WO1994003102A1 - Moniteur optique (oxymetre, etc.) a suppression d'artefact du au mouvement - Google Patents
Moniteur optique (oxymetre, etc.) a suppression d'artefact du au mouvement Download PDFInfo
- Publication number
- WO1994003102A1 WO1994003102A1 PCT/GB1993/001630 GB9301630W WO9403102A1 WO 1994003102 A1 WO1994003102 A1 WO 1994003102A1 GB 9301630 W GB9301630 W GB 9301630W WO 9403102 A1 WO9403102 A1 WO 9403102A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- light
- photodetector
- wavelengths
- signals
- different
- Prior art date
Links
- 230000033001 locomotion Effects 0.000 title claims abstract description 26
- 230000003287 optical effect Effects 0.000 title claims abstract description 9
- 230000001629 suppression Effects 0.000 title description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 10
- 239000001301 oxygen Substances 0.000 claims abstract description 10
- 239000008280 blood Substances 0.000 claims abstract description 9
- 210000004369 blood Anatomy 0.000 claims abstract description 9
- 238000012545 processing Methods 0.000 claims description 12
- 238000012806 monitoring device Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 238000012544 monitoring process Methods 0.000 abstract description 4
- 230000005540 biological transmission Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002106 pulse oximetry Methods 0.000 description 2
- 238000004148 unit process Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 238000002496 oximetry Methods 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 230000010349 pulsation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/02416—Detecting, measuring or recording pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
- A61B5/7207—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts
- A61B5/7214—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts using signal cancellation, e.g. based on input of two identical physiological sensors spaced apart, or based on two signals derived from the same sensor, for different optical wavelengths
Definitions
- OPTICAL MONITOR OXIMETER, ETC.
- This invention relates to an optical monitoring or measuring device with motion artefact suppression.
- Motion artefact is a significant problem in pulse oximeters, and can render these devices inoperative for up to
- an optical measuring or monitoring device which comprises light source means for emitting one or more light beams which includes light of a plurality of different wavelengths, photodetector means for receiving said light beam or beams after passing through or being reflected within living tissue and arranged to provide signals corresponding to the intensities of the respective wavelengths received by the photodetector means, the arrangement being such that the quiescent (or "DC") signal levels corresponding to the different wavelengths bear a predetermined relationship with each other, and signal processing means for processing the output signals from the photodetector means to cancel out variations due to motion artefact and to provide an output representing a parameter to be measured or monitored and substantially unaffected by motion artefact.
- light source means for emitting one or more light beams which includes light of a plurality of different wavelengths
- photodetector means for receiving said light beam or beams after passing through or being reflected within living tissue and arranged to provide signals corresponding to the intensities of the respective wavelengths received by the photodetector means, the arrangement being such that the qui
- a pulse oximetry device For example, in a pulse oximetry device, light of two or more wavelengths is passed through or reflected within living tissue. At each wavelength, there is a fixed “DC” intensity of light received by the photodetector, with a pulsatile “AC” component (caused by arterial pulsation) superimposed thereon.
- a pulse oximeter uses two wavelengths and the signal processing unit processes the signals from the photodetector, corresponding to these two wavelengths, to provide a measure of pulse rate or blood oxygen saturation.
- the signal processing unit processes the three signals from the photodetector firstly to cancel out the motion artefact and then to determine the pulse rate and/or blood oxygen saturation.
- a device In general, where a device normally uses n different wavelengths of light and processes the n corresponding output signals from the photodetector to determine the value of the parameter being measured or monitored, in accordance with this invention the device will use an additional wavelength (n + 1) wavelengths altogether, so that the motion artefact can be cancelled out.
- n + 1) wavelengths Preferably high accuracy readings are made by the controller of each of the three sources via a single sensor and a single hardware conversion block. From these readings, three difference signals are produced. Because these (AC) difference signals have reduced motion artefact signal and directly reflect the different absorption levels in the tissue, they can be used in combination as indicators of the oxygen saturation level.
- Preferably additional real time digital filtering of the signals is used to reduce 50/60Hz components and to correlate input signals to improve noise rejection.
- the input channels may be continuously monitored by the processor to ensure that the effects of component aging or temperature drifting are eliminated.
- Preferably most of the signal processing is performed in software so the costs of the unit is low and there is no requirement for very accurate hardware matching.
- the device comprises three LED's 1,2,3 emitting different wavelengths of light for transmission through or reflection from within living tissue, indicated schematically at T.
- the device further comprises photodetectors 11,12,13 for receiving each of the transmitted or reflected light beams.
- the device includes a control means 20, arranged to adjust the power applied to the LED's, to give a "DC" signal level, in the outputs from the photodetectors 11,12,13, which is equal for all three wavelengths: this can be achieved very accurately. Then:
- the OAC's are the observed AC signals from the photodetector, the AC'S are the true AC signals, and MA is the motion artefact.
- the device further includes a signal processor 30, in which:
- OAC ⁇ l is subtracted from OAC ⁇ 2, giving AC ⁇ l - AC ⁇ 2;
- OAC ⁇ 2 is subtracted from OAC ⁇ 3, giving AC ⁇ 2 - AC ⁇ 3
- the signal processing unit then extracts the original AC components in accordance with the following:
- Equation 8 Rearranging Equation 8 to quadratic form :
- Equation 9 a
- Equation 9 b
- %Sa02 F. AC ⁇ 2 + K4. AC ⁇ 3
- the motion artefact signals differ from each other by 5 to 20% implying a degree of rejection of between 20 and 5 times. How close this figure is to 0% depends on the severity of the physical disturbance causing the artefact, and probably on the sensor design.
- the light source at all wavelengths are point sourced, that is they originate as far as their path through the medium is concerned at a single point.
- the configuration of the light sources is constrained by the physical dimensions of the sources, i.e. they are as close as is physically possible.
- a light guide method may be used to make all light sources originate from a single point.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Physiology (AREA)
- Signal Processing (AREA)
- Artificial Intelligence (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Psychiatry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Optics & Photonics (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Un dispositif optique, utilisé notamment dans le contrôle de la fréquence du pouls et/ou de la saturation d'oxygène dans le sang, comprend une source lumineuse (1, 2, 3) émettant de la lumière à trois longueurs d'ondes différentes, et un photodétecteur (11, 12, 13) recevant de la lumière après la transmission à travers le tissu vivant (T) ou la réflexion dans celui-ci afin d'obtenir des signaux correspondant aux intensités des longueurs d'ondes respectives reçues par le photodétecteur. L'agencement est tel que les niveaux au repos (ou 'CC') des trois signaux de sortie sont sensiblement égaux. Un processeur de signaux forme deux signaux représentant les différences entre deux paires différentes des trois sorties du photodétecteur afin d'éliminer les variations (artefact dû au mouvement) dues au mouvement du sujet. Les deux signaux représentant les différences sont ensuite traités afin d'extraire les composantes de courant alternatif dans les sorties des photodétecteurs, et à partir desquelles on peut déterminer la fréquence du pouls et la saturation d'oxygène dans le sang.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU47198/93A AU4719893A (en) | 1992-08-01 | 1993-08-02 | Optical monitor (oximeter, etc.) with motion artefact suppression |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9216431.8 | 1992-08-01 | ||
GB929216431A GB9216431D0 (en) | 1992-08-01 | 1992-08-01 | Optical monitoring or measuring artefact suppression |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994003102A1 true WO1994003102A1 (fr) | 1994-02-17 |
Family
ID=10719722
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1993/001630 WO1994003102A1 (fr) | 1992-08-01 | 1993-08-02 | Moniteur optique (oxymetre, etc.) a suppression d'artefact du au mouvement |
Country Status (4)
Country | Link |
---|---|
AU (1) | AU4719893A (fr) |
GB (1) | GB9216431D0 (fr) |
WO (1) | WO1994003102A1 (fr) |
ZA (1) | ZA935579B (fr) |
Cited By (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5517988A (en) * | 1993-12-11 | 1996-05-21 | Hewlett-Packard Company | Method for detecting an irregular state in a non-invasive pulse oximeter system |
EP0733340A1 (fr) * | 1995-03-23 | 1996-09-25 | Seiko Instruments Inc. | Indicateur de la fréquence du pouls |
GB2300045A (en) * | 1995-04-11 | 1996-10-23 | Yoav Paltieli | Optical fibre endoscope |
WO1997000041A1 (fr) * | 1995-06-14 | 1997-01-03 | Nellcor Puritan Bennett Incorporated | Procede permettant d'eliminer un artefact du au mouvement et le bruit dans une oxymetrie du pouls et appareil correspondant |
DE19609410A1 (de) * | 1996-03-04 | 1997-09-11 | Biotronik Mess & Therapieg | Vorrichtung zur Bestimmung der Blutsauerstoffsättigung |
WO1997036538A1 (fr) * | 1996-04-01 | 1997-10-09 | Kontron Instruments Ag | Detection de signaux parasites lors de mesures pulsoxymetriques |
WO1998004903A1 (fr) * | 1996-07-26 | 1998-02-05 | Kontron Instruments Ag | Procede de determination non invasive de la saturation en oxygene de tissus vascularises |
DE19647877A1 (de) * | 1996-11-19 | 1998-05-28 | Metrax Gmbh | Verfahren und Schaltungsanordnung zur Ermittlung der Sauerstoffsättigung im Blut |
WO1999032030A1 (fr) | 1997-12-22 | 1999-07-01 | Btg International Limited | Reduction des artefacts en photoplethysmographie |
WO2000009004A2 (fr) | 1998-08-13 | 2000-02-24 | Whitland Research Limited | Dispositif optique |
US6104938A (en) * | 1996-06-12 | 2000-08-15 | Instrumentarium Oy | Procedure, apparatus and detector for the determination of fractional oxygen saturation |
EP1297784A1 (fr) | 2001-09-28 | 2003-04-02 | C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa | Procédé et dispositif de mesure du pouls |
WO2003077756A1 (fr) * | 2002-03-19 | 2003-09-25 | Federalnoe Gosudarstvennoe Unitarnoe Predpriyatie Nauchno-Issledovatelskiy Institut 'polyus' | Procede de determination de l'etat d'un tissu biologique (variantes) et systeme diagnostique pour mettre en oeuvre ce procede |
US6658277B2 (en) | 2001-09-13 | 2003-12-02 | Imagyn Medical Technologies, Inc. | Signal processing method and device for signal-to-noise improvement |
US6801799B2 (en) | 2000-10-05 | 2004-10-05 | Cybro Medical, Ltd. | Pulse oximeter and method of operation |
WO2005087098A1 (fr) * | 2004-03-09 | 2005-09-22 | Nellcor Puritan Bennett Incorporated | Elimination d'artefacts de mouvements d'oxymetrie des pulsations par absorption proche de l'infrarouge par l'eau |
US6997879B1 (en) | 2002-07-09 | 2006-02-14 | Pacesetter, Inc. | Methods and devices for reduction of motion-induced noise in optical vascular plethysmography |
WO2006097437A1 (fr) | 2005-03-14 | 2006-09-21 | Spectrum Medical Llp | Surveillance de substances predeterminees dans le sang |
WO2008042147A2 (fr) * | 2006-09-29 | 2008-04-10 | Nellcor Puritan Bennett Llc | Réseau de diodes électroluminescentes symétrique pour l'oximétrie pulsée |
US7684842B2 (en) | 2006-09-29 | 2010-03-23 | Nellcor Puritan Bennett Llc | System and method for preventing sensor misuse |
US7738935B1 (en) | 2002-07-09 | 2010-06-15 | Pacesetter, Inc. | Methods and devices for reduction of motion-induced noise in pulse oximetry |
US7774037B2 (en) | 1998-07-04 | 2010-08-10 | Whitland Research Limited | Non-invasive measurement of blood analytes |
US8219170B2 (en) | 2006-09-20 | 2012-07-10 | Nellcor Puritan Bennett Llc | System and method for practicing spectrophotometry using light emitting nanostructure devices |
US8265724B2 (en) | 2007-03-09 | 2012-09-11 | Nellcor Puritan Bennett Llc | Cancellation of light shunting |
US8280469B2 (en) | 2007-03-09 | 2012-10-02 | Nellcor Puritan Bennett Llc | Method for detection of aberrant tissue spectra |
US8315685B2 (en) | 2006-09-27 | 2012-11-20 | Nellcor Puritan Bennett Llc | Flexible medical sensor enclosure |
US8600469B2 (en) | 2005-09-29 | 2013-12-03 | Covidien Lp | Medical sensor and technique for using the same |
US8708900B2 (en) | 2007-12-26 | 2014-04-29 | Covidien Lp | LED drive circuit and method for using same |
US8862194B2 (en) | 2008-06-30 | 2014-10-14 | Covidien Lp | Method for improved oxygen saturation estimation in the presence of noise |
US8930145B2 (en) | 2010-07-28 | 2015-01-06 | Covidien Lp | Light focusing continuous wave photoacoustic spectroscopy and its applications to patient monitoring |
US8965473B2 (en) | 2005-09-29 | 2015-02-24 | Covidien Lp | Medical sensor for reducing motion artifacts and technique for using the same |
USD736250S1 (en) | 2008-06-30 | 2015-08-11 | Covidien Lp | Portion of a display panel with an indicator icon |
US9326731B2 (en) | 2011-03-25 | 2016-05-03 | Nitto Denko Corporation | Method of measuring an artefact removed photoplethysmographic (PPG) signal and a measurement system |
US9351674B2 (en) | 2005-03-03 | 2016-05-31 | Covidien Lp | Method for enhancing pulse oximetry calculations in the presence of correlated artifacts |
WO2016166290A1 (fr) * | 2015-04-15 | 2016-10-20 | Koninklijke Philips N.V. | Capteur de granularité à laser optique permettant de mesurer un paramètre de perfusion sanguine |
CN106248579A (zh) * | 2016-08-31 | 2016-12-21 | 马东阁 | 一种oled血液检测设备 |
WO2017055307A1 (fr) * | 2015-09-28 | 2017-04-06 | Koninklijke Philips N.V. | Capteur des signes vitaux et procédé de mesure des signes vitaux d'un utilisateur |
US9833146B2 (en) | 2012-04-17 | 2017-12-05 | Covidien Lp | Surgical system and method of use of the same |
US9895068B2 (en) | 2008-06-30 | 2018-02-20 | Covidien Lp | Pulse oximeter with wait-time indication |
US10022058B2 (en) | 2006-09-28 | 2018-07-17 | Covidien Lp | System and method for pulse rate calculation using a scheme for alternate weighting |
US10076276B2 (en) | 2008-02-19 | 2018-09-18 | Covidien Lp | Methods and systems for alerting practitioners to physiological conditions |
US10426360B2 (en) | 2013-05-15 | 2019-10-01 | Pulseon Oy | Portable pulse measuring device |
Families Citing this family (1)
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AUPN740796A0 (en) * | 1996-01-04 | 1996-01-25 | Circuitry Systems Limited | Biomedical data collection apparatus |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
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US4266554A (en) * | 1978-06-22 | 1981-05-12 | Minolta Camera Kabushiki Kaisha | Digital oximeter |
EP0102816A2 (fr) * | 1982-09-02 | 1984-03-14 | Nellcor Incorporated | Mesure de pouls et de teneur en oxygène |
WO1988001147A1 (fr) * | 1986-08-18 | 1988-02-25 | Physio-Control Corporation | Procede et appareil de reglage a contre-reaction pour le traitement de signaux utilises pour mesurer l'oxygene |
EP0286142A2 (fr) * | 1987-04-09 | 1988-10-12 | Sumitomo Electric Industries, Ltd. | Oxymètre à réflexion |
EP0303502A1 (fr) * | 1987-08-14 | 1989-02-15 | Btg International Limited | Système de réjection des signaux dûs aux mouvements parasites pour des dispositifs d'oxymétrie et de mesure du rythme cardiaque |
US4819752A (en) * | 1987-10-02 | 1989-04-11 | Datascope Corp. | Blood constituent measuring device and method |
EP0479322A2 (fr) * | 1990-10-03 | 1992-04-08 | Spacelabs, Inc. | Dispositif pour détecter le mouvement d'un transducteur |
US5190038A (en) * | 1989-11-01 | 1993-03-02 | Novametrix Medical Systems, Inc. | Pulse oximeter with improved accuracy and response time |
-
1992
- 1992-08-01 GB GB929216431A patent/GB9216431D0/en active Pending
-
1993
- 1993-08-02 ZA ZA935579A patent/ZA935579B/xx unknown
- 1993-08-02 AU AU47198/93A patent/AU4719893A/en not_active Abandoned
- 1993-08-02 WO PCT/GB1993/001630 patent/WO1994003102A1/fr active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
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US4266554A (en) * | 1978-06-22 | 1981-05-12 | Minolta Camera Kabushiki Kaisha | Digital oximeter |
EP0102816A2 (fr) * | 1982-09-02 | 1984-03-14 | Nellcor Incorporated | Mesure de pouls et de teneur en oxygène |
WO1988001147A1 (fr) * | 1986-08-18 | 1988-02-25 | Physio-Control Corporation | Procede et appareil de reglage a contre-reaction pour le traitement de signaux utilises pour mesurer l'oxygene |
EP0286142A2 (fr) * | 1987-04-09 | 1988-10-12 | Sumitomo Electric Industries, Ltd. | Oxymètre à réflexion |
EP0303502A1 (fr) * | 1987-08-14 | 1989-02-15 | Btg International Limited | Système de réjection des signaux dûs aux mouvements parasites pour des dispositifs d'oxymétrie et de mesure du rythme cardiaque |
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Cited By (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5517988A (en) * | 1993-12-11 | 1996-05-21 | Hewlett-Packard Company | Method for detecting an irregular state in a non-invasive pulse oximeter system |
US5749366A (en) * | 1995-03-23 | 1998-05-12 | Seiko Instruments Inc. | Motion compensating pulse rate monitor with motion sensor and level discriminator |
EP0733340A1 (fr) * | 1995-03-23 | 1996-09-25 | Seiko Instruments Inc. | Indicateur de la fréquence du pouls |
EP1506735A3 (fr) * | 1995-03-23 | 2005-05-04 | Seiko Instruments Inc. | Procédé de surveillance de la fréquence du pouls |
GB2300045A (en) * | 1995-04-11 | 1996-10-23 | Yoav Paltieli | Optical fibre endoscope |
GB2300045B (en) * | 1995-04-11 | 1999-06-09 | Yoav Paltieli | Optical-fiber type endoscope |
US5645060A (en) * | 1995-06-14 | 1997-07-08 | Nellcor Puritan Bennett Incorporated | Method and apparatus for removing artifact and noise from pulse oximetry |
WO1997000041A1 (fr) * | 1995-06-14 | 1997-01-03 | Nellcor Puritan Bennett Incorporated | Procede permettant d'eliminer un artefact du au mouvement et le bruit dans une oxymetrie du pouls et appareil correspondant |
DE19609410A1 (de) * | 1996-03-04 | 1997-09-11 | Biotronik Mess & Therapieg | Vorrichtung zur Bestimmung der Blutsauerstoffsättigung |
DE19609410C2 (de) * | 1996-03-04 | 2002-04-25 | Biotronik Mess & Therapieg | Vorrichtung zur Bestimmung der Blutsauerstoffsättigung |
WO1997036538A1 (fr) * | 1996-04-01 | 1997-10-09 | Kontron Instruments Ag | Detection de signaux parasites lors de mesures pulsoxymetriques |
US6181959B1 (en) | 1996-04-01 | 2001-01-30 | Kontron Instruments Ag | Detection of parasitic signals during pulsoxymetric measurement |
US6104938A (en) * | 1996-06-12 | 2000-08-15 | Instrumentarium Oy | Procedure, apparatus and detector for the determination of fractional oxygen saturation |
WO1998004903A1 (fr) * | 1996-07-26 | 1998-02-05 | Kontron Instruments Ag | Procede de determination non invasive de la saturation en oxygene de tissus vascularises |
US6151107A (en) * | 1996-07-26 | 2000-11-21 | Linde Medical Sensors Ag | Method of non-invasive determination of oxygen saturation in tissue in which blood is circulating |
DE19647877A1 (de) * | 1996-11-19 | 1998-05-28 | Metrax Gmbh | Verfahren und Schaltungsanordnung zur Ermittlung der Sauerstoffsättigung im Blut |
DE19647877C2 (de) * | 1996-11-19 | 2000-06-15 | Univ Ilmenau Tech | Verfahren und Schaltungsanordnung zur Ermittlung der Sauerstoffsättigung im Blut |
WO1999032030A1 (fr) | 1997-12-22 | 1999-07-01 | Btg International Limited | Reduction des artefacts en photoplethysmographie |
US7774037B2 (en) | 1998-07-04 | 2010-08-10 | Whitland Research Limited | Non-invasive measurement of blood analytes |
US7236813B2 (en) | 1998-08-13 | 2007-06-26 | Edwards Lifesciences Corporation | Optical device |
US7221970B2 (en) | 1998-08-13 | 2007-05-22 | Edwards Lifesciences Corporation | Optical device |
WO2000009004A2 (fr) | 1998-08-13 | 2000-02-24 | Whitland Research Limited | Dispositif optique |
WO2000009004A3 (fr) * | 1998-08-13 | 2000-06-02 | Whitland Res Ltd | Dispositif optique |
US6842635B1 (en) | 1998-08-13 | 2005-01-11 | Edwards Lifesciences Llc | Optical device |
EP1598003A3 (fr) * | 1998-08-13 | 2006-03-01 | Whitland Research Limited | Dispositif optique |
EP1598003A2 (fr) | 1998-08-13 | 2005-11-23 | Whitland Research Limited | Dispositif optique |
US6801799B2 (en) | 2000-10-05 | 2004-10-05 | Cybro Medical, Ltd. | Pulse oximeter and method of operation |
US6658277B2 (en) | 2001-09-13 | 2003-12-02 | Imagyn Medical Technologies, Inc. | Signal processing method and device for signal-to-noise improvement |
US7027850B2 (en) | 2001-09-13 | 2006-04-11 | Conmed Corporation | Signal processing method and device for signal-to-noise improvement |
US7060035B2 (en) | 2001-09-13 | 2006-06-13 | Conmed Corporation | Signal processing method and device for signal-to-noise improvement |
EP1297784A1 (fr) | 2001-09-28 | 2003-04-02 | C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa | Procédé et dispositif de mesure du pouls |
WO2003077756A1 (fr) * | 2002-03-19 | 2003-09-25 | Federalnoe Gosudarstvennoe Unitarnoe Predpriyatie Nauchno-Issledovatelskiy Institut 'polyus' | Procede de determination de l'etat d'un tissu biologique (variantes) et systeme diagnostique pour mettre en oeuvre ce procede |
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Also Published As
Publication number | Publication date |
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GB9216431D0 (en) | 1992-09-16 |
ZA935579B (en) | 1994-02-02 |
AU4719893A (en) | 1994-03-03 |
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