WO2003053422A3 - Methodes et compositions pour le traitement de pathologies respiratoires - Google Patents

Methodes et compositions pour le traitement de pathologies respiratoires Download PDF

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Publication number
WO2003053422A3
WO2003053422A3 PCT/FR2002/004506 FR0204506W WO03053422A3 WO 2003053422 A3 WO2003053422 A3 WO 2003053422A3 FR 0204506 W FR0204506 W FR 0204506W WO 03053422 A3 WO03053422 A3 WO 03053422A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
treating respiratory
pathologies
respiratory pathologies
Prior art date
Application number
PCT/FR2002/004506
Other languages
English (en)
Other versions
WO2003053422A2 (fr
Inventor
Lionel Bueno
Original Assignee
Rytek
Lionel Bueno
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0116706A external-priority patent/FR2833839A1/fr
Application filed by Rytek, Lionel Bueno filed Critical Rytek
Priority to AU2002364679A priority Critical patent/AU2002364679A1/en
Priority to EP02805413A priority patent/EP1455767A2/fr
Priority to CA002470442A priority patent/CA2470442A1/fr
Priority to US10/498,094 priority patent/US20050019314A1/en
Publication of WO2003053422A2 publication Critical patent/WO2003053422A2/fr
Publication of WO2003053422A3 publication Critical patent/WO2003053422A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente demande concerne des compositions et méthodes pour letraitement de pathologies respiratoires. Elle concerne également des compositions et méthodes permettant de réguler la perméabilité paracellulaire de l'épithélium pulmonaire. Les compositions et méthodes de l'invention reposent notamment sur l'utilisation d'agents ou de conditions modulant la tension du cytosquelette, plus particulièrement des composés inhibant la contraction de la chaîne légère de la myosine des cellules épithéliales pulmonaires, notamment des entérocytes. L'invention est utilisable pour le traitement préventif ou curatif de pathologies variées, telles que asthme, allergies, maladies obstructives, etc., chez les mammifères, notamment les humains.
PCT/FR2002/004506 2001-12-21 2002-12-20 Methodes et compositions pour le traitement de pathologies respiratoires WO2003053422A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002364679A AU2002364679A1 (en) 2001-12-21 2002-12-20 Method and compositions for treating respiratory pathologies
EP02805413A EP1455767A2 (fr) 2001-12-21 2002-12-20 Methodes et compositions pour le traitement de pathologies respiratoires
CA002470442A CA2470442A1 (fr) 2001-12-21 2002-12-20 Methodes et compositions pour le traitement de pathologies respiratoires
US10/498,094 US20050019314A1 (en) 2001-12-21 2002-12-20 Method and compositions for treating respiratory pathologies

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR01/16706 2001-12-21
FR0116706A FR2833839A1 (fr) 2001-12-21 2001-12-21 Methodes et compositions pour le traitement de pathologies respiratoires
FR02/08606 2002-07-09
FR0208606A FR2833840B1 (fr) 2001-12-21 2002-07-09 Methodes et compositions pour le traitement de pathologies respiratoires

Publications (2)

Publication Number Publication Date
WO2003053422A2 WO2003053422A2 (fr) 2003-07-03
WO2003053422A3 true WO2003053422A3 (fr) 2004-04-15

Family

ID=26213306

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/004506 WO2003053422A2 (fr) 2001-12-21 2002-12-20 Methodes et compositions pour le traitement de pathologies respiratoires

Country Status (12)

Country Link
US (2) US20030125321A1 (fr)
EP (1) EP1455767A2 (fr)
AR (1) AR038042A1 (fr)
AU (1) AU2002364679A1 (fr)
CA (1) CA2470442A1 (fr)
FR (1) FR2833840B1 (fr)
PA (1) PA8562701A1 (fr)
PE (1) PE20030853A1 (fr)
SV (1) SV2003001439A (fr)
TW (1) TW200305447A (fr)
UY (1) UY27589A1 (fr)
WO (1) WO2003053422A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US20050129679A1 (en) * 2003-12-15 2005-06-16 Nastech Pharmaceutical Company Inc. Method for opening tight junctions
TWI357414B (en) * 2003-12-17 2012-02-01 Wyeth Llc Aβ immunogenic peptide carrier conjugates and meth
WO2006023844A2 (fr) * 2004-08-20 2006-03-02 Entremed, Inc. Compositions et procedes comportant des antagonistes de recepteur active par la proteinase
FR2879100B1 (fr) * 2004-12-09 2007-07-06 Lionel Bueno Compositions pour le traitement des pathologies oculaires de surface et de la retine
EP2111863B1 (fr) 2005-10-26 2012-03-28 Asahi Kasei Pharma Corporation Combinaison du fasudil et bosentan pour le traitement de l'hypertension artérielle pulmonaire
EP2091551B1 (fr) * 2006-11-03 2020-01-15 Alba Therapeutics Corporation Procede de traitement de l'asthme
US20150038674A1 (en) * 2013-08-05 2015-02-05 Bayrak Bertan Boran Use of glp-2 analogues in pulmonary diseases for therapeutic purpose

Citations (3)

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Publication number Priority date Publication date Assignee Title
EP0638564A1 (fr) * 1993-02-19 1995-02-15 Asahi Kasei Kogyo Kabushiki Kaisha Derive de benzothiazolesulfonamide, procede de production et application de ce derive
US5883114A (en) * 1992-05-30 1999-03-16 Goedecke Aktiengesellschaft Indolocarbazole imides and the use thereof
WO2000003746A2 (fr) * 1998-07-14 2000-01-27 The Brigham And Women's Hospital, Inc. Remise a niveau de la synthase dl'oxyde nitrique des cellules endotheliales de type iii par des agents venant disloquer l'organisation cytosquelettique de l'actine

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Publication number Priority date Publication date Assignee Title
US3748A (en) * 1844-09-17 Improvement in ratoon and cane cutters
US5030631A (en) * 1989-11-27 1991-07-09 Schering Corporation Tricylclic arylsulfonamides
FR2674434B1 (fr) * 1991-03-27 1993-06-18 Nativelle Sa Ets Nouvelle composition pharmaceutique a base de taurine pour l'administration par inhalation.
US5336503A (en) * 1992-03-31 1994-08-09 Daiichi Pharmaceutical Co., Ltd. Anti-peptic ulcer agent
AU703540B2 (en) * 1996-03-26 1999-03-25 Meddiss, Incorporated Methods for inducing analgesia or anesthesia and treating or preventing ischemic injury of tissues in general
CZ301044B6 (cs) * 1996-08-12 2009-10-21 Mitsubishi Tanabe Pharma Léciva obsahující amidové deriváty inhibující Rho kinázu
EP1015492A2 (fr) * 1997-09-19 2000-07-05 Magainin Pharmaceuticals Inc. Facteurs associes a l'asthme comme cibles pour traiter les allergies atopiques y compris l'asthme et les troubles apparentes
DE60128701T2 (de) * 2000-08-15 2008-02-07 Immunex Corp., Thousand Oaks Claudin polypeptide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5883114A (en) * 1992-05-30 1999-03-16 Goedecke Aktiengesellschaft Indolocarbazole imides and the use thereof
EP0638564A1 (fr) * 1993-02-19 1995-02-15 Asahi Kasei Kogyo Kabushiki Kaisha Derive de benzothiazolesulfonamide, procede de production et application de ce derive
WO2000003746A2 (fr) * 1998-07-14 2000-01-27 The Brigham And Women's Hospital, Inc. Remise a niveau de la synthase dl'oxyde nitrique des cellules endotheliales de type iii par des agents venant disloquer l'organisation cytosquelettique de l'actine

Non-Patent Citations (19)

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Title
AHDIEH M ET AL: "LUNG EPITHELIAL BARRIER FUNCTION AND WOUND HEALING ARE DECREASED BY IL-4 AND IL-13 ENHANCED BY IFN-GAMMA", AMERICAN JOURNAL OF PHYSIOLOGY. CELL PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 281, no. 6, December 2001 (2001-12-01), pages C2029 - C2038, XP008007756, ISSN: 0363-6143 *
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 11, no. 6, 1994, pages 676 - 681, ISSN: 1044-1549 *
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CITI S ET AL: "CYTOSKELETAL INVOLVEMENT IN THE MODULATION OF CELL-CELL JUNCTIONS BY THE PROTEIN KINASE INHIBITOR H-7", JOURNAL OF CELL SCIENCE, ESSEX, GB, vol. 107, no. 3, 1994, pages 683 - 692, XP002040798 *
CITI S: "PROTEIN KINASE INHIBITORS PREVENT JUNCTIONS DISSOCIATION INDUCED BY LOW EXTRACELLULAR CALCIUM IN MDCK EPITHELIAL CELLS", JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIVERSITY PRESS, NEW YORK, US, US, vol. 117, no. 1, April 1992 (1992-04-01), pages 169 - 178, XP008007882, ISSN: 0021-9525 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1994, LIU XUELIANG ET AL: "Myosin Light Chain Phosphatase Activity in Ragweed Pollen-Sensitized Canine Tracheal Smooth Muscle", XP002256897, Database accession no. PREV199598078691 *
DATABASE MEDLINE [online] November 1990 (1990-11-01), OHASHI Y ET AL: "[Relationship between bronchial reactivity to inhaled acetylcholine, eosinophil infiltration and a widening of the intercellular space in patients with asthma]", XP002216574, Database accession no. NLM2288500 *
GARCIA J G ET AL: "Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration.", JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD.: 1985) UNITED STATES MAY 1998, vol. 84, no. 5, May 1998 (1998-05-01), pages 1817 - 1821, XP001165792, ISSN: 8750-7587 *
GARCIA J G ET AL: "Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60(src).", THE AMERICAN JOURNAL OF PHYSIOLOGY. UNITED STATES JUN 1999, vol. 276, no. 6 Pt 1, June 1999 (1999-06-01), pages L989 - L998, XP002256896, ISSN: 0002-9513 *
GODFREY R W A: "HUMAN AIRWAY EPITHELIAL TIGHT JUNCTIONS", MICROSCOPY RESEARCH AND TECHNIQUE, WILEY-LISS, CHICHESTER, GB, vol. 38, no. 5, 1 September 1997 (1997-09-01), pages 488 - 499, XP008007862, ISSN: 1059-910X *
KOBAYASHI K ET AL: "MECHANISM OF HYDROGEN PEROXIDE-INDUCED INHIBITION OF SHEEP AIRWAY CILIA", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 6, no. 6, 1992, pages 667 - 673, XP008022800, ISSN: 1044-1549 *
KOBAYASHI N ET AL: "IMMUNOHISTOCHEMICAL STUDY OF E-CADHERIN AND ZO-1 IN ALLERGIC NASAL EPITHELIUM OF THE GUINEA PIG", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, XX, XX, vol. 116, no. 3, July 1998 (1998-07-01), pages 196 - 205, XP008007809, ISSN: 1018-2438 *
LEFF A R: "Pharmacologic management of asthma", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 1998 UNITED STATES, vol. 101, no. 2 II, 1998, pages S397 - S399, XP008022810, ISSN: 0091-6749 *
MARUOKA ET AL.: "Involvement of Rho and Myosin Light Chain Kinase in neutrophil elastase-induced morphological changes in airway epithelial cells", AM. J. RESPIR. CRITICAL CARE MED., vol. 159, no. 3suppl., 1999, pages a187, XP008022808 *
PARKER J C: "Inhibitors of myosin light chain kinase and phosphodiesterase reduce ventilator-induced lung injury.", JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD.: 1985) UNITED STATES DEC 2000, vol. 89, no. 6, December 2000 (2000-12-01), pages 2241 - 2248, XP001165791, ISSN: 8750-7587 *
PETRACHE I ET AL: "DIFFERENTIAL EFFECT OF MLC KINASE IN TNF-ALPHA-INDUCED ENDOTHELIAL CELL APOPTOSIS AND BARRIER DYSFUNCTION", AMERICAN JOURNAL OF PHYSIOLOGY. LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, XX, XX, vol. 280, no. 6, June 2001 (2001-06-01), pages L1168 - L1178, XP001128712, ISSN: 1040-0605 *
See also references of EP1455767A2 *
VOLBERG T ET AL: "Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system.", CELL MOTILITY AND THE CYTOSKELETON. UNITED STATES 1994, vol. 29, no. 4, 1994, pages 321 - 338, XP008022805, ISSN: 0886-1544 *
WYATT T A ET AL: "Stimulation of protein kinase C activity by tumor necrosis factor-[alpha] in bovine bronchial epithelial cells", AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 1997 UNITED STATES, vol. 273, no. 5 17-5, 1997, pages L1007 - L1012, XP001165793, ISSN: 1040-0605 *

Also Published As

Publication number Publication date
AU2002364679A1 (en) 2003-07-09
TW200305447A (en) 2003-11-01
WO2003053422A2 (fr) 2003-07-03
UY27589A1 (es) 2003-05-30
FR2833840B1 (fr) 2010-06-18
FR2833840A1 (fr) 2003-06-27
US20050019314A1 (en) 2005-01-27
PA8562701A1 (es) 2004-02-16
SV2003001439A (es) 2003-11-04
PE20030853A1 (es) 2003-10-28
AU2002364679A8 (en) 2003-07-09
EP1455767A2 (fr) 2004-09-15
US20030125321A1 (en) 2003-07-03
AR038042A1 (es) 2004-12-22
CA2470442A1 (fr) 2003-07-03

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