WO2003026683A1 - Produit de soins de sante permettant de stimuler l'immunite et de retarder le vieillissement - Google Patents

Produit de soins de sante permettant de stimuler l'immunite et de retarder le vieillissement Download PDF

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Publication number
WO2003026683A1
WO2003026683A1 PCT/CN2002/000616 CN0200616W WO03026683A1 WO 2003026683 A1 WO2003026683 A1 WO 2003026683A1 CN 0200616 W CN0200616 W CN 0200616W WO 03026683 A1 WO03026683 A1 WO 03026683A1
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WO
WIPO (PCT)
Prior art keywords
health
extract
dilong
cordyceps
ganoderma lucidum
Prior art date
Application number
PCT/CN2002/000616
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English (en)
Chinese (zh)
Inventor
Xiaoping Zhu
Yaohui Zeng
Original Assignee
Xiaoping Zhu
Yaohui Zeng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xiaoping Zhu, Yaohui Zeng filed Critical Xiaoping Zhu
Publication of WO2003026683A1 publication Critical patent/WO2003026683A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the invention relates to a health care product capable of regulating immune function and delaying aging, in particular, it is a pure natural oral health care product which is made of Chinese herbal medicine with the same origin of medicine and food.
  • antibiotics there are more than ten kinds of antibiotics, 7-8 kinds of phytochemicals, more than ten kinds of deepening agents, nearly ten kinds of anti-metabolites, and more than ten kinds of enzymes, hormones and other classes.
  • the effect is not ideal, and it has toxic and side effects.
  • health foods can regulate the body's immune function, so as to improve the body's resistance, enhance people's health, and reduce the incidence of diseases.
  • the task of the present invention is to provide a health care product that can regulate immune function and delay aging, thereby improving people's resistance to disease, reducing the occurrence of diseases, enhancing people's health, and also supporting the coordination of postoperative and radiochemical processes for tumor patients. Use to prevent recurrence and metastasis after surgery. To achieve the above tasks, the following technical solutions are used:
  • a health-care product capable of regulating immune function and delaying aging which is characterized in that it is an oral health-care product made by pulverizing and mixing the following weight ratio raw materials at a temperature of -15 ° C:
  • the Ganoderma lucidum and Cordyceps sinensis powder is pulverized to a temperature of less than 800 mesh at a temperature of -15 ° C; the ground dragon extract is prepared by the following method, first the ground dragon is washed and added 1. 5-4.
  • the health product of the present invention uses Cordyceps sinensis powder, Ganoderma lucidum powder, and Dilong powder extract, and is thoroughly mixed to prepare an oral health product.
  • the formula is based on:
  • the raw materials of the health products of the present invention are all precious Chinese herbal medicines with the same origin of medicine and food, and have been summarized through a large number of experimental studies. Among them:
  • Ganoderma is the fruiting body of Basidiomycete polymycete Ganoderma lucidum, often Tissue separation method was used to isolate and cultivate Ganoderma lucidum fruit body.
  • Ganoderma lucidum The chemical composition of Ganoderma lucidum is very complicated. So far, more than 150 compounds have been isolated from Ganoderma lucidum. Many experiments have shown that Ganoderma lucidum acid, Ganoderma lucidum polysaccharide, Ganoderma adenosine and organic germanium are the main active ingredients of Ganoderma. Antitumor activity. Ganoderma has the functions of analgesia, sedation, inhibition of histamine release, detoxification, liver protection, and toxin killing of tumor cells. Ganoderma adenosine derivative It has a strong effect of lowering blood viscosity, inhibiting the accumulation of small plates in the body, improving blood oxygen supply capacity and accelerating blood circulation.
  • Ganoderma lucidum can increase the activity of superoxide dismutase (SOD), have antithrombotic formation and improve the ability of red blood cells to deform, can promote the proliferation of lymphocytes, and enhance the phagocytosis and lethality of macrophages, cells and T cells.
  • SOD superoxide dismutase
  • the Compendium of Materia Medica contains "Sweetness and peace of mind, entry into the lungs and kidneys of the two meridians, tonifying the lungs and kidneys, invigorating the essence, relieving cough, phlegm, treating cough, and treating dysentery.”
  • Artificial Cordyceps sinensis is a silk body produced by fermentation of Cordyceps fungi isolated from fresh samples of Cordyceps sinensis.
  • the experimental analysis showed that the components of cultured Cordyceps sinensis were equivalent to those of natural Cordyceps sinensis. The effects are basically the same, providing a basis for the clinical of the two.
  • the composition of Cordyceps sinensis contains mainly polysaccharide, cordycepin, cordycepin, more than 20 kinds of acid and 17 kinds of inorganic elements.
  • cordyceps sinensis and artificial mycelium extracts on mouse peritoneal macrophages may be a non-specific immune enhancer through phagocytosis experiments in mice, cross-matching tests in vitro, and acid phosphatase activity measurement.
  • Cordyceps sinensis polysaccharides By observing the immunoregulatory effects of Cordyceps sinensis polysaccharides and the tonic effect on the body, it has been initially proved that it is an effective ingredient of Cordyceps sinensis's tonic and nourishing effects.
  • Cordyceps polysaccharide has obvious activation effect on phagocytic function of reticuloendothelial system and peritoneal macrophages, and has certain effects on lymphocyte transformation. enhancement.
  • Cordyceps sinensis and Cordyceps mycelium 3g / kg can increase the content of superoxide dismutase (SOD) in liver tissue of mice.
  • SOD superoxide dismutase
  • In vitro experiments have similar results and can inhibit the formation of lipid shield peroxides.
  • Cordyceps mycelium can inhibit the activity of monoamine oxidase in the brain of rats, and its effect on immune function suggests that Cordyceps sinensis and Cordyceps mycelium have anti-aging effects.
  • the isolated small molecule is extracted.
  • the results of animal experiments show that it can significantly increase the number of thymic and spleen nucleated cells in mice, increase the phagocytic function of mouse macrophages, and make white blood cells in peripheral blood. The increase in number reveals that this component has the effect of improving the body's immunity.
  • mice When mice were inoculated with S 18 . And H 22 and S 294 , EMT-6 and other tumor cells, ⁇ B or gastric perfusion with Dilong extract, showing good antitumor effect.
  • the tumor weight in the administration group was significantly different from that in the control group (P ⁇ 0.01).
  • Dilong extract has a good effect of activating plasminogen and directly dissolving fibrin in the blood, reducing blood viscosity.
  • the health product of the present invention is used as a test substance to carry out tests of regulating immune function and delaying aging effect, and the results are as follows: The test is based on the "functional evaluation procedure and detection method of health food",
  • Kunming female secondary mice weighing 18-22 g were randomly divided into four groups according to body weight.
  • the test amount was a human body recommended product of 1.8 g / day and 60 kg body weight. It was divided into three doses: low, medium and high.
  • the drug was administered once a day, and the control group was perfused with water, and the results were measured for four consecutive weeks. Results:
  • test results The test animals and doses were the same as before, and the indicators of each group of mice were measured after 58 days of continuous drug administration. test results:
  • Serum lipid peroxide content is determined as shown in the table below.
  • Table 4 Determination of serum lipid peroxide content
  • the health product of the present invention has the functions of regulating immune function and delaying aging, and it can also inoculate sarcoma S 18 . Has a suppressing effect.
  • the technology of the present invention has the following advantages and effects:
  • the product of the present invention uses raw materials of the same origin as medicine and food. It is a health product that can regulate immunity and delay aging. It is suitable for patients with immune dysfunction, and it is also suitable for tumor patients after surgery and during chemotherapy and radiotherapy. Used together to prevent recurrence and metastasis after surgery.
  • the formula is scientific and reasonable. After the three components are compatible with each other, the advantages are complementary. It can form a kind of attractant similar to biological response modifier (BRM). By enhancing the body's immune function, it can mobilize the BRM process in the body, improve NK cell activity, and enhance phagocytic cells. Phagocytosis function, increase white blood cells to improve the symptoms of tumor patients, improve patients' tolerance to radiotherapy and chemotherapy, and docking Seed sarcoma S 18 . Has a suppressing effect.
  • BRM biological response modifier
  • the ground dragon was washed, and 1.5 times normal saline was added at 50 ° C to perform autolysis. After centrifugation to remove the residue, the collected supernatant was subjected to the first ultrafiltration. M was 70,000 columns. The filtrate was subjected to secondary ultrafiltration, with M of 25,000 columns, and the retentate was chromatographed on a G-75 column, washed with physiological saline, and the active peaks were collected, and freeze-dried to make ground dragon extract for future use.
  • the Ganoderma lucidum and Cordyceps sinensis were pulverized to 800 mesh at a temperature of -15 ° C, and made into powder for use.
  • the earthworm was washed, 3.0 times normal saline was added for autolysis at a temperature of 40 ° C, and the residue was collected by centrifugation, and the collected supernatant was subjected to the first ultrafiltration.
  • the M was 80,000 columns.
  • the filtrate was subjected to a second ultrafiltration, and the M was 20, 000 columns.
  • the retentate was chromatographed on a G-75 column, washed with physiological saline, and the active peaks were collected, and the ground dragon extract was prepared by water-drying for use. 8kg, ⁇ -It is mixed with granules at 15 ° C and filled with gum ft, which is the health product of the present invention.
  • the earthworm was washed, and 4.5 times normal saline was added at 25 ° C for autolysis. After centrifugation to remove the residue, the collected supernatant was subjected to the first ultrafiltration. The M was 100,000 columns. The filtrate was subjected to a second ultrafiltration, with M of 15 thousand columns, and the retentate was chromatographed on a G-75 column using normal saline. Rinse, collect the active peaks, freeze-dry to make ground dragon extract for future use, and then crush the ganoderma lucidum and cordyceps -15 ° C to 1250 mesh to make powder for future use. Finally, take the above-prepared ground dragon extract 3 Okg, Ganoderma lucidum 1. Okg and Cordyceps 0.5 kg, mixed and granulated at -15 ° C and loaded into the thigh, which is the health product of the present invention.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Nutrition Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention se rapporte à un produit de soins de santé à administration orale permettant de stimuler l'immunité et de retarder le vieillissement. Il est composé de Ganoderma, de Cordyceps et d'un extrait de Lombric selon un rapport de 1-4:0,5-2,5:0,5-3. De nombreux tests ont démontré que le produit fait preuve d'une forte résistance à l'oxydation, peut stimuler la résistibilité du corps aux maladies et retarder le vieillissement. Pour les personnes souffrant d'immunodéficience, le produit de cette invention est un bon régime alimentaire. Il peut être administré à des patients ayant été opéré de tumeurs ou être combiné à une radiothérapie et chimiothérapie. Son administration a pour but d'empêcher la récidive post-opératoire et l'apparition de métastase.
PCT/CN2002/000616 2001-09-05 2002-09-04 Produit de soins de sante permettant de stimuler l'immunite et de retarder le vieillissement WO2003026683A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN01131281.5 2001-09-05
CN01131281A CN1121237C (zh) 2001-09-05 2001-09-05 可调节免疫功能和延缓衰老的保健品

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WO2003026683A1 true WO2003026683A1 (fr) 2003-04-03

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PCT/CN2002/000616 WO2003026683A1 (fr) 2001-09-05 2002-09-04 Produit de soins de sante permettant de stimuler l'immunite et de retarder le vieillissement

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WO (1) WO2003026683A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100353828C (zh) * 2004-06-04 2007-12-12 毛福森 提高人体免疫功能的真菌复合产品及其制备方法
CN107441126B (zh) * 2017-08-01 2021-09-10 李庆杰 一种具有提高nk细胞肿瘤杀伤活性的大型真菌组合物及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1083365A (zh) * 1993-08-11 1994-03-09 沈阳市好猫生物技术研究所 北冬虫夏草滋补酒及其制备方法
CN1085433A (zh) * 1993-07-03 1994-04-20 沈阳市好猫生物技术研究所 草灵营养液及其制备方法
CN1114883A (zh) * 1994-11-30 1996-01-17 南京金宁信息技术研究所 活性地龙干粉的制备方法
CN1170578A (zh) * 1996-07-17 1998-01-21 中国人民解放军第四军医大学 地龙胶囊

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1085433A (zh) * 1993-07-03 1994-04-20 沈阳市好猫生物技术研究所 草灵营养液及其制备方法
CN1083365A (zh) * 1993-08-11 1994-03-09 沈阳市好猫生物技术研究所 北冬虫夏草滋补酒及其制备方法
CN1114883A (zh) * 1994-11-30 1996-01-17 南京金宁信息技术研究所 活性地龙干粉的制备方法
CN1170578A (zh) * 1996-07-17 1998-01-21 中国人民解放军第四军医大学 地龙胶囊

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CN1336235A (zh) 2002-02-20
CN1121237C (zh) 2003-09-17

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