WO2004005484A3 - Snrks as modifiers of chk and branching morphogenesis and methods of use - Google Patents

Snrks as modifiers of chk and branching morphogenesis and methods of use Download PDF

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Publication number
WO2004005484A3
WO2004005484A3 PCT/US2003/021383 US0321383W WO2004005484A3 WO 2004005484 A3 WO2004005484 A3 WO 2004005484A3 US 0321383 W US0321383 W US 0321383W WO 2004005484 A3 WO2004005484 A3 WO 2004005484A3
Authority
WO
WIPO (PCT)
Prior art keywords
chk
branching morphogenesis
methods
snrks
modifiers
Prior art date
Application number
PCT/US2003/021383
Other languages
French (fr)
Other versions
WO2004005484A2 (en
Inventor
Helen Francis-Lang
Siobhan Roche
Timothy S Heuer
Monique Nicoll
Original Assignee
Exelixis Inc
Helen Francis-Lang
Siobhan Roche
Timothy S Heuer
Monique Nicoll
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Helen Francis-Lang, Siobhan Roche, Timothy S Heuer, Monique Nicoll filed Critical Exelixis Inc
Priority to AU2003248881A priority Critical patent/AU2003248881A1/en
Publication of WO2004005484A2 publication Critical patent/WO2004005484A2/en
Publication of WO2004005484A3 publication Critical patent/WO2004005484A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Human SNRK genes are identified as modulators of CHK and branching morphogenesis, and thus are therapeutic targets for disorders associated with defective CHK and branching morphogenesis function. Methods for identifying modulators of CHK and branching morphogenesis, comprising screening for agents that modulate the activity of SNRK are provided.
PCT/US2003/021383 2002-07-10 2003-07-09 Snrks as modifiers of chk and branching morphogenesis and methods of use WO2004005484A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003248881A AU2003248881A1 (en) 2002-07-10 2003-07-09 Snrks as modifiers of chk and branching morphogenesis and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39484502P 2002-07-10 2002-07-10
US60/394,845 2002-07-10

Publications (2)

Publication Number Publication Date
WO2004005484A2 WO2004005484A2 (en) 2004-01-15
WO2004005484A3 true WO2004005484A3 (en) 2004-05-06

Family

ID=30115774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/021383 WO2004005484A2 (en) 2002-07-10 2003-07-09 Snrks as modifiers of chk and branching morphogenesis and methods of use

Country Status (2)

Country Link
AU (1) AU2003248881A1 (en)
WO (1) WO2004005484A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT513874B1 (en) 2013-02-05 2015-02-15 Aba Hörtnagl Gmbh Belt buckle for detachable connection of a belt
CN117305452B (en) * 2023-09-27 2024-05-03 山东大学第二医院 Application of human SNRK mRNA in non-small cell lung cancer diagnosis, targeted therapy and prognosis evaluation and kit

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000053746A2 (en) * 1999-03-11 2000-09-14 University Of Bristol Method of delaying or inhibiting sprouting in plants
US6342656B1 (en) * 1999-07-21 2002-01-29 The Regents Of The University Of California Regulation of source-sink relationships and responses to stress conditions in plants

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000053746A2 (en) * 1999-03-11 2000-09-14 University Of Bristol Method of delaying or inhibiting sprouting in plants
US6342656B1 (en) * 1999-07-21 2002-01-29 The Regents Of The University Of California Regulation of source-sink relationships and responses to stress conditions in plants

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CARRARO ET AL.: "In silico characterization and expression analyses of sugarcane putative sucrose non-fermenting-1 (SNF1) related kinases", GENETICS AND MOLECULAR BIOLOGY, vol. 24, no. 1-4, 2001, pages 35 - 41, XP002975078 *
DE BELLE ET AL.: "Expression of Drosophila mushroom mutations in alternative genetic backgrounds: A case study of the mushroom body miniature gene (MBM)", PROC. NATL. ACAD. SCI. USA, vol. 93, September 1996 (1996-09-01), pages 9875 - 9880, XP002975079 *
YU ET AL.: "The Grapes checkpoint coordinates nuclear envelope breakdown and chromosome condensation", NATURE CELL BIOLOGY, vol. 2, September 2000 (2000-09-01), pages 609 - 615, XP002975080 *

Also Published As

Publication number Publication date
AU2003248881A8 (en) 2004-01-23
AU2003248881A1 (en) 2004-01-23
WO2004005484A2 (en) 2004-01-15

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