 2003-09-15 MBMs AS MODIFIERS OF BRANCHING MORPHOGENESIS AND METHODS OF USE

Country Status (2)

Country Link
AU (1) AU2003272449A1 (en)
WO (1) WO2004024891A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10353366B3 (en) 2003-11-14 2004-11-18 Magnetic Autocontrol Gmbh Drive arrangement passage barrier, door or gate has brushless DC servomotor with associated servo regulator; drive shaft of DC servomotor is directly connected to drive shaft of barrier element

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010331A1 (en) * 1992-10-29 1994-05-11 The Australian National University Angiogenesis inhibitory antibodies

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010331A1 (en) * 1992-10-29 1994-05-11 The Australian National University Angiogenesis inhibitory antibodies

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BARENDSZ-JANSON ET AL: "In vitro tumor angiogenesis assays: plasminogen lysine binding site 1 inhibits in vitro tumor-induced angiogenesis", J. VASC. RES., vol. 35, 1998, pages 109 - 114, XP000929510 *
CLINICAL CANCER RESEARCH, vol. 7, no. 11, November 2001 (2001-11-01), pages 3598 - 3605 *
DATABASE MEDLINE [online] OLSON ET AL: "Prevention of human prostate cancer metastasis in athymic mice by antisense targeting of human angiogenin", XP002978108, accession no. STN Database accession no. 11705882 *
LEE ET AL: "Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish", PNAS, vol. 99, no. 16, 6 August 2002 (2002-08-06), pages 10470 - 10475, XP002258880 *

Also Published As

Publication number Publication date
AU2003272449A1 (en) 2004-04-30
AU2003272449A8 (en) 2004-04-30
WO2004024891A2 (en) 2004-03-25

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