WO2003080621A1 - Procede de preparation et produits intermediaires d'imidazopyrimidines substituees - Google Patents

Procede de preparation et produits intermediaires d'imidazopyrimidines substituees Download PDF

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Publication number
WO2003080621A1
WO2003080621A1 PCT/US2003/008301 US0308301W WO03080621A1 WO 2003080621 A1 WO2003080621 A1 WO 2003080621A1 US 0308301 W US0308301 W US 0308301W WO 03080621 A1 WO03080621 A1 WO 03080621A1
Authority
WO
WIPO (PCT)
Prior art keywords
fluoro
compound
reaction
trifluoromethyl
represents hydrogen
Prior art date
Application number
PCT/US2003/008301
Other languages
English (en)
Inventor
Wenjie Li
Dongwei Cai
R. Scott Hoerrner
Mark S. Jensen
Robert D. Larsen
Nicos A. Petasis
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Priority to AU2003223295A priority Critical patent/AU2003223295A1/en
Publication of WO2003080621A1 publication Critical patent/WO2003080621A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

L'invention concerne un nouveau procédé de préparation d'imidazo[1,2-a]pyrimidines, substituées en position 3 par un groupe chlorophényle substitué. Ces composés s'utilisent dans la synthèse de ligands du récepteur GABAA dans le traitement de troubles mentaux délétères. Ladite invention concerne également des produits intermédiaires obtenus à partir dudit procédé et utilisés dans la synthèse de ligands du récepteur GABAA.
PCT/US2003/008301 2002-03-19 2003-03-17 Procede de preparation et produits intermediaires d'imidazopyrimidines substituees WO2003080621A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003223295A AU2003223295A1 (en) 2002-03-19 2003-03-17 Process and intermediates to substituted imidazopyrimidines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36563002P 2002-03-19 2002-03-19
US60/365,630 2002-03-19

Publications (1)

Publication Number Publication Date
WO2003080621A1 true WO2003080621A1 (fr) 2003-10-02

Family

ID=28454691

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/008301 WO2003080621A1 (fr) 2002-03-19 2003-03-17 Procede de preparation et produits intermediaires d'imidazopyrimidines substituees

Country Status (2)

Country Link
AU (1) AU2003223295A1 (fr)
WO (1) WO2003080621A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767675B2 (en) 2006-11-22 2010-08-03 Incyte Corporation Imidazotriazines and imidazopyrimidines as kinase inhibitors
US7915408B2 (en) 2006-08-07 2011-03-29 Incyte Corporation Triazolotriazines as kinase inhibitors
US8420645B2 (en) 2008-05-21 2013-04-16 Incyte Corporation Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
US8487096B2 (en) 2010-02-03 2013-07-16 Incyte Corporation Imidazo[1,2-B][1,2,4]triazines as C-MET inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001043978A (ja) * 1999-07-29 2001-02-16 Mitsui Chemicals Inc 有機電界発光素子

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001043978A (ja) * 1999-07-29 2001-02-16 Mitsui Chemicals Inc 有機電界発光素子

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7915408B2 (en) 2006-08-07 2011-03-29 Incyte Corporation Triazolotriazines as kinase inhibitors
US8143251B2 (en) 2006-08-07 2012-03-27 Incyte Corporation Triazolotriazines as kinase inhibitors
US10738052B2 (en) 2006-11-22 2020-08-11 Incyte Holdings Corporation Imidazotriaines and imidazopyrimidines as kinase inhibitors
US7767675B2 (en) 2006-11-22 2010-08-03 Incyte Corporation Imidazotriazines and imidazopyrimidines as kinase inhibitors
US9944645B2 (en) 2006-11-22 2018-04-17 Incyte Corporation Imidazotriazines and imidazopyrimidines as kinase inhibitors
US11261191B2 (en) 2006-11-22 2022-03-01 Incyte Holdings Corporation Imidazotriaines and imidazopyrimidines as kinase inhibitors
US8420645B2 (en) 2008-05-21 2013-04-16 Incyte Corporation Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
US8901123B2 (en) 2008-05-21 2014-12-02 Incyte Corporation Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-B][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
US11452726B2 (en) 2008-05-21 2022-09-27 Incyte Corporation Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
US10245265B2 (en) 2008-05-21 2019-04-02 Incyte Incorporation Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-B][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
US10799509B2 (en) 2008-05-21 2020-10-13 Incyte Corporation Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-B][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
US8487096B2 (en) 2010-02-03 2013-07-16 Incyte Corporation Imidazo[1,2-B][1,2,4]triazines as C-MET inhibitors
US10472367B2 (en) 2010-02-03 2019-11-12 Incyte Incorporation Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors
US10919901B2 (en) 2010-02-03 2021-02-16 Incyte Holdings Corporation Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors
US9988387B2 (en) 2010-02-03 2018-06-05 Incyte Holdings Corporation Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors
US9221824B2 (en) 2010-02-03 2015-12-29 Incyte Holdings Corporation Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors

Also Published As

Publication number Publication date
AU2003223295A1 (en) 2003-10-08

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