WO2003045314A3 - Mhyps as modifiers of branching morphogenesis and methods of use - Google Patents

Mhyps as modifiers of branching morphogenesis and methods of use Download PDF

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Publication number
WO2003045314A3
WO2003045314A3 PCT/US2002/037633 US0237633W WO03045314A3 WO 2003045314 A3 WO2003045314 A3 WO 2003045314A3 US 0237633 W US0237633 W US 0237633W WO 03045314 A3 WO03045314 A3 WO 03045314A3
Authority
WO
WIPO (PCT)
Prior art keywords
branching morphogenesis
methods
mhyps
modifiers
mhyp
Prior art date
Application number
PCT/US2002/037633
Other languages
French (fr)
Other versions
WO2003045314A2 (en
Inventor
Felix D Karim
Lisa Ryner
Thierry T Diagana
Gregory D Plowman
Original Assignee
Exelixis Inc
Felix D Karim
Lisa Ryner
Thierry T Diagana
Gregory D Plowman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Felix D Karim, Lisa Ryner, Thierry T Diagana, Gregory D Plowman filed Critical Exelixis Inc
Priority to AU2002350245A priority Critical patent/AU2002350245A1/en
Publication of WO2003045314A2 publication Critical patent/WO2003045314A2/en
Publication of WO2003045314A3 publication Critical patent/WO2003045314A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Human MHYP genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for a agents that modulate the activity of MHYP are provided.
PCT/US2002/037633 2001-11-26 2002-11-25 Mhyps as modifiers of branching morphogenesis and methods of use WO2003045314A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002350245A AU2002350245A1 (en) 2001-11-26 2002-11-25 Mhyps as modifiers of branching morphogenesis and methods of use

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33337201P 2001-11-26 2001-11-26
US33338601P 2001-11-26 2001-11-26
US60/333,372 2001-11-26
US60/333,386 2001-11-26

Publications (2)

Publication Number Publication Date
WO2003045314A2 WO2003045314A2 (en) 2003-06-05
WO2003045314A3 true WO2003045314A3 (en) 2003-11-13

Family

ID=26988699

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/037633 WO2003045314A2 (en) 2001-11-26 2002-11-25 Mhyps as modifiers of branching morphogenesis and methods of use

Country Status (2)

Country Link
AU (1) AU2002350245A1 (en)
WO (1) WO2003045314A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2527905A1 (en) * 2003-06-19 2005-01-13 Exelixis, Inc. Nadks as modifiers of branching morphogenesis and methods of use
WO2005072470A2 (en) * 2004-01-28 2005-08-11 Exelixis, Inc Mbms as modifiers of branching morphogenesis and methods of use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235033A (en) * 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5840532A (en) * 1997-01-21 1998-11-24 Board Of Regents, The University Of Texas System Neuronal bHLH-PAS domain proteins
US6120799A (en) * 1997-03-12 2000-09-19 The Regents Of The University Of California Cationic lipid compositions targeting angiogenic endothelial cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235033A (en) * 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5840532A (en) * 1997-01-21 1998-11-24 Board Of Regents, The University Of Texas System Neuronal bHLH-PAS domain proteins
US6120799A (en) * 1997-03-12 2000-09-19 The Regents Of The University Of California Cationic lipid compositions targeting angiogenic endothelial cells

Also Published As

Publication number Publication date
AU2002350245A1 (en) 2003-06-10
AU2002350245A8 (en) 2003-06-10
WO2003045314A2 (en) 2003-06-05

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