WO2003045329A3 - Procedes de purification de levofloxacine - Google Patents
Procedes de purification de levofloxacine Download PDFInfo
- Publication number
- WO2003045329A3 WO2003045329A3 PCT/US2002/038182 US0238182W WO03045329A3 WO 2003045329 A3 WO2003045329 A3 WO 2003045329A3 US 0238182 W US0238182 W US 0238182W WO 03045329 A3 WO03045329 A3 WO 03045329A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- levofloxacin
- purification
- methods
- purified
- antioxidant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Epoxy Compounds (AREA)
Abstract
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002365416A AU2002365416A1 (en) | 2001-11-29 | 2002-11-27 | Methods for the purification of levofloxacin |
JP2003546834A JP2005527484A (ja) | 2001-11-29 | 2002-11-27 | レボフロキサシンの精製製法 |
KR10-2004-7008039A KR20040058336A (ko) | 2001-11-29 | 2002-11-27 | 레보플록사신의 정제 방법 |
MXPA04005196A MXPA04005196A (es) | 2001-11-29 | 2002-11-27 | Metodos para la purificacion de levofloxacina. |
CA002466860A CA2466860A1 (fr) | 2001-11-29 | 2002-11-27 | Procedes de purification de levofloxacine |
IL16217202A IL162172A0 (en) | 2001-11-29 | 2002-11-27 | Methods for the purification of levofloxacin |
EP02791339A EP1460997A4 (fr) | 2001-11-29 | 2002-11-27 | Procedes de purification de levofloxacine |
HU0500285A HUP0500285A3 (en) | 2001-11-29 | 2002-11-27 | Methods for the purification of levofloxacin |
IS7288A IS7288A (is) | 2001-11-29 | 2004-05-27 | Aðferðir til að hreinsa levófloxasín |
HR20040546A HRP20040546A2 (en) | 2001-11-29 | 2004-06-15 | Methods for the purification of levofloxacin |
NO20042731A NO20042731L (no) | 2001-11-29 | 2004-06-29 | Fremgangsmater for rensing av levofloxacin |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33431601P | 2001-11-29 | 2001-11-29 | |
US60/334,316 | 2001-11-29 | ||
US35493902P | 2002-02-11 | 2002-02-11 | |
US60/354,939 | 2002-02-11 | ||
US26296502A | 2002-10-03 | 2002-10-03 | |
US10/262,965 | 2002-10-03 | ||
US10/263,192 | 2002-10-03 | ||
US10/263,192 US7629458B2 (en) | 2001-10-03 | 2002-10-03 | Preparation of levofloxacin and hemihydrate thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003045329A2 WO2003045329A2 (fr) | 2003-06-05 |
WO2003045329A3 true WO2003045329A3 (fr) | 2004-02-19 |
Family
ID=31892240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/038182 WO2003045329A2 (fr) | 2001-11-29 | 2002-11-27 | Procedes de purification de levofloxacine |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1460997A4 (fr) |
JP (3) | JP2005527484A (fr) |
CN (1) | CN1596256A (fr) |
AU (1) | AU2002365416A1 (fr) |
CA (1) | CA2466860A1 (fr) |
HR (1) | HRP20040546A2 (fr) |
HU (1) | HUP0500285A3 (fr) |
IL (1) | IL162172A0 (fr) |
IS (1) | IS7288A (fr) |
MX (1) | MXPA04005196A (fr) |
NO (1) | NO20042731L (fr) |
PL (1) | PL374558A1 (fr) |
WO (1) | WO2003045329A2 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7629458B2 (en) | 2001-10-03 | 2009-12-08 | Teva Pharmaceutical Industries Ltd. | Preparation of levofloxacin and hemihydrate thereof |
AU2003285625A1 (en) * | 2002-12-16 | 2004-07-09 | Ranbaxy Laboratories Limited | Pure levofloxacin hemihydrate and processes for preparation thereof |
KR100704641B1 (ko) * | 2004-07-21 | 2007-04-06 | 주식회사유한양행 | 고순도의 레보플록사신 제조방법 |
JP2006273718A (ja) * | 2005-03-28 | 2006-10-12 | Shiono Chemical Co Ltd | レボフロキサシン・1/2水和物の製法 |
CN1321121C (zh) * | 2005-04-21 | 2007-06-13 | 浙江医药股份有限公司新昌制药厂 | 左氧氟沙星制备及后处理方法 |
US7964723B2 (en) | 2008-08-02 | 2011-06-21 | Apeloa-Kangyu | And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate |
CN102070650B (zh) * | 2011-01-28 | 2012-06-27 | 山东省药品检验所 | 左氧氟沙星-n-氧化物的制备方法 |
US20120251685A1 (en) * | 2011-04-04 | 2012-10-04 | Martek Biosciences Corporation | Oil-in-Water Emulsions Comprising a Polyunsaturated Fatty Acid and Methods of Making the Same |
CN105823851A (zh) * | 2015-12-15 | 2016-08-03 | 浙江海洋学院 | 一种检测海水中氧氟沙星对映体的方法 |
CN108218892A (zh) * | 2018-03-16 | 2018-06-29 | 乐山职业技术学院 | 一种左氧氟沙星的纯化方法 |
CN114507242B (zh) * | 2022-01-26 | 2023-05-19 | 上虞京新药业有限公司 | 高光学纯度左氧氟沙星的制备方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5142046A (en) * | 1985-06-20 | 1992-08-25 | Daiichi Pharmaceutical Co., Ltd. | Optically active pyridobenzoxazine derivatives and intermediates thereof |
US5237060A (en) * | 1985-12-10 | 1993-08-17 | Bayer Aktiengesellschaft | Process of preparing enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids |
US5521310A (en) * | 1992-10-07 | 1996-05-28 | Derivados Del Etilo, S.A. | Process to obtain benzoxazines to be used for the synthesis of ofloxazine, levofloxazine and derivatives |
US5539110A (en) * | 1994-03-22 | 1996-07-23 | Korea Institute Of Science And Technology | Method for the preparation of (-)piperazine benzoxazine derivatives |
US5545737A (en) * | 1990-03-01 | 1996-08-13 | Daiichi Pharmaceutical Co., Ltd. | Process for selectively producing an (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7h-pyrido (1,2,3, -de) (1,4) benzoxazine-6-carboxylic acid hemihydrate or monohydrate |
US6316618B1 (en) * | 1998-02-24 | 2001-11-13 | Samsung Electronics Co., Ltd. | Process for preparing (-)pyridobenzoxazine carboxylic acid derivatives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7629458B2 (en) * | 2001-10-03 | 2009-12-08 | Teva Pharmaceutical Industries Ltd. | Preparation of levofloxacin and hemihydrate thereof |
-
2002
- 2002-11-27 AU AU2002365416A patent/AU2002365416A1/en not_active Abandoned
- 2002-11-27 PL PL02374558A patent/PL374558A1/xx not_active Application Discontinuation
- 2002-11-27 EP EP02791339A patent/EP1460997A4/fr not_active Withdrawn
- 2002-11-27 IL IL16217202A patent/IL162172A0/xx unknown
- 2002-11-27 WO PCT/US2002/038182 patent/WO2003045329A2/fr active Application Filing
- 2002-11-27 CA CA002466860A patent/CA2466860A1/fr not_active Abandoned
- 2002-11-27 JP JP2003546834A patent/JP2005527484A/ja active Pending
- 2002-11-27 HU HU0500285A patent/HUP0500285A3/hu unknown
- 2002-11-27 MX MXPA04005196A patent/MXPA04005196A/es not_active Application Discontinuation
- 2002-11-27 CN CNA028236440A patent/CN1596256A/zh active Pending
-
2004
- 2004-05-27 IS IS7288A patent/IS7288A/is unknown
- 2004-06-15 HR HR20040546A patent/HRP20040546A2/hr not_active Application Discontinuation
- 2004-06-29 NO NO20042731A patent/NO20042731L/no not_active Application Discontinuation
-
2006
- 2006-05-01 JP JP2006127862A patent/JP2006219496A/ja not_active Withdrawn
-
2007
- 2007-08-22 JP JP2007216178A patent/JP2008007517A/ja active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5142046A (en) * | 1985-06-20 | 1992-08-25 | Daiichi Pharmaceutical Co., Ltd. | Optically active pyridobenzoxazine derivatives and intermediates thereof |
US5237060A (en) * | 1985-12-10 | 1993-08-17 | Bayer Aktiengesellschaft | Process of preparing enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids |
US5545737A (en) * | 1990-03-01 | 1996-08-13 | Daiichi Pharmaceutical Co., Ltd. | Process for selectively producing an (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7h-pyrido (1,2,3, -de) (1,4) benzoxazine-6-carboxylic acid hemihydrate or monohydrate |
US5521310A (en) * | 1992-10-07 | 1996-05-28 | Derivados Del Etilo, S.A. | Process to obtain benzoxazines to be used for the synthesis of ofloxazine, levofloxazine and derivatives |
US5539110A (en) * | 1994-03-22 | 1996-07-23 | Korea Institute Of Science And Technology | Method for the preparation of (-)piperazine benzoxazine derivatives |
US6316618B1 (en) * | 1998-02-24 | 2001-11-13 | Samsung Electronics Co., Ltd. | Process for preparing (-)pyridobenzoxazine carboxylic acid derivatives |
Also Published As
Publication number | Publication date |
---|---|
CN1596256A (zh) | 2005-03-16 |
HUP0500285A3 (en) | 2009-03-30 |
HRP20040546A2 (en) | 2004-10-31 |
NO20042731L (no) | 2004-06-29 |
JP2006219496A (ja) | 2006-08-24 |
WO2003045329A2 (fr) | 2003-06-05 |
HUP0500285A2 (hu) | 2005-06-28 |
PL374558A1 (en) | 2005-10-31 |
AU2002365416A1 (en) | 2003-06-10 |
JP2005527484A (ja) | 2005-09-15 |
EP1460997A4 (fr) | 2005-06-15 |
IL162172A0 (en) | 2005-11-20 |
EP1460997A2 (fr) | 2004-09-29 |
CA2466860A1 (fr) | 2003-06-05 |
JP2008007517A (ja) | 2008-01-17 |
MXPA04005196A (es) | 2005-11-23 |
IS7288A (is) | 2004-06-21 |
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