AR038042A1 - Metodos y composiciones para el tratamiento de patologias respiratorias - Google Patents
Metodos y composiciones para el tratamiento de patologias respiratoriasInfo
- Publication number
- AR038042A1 AR038042A1 ARP020104998A ARP020104998A AR038042A1 AR 038042 A1 AR038042 A1 AR 038042A1 AR P020104998 A ARP020104998 A AR P020104998A AR P020104998 A ARP020104998 A AR P020104998A AR 038042 A1 AR038042 A1 AR 038042A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- respiratory
- light chain
- myosin light
- mlck
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Uso de un compuesto (agente o molécula, o combinación de ellos, que inhibe/n la modulación de la tensión citoesquelética) que inhibe la contracción de la cadena ligera de miosina de células epiteliales pulmonares, para preparar un medicamento para el tratamiento preventivo o curativo de patologías respiratorias excluyendo hipoxia inducida por dichas enfermedades respiratorias. En particular, compuestos que inhiben la fosforilación de la cadena ligera de miosina. Dichos compuestos pueden ejemplificarse, en particular, a través de los inhibidores de cadena ligera de miosina, MLCK. Un ejemplo específico de dicho inhibidor selectivo de este tipo (MLCK) es el compuesto ML-7 (1-(5-yodanaftalen-1-sulfonil)-1H-hexahidro-1,4-diazepina), el compuesto es un activador de la miosina fosfatasa. Uso donde dicho compuesto reduce la permeabilidad paracelular del epitelio pulmonar, sin presentar un efecto significativo sobre la permeabilidad endotelial vascular. Dicho uso para preparar un medicamento para reducir la sensibilización a los alergenos en sujetos que presentan o son sensibles a las enfermedades respiratorias y para el tratamiento preventivo o curativo de alergias, asma o enfermedades obstructivas; para reducir la migración transepitelial de células inmunes y la acumulación de células inmunes en el pulmón de sujetos con una patología respiratoria. El compuesto se administra por vía oral o por inhalación, junto con otro agente activo seleccionado del grupo integrado por beta-2-agonistas, anticolinérgicos, corticosteroides y antileucotrienos, para ser utilizados en combinación, separados o distribuidos en el tiempo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0116706A FR2833839A1 (fr) | 2001-12-21 | 2001-12-21 | Methodes et compositions pour le traitement de pathologies respiratoires |
| FR0208606A FR2833840B1 (fr) | 2001-12-21 | 2002-07-09 | Methodes et compositions pour le traitement de pathologies respiratoires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038042A1 true AR038042A1 (es) | 2004-12-22 |
Family
ID=26213306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020104998A AR038042A1 (es) | 2001-12-21 | 2002-12-19 | Metodos y composiciones para el tratamiento de patologias respiratorias |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20030125321A1 (es) |
| EP (1) | EP1455767A2 (es) |
| AR (1) | AR038042A1 (es) |
| AU (1) | AU2002364679A1 (es) |
| CA (1) | CA2470442A1 (es) |
| FR (1) | FR2833840B1 (es) |
| PA (1) | PA8562701A1 (es) |
| PE (1) | PE20030853A1 (es) |
| SV (1) | SV2003001439A (es) |
| TW (1) | TW200305447A (es) |
| UY (1) | UY27589A1 (es) |
| WO (1) | WO2003053422A2 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| US20050129679A1 (en) * | 2003-12-15 | 2005-06-16 | Nastech Pharmaceutical Company Inc. | Method for opening tight junctions |
| MY144231A (en) * | 2003-12-17 | 2011-08-15 | Wyeth Corp | Aß IMMUNOGENIC PEPTIDE CARRIER CONJUGATES AND METHODS OF PRODUCING SAME |
| US20060063930A1 (en) * | 2004-08-20 | 2006-03-23 | Agoston Gregory E | Compositions and methods comprising proteinase activated receptor antagonists |
| FR2879100B1 (fr) * | 2004-12-09 | 2007-07-06 | Lionel Bueno | Compositions pour le traitement des pathologies oculaires de surface et de la retine |
| ATE551059T1 (de) * | 2005-10-26 | 2012-04-15 | Asahi Kasei Pharma Corp | Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie |
| US20100144646A1 (en) * | 2006-11-03 | 2010-06-10 | Blake Paterson | Method of diagnosing and treating asthma |
| US20150038674A1 (en) * | 2013-08-05 | 2015-02-05 | Bayrak Bertan Boran | Use of glp-2 analogues in pulmonary diseases for therapeutic purpose |
| FR3145744A1 (fr) | 2023-02-11 | 2024-08-16 | Marc Grosman | Drone comportant au moins une pile à combustible, un calculateur dont un élément quantique ou supraconducteur, capable de réaliser plusieurs tâches au cours d’un vol sur zone difficile d’accès. |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3748A (en) * | 1844-09-17 | Improvement in ratoon and cane cutters | ||
| US5030631A (en) * | 1989-11-27 | 1991-07-09 | Schering Corporation | Tricylclic arylsulfonamides |
| FR2674434B1 (fr) * | 1991-03-27 | 1993-06-18 | Nativelle Sa Ets | Nouvelle composition pharmaceutique a base de taurine pour l'administration par inhalation. |
| US5336503A (en) * | 1992-03-31 | 1994-08-09 | Daiichi Pharmaceutical Co., Ltd. | Anti-peptic ulcer agent |
| DE4217964A1 (de) * | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
| WO1994019336A1 (en) * | 1993-02-19 | 1994-09-01 | Asahi Kasei Kogyo Kabushiki Kaisha | Benzothiazolesulfonamide derivative, process for producing the same, and use thereof |
| AU703540B2 (en) * | 1996-03-26 | 1999-03-25 | Meddiss, Incorporated | Methods for inducing analgesia or anesthesia and treating or preventing ischemic injury of tissues in general |
| PT956865E (pt) * | 1996-08-12 | 2007-07-30 | Mitsubishi Pharma Corp | Medicamentos compreendendo inibidores da rho cinase. |
| EP1015492A2 (en) * | 1997-09-19 | 2000-07-05 | Magainin Pharmaceuticals Inc. | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders |
| AU4990599A (en) * | 1998-07-14 | 2000-02-07 | Brigham And Women's Hospital | Upregulation of type iii endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization |
| ATE363531T1 (de) * | 2000-08-15 | 2007-06-15 | Immunex Corp | Claudin polypeptide |
-
2002
- 2002-07-09 FR FR0208606A patent/FR2833840B1/fr not_active Expired - Fee Related
- 2002-12-18 UY UY27589A patent/UY27589A1/es not_active Application Discontinuation
- 2002-12-18 SV SV2002001439A patent/SV2003001439A/es not_active Application Discontinuation
- 2002-12-19 AR ARP020104998A patent/AR038042A1/es not_active Application Discontinuation
- 2002-12-20 AU AU2002364679A patent/AU2002364679A1/en not_active Abandoned
- 2002-12-20 PA PA20028562701A patent/PA8562701A1/es unknown
- 2002-12-20 TW TW091136815A patent/TW200305447A/zh unknown
- 2002-12-20 EP EP02805413A patent/EP1455767A2/fr not_active Withdrawn
- 2002-12-20 US US10/324,958 patent/US20030125321A1/en not_active Abandoned
- 2002-12-20 US US10/498,094 patent/US20050019314A1/en not_active Abandoned
- 2002-12-20 WO PCT/FR2002/004506 patent/WO2003053422A2/fr not_active Application Discontinuation
- 2002-12-20 CA CA002470442A patent/CA2470442A1/fr not_active Abandoned
-
2003
- 2003-01-06 PE PE2003000015A patent/PE20030853A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002364679A1 (en) | 2003-07-09 |
| SV2003001439A (es) | 2003-11-04 |
| WO2003053422A2 (fr) | 2003-07-03 |
| US20050019314A1 (en) | 2005-01-27 |
| FR2833840A1 (fr) | 2003-06-27 |
| PA8562701A1 (es) | 2004-02-16 |
| US20030125321A1 (en) | 2003-07-03 |
| WO2003053422A3 (fr) | 2004-04-15 |
| CA2470442A1 (fr) | 2003-07-03 |
| PE20030853A1 (es) | 2003-10-28 |
| TW200305447A (en) | 2003-11-01 |
| UY27589A1 (es) | 2003-05-30 |
| EP1455767A2 (fr) | 2004-09-15 |
| FR2833840B1 (fr) | 2010-06-18 |
| AU2002364679A8 (en) | 2003-07-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |