WO2003026408A1 - Modèle animal présentant une surexpression de régucalcine - Google Patents
Modèle animal présentant une surexpression de régucalcine Download PDFInfo
- Publication number
- WO2003026408A1 WO2003026408A1 PCT/JP2002/009611 JP0209611W WO03026408A1 WO 2003026408 A1 WO2003026408 A1 WO 2003026408A1 JP 0209611 W JP0209611 W JP 0209611W WO 03026408 A1 WO03026408 A1 WO 03026408A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- rat
- regucalcin
- overexpression
- full
- expression vector
- Prior art date
Links
- 102000017955 Regucalcin Human genes 0.000 title abstract 4
- 108050007056 Regucalcin Proteins 0.000 title abstract 4
- 241001465754 Metazoa Species 0.000 title abstract 3
- 230000002018 overexpression Effects 0.000 title abstract 2
- 239000002299 complementary DNA Substances 0.000 abstract 3
- 208000020084 Bone disease Diseases 0.000 abstract 2
- 102000002322 Egg Proteins Human genes 0.000 abstract 2
- 108010000912 Egg Proteins Proteins 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 210000004185 liver Anatomy 0.000 abstract 2
- 210000004681 ovum Anatomy 0.000 abstract 2
- 108020004635 Complementary DNA Proteins 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 101000582783 Rattus norvegicus Regucalcin Proteins 0.000 abstract 1
- 230000037396 body weight Effects 0.000 abstract 1
- 230000014509 gene expression Effects 0.000 abstract 1
- 230000000877 morphologic effect Effects 0.000 abstract 1
- 210000003101 oviduct Anatomy 0.000 abstract 1
- 238000011824 transgenic rat model Methods 0.000 abstract 1
- 235000019786 weight gain Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Physics & Mathematics (AREA)
- Animal Husbandry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020047004105A KR100611804B1 (ko) | 2001-09-20 | 2002-09-19 | 레규칼신 과잉발현 모델동물 |
DE60238850T DE60238850D1 (de) | 2001-09-20 | 2002-09-19 | Rattenmodell mit regucalcin-überexpression |
EP02799483A EP1437043B1 (en) | 2001-09-20 | 2002-09-19 | Rat model with overexpression of regucalcin |
US10/804,515 US7355093B2 (en) | 2001-09-20 | 2004-03-19 | Model animal with overexpression of regucalcin |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001287698 | 2001-09-20 | ||
JP2001/287698 | 2001-09-20 | ||
JP2002/177666 | 2002-06-18 | ||
JP2002177666A JP3949520B2 (ja) | 2001-09-20 | 2002-06-18 | レギュカルチン過剰発現モデル動物 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/804,515 Continuation-In-Part US7355093B2 (en) | 2001-09-20 | 2004-03-19 | Model animal with overexpression of regucalcin |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003026408A1 true WO2003026408A1 (fr) | 2003-04-03 |
Family
ID=26622632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/009611 WO2003026408A1 (fr) | 2001-09-20 | 2002-09-19 | Modèle animal présentant une surexpression de régucalcine |
Country Status (6)
Country | Link |
---|---|
US (1) | US7355093B2 (ja) |
EP (1) | EP1437043B1 (ja) |
JP (1) | JP3949520B2 (ja) |
KR (1) | KR100611804B1 (ja) |
DE (1) | DE60238850D1 (ja) |
WO (1) | WO2003026408A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20070117002A (ko) * | 2003-11-04 | 2007-12-11 | 도꾸리쯔교세이호징 가가꾸 기쥬쯔 신꼬 기꼬 | 고지혈증·고알부민혈증 모델 동물 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0797399A (ja) * | 1993-09-29 | 1995-04-11 | Fujirebio Inc | 新規ポリペプチド及びヒト老化マーカータンパクsmp30測定用試薬 |
JPH07123985A (ja) * | 1993-11-09 | 1995-05-16 | Masayoshi Yamaguchi | レギュカルチンをコードするdna断片 |
JPH1026623A (ja) * | 1996-07-10 | 1998-01-27 | Masayoshi Yamaguchi | 肝疾患患者血清の鑑別方法 |
JPH119140A (ja) * | 1997-04-30 | 1999-01-19 | Takeda Chem Ind Ltd | 25−水酸化ビタミンd3 24−水酸化酵素遺伝子導入動物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPO856097A0 (en) * | 1997-08-14 | 1997-09-04 | Commonwealth Scientific And Industrial Research Organisation | Vector |
JPH11155420A (ja) * | 1997-12-02 | 1999-06-15 | Snow Brand Milk Prod Co Ltd | トランスジェニック動物 |
JP2004267002A (ja) * | 2000-10-23 | 2004-09-30 | Naoki Maruyama | セネッセンスマーカープロテイン30欠損動物、抗体およびその作製方法 |
-
2002
- 2002-06-18 JP JP2002177666A patent/JP3949520B2/ja not_active Expired - Fee Related
- 2002-09-19 KR KR1020047004105A patent/KR100611804B1/ko not_active IP Right Cessation
- 2002-09-19 EP EP02799483A patent/EP1437043B1/en not_active Expired - Lifetime
- 2002-09-19 WO PCT/JP2002/009611 patent/WO2003026408A1/ja active Application Filing
- 2002-09-19 DE DE60238850T patent/DE60238850D1/de not_active Expired - Lifetime
-
2004
- 2004-03-19 US US10/804,515 patent/US7355093B2/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0797399A (ja) * | 1993-09-29 | 1995-04-11 | Fujirebio Inc | 新規ポリペプチド及びヒト老化マーカータンパクsmp30測定用試薬 |
JPH07123985A (ja) * | 1993-11-09 | 1995-05-16 | Masayoshi Yamaguchi | レギュカルチンをコードするdna断片 |
JPH1026623A (ja) * | 1996-07-10 | 1998-01-27 | Masayoshi Yamaguchi | 肝疾患患者血清の鑑別方法 |
JPH119140A (ja) * | 1997-04-30 | 1999-01-19 | Takeda Chem Ind Ltd | 25−水酸化ビタミンd3 24−水酸化酵素遺伝子導入動物 |
Non-Patent Citations (1)
Title |
---|
See also references of EP1437043A4 * |
Also Published As
Publication number | Publication date |
---|---|
JP2003164238A (ja) | 2003-06-10 |
EP1437043A4 (en) | 2007-01-17 |
KR20040090947A (ko) | 2004-10-27 |
US20040250306A1 (en) | 2004-12-09 |
EP1437043A1 (en) | 2004-07-14 |
US7355093B2 (en) | 2008-04-08 |
DE60238850D1 (de) | 2011-02-17 |
KR100611804B1 (ko) | 2006-08-11 |
EP1437043B1 (en) | 2011-01-05 |
JP3949520B2 (ja) | 2007-07-25 |
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