WO2003095453A1 - Composes a activite antihelicobacter - Google Patents

Composes a activite antihelicobacter Download PDF

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Publication number
WO2003095453A1
WO2003095453A1 PCT/JP2003/005795 JP0305795W WO03095453A1 WO 2003095453 A1 WO2003095453 A1 WO 2003095453A1 JP 0305795 W JP0305795 W JP 0305795W WO 03095453 A1 WO03095453 A1 WO 03095453A1
Authority
WO
WIPO (PCT)
Prior art keywords
ulcer
against helicobacter
same
compounds against
employed
Prior art date
Application number
PCT/JP2003/005795
Other languages
English (en)
French (fr)
Inventor
Giichi Sugimori
Moriyasu Masui
Kuniyoshi Nishida
Yasushi Hasegawa
Naotake Kobayashi
Original Assignee
Shionogi & Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co., Ltd. filed Critical Shionogi & Co., Ltd.
Priority to AU2003235908A priority Critical patent/AU2003235908A1/en
Publication of WO2003095453A1 publication Critical patent/WO2003095453A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PCT/JP2003/005795 2002-05-13 2003-05-08 Composes a activite antihelicobacter WO2003095453A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003235908A AU2003235908A1 (en) 2002-05-13 2003-05-08 Compounds against helicobacter activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002-137845 2002-05-13
JP2002137845 2002-05-13

Publications (1)

Publication Number Publication Date
WO2003095453A1 true WO2003095453A1 (fr) 2003-11-20

Family

ID=29416824

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/005795 WO2003095453A1 (fr) 2002-05-13 2003-05-08 Composes a activite antihelicobacter

Country Status (3)

Country Link
AU (1) AU2003235908A1 (ja)
TW (1) TW200407323A (ja)
WO (1) WO2003095453A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7291429B2 (en) * 2003-11-21 2007-11-06 Samsung Electronics Co., Ltd. Naphthalenetetracarboxylic acid diimide derivatives and electrophotographic photoconductive material using the derivatives
WO2015160251A1 (en) * 2014-04-15 2015-10-22 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno New anti-clostridium compounds
WO2021108317A1 (en) * 2019-11-27 2021-06-03 Hunt Perovskite Technologies, L.L.C. Non-fullerene acceptors (nfas) as interfacial layers in perovskite semiconductor devices
CN115073457A (zh) * 2022-08-09 2022-09-20 中国科学院长春应用化学研究所 一种萘双亚胺衍生物及其制备方法、应用

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3544303A (en) * 1968-04-03 1970-12-01 Stanford Research Inst Aromatic carboximides as herbicides
EP0031065A2 (de) * 1979-12-20 1981-07-01 Bayer Ag Naphthalintetracarbonsäurediimide als elektrische Halbleiter und Photoleiter
EP0263705A2 (en) * 1986-10-07 1988-04-13 Mitsubishi Kasei Corporation The use of thermoplastic polyester resin composition for UV-screening
JPH02252585A (ja) * 1989-03-28 1990-10-11 Mitsubishi Kasei Corp 画像の保護方法
JPH02255789A (ja) * 1989-03-29 1990-10-16 Asahi Chem Ind Co Ltd 有機電場発光素子
JPH08301892A (ja) * 1995-05-05 1996-11-19 F Hoffmann La Roche Ag 新規なアミノ糖の硫酸エステル
EP0769532A1 (de) * 1995-10-12 1997-04-23 Ciba SC Holding AG Naphthalinlactamimid-Fluoreszenzfarbstoffe
JP2000113504A (ja) * 1998-10-05 2000-04-21 Mitsui Chemicals Inc 光記録媒体
JP2001040237A (ja) * 1999-07-28 2001-02-13 Kyocera Mita Corp フタロシアニン結晶及びその製造方法と、これを含有した電子写真感光体
WO2002040479A1 (fr) * 2000-11-14 2002-05-23 Shionogi & Co., Ltd. Agents de traitement des infections a helicobacter

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3544303A (en) * 1968-04-03 1970-12-01 Stanford Research Inst Aromatic carboximides as herbicides
EP0031065A2 (de) * 1979-12-20 1981-07-01 Bayer Ag Naphthalintetracarbonsäurediimide als elektrische Halbleiter und Photoleiter
EP0263705A2 (en) * 1986-10-07 1988-04-13 Mitsubishi Kasei Corporation The use of thermoplastic polyester resin composition for UV-screening
JPH02252585A (ja) * 1989-03-28 1990-10-11 Mitsubishi Kasei Corp 画像の保護方法
JPH02255789A (ja) * 1989-03-29 1990-10-16 Asahi Chem Ind Co Ltd 有機電場発光素子
JPH08301892A (ja) * 1995-05-05 1996-11-19 F Hoffmann La Roche Ag 新規なアミノ糖の硫酸エステル
EP0769532A1 (de) * 1995-10-12 1997-04-23 Ciba SC Holding AG Naphthalinlactamimid-Fluoreszenzfarbstoffe
JP2000113504A (ja) * 1998-10-05 2000-04-21 Mitsui Chemicals Inc 光記録媒体
JP2001040237A (ja) * 1999-07-28 2001-02-13 Kyocera Mita Corp フタロシアニン結晶及びその製造方法と、これを含有した電子写真感光体
WO2002040479A1 (fr) * 2000-11-14 2002-05-23 Shionogi & Co., Ltd. Agents de traitement des infections a helicobacter

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANDRICOPULO A.D. ET AL.: "Analgesic activity of cyclic imides: 1,8-naphthalimide and 1,4,5,8-naphthalenediimide derivatives", IL FARMACO, vol. 55, no. 4, 2000, pages 319 - 321, XP002907644 *
GREEN S. ET AL.: "Intramolecular photoinduced electron transfer from nitroxyl radicals", J. PHYS. CHEM., vol. 99, no. 40, 1995, pages 14752 - 14757, XP002971035 *
MATSUGO S. ET AL.: "DNA strand scission and cell-killing activity of hydroperoxynaphthalimide derivatives upon photoirradiation", NUCLEIC ACID SYMP. SER. (SYMP. NUCLEIC ACIDS CHEMICAL, 18TH, 1991), no. 25, 1991, 110, pages - 109, XP002907643 *
MORI Y. ET AL.: "Spin effects on decay dynamics of charge-separated states generated by photoinduced electron transfer in zinc porphyrin-naphthalenedi-imide dyads", J. PHYS. CHEM. A, vol. 106, no. 18, 9 May 2002 (2002-05-09), pages 4453 - 4467, XP002971037 *
PAULL K.D. ET AL.: "Computer assisted structure-activity correlation, evaluation of benzo(de) isoquinoline-1,3-dones and related compounds as antitumor agents", ARZNEIM.-FORSCH., vol. 34, no. 10, 1984, pages 1243 - 1246, XP002107873 *
TABAKOVIC I. ET AL.: "Dendrimes peripherally modified with anion radicals that from pi-Stacks", CHEM. MATER., vol. 9, no. 3, 1997, pages 736 - 745, XP002971036 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7291429B2 (en) * 2003-11-21 2007-11-06 Samsung Electronics Co., Ltd. Naphthalenetetracarboxylic acid diimide derivatives and electrophotographic photoconductive material using the derivatives
WO2015160251A1 (en) * 2014-04-15 2015-10-22 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno New anti-clostridium compounds
US10596164B2 (en) 2014-04-15 2020-03-24 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Anti-clostridium compounds
WO2021108317A1 (en) * 2019-11-27 2021-06-03 Hunt Perovskite Technologies, L.L.C. Non-fullerene acceptors (nfas) as interfacial layers in perovskite semiconductor devices
US11264572B2 (en) 2019-11-27 2022-03-01 Cubicpv Inc. Non-fullerene acceptors (NFAS) as interfacial layers in perovskite semiconductor devices
EP4065580A4 (en) * 2019-11-27 2024-01-10 Cubicpv Inc NON-FULLERENE ACCEPTORS (NFAS) USED AS INTERFACIAL LAYERS IN PEROVSKITE-TYPE SEMICONDUCTOR DEVICES
CN115073457A (zh) * 2022-08-09 2022-09-20 中国科学院长春应用化学研究所 一种萘双亚胺衍生物及其制备方法、应用
CN115073457B (zh) * 2022-08-09 2024-02-13 中国科学院长春应用化学研究所 一种萘双亚胺衍生物及其制备方法、应用

Also Published As

Publication number Publication date
TW200407323A (en) 2004-05-16
AU2003235908A1 (en) 2003-11-11

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