WO2003082960A1 - Procede de production d'un gel - Google Patents

Procede de production d'un gel Download PDF

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Publication number
WO2003082960A1
WO2003082960A1 PCT/NL2003/000243 NL0300243W WO03082960A1 WO 2003082960 A1 WO2003082960 A1 WO 2003082960A1 NL 0300243 W NL0300243 W NL 0300243W WO 03082960 A1 WO03082960 A1 WO 03082960A1
Authority
WO
WIPO (PCT)
Prior art keywords
gel
temperature
hydrocarbon oil
heated
block copolymer
Prior art date
Application number
PCT/NL2003/000243
Other languages
English (en)
Inventor
Derk Johan Lammers
Paul Van Dansik
Original Assignee
Holdingmaatschappij Nutricos International B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Holdingmaatschappij Nutricos International B.V. filed Critical Holdingmaatschappij Nutricos International B.V.
Priority to AU2003235408A priority Critical patent/AU2003235408A1/en
Publication of WO2003082960A1 publication Critical patent/WO2003082960A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/90—Block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/09—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in organic liquids
    • C08J3/11—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in organic liquids from solid polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/28—Treatment by wave energy or particle radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/81—Preparation or application process involves irradiation

Definitions

  • the present invention relates to a method of producing a gel in accordance with the preamble of claim 1.
  • a general disadvantage is that the temperature at the wall of the vessel, near the heating element, will be considerably higher than the temperature of the material located somewhere else in the vessel. If the wall temperature is too high, there is a possibility of the material decomposing. In order to avoid decomposition, the wall temperature will have to stay within limits, so that heating may take a long time.
  • a particular object of the invention is to provide a method, which allows an even heating of the starting substances.
  • Another object of the invention is to provide a method, which allows the starting substances to be trea ed quickly.
  • a final object of the invention is to provide a method, which allows at least one of the starting substances to be heated in a predictable manner.
  • Electromagnetic radiation is understood to be radiation of a frequency such that at least one of the components can be heated directly. Possible applicable frequency ranges are 30 kHz - 3 MHz (induction; magnetic radiation) , 3 MHz - 300 MHz (radio frequency) , and 300 MHz - 30 GHz (microwave frequency) . This provides an even heating of at least one of the starting substances. More in particular, it provides even heating through the total quantity of the at least one starting substance.
  • gel is understood to be a solvent that is completely absorbed by a carrier so that in a state of rest, no free solvent is present any more.
  • the carrier is usually formed by a cross-linked (co) polymer. Gels are amorphous and there is no self- aggregation. Gels are heterogeneous systems consisting of assemblies of solids, comparable to sponges.
  • the hydrocarbon oil is heated in the manner described above and the at least one block copolymer is dispersed in the heated hydrocarbon oil. This provides a very thorough and even distribution of the block copolymer in the oil.
  • the temperature to which the hydrocarbon oil needs to be heated depends on the nature of the oil and the nature of the block copolymer.
  • the oil is in any case heated to a temperature of at least 15 °C.
  • a temperature is very suitable if a block copolymer is used such as, for example, the di- and triblock copolymers available from Kraton. Other suppliers of block copolymers are, for example, Uniquima, Hoechst and BASF.
  • the temperature is at least 65 °C. Further preferred is a temperature of at least 95 °C, still more preferred is 110 °C.
  • An upper limit is herewith defined by the decomposition temperature of the starting substances.
  • the temperature of the formed, dispersed mixture is elevated further. This improves the degasification of the mixture.
  • the gels formed according to the invention exhibit a particularly good dispersion, which is probably caused by the even manner of heating with the aid of microwaves.
  • the gels produced with the aid of the method according to the invention are very clear. Because of their clear appearance, the gels according to the invention are very useful in the sector of personal care products, such as perfumes, skin care, hair care, make-up, but also nail care and oral care.
  • Cooling of the formed gel may take place in several ways, for example, by heat dissipation to the environment. Forced cooling is also possible, for example, by conducting the gel through a pipe cooler or optionally through a plate heat exchanger. If very fast cooling is required, cryogenic cooling may be used. Such a manner of cooling is mainly determined by the viscosity of the gel. A person skilled in the art can easily determine a suitable method.
  • oils can be used as starting substances.
  • oil refers to those compounds that are capable of forming a gel with the block copolymers according to the invention. Examples of these are mentioned in claim 7.
  • the block copolymers may also be selected from a large number of different block copolymers. These are mentioned in their general form in claim 8. Examples of commercially available block copolymers are di- and tri- block copolymers of styrene and polyolefin groups, such as the commercially available KRATON® polymers.
  • the gels according to the invention have numerous favorable properties: they are transparent, are able to retain heat or cold as required, are waterproof and/or water resistant, are durable, have an easily controllable stickiness, and are film forming.
  • the starting substances are preferably mixed with the aid of a disperser. Particularly preferred is a dis- perser operating with much turbulence and little shearing.
  • an example of a suitable type of stirrer is, for example, the Tyfoon DW series stirrer. Such a stirrer works by displacement and cutting.
  • a particular advantage according to the invention is obtained by the fact that the same can be embodied as a semi-continuous or as continuous method. Until now it was only possible to produce the gels mentioned in the preamble by methods operating in batches. According to the invention it is possible to carry out the method as semi- continuous method by introducing a particular amount of oil into a starting vessel, heating the same and adding the block copolymers. The block copolymers may be added prior to heating, or simultaneous with heating, or optionally after heating to the desired temperature.
  • the invention may be implemented, for example, as follows: the starting sub- stances are fed separately into a static mixer, by means of supply pumps or the like. Prior to feeding the oil to the static mixer, it may be heated to the desired temperature. In order to avoid that the oil cools down in the mixer, the jacket of. the static mixer may also be main- tained at this operating temperature. The length of the static mixer must be chosen such that on egress from the static mixer, the desired degree of dispersion is obtained. The static mixer must of course be embodied such that complete dispersion can be guaranteed. To cool the resulting gel, which still has the elevated temperature, it can then be fed immediately to a cooler. According to another preferred embodiment it is possible to further elevate the temperature in order to promote degasifica- tion. In that case the temperature must be reduced after degasification.
  • NEXBASE® 2006FG polydecene
  • the mixture was then further heated in a microwave device for 3 minutes at 650 W. The temperature was elevated to 150°C. After that the mixture was cooled to a temperature of 120°C and maintained at this temperature for 20 minutes. The major part of the air was removed.
  • an oil is heated to a temperature of 120-140°C in a vessel having a heating jacket, the block copolymer is added, and this mixture is stirred for 4 to 6 hours with the aid of a propeller mixer or an anchor mixer until the said elevated temperature of 120-140°C was reached.
  • This mixing should take approximately 4 to 6 hours.
  • an antioxidant Especially tertiary carbon atoms present in the oil are sensitive to peroxidation.
  • This known method therefore has the disadvantage that it is obligatory to add extra sub- stances and that heating takes a very long time.
  • An alternative method according to the invention for preparing the gel with the aid of a microwave device can take place in a loop reactor.
  • the advantage of a loop reactor as shown in the Figures 2 and 3, is that the method can be carried out continuously or semi- continuously.
  • the oil is fed through a microwave device in order to elevate the temperature of the oil.
  • the block copolymer is added.
  • the mixture may be mixed in a static mixer or in another suitable mixer such as an extruder. After that, the mixture may optionally again be fed through the microwave.
  • the reactor may be embodied as shown in the Figures 2 and 3.
  • the mixer may be embodied in various ways. The final form and type are determined by the properties of the starting substances and of the gel to be obtained. It is also possible to use two or more separate microwave devices instead of a single one.
  • the block copolymer used is a generally available styrene-ethylene/propylene block copolymer.
  • Other block copolymers that form a gel when being mixed with a hydrocarbon oil are obviously also suitable. Examples include the remaining commercially available KRATON® series of block copolymers. Block copolymers that are equivalent with respect to the results to be obtained and available from other companies, can also be used in accordance with the present invention.
  • the gel according to the invention is especially useful in the production of cosmetics, pharmaceuticals, foodstuffs, or domestic and industrial products.
  • the gel can be used in particular in a plaster to be applied to the body, wherein the gel serves as thermal source for warm or cold.
  • the plaster comprises a predetermined amount of the gel.
  • the gel may optionally comprise further excipients. For example, by cooling the gel in a refrigerator or conversely, by heating it in a microwave, it can be conveniently used for a treatment of a surface of a body. A use may be found in the field of physiotherapy, with burns, with first aid generally and in the domestic sphere.
  • the gel according to the invention is further particularly useful in the production of perfume, skin care products, hair care products, nail care products, oral cleansing agents and make-up.
  • the gel according to the invention can be used especially well as alcohol thickener.
  • a particular embodiment comprises the addition of suitable metal particles to the gel or to one of the starting substances, facilitating heating by means of, for example, induction.
  • suitable metals and the form and size in which they have to be present can be determined quite simply by a person skilled in the art.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne un procédé destiné à produire un gel. Ce procédé consiste à mélanger une huile hydrocarbure et au moins un copolymère bloc. Elle est caractérisée en ce qu'au moins un des composants est chauffé à l'aide d'un rayonnement électromagnétique. De préférence, l'huile, à laquelle au moins un des copolymères blocs est ajouté, est chauffée au moyen de micro-ondes. La dispersion est réalisée à l'aide d'un émulsifiant agissant avec plus de turbulence et moins de cisaillement.
PCT/NL2003/000243 2002-03-29 2003-03-31 Procede de production d'un gel WO2003082960A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003235408A AU2003235408A1 (en) 2002-03-29 2003-03-31 Method of producing a gel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1020282 2002-03-29
NL1020282A NL1020282C2 (nl) 2002-03-29 2002-03-29 Werkwijze voor het vervaardigen van een gel.

Publications (1)

Publication Number Publication Date
WO2003082960A1 true WO2003082960A1 (fr) 2003-10-09

Family

ID=28673123

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2003/000243 WO2003082960A1 (fr) 2002-03-29 2003-03-31 Procede de production d'un gel

Country Status (3)

Country Link
AU (1) AU2003235408A1 (fr)
NL (1) NL1020282C2 (fr)
WO (1) WO2003082960A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992010537A1 (fr) * 1990-12-14 1992-06-25 Henkel Kommanditgesellschaft Auf Aktien Lyogel, sa preparation et son utilisation pour l'etanchement
WO1994012190A1 (fr) * 1991-02-04 1994-06-09 Pennzoil Products Company Compositions utilisees comme produit de soin et de beaute
WO1994026406A1 (fr) * 1993-05-18 1994-11-24 Hoechst Aktiengesellschaft Procede de sechage sous-critique d'aerogels
WO2002003939A2 (fr) * 2000-07-10 2002-01-17 Unilever Plc Composition antisudorifique

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992010537A1 (fr) * 1990-12-14 1992-06-25 Henkel Kommanditgesellschaft Auf Aktien Lyogel, sa preparation et son utilisation pour l'etanchement
WO1994012190A1 (fr) * 1991-02-04 1994-06-09 Pennzoil Products Company Compositions utilisees comme produit de soin et de beaute
WO1994026406A1 (fr) * 1993-05-18 1994-11-24 Hoechst Aktiengesellschaft Procede de sechage sous-critique d'aerogels
WO2002003939A2 (fr) * 2000-07-10 2002-01-17 Unilever Plc Composition antisudorifique

Also Published As

Publication number Publication date
NL1020282C2 (nl) 2003-09-30
AU2003235408A1 (en) 2003-10-13

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