WO2005072470A3 - Mbms as modifiers of branching morphogenesis and methods of use - Google Patents

Mbms as modifiers of branching morphogenesis and methods of use Download PDF

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Publication number
WO2005072470A3
WO2005072470A3 PCT/US2005/003526 US2005003526W WO2005072470A3 WO 2005072470 A3 WO2005072470 A3 WO 2005072470A3 US 2005003526 W US2005003526 W US 2005003526W WO 2005072470 A3 WO2005072470 A3 WO 2005072470A3
Authority
WO
WIPO (PCT)
Prior art keywords
branching morphogenesis
methods
mbms
modifiers
mbm
Prior art date
Application number
PCT/US2005/003526
Other languages
French (fr)
Other versions
WO2005072470A2 (en
Inventor
Gregory D Plowman
Felix D Karim
Candace Swimmer
Hinrich Alexander Habeck
Thomas I Koblizek
Stefan Schulte-Merker
Ulrike Langheinrich
Gordon Mark Stott
Torsten Trowe
Andreas Michael Vogel
Joerg Heinrich Odenthal
Jochen Konrad Scheel
Torsten Tilmann Will
Yisheng Jin
Lynn Margaret Bjerke
Original Assignee
Exelixis Inc
Gregory D Plowman
Felix D Karim
Candace Swimmer
Hinrich Alexander Habeck
Thomas I Koblizek
Stefan Schulte-Merker
Ulrike Langheinrich
Gordon Mark Stott
Torsten Trowe
Andreas Michael Vogel
Joerg Heinrich Odenthal
Jochen Konrad Scheel
Torsten Tilmann Will
Yisheng Jin
Lynn Margaret Bjerke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Gregory D Plowman, Felix D Karim, Candace Swimmer, Hinrich Alexander Habeck, Thomas I Koblizek, Stefan Schulte-Merker, Ulrike Langheinrich, Gordon Mark Stott, Torsten Trowe, Andreas Michael Vogel, Joerg Heinrich Odenthal, Jochen Konrad Scheel, Torsten Tilmann Will, Yisheng Jin, Lynn Margaret Bjerke filed Critical Exelixis Inc
Publication of WO2005072470A2 publication Critical patent/WO2005072470A2/en
Publication of WO2005072470A3 publication Critical patent/WO2005072470A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5032—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on intercellular interactions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Human MBM genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MBM are provided.
PCT/US2005/003526 2004-01-28 2005-01-27 Mbms as modifiers of branching morphogenesis and methods of use WO2005072470A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53983504P 2004-01-28 2004-01-28
US60/539,835 2004-01-28

Publications (2)

Publication Number Publication Date
WO2005072470A2 WO2005072470A2 (en) 2005-08-11
WO2005072470A3 true WO2005072470A3 (en) 2006-03-23

Family

ID=34826137

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/003526 WO2005072470A2 (en) 2004-01-28 2005-01-27 Mbms as modifiers of branching morphogenesis and methods of use

Country Status (1)

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WO (1) WO2005072470A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110200987A1 (en) * 2006-08-24 2011-08-18 Government Of The United States Of America, As Represented By The Secretary, Department Of Health Compositions and methods for modifying cellular properties
CA3083951A1 (en) * 2017-11-30 2019-06-06 Amicus Therapeutics, Inc. Cdkl5 expression variants and cdkl5 fusion proteins

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965396A (en) * 1998-01-13 1999-10-12 Zeneca Limited Human lymph node derived GTPase
WO2003045314A2 (en) * 2001-11-26 2003-06-05 Exelixis Inc. Mhyps as modifiers of branching morphogenesis and methods of use
WO2003046222A1 (en) * 2001-11-26 2003-06-05 Exelixis, Inc. MAP4Ks AS MODIFIERS OF BRANCHING MORPHOGENESIS AND METHODS OF USE
WO2003045321A2 (en) * 2001-11-26 2003-06-05 Exelixis, Inc. MBMs AS MODIFIERS OF BRANCHING MORPHOGENESIS AND METHODS OF USE

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965396A (en) * 1998-01-13 1999-10-12 Zeneca Limited Human lymph node derived GTPase
WO2003045314A2 (en) * 2001-11-26 2003-06-05 Exelixis Inc. Mhyps as modifiers of branching morphogenesis and methods of use
WO2003046222A1 (en) * 2001-11-26 2003-06-05 Exelixis, Inc. MAP4Ks AS MODIFIERS OF BRANCHING MORPHOGENESIS AND METHODS OF USE
WO2003045321A2 (en) * 2001-11-26 2003-06-05 Exelixis, Inc. MBMs AS MODIFIERS OF BRANCHING MORPHOGENESIS AND METHODS OF USE

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZHAO ET AL: "Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture.", DEVELOPMENTAL BIOLOGY., vol. 194, 1998, pages 182 - 195 *

Also Published As

Publication number Publication date
WO2005072470A2 (en) 2005-08-11

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