WO2003101500A1 - Dosing membrane - Google Patents

Dosing membrane Download PDF

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Publication number
WO2003101500A1
WO2003101500A1 PCT/EP2002/005913 EP0205913W WO03101500A1 WO 2003101500 A1 WO2003101500 A1 WO 2003101500A1 EP 0205913 W EP0205913 W EP 0205913W WO 03101500 A1 WO03101500 A1 WO 03101500A1
Authority
WO
WIPO (PCT)
Prior art keywords
metering diaphragm
characterized
diaphragm according
preceding
micropores
Prior art date
Application number
PCT/EP2002/005913
Other languages
German (de)
French (fr)
Inventor
Heinz Nieweg
Original Assignee
Oxyphen Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxyphen Ag filed Critical Oxyphen Ag
Priority to PCT/EP2002/005913 priority Critical patent/WO2003101500A1/en
Publication of WO2003101500A1 publication Critical patent/WO2003101500A1/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B3/00Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar form ; Layered products having particular features of form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L9/00Disinfection, sterilisation or deodorisation of air
    • A61L9/015Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
    • A61L9/04Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating
    • A61L9/12Apparatus, e.g. holders, therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B7/00Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
    • B32B7/04Interconnection of layers
    • B32B7/06Interconnection of layers permitting easy separation

Abstract

Disclosed is a dosing membrane (1) for releasing active substances in a controlled manner, comprising a peelable coating film (2) which ensures that the dosing membrane (1) is securely closed during transport and storage before being used and the active substances are released only once the coating film (2) has been removed. The inventive dosing film (1) comprises penetrating micropores (10) as well as blind pores (12) which provide for improved adhesion to a container wall (3).

Description

metering diaphragm

The invention relates to a metering diaphragm for closing a container, which is penetrated for the controlled release of an active ingredient of micropores therein and is peripherally sealingly fixed to a container wall.

For many operations, such as in the transdermal delivery of drugs, in the room scenting in the insecticidal delivery to the environment, etc., is to take place over a greater or lesser period as uniform as possible release of active ingredients in a controlled ie. It is also important that the release takes place only when the corresponding effect is to be achieved. Polymer films are commonly used for such membranes.

From US 3,951,622, such a metering diaphragm is known, in which a safe closure by an impermeable to the components of the active ingredient to be released cover or envelope is achieved. It is used a non-porous membrane which provides a diffusion process deö active agent through the membrane for the purpose of release of the drug. However, this diffusion limits the range of applications because not every agent does not diffuse equally well or some through the membrane material through. This may cause undesirable side effects that an active substance, consisting of several components, is separated at different diffusion behavior -the components in various proportions and does not emerge in the original composition.

From US 5,804,264 a metering diaphragm is also known. Here, it is non-porous layers through which the active substance release is also carried out by means of a diffusion through the membranes.

From EP 0912199 a dosing device is further known that can be used on a air freshener and a peelable cover film. The peelable film has no studs, whereby the seal is only ensured for the leakage of the active substance, if present in the vapor (gaseous) state. For liquid active ingredients, the sealing properties of the peelable film are not sufficient.

The present invention has for its object to improve the above-described type metering diaphragm so that a safe closure of the pore area of ​​the metering diaphragm during transport and storage is until the desired release time of the active ingredient ensured, and the membrane exposed a uniform release even multi-component substances in gaseous and / or liquid form provides.

The object is achieved in that the metering diaphragm includes side blind pores, which contact the container wall separating resistance increasing, and in that the metering diaphragm is covered prior to use by an openable shutter or a sealed-peelable cover sheet whose Peelwiderstand is less than the membrane separation resistance at the container wall is.

Advantageous embodiments are disclosed in the dependent claims.

This novel metering diaphragm is provided with through nearly cylindrical pores for the passage of the active substance and additionally has on one side on blind pores. This blind pores gain due to increased roughness better adhesion of the membrane to the material reservoir containing the evaporated or seeping active ingredient. Sub-reservoir any container or envelope is to be understood, which is able to retain an active ingredient or an active ingredient impregnated with the third substance.

Advantageous embodiments are described with reference to FIGS.

It shows:

Fig. 1 membrane cutout closed with a peelable

Foil, Fig. 2 membrane segment, separated by a peelable foil,

Fig. 3 a dosing nozzle for welding in side and plan and 3 b

Fig. 4 metering diaphragm with screw cap.

The metering diaphragm according to the invention for the controlled release of active ingredients has two essential parts in an embodiment, namely a micro-porous membrane 1 and a peelable film 2. The diaphragm 1 is positioned on the wall of a reservoir. 3 On the opposite side of the reservoir 3 of the membrane 1, the film 2 is applied. With the action of pressure and temperature, the said parts, which consist of weldable plastic or have a corresponding surface coating are preferably in a single operation, welded together. The peelable layer 2 consists of a composite film which is laminated under the above-mentioned action of pressure and heat to the membrane. 1 In this case, arising from the relatively stronger than the cover layer 20 softening compound layer 21 micro burl 11 which penetrate into the through micropores 10 of the diaphragm 1, and these tightly.

By further advantageous design of the membrane 1 with blind pores 12 on the reservoir 3 side facing, it is ensured that the sealing connection between the pump diaphragm 1 and the wall of the reservoir 3 containing the active substance, a higher separation resistance than the connection between the metering diaphragm 1 and the peelable cover film 2. the metering diaphragm 1 preferably has in the edge region 30 no through pores 10, and the cover 2, there is at least not welded in a handle portion 22nd

However, the invention is not limited to such an embodiment. For example, the peelable film 2 is such provided with a strip-shaped adhesive sheet on handling in the edge region 30, that is the good storage and

Transport properties, which are given by the micro burl 11, until the first use retains, after which the adhesive strip allows the peelable film wiederaufzukleben 2 several times after a first removal of the membrane. 1 Thus, the remaining active ingredient can perform as a later or advise exhibit use.

For others, not relevant this invention ranges suitable adhesive are well known. For example, from EP 0276557.

The same adhesion effect, as an adhesive for the purpose of storage of remaining active ingredient for future use, is advantageously achieved in another embodiment by a modification of the membrane surface. This modification of the membrane surface produces a polarizing or magnetized interaction between the peelable film and the membrane. This modification can be carried out both in the form of a strip which lies opposite the outer edge of the film, or on the whole membrane surface, or in accordance with a different geometric pattern. An embodiment of the use of the metering diaphragm 1.2, FIGS. 3a and 3b in side and plan view. There, a nozzle 4 is shown made from plastic, which is welded at a tapered end of the front side completely with the metering diaphragm 1 and the outside 'cover sheet 2 and carries a welding flange 40 at an expanded end with which it is to weld in a foil bag o. The like. , Such stub 4 represents an independent commodity.

Another embodiment of the pump diaphragm 1 is shown in FIG. 4. The membrane 1 is welded onto an annular seal 5, which is screwed tightly with a screw sleeve 50 on a bottle neck 51 and is sealed with a screw cap 52nd Preferably, the pump diaphragm 1 is closed by a peelable cover sheet 2 before the first use. Later serving as an interim closure, the screw cap 52. Both the Dosierfolie with the annular seal 5 and the thus stocked sleeve 50 and cap 52 are traded items.

One of the exact desired dosage of an active substance corresponding membrane is arranged in each case according to its properties, which are crucial for the passage of the pores by a suitable dimensioning of the pore size and density of the pores.

There are pore diameter of 0.01 .mu.m to 15 .mu.m by a Aufätzen of ionisation suitable prepare respectively. The density of the channels may be 1.5 x 10 4 to 7 x 10 9 amount per cm 2.

The blind pores 12 should enforce a maximum of 90% of the film thickness. A film of polyethylene terephthalate is well proven as a metering diaphragm. The film thickness should be between 5 and 100 microns. The cover sheet is expediently designed as a composite film whose outer layer is made of polyester or aluminum foil.

For resealing a force-sensitive adhesive layer is attached to the edge region or a polarizing or mangneti- sierende modification of the foils arranged there, which has such an interaction that it provides a re-adhesion after each withdrawal.

The pores are depicted perpendicular to the extension of the film; but they can occupy a space angle of up to 90 °.

Claims

claims
1. metering diaphragm for closing a container, which is penetrated for the controlled release of a material of micropores (10) contained therein, and is peripherally sealingly fixed to a container wall (3), characterized in that the metering diaphragm (1) on one side contains blind pores (12) which contact the container wall (3) release resistance increasing, and in that the metering diaphragm prior to use of einenm disclose closure (52) or a sealed-peelable cover sheet (2) is covered, the Peelwiderstand is less than the membrane separation resistance at the container wall (3) is.
2. metering diaphragm according to claim 1, characterized in that in the membrane. (1) contained continuous micropores (10) having a pore density and such a pore diameter that in each case adapted to the active ingredient properties, a desired drug release rate occurs.
3. metering diaphragm according to claim 1 or 2, characterized in that the through micropores (10) are virtually cylindrical and have a diameter of 0.01 to 15 microns.
4. metering diaphragm according to any one of the preceding claims, characterized in that they through micropores 10 4 to 7 x includes (10) at a density between 1.5 x 10 9 per cm 2.
5. metering diaphragm according to any one of the preceding claims, characterized in that the through micropores (10) extend at an angle to the film surface from 45 ° to 135 °.
6. metering diaphragm according to any one of the preceding claims, characterized in that the density of blind pores (12) of at least 50% but not more than one hundred times the density of the - continuous micropores (10).
7. metering diaphragm according to any one of the preceding claims, characterized in that the membrane (1) thickness (D) has a between 5 and 100 microns.
8. metering diaphragm according to claim 7, characterized in that the depth of the blind pores (12) less than 90% of the membrane thickness (D).
9. The metering diaphragm according to claim 1, characterized in that the metering diaphragm (1) closed at one end regions (30) in which no continuous micropores (10) but only blind pores (12) are present, whereby the peelable cover sheet (2) in this region (30) having reduced adhesion.
10. metering diaphragm according to claim 9, characterized in that the closed portion (30) of the Dosierme bran (1) on the pore-free side with a protective layer (31), in particular a layer of lacquer is equipped to an adhesion of the cover sheet (2) the metering diaphragm (1) in this area (30) sure to be prevented. - lu ¬
ll. Metering diaphragm according to any one of the preceding claims, characterized in that the metering diaphragm (1) consists of polyethylene terephthalate.
12. metering diaphragm according to any one of the preceding claims, characterized in that the covering film (2) is a composite film whose inner peelable layer (21) is pressed under pressure and heat on its side 'of the metering diaphragm (1) having only the through- contains micropores (10) that the material of the peelable layer (21) is pressed into the micropores (10) and closes it sealingly.
13. metering diaphragm according to any one of the preceding claims, characterized in that the outer layer (22) of the composite film (21, 22) of polyester or aluminum.
14. metering diaphragm according to any one of the preceding claims, characterized in that along an outer periphery of the peelable cover sheet (2) an adhesive tape is attached which enables multiple removal and reattachment of the cover film (21) on the surface of the metering diaphragm (1).
15. metering diaphragm according to claim 14, characterized in that a modification of the surface of the metering diaphragm, a polarizing or magnetized interaction with the peelable cover sheet (2) provides, so that a multiple removal and reattachment of the peelable cover sheet (2) on the surface of the metering diaphragm (1 ) is made possible.
16. metering diaphragm according to any one of the preceding claims, characterized in that it is welded to an edge portion of a tapered towards the latter connection (4) of plastics material which carries a weldable flange (40) at its other end portion extended.
17. metering diaphragm according to one of claims 1 to 15, characterized in that it is directly welded or with or without the cover sheet (2) on a screw sleeve (50) via a sealing ring (50) is arranged to be screwed onto a container neck.
18. metering diaphragm according to claim 16, characterized in that the screw sleeve (50) carries a screw cap (52).
PCT/EP2002/005913 2002-05-29 2002-05-29 Dosing membrane WO2003101500A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/EP2002/005913 WO2003101500A1 (en) 2002-05-29 2002-05-29 Dosing membrane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2002/005913 WO2003101500A1 (en) 2002-05-29 2002-05-29 Dosing membrane

Publications (1)

Publication Number Publication Date
WO2003101500A1 true WO2003101500A1 (en) 2003-12-11

Family

ID=29594993

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/005913 WO2003101500A1 (en) 2002-05-29 2002-05-29 Dosing membrane

Country Status (1)

Country Link
WO (1) WO2003101500A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018054458A1 (en) * 2016-09-21 2018-03-29 Zobele Holding S.P.A. Volatile substance dispensing device and fabrication method thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3951622A (en) * 1974-12-04 1976-04-20 Wilk Immanuel J Time release perfume method and device
US4157787A (en) * 1977-08-23 1979-06-12 Milpak Incorporated Air freshener dispenser
US4634614A (en) * 1983-01-14 1987-01-06 Firmenich S.A. Devices for perfuming ambient air and enclosed spaces
EP0327025A1 (en) * 1988-02-04 1989-08-09 Sartorius Ag Porous membrane filter having fluid impermeable places and their use
US5230867A (en) * 1991-04-05 1993-07-27 Waterbury Companies, Inc. Extended release fragrance dispensing cartridge
WO1994006480A1 (en) * 1992-09-22 1994-03-31 Reckitt & Colman Products Limited Emanator for volatile liquids
WO1994025370A1 (en) * 1993-05-04 1994-11-10 Drackett Brands, Inc. Packaging system for dispensing cartridge for volatiles and method of providing such a system
DE19709110A1 (en) * 1997-03-06 1998-09-17 Wolfgang Zuber Aromatic packing

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3951622A (en) * 1974-12-04 1976-04-20 Wilk Immanuel J Time release perfume method and device
US4157787A (en) * 1977-08-23 1979-06-12 Milpak Incorporated Air freshener dispenser
US4634614A (en) * 1983-01-14 1987-01-06 Firmenich S.A. Devices for perfuming ambient air and enclosed spaces
EP0327025A1 (en) * 1988-02-04 1989-08-09 Sartorius Ag Porous membrane filter having fluid impermeable places and their use
US5230867A (en) * 1991-04-05 1993-07-27 Waterbury Companies, Inc. Extended release fragrance dispensing cartridge
WO1994006480A1 (en) * 1992-09-22 1994-03-31 Reckitt & Colman Products Limited Emanator for volatile liquids
WO1994025370A1 (en) * 1993-05-04 1994-11-10 Drackett Brands, Inc. Packaging system for dispensing cartridge for volatiles and method of providing such a system
DE19709110A1 (en) * 1997-03-06 1998-09-17 Wolfgang Zuber Aromatic packing

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018054458A1 (en) * 2016-09-21 2018-03-29 Zobele Holding S.P.A. Volatile substance dispensing device and fabrication method thereof

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