WO2003025570A1 - Method of examining (-) strand rna virus vector having lowered ability to form grains and method of constructing the same - Google Patents

Method of examining (-) strand rna virus vector having lowered ability to form grains and method of constructing the same Download PDF

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Publication number
WO2003025570A1
WO2003025570A1 PCT/JP2002/009558 JP0209558W WO03025570A1 WO 2003025570 A1 WO2003025570 A1 WO 2003025570A1 JP 0209558 W JP0209558 W JP 0209558W WO 03025570 A1 WO03025570 A1 WO 03025570A1
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Prior art keywords
ability
vector
strand rna
lowered
rna virus
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Application number
PCT/JP2002/009558
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English (en)
French (fr)
Inventor
Makoto Inoue
Yumiko Tokusumi
Akihiro Iida
Mamoru Hasegawa
Original Assignee
Dnavec Research Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dnavec Research Inc. filed Critical Dnavec Research Inc.
Priority to JP2003529148A priority Critical patent/JPWO2003025570A1/ja
Priority to KR10-2004-7003888A priority patent/KR20040039366A/ko
Priority to CA002460778A priority patent/CA2460778A1/en
Priority to US10/489,384 priority patent/US20050130123A1/en
Priority to EP20020765579 priority patent/EP1437593A1/en
Priority to US10/316,538 priority patent/US20030166252A1/en
Priority to US10/316,535 priority patent/US7226786B2/en
Publication of WO2003025570A1 publication Critical patent/WO2003025570A1/ja
Priority to US11/515,341 priority patent/US20070009949A1/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18841—Use of virus, viral particle or viral elements as a vector
    • C12N2760/18843—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18861—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
PCT/JP2002/009558 1999-05-18 2002-09-18 Method of examining (-) strand rna virus vector having lowered ability to form grains and method of constructing the same WO2003025570A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2003529148A JPWO2003025570A1 (ja) 2001-09-18 2002-09-18 粒子形成能が低下した（−）鎖ｒｎａウィルスベクターの検査方法および製造方法
KR10-2004-7003888A KR20040039366A (ko) 2001-09-18 2002-09-18 입자 형성능이 저하된 （－）가닥 ｒｎａ 바이러스 벡터의 검사방법 및 제조방법
CA002460778A CA2460778A1 (en) 2001-09-18 2002-09-18 Methods for testing and producing (-) strand rna virus vectors with reduced particle formation ability
US10/489,384 US20050130123A1 (en) 2001-09-18 2002-09-18 Methods of examining (-) strand rna virus vectors having lowered ability to form grains and method of constructing the same
EP20020765579 EP1437593A1 (en) 2001-09-18 2002-09-18 Method of examining (-)-strand rna virus vector having lowered ability to form grains and method of constructing the same
US10/316,538 US20030166252A1 (en) 1999-05-18 2002-12-10 Paramyxovirus-derived RNP
US10/316,535 US7226786B2 (en) 1999-05-18 2002-12-10 Envelope gene-deficient Paramyxovirus vector
US11/515,341 US20070009949A1 (en) 1999-05-18 2006-09-01 Paramyxovirus-derived RNP

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001283451 2001-09-18
JP2001-283451 2001-09-18
JP2001356336 2001-11-21
JP2001-356336 2001-11-21

Publications (1)

Publication Number Publication Date
WO2003025570A1 true WO2003025570A1 (en) 2003-03-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/009558 WO2003025570A1 (en) 1999-05-18 2002-09-18 Method of examining (-) strand rna virus vector having lowered ability to form grains and method of constructing the same

Country Status (7)

Country Link
US (1) US20050130123A1 (ja)
EP (1) EP1437593A1 (ja)
JP (1) JPWO2003025570A1 (ja)
KR (1) KR20040039366A (ja)
CN (1) CN1633599A (ja)
CA (1) CA2460778A1 (ja)
WO (1) WO2003025570A1 (ja)

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005005645A1 (en) * 2003-06-13 2005-01-20 Apath, Llc Negative strand rna virus replicon
JP2006180780A (ja) * 2004-12-27 2006-07-13 National Institute Of Advanced Industrial & Technology 持続感染型センダイウイルスベクター
WO2006134917A1 (ja) 2005-06-14 2006-12-21 Dnavec Corporation 抗体の作製方法
WO2006137517A1 (ja) * 2005-06-24 2006-12-28 Dnavec Corporation 幼少個体への遺伝子導入用ベクター
WO2007083644A1 (ja) * 2006-01-17 2007-07-26 Dnavec Corporation 新規タンパク質発現系
WO2007139178A1 (ja) 2006-05-31 2007-12-06 Dnavec Corporation アルツハイマー病治療薬
WO2008007581A1 (fr) 2006-07-13 2008-01-17 Dnavec Corporation Vecteur de virus paramyxoviridae non répliquant
US7402427B2 (en) 2002-04-30 2008-07-22 Dnavec Research Inc. Vectors with modified protease-dependent tropism
JP2008529508A (ja) * 2005-02-11 2008-08-07 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ ワクチンとしての複製欠損ｒｎａ−ウイルス
WO2008096811A1 (ja) 2007-02-07 2008-08-14 Dnavec Corporation 弱毒化マイナス鎖rnaウイルス
JP2008536476A (ja) * 2005-04-20 2008-09-11 ディナベック株式会社 アルツハイマー病の治療のための安全性に優れた鼻腔内投与可能遺伝子ワクチン
WO2008136438A1 (ja) 2007-04-27 2008-11-13 Kyushu University, National University Corporation 遺伝子治療用ウイルスベクター
US7521043B2 (en) 2004-01-13 2009-04-21 Dnavec Research Inc. Gene therapy for tumors using minus-strand RNA viral vectors encoding immunostimulatory cytokines
WO2010008054A1 (ja) 2008-07-16 2010-01-21 ディナベック株式会社 染色体非組み込み型ウイルスベクターを用いてリプログラムされた細胞を製造する方法
WO2010050586A1 (ja) 2008-10-31 2010-05-06 ディナベック株式会社 組み換え蛋白質の発現を増強する方法
WO2011083881A1 (ja) 2010-01-08 2011-07-14 国立大学法人京都大学 タウオパチー治療用ワクチン
WO2012029770A1 (ja) 2010-08-30 2012-03-08 ディナベック株式会社 多能性幹細胞を誘導するための組成物およびその使用
EP2434020A2 (en) 2004-01-22 2012-03-28 Dnavec Research Inc. Method of producing minus strand RNA virus vector with the use of hybrid promoter containing cytomegalovirus enhancer and avian beta-actin promoter
US8889118B2 (en) 2004-06-24 2014-11-18 Dna Vec Research Inc. Anticancer agent containing dendritic cell having RNA virus transferred thereinto
WO2015046229A1 (ja) 2013-09-24 2015-04-02 ディナベック株式会社 多能性幹細胞の誘導効率を改善する方法
WO2019017438A1 (ja) 2017-07-21 2019-01-24 株式会社Ｉｄファーマ 標的配列を改変するためのポリヌクレオチドおよびその使用
WO2022050419A1 (ja) 2020-09-04 2022-03-10 Ｈｅａｒｔｓｅｅｄ株式会社 ｉＰＳ細胞の品質改善剤、ｉＰＳ細胞の製造方法、ｉＰＳ細胞、及びｉＰＳ細胞製造用組成物
WO2022138964A1 (ja) 2020-12-25 2022-06-30 国立大学法人京都大学 体細胞からのナイーブ型ヒトｉＰＳ細胞製造方法
WO2023277069A1 (ja) 2021-06-30 2023-01-05 株式会社レプリテック マイナス鎖ｒｎａウイルスベクターの製造方法および製造されたマイナス鎖ｒｎａウイルスベクター
WO2023127871A1 (ja) * 2021-12-27 2023-07-06 株式会社レプリテック 温度感受性のマイナス鎖ｒｎａウイルスまたはウイルスベクターおよびそのｒｎａゲノム

Families Citing this family (5)

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JPWO2005001082A1 (ja) * 2003-06-30 2006-08-10 株式会社ディナベック研究所 高変異領域が改変された遺伝子を搭載するマイナス鎖ｒｎａウイルスベクター
WO2005042737A1 (ja) * 2003-11-04 2005-05-12 Dnavec Research Inc. 遺伝子導入された樹状細胞の製造方法
CA2554198A1 (en) * 2004-01-22 2005-08-04 Dnavec Research Inc. Process for producing virus vector
WO2005097988A1 (ja) * 2004-03-23 2005-10-20 Dnavec Research Inc. 組織の維持および／または修復に関連する骨髄関連細胞
JP4936482B2 (ja) * 2007-04-13 2012-05-23 独立行政法人産業技術総合研究所 改良された持続感染型センダイウイルスベクター

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Cited By (38)

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Publication number Priority date Publication date Assignee Title
US7709621B2 (en) 2002-04-30 2010-05-04 Dnavec Research Inc. Vectors with modified protease-dependent tropism
US7402427B2 (en) 2002-04-30 2008-07-22 Dnavec Research Inc. Vectors with modified protease-dependent tropism
WO2005005645A1 (en) * 2003-06-13 2005-01-20 Apath, Llc Negative strand rna virus replicon
US7585667B2 (en) 2003-06-13 2009-09-08 The United States Of America As Represented By The Department Of Health And Human Services Negative strand RNA virus replicon
US7521043B2 (en) 2004-01-13 2009-04-21 Dnavec Research Inc. Gene therapy for tumors using minus-strand RNA viral vectors encoding immunostimulatory cytokines
US8741650B2 (en) 2004-01-22 2014-06-03 Dnavec Research Inc. Methods for producing minus-strand RNA viral vectors using hybrid promoter comprising cytomegalovirus enhancer and chicken β-actin promoter
EP2434020A2 (en) 2004-01-22 2012-03-28 Dnavec Research Inc. Method of producing minus strand RNA virus vector with the use of hybrid promoter containing cytomegalovirus enhancer and avian beta-actin promoter
US8889118B2 (en) 2004-06-24 2014-11-18 Dna Vec Research Inc. Anticancer agent containing dendritic cell having RNA virus transferred thereinto
JP2006180780A (ja) * 2004-12-27 2006-07-13 National Institute Of Advanced Industrial & Technology 持続感染型センダイウイルスベクター
JP2008529508A (ja) * 2005-02-11 2008-08-07 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ ワクチンとしての複製欠損ｒｎａ−ウイルス
US11028409B2 (en) 2005-02-11 2021-06-08 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Replication-deficient RNA viruses as vaccines
JP2008536476A (ja) * 2005-04-20 2008-09-11 ディナベック株式会社 アルツハイマー病の治療のための安全性に優れた鼻腔内投与可能遺伝子ワクチン
WO2006134917A1 (ja) 2005-06-14 2006-12-21 Dnavec Corporation 抗体の作製方法
WO2006137517A1 (ja) * 2005-06-24 2006-12-28 Dnavec Corporation 幼少個体への遺伝子導入用ベクター
WO2007083644A1 (ja) * 2006-01-17 2007-07-26 Dnavec Corporation 新規タンパク質発現系
WO2007139178A1 (ja) 2006-05-31 2007-12-06 Dnavec Corporation アルツハイマー病治療薬
WO2008007581A1 (fr) 2006-07-13 2008-01-17 Dnavec Corporation Vecteur de virus paramyxoviridae non répliquant
WO2008096811A1 (ja) 2007-02-07 2008-08-14 Dnavec Corporation 弱毒化マイナス鎖rnaウイルス
WO2008136438A1 (ja) 2007-04-27 2008-11-13 Kyushu University, National University Corporation 遺伝子治療用ウイルスベクター
JPWO2010008054A1 (ja) * 2008-07-16 2012-01-05 ディナベック株式会社 染色体非組み込み型ウイルスベクターを用いてリプログラムされた細胞を製造する方法
EP3075850A1 (en) 2008-07-16 2016-10-05 IP Pharma Co., Ltd. Method for production of reprogrammed cell using chromosomally unintegrated virus vector
US11136594B2 (en) 2008-07-16 2021-10-05 Id Pharma Co., Ltd. Method for production of reprogrammed cell using chromosomally unintegrated virus vector
WO2010008054A1 (ja) 2008-07-16 2010-01-21 ディナベック株式会社 染色体非組み込み型ウイルスベクターを用いてリプログラムされた細胞を製造する方法
US9695445B2 (en) 2008-07-16 2017-07-04 Id Pharma Co., Ltd. Method for production of reprogrammed cell using chromosomally unintegrated virus vector
JP5763340B2 (ja) * 2008-07-16 2015-08-12 ディナベック株式会社 染色体非組み込み型ウイルスベクターを用いてリプログラムされた細胞を製造する方法
US9127256B2 (en) 2008-07-16 2015-09-08 Dnavec Corporation Method for production of reprogrammed cell using chromosomally unintegrated virus vector
JP2015164434A (ja) * 2008-07-16 2015-09-17 株式会社Ｉｄファーマ 染色体非組み込み型ウイルスベクターを用いてリプログラムされた細胞を製造する方法
JP2016105729A (ja) * 2008-07-16 2016-06-16 株式会社Ｉｄファーマ 染色体非組み込み型ウイルスベクターを用いてリプログラムされた細胞を製造する方法
WO2010050586A1 (ja) 2008-10-31 2010-05-06 ディナベック株式会社 組み換え蛋白質の発現を増強する方法
WO2011083881A1 (ja) 2010-01-08 2011-07-14 国立大学法人京都大学 タウオパチー治療用ワクチン
WO2012029770A1 (ja) 2010-08-30 2012-03-08 ディナベック株式会社 多能性幹細胞を誘導するための組成物およびその使用
WO2015046229A1 (ja) 2013-09-24 2015-04-02 ディナベック株式会社 多能性幹細胞の誘導効率を改善する方法
US10975358B2 (en) 2013-09-24 2021-04-13 Id Pharma Co., Ltd. Method for improving efficiency of inducing pluripotent stem cell
WO2019017438A1 (ja) 2017-07-21 2019-01-24 株式会社Ｉｄファーマ 標的配列を改変するためのポリヌクレオチドおよびその使用
WO2022050419A1 (ja) 2020-09-04 2022-03-10 Ｈｅａｒｔｓｅｅｄ株式会社 ｉＰＳ細胞の品質改善剤、ｉＰＳ細胞の製造方法、ｉＰＳ細胞、及びｉＰＳ細胞製造用組成物
WO2022138964A1 (ja) 2020-12-25 2022-06-30 国立大学法人京都大学 体細胞からのナイーブ型ヒトｉＰＳ細胞製造方法
WO2023277069A1 (ja) 2021-06-30 2023-01-05 株式会社レプリテック マイナス鎖ｒｎａウイルスベクターの製造方法および製造されたマイナス鎖ｒｎａウイルスベクター
WO2023127871A1 (ja) * 2021-12-27 2023-07-06 株式会社レプリテック 温度感受性のマイナス鎖ｒｎａウイルスまたはウイルスベクターおよびそのｒｎａゲノム

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CN1633599A (zh) 2005-06-29
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