WO2003077756A1 - Procede de determination de l'etat d'un tissu biologique (variantes) et systeme diagnostique pour mettre en oeuvre ce procede - Google Patents

Procede de determination de l'etat d'un tissu biologique (variantes) et systeme diagnostique pour mettre en oeuvre ce procede Download PDF

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Publication number
WO2003077756A1
WO2003077756A1 PCT/RU2003/000048 RU0300048W WO03077756A1 WO 2003077756 A1 WO2003077756 A1 WO 2003077756A1 RU 0300048 W RU0300048 W RU 0300048W WO 03077756 A1 WO03077756 A1 WO 03077756A1
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WIPO (PCT)
Prior art keywords
radiation
τκani
biοlοgichesκοy
optical
chτο
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PCT/RU2003/000048
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English (en)
Russian (ru)
Inventor
Roman Viktorovich Gorenkov
Alexandr Appolonovich Kazakov
Mikhail Mikhailovich Nazarenko
Dmitrii Alexeevich Rogatkin
Viacheslav Nikolaevich Svirin
Alexandr Sergeevich Cherkasov
Vladimir Panaitovich Chernenko
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Federalnoe Gosudarstvennoe Unitarnoe Predpriyatie Nauchno-Issledovatelskiy Institut 'polyus'
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Publication of WO2003077756A1 publication Critical patent/WO2003077756A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence

Definitions

  • the means and devices for biological contact with the livelihoods of the known biological plants are known ( ⁇ 1545346 ⁇ 1 06/18/1984; ue 148191985 ⁇ 19.11.
  • the list of known methods and devices has a number of significant disadvantages.
  • the described devices for fluorescence diagnostics do not take into account the possibility of introducing a significant error in the measurements due to the emitted emitting light
  • the biological tissue calculates, for example, the increase in the absorption rate, and the increase in 9
  • the lengths of the wave of electromagnetic radiation are chosen in accordance with
  • a handy signal is detected and emitted that is detected by a static and dynamic signal that is biologically
  • SIGNIFICANT FOX (DR. 26) 10 filters are divided into variable and fixed components and then they are sent to the diagnostic processing unit.
  • Diagn ⁇ s ⁇ iches ⁇ aya sis ⁇ ema for ⁇ edeleniya s ⁇ s ⁇ yaniya bi ⁇ l ⁇ giches ⁇ y ⁇ ani, ⁇ ealizuyuschaya ⁇ edlagaemy s ⁇ s ⁇ b diagn ⁇ s ⁇ i ⁇ i, v ⁇ lyuchae ⁇ a is ⁇ chni ⁇ i ele ⁇ magni ⁇ n ⁇ g ⁇ radiation gene ⁇ i ⁇ uyuschie radiation ⁇ iches ⁇ m dia ⁇ az ⁇ ne, sis ⁇ emu ⁇ ans ⁇ i ⁇ v ⁇ i radiation ⁇ is ⁇ chni ⁇ v radiation ⁇ issleduem ⁇ y ⁇ ani and sis ⁇ emu ⁇ ans ⁇ i ⁇ v ⁇ i v ⁇ ichn ⁇ g ⁇ radiation ⁇ ⁇ ani in sis ⁇ emu ⁇ b ⁇ ab ⁇ i in sis ⁇ emu ⁇ b ⁇ ab ⁇ i
  • the system of pulsed radiation emits a small (not less than two) intensities of the pulsed radiation emitted by the emitted radiation.
  • the systems of the hazardous radiation and the hazardous radiation from the sources of the studied fabric can be executed in the form of an optional plug-in.
  • the first unit can be used to register signals from the main detector for the length of the wavelength of the radiation sources, and the second unit - for
  • the outputs of the receivers of the first integrated optical unit are associated with the output of the amplified unit, which is increased as a result of a large increase in the signal
  • the direct integrated optical unit has been implemented
  • Fig. 1 General block diagram of the proposed diagnostic system.
  • ⁇ a ⁇ ig. 2 block diagram of the source of radiation sources.
  • ⁇ a ⁇ ig. 3 devices of optical-electronic blocks of registration and 5 highlighting useful signals.
  • ⁇ a ⁇ ig. 4 flowchart of the data processing algorithm.
  • ⁇ a ⁇ ig. 5 - a schematic explanation of the equation of transference.
  • ⁇ ° 1 - a table, on a short notice the conditional algorithm for diagnosing the state of a tissue is presented.
  • w P ⁇ edlagae maya diagn ⁇ s ⁇ iches ⁇ aya sis ⁇ ema ( ⁇ ig.1) s ⁇ de ⁇ zhi ⁇ in sv ⁇ em s ⁇ s ⁇ ave shes ⁇ ⁇ sn ⁇ vny ⁇ bl ⁇ v (uzl ⁇ v) bl ⁇ is ⁇ chni ⁇ v ⁇ e ⁇ vichn ⁇ g ⁇ uz ⁇ l ⁇ sn ⁇ g ⁇ ⁇ iches ⁇ g ⁇ radiation 1 sis ⁇ emu ⁇ ans ⁇ i ⁇ v ⁇ i radiation ⁇ 2 issleduem ⁇ y bi ⁇ l ⁇ giches ⁇ y ⁇ ani 3 sis ⁇ emu radiation ⁇ ans ⁇ i ⁇ v ⁇ i 4 ⁇ bi ⁇ ani ⁇ b ⁇ a ⁇ n ⁇ in diagn ⁇ s ⁇ iches ⁇ uyu sis ⁇ emu, ⁇ i ⁇ - 15 electronic unit for detecting radiation and isolating from badly useful signals 5 and unit for processing the diagnostics 6. In general, there is a 5 It is
  • Bl ⁇ is ⁇ chni ⁇ v ⁇ e ⁇ vichn ⁇ g ⁇ radiation ⁇ ig.2 s ⁇ s ⁇ i ⁇ nab ⁇ a of (at least 2 sh ⁇ .)
  • Laze ⁇ ny ⁇ and / or radiation sve ⁇ di ⁇ dny ⁇ is ⁇ chni ⁇ v 7 ⁇ azhdy 25 of ⁇ y ⁇ ⁇ ab ⁇ ae ⁇ in sv ⁇ em ⁇ deln ⁇ m uz ⁇ m s ⁇ e ⁇ aln ⁇ m dia ⁇ az ⁇ ne lengths of v ⁇ ln ⁇ bscheg ⁇ s ⁇ e ⁇ aln ⁇ g ⁇ in ⁇ e ⁇ vala 0.2 -100 m ⁇ m.
  • ⁇ y ⁇ dy is ⁇ chni ⁇ v radiation 7 s ⁇ edineny s ⁇ radiation smesi ⁇ elem 8 ⁇ bes ⁇ echivayuschim ⁇ dn ⁇ v ⁇ emenny or ⁇ che ⁇ edny vv ⁇ d vse ⁇ is ⁇ chni ⁇ v radiation into a single radiation sis ⁇ emu ⁇ ans ⁇ i ⁇ v ⁇ i (na ⁇ ime ⁇ , sve ⁇ v ⁇ d) ⁇ bi ⁇ ani 3.
  • z ⁇ S ⁇ edinenie m ⁇ zhe ⁇ by ⁇ vy ⁇ lnen ⁇ ⁇ s ⁇ eds ⁇ v ⁇ m sb ⁇ a a single zhgu ⁇ vse ⁇
  • SIGNIFICANT FOX 13 ⁇ delny ⁇ ⁇ iches ⁇ i ⁇ v ⁇ l ⁇ n, iduschi ⁇ ⁇ ⁇ azhd ⁇ g ⁇ izlucha ⁇ elya, zhgu ⁇ more s ⁇ yagae ⁇ sya with ⁇ bschim ⁇ iches ⁇ im v ⁇ l ⁇ n ⁇ m (smesi ⁇ elem) or ⁇ s ⁇ eds ⁇ v ⁇ m sis ⁇ emy linz ⁇ vy ⁇ ⁇ be ⁇ iv ⁇ v, ⁇ llima ⁇ v and / or sele ⁇ ivny ⁇ ⁇ lu ⁇ z ⁇ achny ⁇ ze ⁇ al, ⁇ usi ⁇ uyuschi ⁇ and na ⁇ avlyayuschi ⁇ radiation ⁇ bschee ⁇ v ⁇ l ⁇ n ⁇ or ⁇ bschy vy ⁇ dn ⁇ y ⁇ be ⁇ iv, ⁇ sveschayuschy bi ⁇ an.
  • the size of the wiring harness with a size of ⁇ 2 mm allows you to use it in endoscopic systems.
  • the quantity of emitters and their working lengths are mainly based on the separation of biochemistry or other types of biochemistry
  • the discreet working wavelengths are selected on the basis of their matching with the complex spectral absorption, scattering, luminescence and ⁇ . ⁇ . Regulated biochemistry components. In general, these wavelengths are well known from literary sources (Judenfrand S. “Fluorescence analysis in biology and medicine” - ⁇ ., ⁇ Economics ⁇ , 1965, ⁇ . ⁇ . ⁇ . ⁇ . ⁇ . ⁇ ute ⁇ 1. ⁇ réelle Congress ⁇ , ⁇ .36, # 12, 1989 - ⁇ 1146-1154).
  • ⁇ a ⁇ va ⁇ ian ⁇ is ⁇ chni ⁇ radiation m ⁇ zhe ⁇ by ⁇ vy ⁇ lnen on ⁇ sn ⁇ ve ⁇ e ⁇ es ⁇ aivaemy ⁇ ⁇ length v ⁇ lny laze ⁇ v and / or sve ⁇ di ⁇ d ⁇ v and ⁇ a ⁇ zhe on ⁇ sn ⁇ ve shi ⁇ l ⁇ sny ⁇ , na ⁇ ime ⁇ lam ⁇ vy ⁇ , is ⁇ chni ⁇ v sve ⁇ a in ⁇ m ⁇ le ⁇ e s ⁇ replaceable nab ⁇ m sve ⁇ il ⁇ v, ⁇ azhdy of ⁇ y ⁇ vy ⁇ ezae ⁇ of ⁇ bscheg ⁇ s ⁇ e ⁇ a lam ⁇ y desired dia ⁇ az ⁇ n lengths v ⁇ ln .
  • ⁇ ans ⁇ i ⁇ v ⁇ a z ⁇ ndi ⁇ uyuscheg ⁇ radiation see. ⁇ ig.1)
  • ⁇ bl ⁇ a is ⁇ chni ⁇ v radiation and ⁇ bi ⁇ ani ⁇ egis ⁇ i ⁇ uem ⁇ g ⁇ v ⁇ ichn ⁇ g ⁇ radiation
  • Block 11 implements static and dynamic, with resolution
  • non-selective dividers amplifiers
  • the optical spectral block 10 implements the selection and statistical registration of weak signals in the side spectra of the negative scattering due to bias (the signal from the fluorescence).
  • CCDs CCDs
  • ком ⁇ онентP is an integral differential, where the parameters of the environment are identical to the determinant of the equation. Conventionally, when comparing the transmission equation, the distribution of a small multiplicity of radiation (at a wavelength of ⁇ ) is increased.
  • ⁇ is the element of the solid angle
  • ⁇ ( ⁇ , ⁇ ') is the phase dispersion function (dispersion index), the char- acteristic separation of the radiation radiation intensity.
  • ⁇ , ( ⁇ ) is the tabular (previously known) coefficient of the inconsequential (small) effect for the VENT -component component of the tissue, with the ⁇ -percussive (small) factor.
  • variable components of the signals from the units are being processed.
  • the average mean scattering and absorption (shielding) of the signals in the biowave are taken into account, which, in the general case, strongly affect the recorded signals (for example, are lower).
  • the dynamic parameters of signals are evaluated by methods of processing signals, for example, methods of analysis, and methods of random methods. ⁇ As a result of processing, we obtain quantitative biological characteristics of the speed of motion, the parameters of the pulsation, variability, and so on. Filling liquids (fluid, lymph, etc.) in the area of diagnosis, which are
  • P ⁇ signals from bl ⁇ a s ⁇ a ⁇ iches ⁇ y ⁇ egis ⁇ atsii b ⁇ vy ⁇ s ⁇ e ⁇ v ( ⁇ lyu ⁇ estsentsii signals and ⁇ . ⁇ .) ⁇ tsenivayu ⁇ ⁇ liches ⁇ venn ⁇ e na ⁇ lenie in ⁇ anya ⁇ ⁇ azlichny ⁇ ⁇ i ⁇ dny ⁇ ⁇ lyu ⁇ estsi ⁇ uyuschi ⁇ vesches ⁇ v ( ⁇ eshenie ⁇ b ⁇ a ⁇ n ⁇ y ⁇ i ⁇ i problem for signal ⁇ v ⁇ lyu ⁇ estsentsii with uche ⁇ m
  • stage 2 The other stage is the general analysis of the physiological and medical status of the tissue at the primary medical diagnostic system. ⁇ Adjust ⁇ divided into stage 2
  • the product is not in operation, it may be missing (0), the activity of the components will be suppressed or not available.
  • Issled ⁇ vanie bi ⁇ lyu ⁇ estsen ⁇ n ⁇ y a ⁇ ivn ⁇ s ⁇ i ⁇ aney ⁇ azal ⁇ increase a ⁇ ivn ⁇ s ⁇ i ⁇ i ⁇ in ⁇ v ⁇ 1,5 d ⁇ 4.5 ⁇ az ⁇ s ⁇ avneniyu with in ⁇ a ⁇ nymi uchas ⁇ ami and znachi ⁇ elny ⁇ azb ⁇ s ⁇ aza ⁇ eley a ⁇ ivn ⁇ s ⁇ i ⁇ lav ⁇ ein ⁇ v ( ⁇ D) and ⁇ i ⁇ idinnu ⁇ le ⁇ id ⁇ v ( ⁇ D ⁇ ) in connection with ne ⁇ dn ⁇ dn ⁇ s ⁇ yu ⁇ v ⁇ snabzheniya ⁇ u ⁇ li.
  • the large volume is slightly higher in the area of granularity compared to the inactive one, which leads to an increase in the low-frequency amplitude associated with a migratory activity.
  • the efficiency of the product, ⁇ , ⁇ does not exceed the rate of the rate. In general, the use of the complex of the above parameters didn’t make it easy to diagnose the malign process, but also to evaluate the dynamics. 22
  • ulcer healing was observed on the basis of gastrointestinal tract formation. This was due to an increase in volumetric circulation in the place of the former localization of the ulcer, a decrease in the activity of the drugs and an increase in the activity of ⁇ D ⁇ and ⁇ .
  • ⁇ a ⁇ im ⁇ b ⁇ az ⁇ m is ⁇ lz ⁇ vanie pain ⁇ g ⁇ ⁇ iches ⁇ g ⁇ me ⁇ da diagn ⁇ s ⁇ i ⁇ i 20 ⁇ zv ⁇ lil ⁇ , v ⁇ ⁇ e ⁇ vy ⁇ , ulcerative di ⁇ e ⁇ entsi ⁇ va ⁇ ⁇ tsess ⁇ ⁇ e ⁇ e ⁇ zhdeniya ulcers ⁇ a ⁇ ( ⁇ dn ⁇ dn ⁇ s ⁇ ⁇ a ⁇ ame ⁇ v changes neznachi ⁇ eln ⁇ e ⁇ vyshenie u ⁇ vnya ⁇ i ⁇ in ⁇ v, ⁇ l ⁇ zhi ⁇ elny e ⁇ e ⁇ ⁇ treatment).
  • EXAMPLE 3 Ischemia of tkane associated with local disturbance of the intestine.
  • Bolshiy ⁇ It suffers from the syndrome of the onset of vibration, which is manifested by acute disturbances of the fingers in the fingers of the fingers in the form of angiomas "white".
  • the disease is manifested in the form of white whitening, pain in the hands, and erectile dysplasia of the fingers - thickening of the distal phalanges, rupture of the sore throat.
  • Example 5 lead induction.
  • the method is effective in the diagnosis of obstructive abnormalities caused by lead intoxication.
  • both static, dynamic and dynamic parameters of the signals being measured are measured, i.e.
  • methods of fluorescence diagnostics, biotherapy, diagnostics, therapy and t. ⁇ . are being implemented.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention se rapporte à la médecine et aux appareils médicaux, en particulier à un procédé de diagnostique optique de l'état physiologique et patho-physiologique des tissus biologiques et aussi aux appareils médicaux diagnostiques permettant de mettre en oeuvre ce procédé, ces appareils étant utilisés pour un contrôle non invasif (non-desrtuctif, au cours de la vie) et pour une surveillance de l'état clinique des tissus humains. L'invention est basée sur des procédés d'obtention d'information par irradiation de la région de tissu examiné à l'aide des sources du rayonnement laser ou du rayonnement à bande étroite de la diode photoémissive aux différentes longueurs d'onde, puissances, polarisations et autres paramètres physiques du rayon qui éclaire le tissu. Le procédé selon l'invention est accompagné par l'analyse de fréquence et spectrale et/ou d'amplitude et spectrale des paramètres du rayonnement secondaire sortant du tissu (le rayonnement réfléchi, diffusé, induit, provoqué, de fond etc.).
PCT/RU2003/000048 2002-03-19 2003-02-14 Procede de determination de l'etat d'un tissu biologique (variantes) et systeme diagnostique pour mettre en oeuvre ce procede WO2003077756A1 (fr)

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RU2002106861 2002-03-19
RU2002106861/14A RU2234242C2 (ru) 2002-03-19 2002-03-19 Способ определения состояния биологической ткани и диагностическая система для его реализации

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US8552359B2 (en) 2009-04-01 2013-10-08 The Curators of the Univesity of Missouri Optical spectroscopy device for non-invasive blood glucose detection and associated method of use
US9566024B2 (en) 2008-05-22 2017-02-14 St. Louis Medical Devices, Inc. Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis
US10542919B2 (en) 2008-03-25 2020-01-28 St. Louis Medical Devices, Inc. Method and system for non-invasive blood glucose detection utilizing spectral data of one or more components other than glucose
US12036019B2 (en) 2021-04-09 2024-07-16 St. Louis Medical Devices, Inc. Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

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