WO2003101500A1 - Membrane de dosage - Google Patents

Membrane de dosage Download PDF

Info

Publication number
WO2003101500A1
WO2003101500A1 PCT/EP2002/005913 EP0205913W WO03101500A1 WO 2003101500 A1 WO2003101500 A1 WO 2003101500A1 EP 0205913 W EP0205913 W EP 0205913W WO 03101500 A1 WO03101500 A1 WO 03101500A1
Authority
WO
WIPO (PCT)
Prior art keywords
dosing
membrane
dosing membrane
membrane according
peelable
Prior art date
Application number
PCT/EP2002/005913
Other languages
German (de)
English (en)
Inventor
Heinz Nieweg
Original Assignee
Oxyphen Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxyphen Ag filed Critical Oxyphen Ag
Priority to PCT/EP2002/005913 priority Critical patent/WO2003101500A1/fr
Publication of WO2003101500A1 publication Critical patent/WO2003101500A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B3/00—Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar form; Layered products having particular features of form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
    • A61L9/04—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating
    • A61L9/12—Apparatus, e.g. holders, therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
    • B32B7/04—Interconnection of layers
    • B32B7/06—Interconnection of layers permitting easy separation

Definitions

  • the invention relates to a metering membrane for closing a container, which is penetrated by micropores for the controlled release of an active ingredient contained therein and is sealingly fixed to the edge of a container wall.
  • Such a metering membrane is known from US Pat. No. 3,951,622, in which a secure closure is achieved by a cover or envelope which is impermeable to the components of the active ingredient to be released.
  • a non-porous membrane is used which brings about a diffusion process of the active substance through the membrane for the purpose of releasing the active substance.
  • this diffusion limits the variety of applications, since not every active ingredient diffuses equally well or some does not diffuse through the membrane material.
  • Undesirable side effects can also arise from the fact that an active ingredient consists of several components exists, with different diffusion behavior - the components are separated in different proportions and does not emerge in the original composition.
  • a dosing membrane is also known from US Pat. No. 5,804,264. These are non-porous layers through which the active ingredient is also released by means of diffusion through the membranes.
  • EP 0 912 199 also discloses a metering device which can be used on a room scent and has a peelable cover film.
  • the peelable film has no nubs, so that the seal for the escape of the active ingredient is only guaranteed if it is present in the vaporous (gaseous) state.
  • the sealing properties of the peelable film are not sufficient for liquid active substances.
  • the present invention has for its object to improve the above-mentioned metering membrane so that a secure closure of the pore area of the metering membrane is ensured during transport and storage until the desired release time of the active ingredient and the membrane exposes a uniform release of multicomponent active ingredients in gaseous form and / or liquid form.
  • the metering membrane contains blind pores on one side which contact the container wall to increase the separation resistance, and in that the metering membrane is covered before use by an open closure or a sealed peelable cover film, the Peel resistance is less than the membrane separation resistance on the container wall.
  • This novel metering membrane is provided with continuous, almost cylindrical pores for the passage of the active ingredient and additionally has blind pores on one side. Thanks to increased roughness, these blind pores ensure better adhesion of the membrane to the material reservoir, which contains the evaporating or seeping active ingredient.
  • a reservoir is understood to mean any container or envelope that is able to store an active substance or a third substance soaked with the active substance.
  • Fig. 4 dosing membrane with screw cap.
  • the metering membrane according to the invention for the controlled release of active substances has two essential parts, namely a microporous membrane 1 and a peelable film 2.
  • the membrane 1 is positioned on the wall of a reservoir 3.
  • the film 2 is applied to the side of the membrane 1 opposite the reservoir 3.
  • the parts mentioned which are made of weldable plastic or have a corresponding surface coating, are preferably welded together in a single operation.
  • the peelable layer 2 consists of a composite film which is laminated to the membrane 1 under the aforementioned action of pressure and heat. In this case, the relatively thicker than the cover layer 20 composite layer 21 micron knobs 11, which penetrate into the continuous micropores 10 of the membrane 1 and seal them tightly.
  • the further advantageous equipment of the membrane 1 with blind pores 12 on the side facing the reservoir 3 ensures that the sealed connection between the The metering membrane 1 and the wall of the reservoir 3, which contains the active ingredient, have a higher separation resistance than the connection between the metering membrane 1 and the peelable cover film 2.
  • the metering membrane 1 preferably has no through pores 10 in the edge region 30, and the cover film 2 is at least there not welded in a grip area 22.
  • the peelable film 2 is provided with a strip-like adhesive strip on the handling in the edge area 30 such that the good storage and
  • Suitable pressure sensitive adhesives are well known for other areas not related to this invention. For example from EP 0 276 557.
  • the same adhesive effect as an adhesive for the purpose of storing the remaining active ingredient for later use is advantageously achieved in a further embodiment by modifying the membrane surface.
  • This modification of the membrane surface produces a polarizing or magnetizing interaction between the peelable film and the membrane.
  • This modification can be carried out either in the form of a strip which lies opposite the outer edge of the film, or on the entire membrane surface, or else in accordance with another geometrical pattern.
  • 3a and 3b show an embodiment of the use of the metering membrane 1, 2 in side and plan view.
  • a connector 4 made of plastic, which is welded all around at a tapered end with the metering membrane 1 and the outside cover foil 2 and carries a welding flange 40 at an enlarged end, with which it is to be welded into a foil bag or the like ,
  • a nozzle 4 represents an independent commercial good.
  • FIG. 4 A further embodiment of the metering membrane 1 is shown in FIG. 4.
  • the membrane 1 is welded onto an annular seal 5, which is tightly screwed onto a bottle neck 51 with a screw sleeve 50 and can be closed with a screw cap 52.
  • the metering membrane 1 is preferably closed with a peelable cover film 2 before the first use.
  • the screw cap 52 later serves as an interim closure. Both the metering film with the ring seal 5 and the sleeve 50 and cap 52 fitted with it are tradable goods.
  • a membrane corresponding to the precisely desired dosage of an active ingredient is designed according to its properties, which are decisive for the passage through the pores, by appropriate dimensioning of the pore size and the density of the pores.
  • Pore diameters from 0.01 ⁇ m to 15 ⁇ m can be produced appropriately by etching on traces of ionization.
  • the density of the channels can be 1.5 x 10 4 to 7 x 10 9 per cm 2 .
  • the blind pores 12 should penetrate a maximum of 90% of the film thickness.
  • a film made of polyethylene terephthalate has proven itself well as a metering membrane.
  • the film thickness should be between 5 and 100 ⁇ m.
  • the cover film is expediently designed as a composite film, the outer layer of which consists of polyester or aluminum foil.
  • a force adhesive layer is applied to the edge area or a polarizing or mangnizing modification of the foils is arranged there, which has such an interaction that it produces a re-adhesion after each peeling off.
  • the pores are shown perpendicular to the extent of the film; however, they can have a solid angle of up to 90 °.

Abstract

L'invention concerne une membrane de dosage (1) servant à la libération contrôlée de principes actifs et comprenant un film de recouvrement pelable (2) qui garantit une fermeture sûre de la membrane de dosage (1) pendant le transport et le stockage avant l'utilisation, la libération des principes actifs ne se produisant qu'après enlèvement du film de recouvrement (2). Le film de dosage (1) selon l'invention comprend, outre des micropores traversants (10), des pores aveugles (12) assurant une adhérence accrue sur une paroi de contenant (3).
PCT/EP2002/005913 2002-05-29 2002-05-29 Membrane de dosage WO2003101500A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/EP2002/005913 WO2003101500A1 (fr) 2002-05-29 2002-05-29 Membrane de dosage

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2002/005913 WO2003101500A1 (fr) 2002-05-29 2002-05-29 Membrane de dosage

Publications (1)

Publication Number Publication Date
WO2003101500A1 true WO2003101500A1 (fr) 2003-12-11

Family

ID=29594993

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/005913 WO2003101500A1 (fr) 2002-05-29 2002-05-29 Membrane de dosage

Country Status (1)

Country Link
WO (1) WO2003101500A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018054458A1 (fr) * 2016-09-21 2018-03-29 Zobele Holding S.P.A. Dispositif de distribution de substance volatile et son procédé de fabrication
GB2570873A (en) * 2018-02-01 2019-08-14 Douwe Egberts Bv Container lid and liner, and method of manufacturing the same

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3951622A (en) * 1974-12-04 1976-04-20 Wilk Immanuel J Time release perfume method and device
US4157787A (en) * 1977-08-23 1979-06-12 Milpak Incorporated Air freshener dispenser
US4634614A (en) * 1983-01-14 1987-01-06 Firmenich S.A. Devices for perfuming ambient air and enclosed spaces
EP0327025A1 (fr) * 1988-02-04 1989-08-09 Sartorius Ag Filtre de membrane poreux ayant des endroits imperméables aux fluides et son utilisation
US5230867A (en) * 1991-04-05 1993-07-27 Waterbury Companies, Inc. Extended release fragrance dispensing cartridge
WO1994006480A1 (fr) * 1992-09-22 1994-03-31 Reckitt & Colman Products Limited Distributeur de liquides volatils
WO1994025370A1 (fr) * 1993-05-04 1994-11-10 Drackett Brands, Inc. Systeme d'emballage pour cartouches distributrices de produits volatils et procede de fabrication dudit systeme
DE19709110A1 (de) * 1997-03-06 1998-09-17 Wolfgang Zuber Membranpackung mit Spezialabdeckung (Membrane) zur Diffusion, Reinigung und/ oder Pflege

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3951622A (en) * 1974-12-04 1976-04-20 Wilk Immanuel J Time release perfume method and device
US4157787A (en) * 1977-08-23 1979-06-12 Milpak Incorporated Air freshener dispenser
US4634614A (en) * 1983-01-14 1987-01-06 Firmenich S.A. Devices for perfuming ambient air and enclosed spaces
EP0327025A1 (fr) * 1988-02-04 1989-08-09 Sartorius Ag Filtre de membrane poreux ayant des endroits imperméables aux fluides et son utilisation
US5230867A (en) * 1991-04-05 1993-07-27 Waterbury Companies, Inc. Extended release fragrance dispensing cartridge
WO1994006480A1 (fr) * 1992-09-22 1994-03-31 Reckitt & Colman Products Limited Distributeur de liquides volatils
WO1994025370A1 (fr) * 1993-05-04 1994-11-10 Drackett Brands, Inc. Systeme d'emballage pour cartouches distributrices de produits volatils et procede de fabrication dudit systeme
DE19709110A1 (de) * 1997-03-06 1998-09-17 Wolfgang Zuber Membranpackung mit Spezialabdeckung (Membrane) zur Diffusion, Reinigung und/ oder Pflege

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018054458A1 (fr) * 2016-09-21 2018-03-29 Zobele Holding S.P.A. Dispositif de distribution de substance volatile et son procédé de fabrication
CN109890427A (zh) * 2016-09-21 2019-06-14 佐贝勒控股股份公司 挥发性物质散发装置及其制造方法
US11534521B2 (en) 2016-09-21 2022-12-27 Zobele Holding S.P.A Volatile substance dispensing device and fabrication method thereof
GB2570873A (en) * 2018-02-01 2019-08-14 Douwe Egberts Bv Container lid and liner, and method of manufacturing the same
GB2570873B (en) * 2018-02-01 2023-03-22 Douwe Egberts Bv Container lid and liner, and method of manufacturing the same

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