WO2003024957A1 - Derives de benzimidazole - Google Patents
Derives de benzimidazole Download PDFInfo
- Publication number
- WO2003024957A1 WO2003024957A1 PCT/JP2002/009551 JP0209551W WO03024957A1 WO 2003024957 A1 WO2003024957 A1 WO 2003024957A1 JP 0209551 W JP0209551 W JP 0209551W WO 03024957 A1 WO03024957 A1 WO 03024957A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- therapeutic effect
- benzimidazole derivatives
- difference
- individuals
- compounds
- Prior art date
Links
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title abstract 2
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000019057 Cytochrome P-450 CYP2C19 Human genes 0.000 abstract 1
- 108010026925 Cytochrome P-450 CYP2C19 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 101150055214 cyp1a1 gene Proteins 0.000 abstract 1
- 230000001079 digestive effect Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003528804A JP4020076B2 (ja) | 2001-09-18 | 2002-09-18 | ベンズイミダゾール誘導体 |
CA002445513A CA2445513A1 (en) | 2001-09-18 | 2002-09-18 | Benzimidazole derivatives |
KR10-2003-7014459A KR20040025677A (ko) | 2001-09-18 | 2002-09-18 | 벤즈이미다졸 유도체 |
AU2002332178A AU2002332178B2 (en) | 2001-09-18 | 2002-09-18 | Benzimidazole derivatives |
EP02767961A EP1428825A4 (en) | 2001-09-18 | 2002-09-18 | benzimidazole derivatives |
US10/380,158 US6884810B2 (en) | 2001-09-18 | 2002-09-18 | Benzimidazole derivatives |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001282918 | 2001-09-18 | ||
JP2001-282918 | 2001-09-18 | ||
JP2002-96101 | 2002-03-29 | ||
JP2002096101 | 2002-03-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003024957A1 true WO2003024957A1 (fr) | 2003-03-27 |
Family
ID=26622397
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/009551 WO2003024957A1 (fr) | 2001-09-18 | 2002-09-18 | Derives de benzimidazole |
Country Status (8)
Country | Link |
---|---|
US (1) | US6884810B2 (ja) |
EP (1) | EP1428825A4 (ja) |
JP (1) | JP4020076B2 (ja) |
KR (1) | KR20040025677A (ja) |
CN (1) | CN1243749C (ja) |
AU (1) | AU2002332178B2 (ja) |
CA (1) | CA2445513A1 (ja) |
WO (1) | WO2003024957A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004077367A1 (ja) * | 2003-02-25 | 2004-09-10 | Zeria Pharmaceutical Co. Ltd. | 四環系スルフェンアミド化合物 |
JP2007522182A (ja) * | 2004-02-12 | 2007-08-09 | イスティチュート スペリオーレ ディ サニータ | プロトンポンプ阻害剤の新規使用 |
JP2008534446A (ja) * | 2005-03-25 | 2008-08-28 | リブゾン ファーマシューティカル グループ インク. | 置換スルホキシド化合物、その調製方法、およびその使用方法 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050148634A1 (en) * | 2002-03-29 | 2005-07-07 | Zeria Pharmaceutical Co., Ltd | 1-N-Aminobenzimidazole derivatives |
CN101978073B (zh) * | 2008-01-25 | 2014-12-10 | 诊疗实验室 | 用于评估药物反应的方法和组合物 |
CN101492459B (zh) * | 2008-01-25 | 2011-04-27 | 山东轩竹医药科技有限公司 | 含烷氧乙酰基二氢异噁唑并吡啶化合物 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4689333A (en) * | 1984-08-16 | 1987-08-25 | Takeda Chemical Industries, Ltd. | 2-(2-pyridylmethylthio (sulfinyl)) benzimidazoles |
EP0268956A2 (en) * | 1986-11-13 | 1988-06-01 | Eisai Co., Ltd. | Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same |
EP0356143A1 (en) * | 1988-08-18 | 1990-02-28 | Takeda Chemical Industries, Ltd. | Injectable solutions |
EP0382489A2 (en) * | 1989-02-10 | 1990-08-16 | Takeda Chemical Industries, Ltd. | Use of benzimidazole derivatives as antibacterial agents |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
ZA854287B (en) | 1984-06-16 | 1986-02-26 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridines,process for their preparation,their use and medicaments containing them |
IL75400A (en) * | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
US4738975A (en) * | 1985-07-02 | 1988-04-19 | Takeda Chemical Industries, Ltd. | Pyridine derivatives, and use as anti-ulcer agents |
JPH0717631B2 (ja) | 1986-03-04 | 1995-03-01 | 武田薬品工業株式会社 | ピリジニウム誘導体およびその製造法 |
JPH0674272B2 (ja) | 1986-11-13 | 1994-09-21 | エーザイ株式会社 | ピリジン誘導体及びそれを含有する潰瘍治療剤 |
US5223515A (en) * | 1988-08-18 | 1993-06-29 | Takeda Chemical Industries, Ltd. | Injectable solution containing a pyridyl methylsulfinylbenzimidazole |
US5877192A (en) * | 1993-05-28 | 1999-03-02 | Astra Aktiebolag | Method for the treatment of gastric acid-related diseases and production of medication using (-) enantiomer of omeprazole |
SE9301830D0 (sv) | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
-
2002
- 2002-09-18 CN CNB028107225A patent/CN1243749C/zh not_active Expired - Fee Related
- 2002-09-18 WO PCT/JP2002/009551 patent/WO2003024957A1/ja not_active Application Discontinuation
- 2002-09-18 AU AU2002332178A patent/AU2002332178B2/en not_active Ceased
- 2002-09-18 KR KR10-2003-7014459A patent/KR20040025677A/ko active IP Right Grant
- 2002-09-18 JP JP2003528804A patent/JP4020076B2/ja not_active Expired - Fee Related
- 2002-09-18 US US10/380,158 patent/US6884810B2/en not_active Expired - Fee Related
- 2002-09-18 EP EP02767961A patent/EP1428825A4/en not_active Withdrawn
- 2002-09-18 CA CA002445513A patent/CA2445513A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4689333A (en) * | 1984-08-16 | 1987-08-25 | Takeda Chemical Industries, Ltd. | 2-(2-pyridylmethylthio (sulfinyl)) benzimidazoles |
EP0268956A2 (en) * | 1986-11-13 | 1988-06-01 | Eisai Co., Ltd. | Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same |
EP0356143A1 (en) * | 1988-08-18 | 1990-02-28 | Takeda Chemical Industries, Ltd. | Injectable solutions |
EP0382489A2 (en) * | 1989-02-10 | 1990-08-16 | Takeda Chemical Industries, Ltd. | Use of benzimidazole derivatives as antibacterial agents |
Non-Patent Citations (1)
Title |
---|
KUBO K. ET AL.: "Synthesis of 2-(((4-fluoroalkoxy-2-pyridyl)methyl)sulfonyl)-1H-benzimidazoles as antiulcer agents", CHEMICAL AND PARMACEUTICAL BULLETIN, vol. 38, no. 10, October 1990 (1990-10-01), TOKYO, JP, pages 2853 - 2858, XP002150630 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004077367A1 (ja) * | 2003-02-25 | 2004-09-10 | Zeria Pharmaceutical Co. Ltd. | 四環系スルフェンアミド化合物 |
JP2007522182A (ja) * | 2004-02-12 | 2007-08-09 | イスティチュート スペリオーレ ディ サニータ | プロトンポンプ阻害剤の新規使用 |
JP2008534446A (ja) * | 2005-03-25 | 2008-08-28 | リブゾン ファーマシューティカル グループ インク. | 置換スルホキシド化合物、その調製方法、およびその使用方法 |
JP4837722B2 (ja) * | 2005-03-25 | 2011-12-14 | リブゾン ファーマシューティカル グループ インク. | 置換スルホキシド化合物、その調製方法、およびその使用方法 |
Also Published As
Publication number | Publication date |
---|---|
US20030236411A1 (en) | 2003-12-25 |
CA2445513A1 (en) | 2003-03-27 |
AU2002332178B2 (en) | 2005-12-08 |
EP1428825A4 (en) | 2005-03-23 |
EP1428825A1 (en) | 2004-06-16 |
CN1511153A (zh) | 2004-07-07 |
JP4020076B2 (ja) | 2007-12-12 |
CN1243749C (zh) | 2006-03-01 |
JPWO2003024957A1 (ja) | 2004-12-24 |
KR20040025677A (ko) | 2004-03-24 |
US6884810B2 (en) | 2005-04-26 |
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