WO2003013556A1

WO2003013556A1 - Medicinal compositions having effects of ameliorating eye diseases and holding eye functions

Info

Publication number: WO2003013556A1
Application number: PCT/JP2001/006672
Authority: WO
Inventors: Chiduko Yamagami; Sueto Yamagami; Hiroshige Itakura
Original assignee: Chiduko Yamagami; Sueto Yamagami; Hiroshige Itakura
Priority date: 2001-08-02
Filing date: 2001-08-02
Publication date: 2003-02-20

Abstract

It is said that active oxygen largely affects eye diseases. In particular, age-related macular degeneration is considered as a serious disease for which no therapeutic method has been established so far. A large amount of active oxygen is generated due to the concentration of light at the macula in the retina. It is estimated that damages due to the active oxygen are accumulated in the macula with aging, thereby resulting in the onset of macular degeneration. Medicinal compositions efficacious against these eye diseases are obtained by the combination of the recent results in Western medicine with traditional Chinese knowledge. These compositions contain as the fundamental main components animal livers, which have been employed as remedies for eye diseases for a long time, and vitamins and carotenoids having a strong effect of eliminating active oxygen from the human body. As the animal livers, use can be made of carp liver, mamushi pit viper liver and sheep liver. Examples of the antioxidants include vitamin C, vitamin E, astaxanthin and lycopene. It is favorable to add powdery blueberry concentrate having an effect of activating the re-synthesis of rhodopsin.

Description

Description Pharmaceutical composition having eye disease ameliorating action and eye function maintaining action

The present invention relates to a pharmaceutical composition having an effect of improving eye diseases, particularly macular degeneration. Background art

With the widespread use of computers and word processors, eye disorders such as asthenopia and visual impairment, or pseudomyopia, are becoming a social problem, and this is one of the causes of lifestyle diseases such as hypertension and heart disease. It is with. Eye diseases are increasing in all age groups, especially in urban areas, due to reduced opportunities to see far away and reduced greenery. In addition, the age-related eye diseases, cataract, macular degeneration, glaucoma, central retinopathy, and retinal detachment, which are caused by aging as the number of elderly people increase, are increasing significantly.

However, the development of therapies for the improvement of these eye diseases or the means of prevention of functional decline has not been sufficiently implemented. In particular, macular degeneration is known as a disease that is difficult to treat, and is considered to be the largest cause of blindness due to aging in Europe and the United States. Nevertheless, no cure has been found so far, and only preventive measures have been suggested, but only antioxidant vitamins are recommended as preventive measures (for example, Jacques PF "The potential preventive effects of vitamins for cataract and age-related macular degeneration Int J Vitam Nutr Res 1999 May Vol.69 No.3 P.198-205).

However, in recent years, with the progress of research, it has become clear that many of these eye diseases, including age-related diseases, are caused by damage to living organisms due to active oxygen generated in the body. "Chinese Pharmaceutical Application and Applied Research System" Vol.13, No.5, "Clinical Medicine for Ophthalmology", Toshiichi Yoshikawa, "Science of Free Radicals" [Kodansha 19 May 1997, published May 10, 2007], Christen WG , "Antioxidant Vitamin and Age-Related Eye Disease", Proc Assoc Am Physicians 1999 Vol.111 No.l p.16-21). For example, the light is most concentrated in the retina In the middle macula, concentrated light generates a particularly large amount of active oxygen, but it is thought that the damage caused by active oxygen accumulates with aging and macular degeneration develops.

In China, on the other hand, the eye is called the visceral window, and it is known that improving the condition of the liver, kidney, and spleen is indispensable for maintaining the function of the eye, as is known by the term `` Seimei Akimae ''. You can also see the prescription for this in the literature. (Note that “Seimei Akimie” is an authoritative dictionary published by the People's Health Publishing Company in 1995, for example, According to the report, "Seikyo Akimae is a combination of Seiko liver fever (which cools down the heat of the liver) and liver fertilizer (which nourishes the liver). Seiryopyretics include white chrysanthemums, summer hay, white peony, mulberry leaves, etc., and hepatiotrope negatives include lycopodium, meisada, dry grass, and citrus soybean. However, many of these two drugs have both a Seongbuk action and a nourishing action, and therefore should be combined with Has been referred to as a medicine. "That there is.).

Domestic medicines are different from medicines managed by doctors, and the ingestion is left to the caretaker's self-management. .

① Since the time management until ingestion becomes insufficient, it is necessary to prevent the deterioration during the storage period, which is easy and irregular.

② The decision on what kind of symptom and which household medicine should be selected depends on one's own judgment, so it is desirable to be able to adapt to as wide a range of symptoms as possible.

(3) The duration of ingestion is longer than that of general medicine prescribed by a physician, so that there is little risk of side effects.

長く In order to prolong the intake period and broaden the indications, it is desirable not only to improve the current symptoms but also to have a basic physical improvement effect. Disclosure of the invention

It is an object of the present invention to obtain a pharmaceutical composition having a ameliorating effect on eye diseases and a function for maintaining eye function that can be taken at all times without fear of side effects, by combining recent research results with conventional Chinese medicine knowledge. And The pharmaceutical composition of the present invention for achieving the above object is a composition comprising a natural product having no fear of side effects as a main component, and is considered to have a peri-, antiquity, and clear-eye effect. It has a basic composition of vitamin bile and carotenoids, which have a high activity of removing active oxygen in the human body, and is difficult to treat in the past due to the synergistic effects of these components. The present invention provides a pharmaceutical composition capable of obtaining a high healing effect even on an eye disease called an intractable disease, for example, age-related macular degeneration. In other words, animal bile, an ancient Chinese herbal medicine, improves the functions of the internal organs such as the liver and kidneys, enhances the natural healing power, and tries to cure eye diseases. The only difference between the rate of healing and the rate of progression of the disorder appeared as a therapeutic effect. Antioxidants, on the other hand, suppress the progress of the disease by removing active oxygen, but do not have the function of remedying the existing disorders. On the other hand, the pharmaceutical composition of the present invention stops the progress of the antioxidant scab by mixing a herbal medicine with an antioxidant having an excellent ability to remove active oxygen. The resulting disorder can be cured by the herbal medicine, and the synergistic effect produces an unprecedented high therapeutic effect even on intractable diseases such as macular degeneration.

The use of animal liver or gall to treat ophthalmic diseases has long been known as vague medicine in China, and in the Old Testament Tobit, the white membrane of the eyes was taught by the angel Raphael. As can be seen from the story of treating fish in the gallbladder, it has been known worldwide for its effects and has a history of more than 2000 years.

In China, among others, snake bile, sheep bile, carp bile, etc. are the most commonly used crude drugs and can be easily obtained from Chinese herbal medicine stores.

Carp bile contains tiprinol, vitamins A, Bl, B2, iron, phosphorus, and other minerals.It has a tonic effect, as well as a clear liver, and a detoxifying effect on the optic nerve and retina. The effect has been awarded, especially in southern China.

Snake gall represented by viper bile contains glycocholate and taurocholate, is rich in calcium, minerals, and vitamins. It is said to be effective for congestion and blurred vision, and is good for nutrition and tonic. Jabushi is to replace part of it with an anti-nose, which also has antipyretic activity Can be done.

Sheep and bile are effective against Seihe Akira, detoxification of fever, pneumocongestion, suppression of brain cell death, and epidemic conjunctivitis.

(It depends on "Shinkinkata".)

In the composition of the present invention, the antioxidant is appropriately selected and blended from vitamin C, vitamin E, astaxanthin, lycopene and the like.

Tomato extract powder contains lycopene, vitamin C, and polyphenol, and is effective in enhancing optic nerve function, preventing / improving age-related macular degeneration, and removing active oxygen. (The same effect can be obtained by adding lycopene and vitamin C instead of tomato powder.)

Astaxanthin has a high active oxygen scavenging effect of 100 to 100 times as high as vitamin E depending on its concentration (Japanese Patent No. 261991 Figure 4 and its description). Description), as well as eye diseases, good for preventing hypertension.

A product manufactured by Itano Frozen Co., Ltd. is commercially available.

Among them, fat-soluble lycopene and vitamin E are said to have their activities in the cell membrane, astaxanthin is mainly said to have its activity on the cell membrane surface, and water-soluble vitamin C is in the aqueous solution such as blood and cell fluid. By having an activity and combining them, a composition having a high ability to remove active oxygen generated inside and outside the cell can be obtained.

The composition of the present invention has been added to this with the addition of a pull-belly concentrate which is said to have been found effective by the Royal Air Force, but from around 1964, the contained anthocyanin was a renewal of rhodopsin, a photoreceptor of the eye. It has been understood that there is an effect of assisting synthesis, improving visual acuity in places, improving visual functions, and expanding the field of view.

In recent years, attention has been paid to active oxygen in a living body, and it has been found that the above-described anthocyanin also has an active oxygen removing effect and is effective in removing vascular disorders. It is also rich in vitamin C.

In addition, it is desirable to add ebisdasa, oobako, chrysanthemum white flower, and gingerbread as a plant-based ingredient having a clear liver action.

In general, both animal-based and plant-based herbs can improve vision, reduce blood pressure, and increase arteriosclerosis. Even ingredients that are considered good,

The animal system is rich in beneficial minerals and is effective for flat-eyed, sedative, sedative, insomnia, headache, dizziness

Botanicals have a clear sensation and a fever effect, and are effective for constipation and blood lipid reduction

At present, it is widely known that in nutrition, it is important to take animal and plant matter in a well-balanced manner. An effect has been observed. Each component used in the pharmaceutical composition of the present invention is

White chrysanthemum extract contains amino acids and vitamin B1, and is effective against semen detoxification, blood pressure lowering, eye strain, keratitis, conjunctivitis, and glaucoma.

Gugigi extract contains vitamins A, B1, B2, C, calcium, phosphorus, and iron, and is effective in strengthening the liver and kidneys, enhancing vision, and reducing blood pressure.

Ebisudasa also has effects on glaucoma, blurred vision, hypertension, hyperlipidemia, and constipation because it also has a clearing effect on the semen, clear feces, blood lipid reduction and blood pressure lowering.

Oobaco is effective in preventing semen, diuresis, cough and diarrhea, sudden chronic inflammation of eyes, glaucoma, bronchitis and urinary tract infection.

Further, if necessary, it is more preferable to mix pearl mussel powder, which has a particularly high synergistic effect with carp-bile, and Ebisuda, which has a high synergistic effect, Senri Mitsue powder.

In addition to the basic composition described above, Sanshu, Ginseng, Megusulinoki, Shichi-jin-san, Chimpi-su, Eight-th eel enriched powder, Kai-Kai ground yellow-stalked tea powder, Shiitake fungi extract powder, Dansin leaf powder, Edible chondroitin powder Thus, a pharmaceutical composition having a wide range of indications can be prepared by blending appropriate components with good balance.

In particular, it is desirable to increase the blood flow to increase the natural healing power and to deliver the antioxidant to the affected area sufficiently.However, white chrysanthemum flower extract, evisugusa, and field ginseng should lower the blood viscosity. Thus, ginseng, rice ginseng, and cayca ground yellow stalk increase the elasticity of blood vessels, and ginseng, kaiky ground yellow stalk, ginkgo biloba and yamagiyu have the effect of increasing blood flow by lowering blood sugar levels. As a result, a synergistic effect of further improving the therapeutic effect in the affected area can be expected.

The action of each component blended in the above composition is as follows. Sanshu, which contains persolic acid and kunnic acid, has renal function enhancement, liver protection, lowers blood pressure, and is tonic, and is used for hepatic and renal function decline and urinary dysfunction. Ginseng produces resistance, enhances immunity, and enhances natural healing power. According to Shinnobu Herb, it is effective for cataracts, and saponin is also good for the optic nerve.

Megusulinoki is said to have the effect of detoxifying Seikan, the antipyretic effect of detoxification, stye, stye, liver disease, antibacterial activity, and control of the height of the liver.

Danjin ginseng powder, which contains flavonoids, saboyun, amino acids and minerals, has hepato-renal strengthening, fever, prevention of eye arteriosclerosis, hemostasis, and vitality.

Chimney powder, which contains flavonoids and limonene, has a digestive promoting effect, a stomachic-regulating effect, and has a protective effect on stomach leaning and discomfort.

Pearl shell powder is rich in minerals such as calcium carbonate, potassium, manganese, copper, zinc, magnesium, etc., and has an effect on erythema, corneal ulcer, cataract, and ocular fundus disease due to the effects of clearing eyes, improving visual acuity, and ulcer repair. Yes, it has the alias of "Year Pearl".

Edible chondroitin powder has the effect of hydrating the lens, rejuvenating and preventing retinal detachment due to aging.

Eighth eel enriched powder is rich in vitamins A, Ca, and iron, and is good for night blindness and strengthening the retina. Kaikai ground yellow tea powder contains carotenoids and vitamin A, and is effective in reducing blood renal function, reducing renal function, diabetes, and urinary dysfunction.

Shiitake mushroom extract powder improves liver function, protects liver cells, and improves immune function.

Chisato Mitsue is rich in calcium, iron, and magnesium, and is good for cataract, conjunctivitis, chronic retinopathy, corneal vitiligo, and opacity, as well as for seizures, as well as hypertension and autonomic imbalance. Works.

Dansan leaf powder is a powder of red ginseng, and red ginseng is also called “red ginseng”. It improves blood circulation and is effective for blood retention.

All of these are easily available at Chinese medicine stores. BEST MODE FOR CARRYING OUT THE INVENTION

In order to provide the composition containing the above components as a pharmaceutical composition in a form that can be ingested on a daily basis, it is most preferable to use a tablet for practical use. An example of the manufacturing method is as follows.

First, extracts are extracted from plant components such as white chrysanthemum flower extract, gugi, ebisdasa, yamayuyu, opapa, ginseng, and megusulinoki, and concentrated to obtain a flow extract. Add carp boiled powder, mamushi boiled powder, sheep boiled powder, rice field ginseng powder, chisato light powder, cock powder, etc. and mix. In addition, 8th eel enriched powder, Kai-Kai ground yellow stem tea powder, Shiitake mushroom extract powder, Dansan leaf powder, edible chondroitin powder, Pul ^^ Lee concentrated powder, astaxanthin, tomato extract powder, pearl shell powder, etc. Combine, add honey powder rich in protein, minerals and vitamins, and oligosaccharides, a nutrient of bifidobacteria, and compress. According to this method, a composition having a high ratio of the active ingredient can be obtained with little need for excipients.

Of the above components, particularly astaxanthin, it is desirable to mix in microcapsules for the following reasons.

① Astaxanthin exhibits a particularly strong ability to scavenge active oxygen. Eliminating active oxygen means that it scavenges active oxygen by itself and is easily oxidized. In air, it oxidizes and decolorizes in about one week, and loses its ability to scavenge active oxygen. In order to constantly ingest as a pharmaceutical composition, especially a household medicine, it must be assumed that the coagulant is stored in the home for several weeks to several months. Air contact must be cut off.

② Astaxanthin derived from natural products, which is approved for use as food, is extracted from crustaceans such as yeast, green algae, and krill, but has a peculiar strong odor. Deodorization is possible by purification using chromatography, but extremely expensive (purity

If it is set to 100%, it will be several million yen Kg), which is unsuitable for daily ingestion as a pharmaceutical composition.

③ Even if tablets are coated with shellac etc. and the odor is suppressed during ingestion, the returning odor due to burp etc. is strong, and it is desirable to enclose them in enteric capsules to eliminate this. Good. However, some of the ingredients that require the action of gastric juice, such as pearl mussel powder and Chisato Mitsue powder, cannot be encapsulated in whole tablets.

Not only astaxanthin, but also antioxidants that are themselves oxidized and lose their ability to scavenge active oxygen, are known to cause oxidative damage to living organisms. Therefore, it is extremely important to prevent oxidation during the storage period as described above. In addition, it is needless to say that it is desirable to shorten the contact time with air and digestive juices present in the intestine after dissolving the capsule. Therefore, it is desirable to prevent the oxidation during storage by encapsulating in a micro force capsule, and to minimize the time for emulsification until it is supplied in the intestine in the form of fine particles and can be absorbed. New

The above (1) is not limited to astaxanthin, but is a common problem for many carotenoids. In the case where coconut, / 3 carotene, lycopene, etc. are also blended, it is desirable to use micro force cells as necessary. However, it is difficult to encapsulate very viscous components such as lycopene in microcapsules. In addition, even if the encapsulated microcapsules are blended, there is a problem that the microcapsules are ruptured due to pressure during tableting.

For this reason, the above problem can be avoided by adsorbing on a fine powder of dextrin, silicon dioxide or the like, blending it as a carotenoid powder, or encapsulating in a microcapsule.

Test example

In order to see the effect of the composition of the present invention, the case where the animal bile and the antioxidant were taken together was compared with the case where only the animal bile was used and the case where the antioxidant was used alone. Each of the 30 patients with eye disorders such as tired eyes, blurred eyes, cataracts, and glaucoma was divided into three groups. Astaxanthin was administered as an antioxidant at 2 O mg / day, and the third group was administered carp bile 5 O mg and astaxanthin 2 O mg / day for 1 month. As a result, the percentage of patients who showed significant improvement was as follows. Obstacle mm Star Sanoten Carp £ L? Star Santen Waved eyes y υ o υ 丄 UU

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Blurred eyes 50 30 1 00

Cataract 40 40 90

Glaucoma 30 30 80

Macular degeneration 30 20 70 Combination example

The following table shows examples of compounding amounts when one tablet is added at 40 Omg with other ingredients added.

Example 1

Ingredients mg Ingredients mg Carp gall 25.0 Chimney powder 5.0 Ginseng 20.0 Snake ginseng 5.0 Field ginseng 40.0 White pearls 3.0 Pearls 30.0 Medsuri tree 3.0 Eight eyes eel 2.0 * Microcapsenole 40.0 White chrysanthemum flower 20.0 Wheat germ 3.0 Glucium 20.0 Shiitake fungi extract 5.0 Hub tea (Ebisudasa) 5.0 Dansin leaves 5.0 Kaikei ground yellow stalk tea 10.0 3.0 Oligosaccharides 3.0 Vitamin E 10.0 Sheep bile 15.0 Vitamin C 40.0 Pluveli 12.0 Anti-nose 5.0 Chondroitin 10.0 10.0Blood stomach 5.0 Honey 10.0 Excipient 8.0 Chisatomitsu 30.0

Total 400.0 * The microcapsules contain 12 mg of lycopene and 12 mg of astaxanthin, and the capsule film is 16 mg. Premature death

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Ingredients mg Ingredients mg Astaxanthin 12 Astaxanthin 12 Kobile 25 Lycopene 12 Blue Berry-20 Kobile 25 Medsuri tree 30 Ebisugusa 50 Mushroom 60 White chrysanthemum flower 50 Excipient 153 Excipient 151

Total 300 Total 300 Example 1 used microcapsules, Examples 4 and 5 used snake bile, and reduced the amount of antioxidants such as lycopene, astaxanthin, and vitamin C. In Example 67, the combination was simplified to about five types. The effect of taking the medicine is shown below based on the experience example that was used with the consent of the subject.

1. A. Lee 6 8 year old male

She was diagnosed one month after visual impairment in her left eye. She had poor vision and a dark shadow in the center of the visual field. Visual acuity decreased to 0.6 on the right and 0.2 on the left, and bleeding and bleeding were observed in the macula.The extent was about 1 PD, with hard bleeding under the macula and foveal fovea. Diagnosis of age-related macular degeneration (wet type) Refused.

When the tablet of Example 1 was taken at a rate of 2 tablets twice a day, visual acuity improved to 0.8 on the right and 0.3 on the left in one and a half months. Exudation of the macula was largely absorbed, and bleeding was partially absorbed. Two months later, visual acuity improved to 0.8 on the right and 0.4 on the left. Exudation and bleeding in the macula were absorbed.

2. S. Liu, 65, male

Right eye visual impairment She was diagnosed for one year. Visual acuity had decreased to the right 0.07 (1.5 left). Elliptical retinal atrophy spots on the ear side of the macula, with a range of about 4 PD, petechial hemorrhage and choroidal neovascularization in them, and diagnosis of age-related macular degeneration (atrophic type) in the right eye Was done.

When the tablet of Example 1 was taken at a rate of 2 tablets X 2 times / day, after one month, the visual acuity became 0.1 right and the central shadow was reduced, but there was no significant change in the fundus. Two months later, his visual acuity remained unchanged at 0.1, but his scotoma was thinner and his area was smaller.

3. H. Wang, 43, male

Suddenly I got a diagnosis that my left eye was not visible. Visual acuity was 1.5 on the right, but decreased to 0.05 on the left. There was optic disc edema in the fundus and marked dilation and meandering in the retinal veins. Small ecchymosis was also scattered in the right eye, and retinal vein occlusion was diagnosed.

When one tablet of Example 1 was taken 2 times X 2 times Z days, after one month, the visual acuity became 1.5 on the right and 0.1 on the left, partially absorbing fundus hemorrhage, dilated veins, meandering Also improved. Two months later, visual acuity remained at 1.5 on the right and 0.1 on the left, but bleeding of the fundus and exudation were further absorbed, and vascular morphology recovered. At the same time, blood pressure, cholesterol, triglycerides, blood sugar, etc. recovered to normal.

4. Y. Liu, 55, male

He was diagnosed with left eyesight impairment. About two years ago, my left eye suddenly disappeared, and at a hospital I was diagnosed with central retinal vein occlusion and received one month of hospitalization. However, the scotoma at the center of the left eye was too bad at the time of consultation, and I could not see anything clearly. Fundus examination showed retinal blood vessel torsion, vein dilation, 1Z2PD atrophy in the macula, and pigmentation The patient was diagnosed with retinal vein occlusion (macular lesion). Visual acuity was 1.2 on the right and 0.1 on the left.

When 2 tablets of Example 1 were taken twice per dose, after 2 months, the visual acuity was 1.2 on the right and 0.2 on the left, the central shadow was thin, and the object was deformed. The degree has also improved. The composition of Example 1 was initially prepared as a health supplement, but the results of trial use of these two cases at the Chunichi Friendship Clinic (Beijing) also helped to improve age-related macular degeneration. It has been found to have a high effect.

5. T.S. 6 2-year-old female

The central part of the visual field became invisible, and as a result of examination by an ophthalmologist, age-related macular degeneration was diagnosed. I was surprised to hear that it was recognized as the first cause of blindness internationally, but was shocked to explain that it was due to degeneration of pigment epithelial cells and that there was no cure for it. .

When the tablet of Example 1 was taken 4 tablets X 3 times a day, the visual field of the central part was opened from about the sixth month. In addition, around the 10th month, the patient had almost no subjective symptoms and was diagnosed with no fear of blindness.

6. A. J. 60-year-old woman

A diabetic retinopathy was announced that the likelihood of blindness was high. After taking the tablet of Example 5 for 6 months, no improvement was observed. When switching to taking the tablet of Example 1 from the seventh month, the following month saw a marked improvement, which surprised the ophthalmologist. Currently, blindness has escaped.

7 .S.I.5 5 year old woman

The cataract recommended surgery to the ophthalmologist. When taking the pill of Example 1, monthly diagnosis confirmed that the lens turbidity had gradually disappeared.In the third month, no operation was required because the lens turbidity was removed. I was relieved.

8. N.K. 6 7 year old male

The patient was diagnosed as diabetic cataract and recommended surgery. The tablet of Example 6 was taken for 3 months but no improvement was observed. Taking the tablet of Example 3 from the fourth month showed some improvement. When the tablet was switched to the tablet of Example 1 from the fifth month, a remarkable improvement was seen at about the sixth month, and the blood glucose level returned to almost normal. 9. OF 62 year old man

She was diagnosed with complications of cataract and glaucoma and was discouraged. The tablet of Example 4 was taken, but no improvement was observed even after 3 months. When switched to the tablet of Example 1 from the fourth month, cataracts and glaucoma also improved around the sixth month, which surprised the ophthalmologist.

10. Y.M. 56 year old male

She had narrow gaze due to glaucoma, and had difficulty working and living. Three months after starting to take the tablet of Example 2, the field of vision was widened, and as a result of the examination, glaucoma was remarkably improved, and there was no fear of blindness. .

11. M.O. 45-year-old woman

If she had been taking steroids for half a year due to rheumatism, she had been diagnosed with cataracts due to lens turbidity due to side effects of steroids. The steroid was discontinued, and the tablet of Example 3 was taken for 6 months. The patient recovered before cataract surgery was performed.

12. K. N. 61-year-old woman

For three months, she was diagnosed with pterodactylosis, a sign of retinal detachment and glaucoma. Taking the tablet of Example 4 three times a day three times a day, the fly mosquito disappeared in the third week.

13. Y.S. 35 year old male

When I went out, my eyes became reddened, and when I drank alcohol, my redness was even worse. He took the tablet of Example 5 three times a day, three tablets at a time, and one month later, he did not fully congest.

14. T.S. 35-year-old man

I started using computers, and my eyestrain became worse. The tablet of Example 6 was taken three to three times, three tablets at a time, and after one week, the eyes were no longer tired. He said that he was lightly congested and his visual acuity improved.

15. M.H. 50 year old man

The eyes were blurred and the newspaper was hard to read. Taking the tablet of Example 6 four times a day three times a day, the haze was removed only on the third day.

16. K. Y. 58-year-old woman

My tears didn't stop and my eyesight dropped from 1.0 to 0.2. Taking the tablet of Example 7 three times a day, four tablets at a time, tears stopped after two weeks. After about a month of taking it, My eyesight has recovered to 0.5.

17. T. T. 65-year-old woman

My eyes and eyes were worried. The tablet of Example 7 was taken three times a day, three tablets at a time, and stopped abruptly one week later. Industrial applicability

As described above, the pharmaceutical composition of the present invention has many synergistic effects between herbal medicines introduced from Kampo medicine and antioxidants, has no fear of side effects, and is considered to be an intractable disease of many eye diseases, especially age-related eye diseases. It has an unprecedented effect in that macular degeneration also has an improving effect.

Claims

The scope of the claims

(1) A pharmaceutical composition for improving eye diseases and maintaining eye function, comprising vitamin bile or oral tinoid as an antioxidant added to an animal bile having a clear liver action.

2. A pharmaceutical composition for improving ocular diseases and maintaining eye function, wherein the composition according to claim 1 is blended with concentrated pruberry.

3. The pharmaceutical composition for improving ocular diseases and maintaining ocular function, wherein the animal gall of claim 1 is carp gall, viper gall, and sheep gall.

(4) The antioxidant of claim 1, which is appropriately selected and blended from antioxidants including vitamin C, vitamin E, astaxanthin, and lycopene, for improving ocular diseases and for eye functions. Pharmaceutical composition for maintenance

(5) A pharmaceutical composition for improving ocular diseases and maintaining ocular function, characterized in that pearl mussel powder is further added to the composition according to any one of (1) to (4).

(6) The composition according to any one of (1) to (5), wherein Ebisugusa, and Chisato Mitsue and / or Oobaco are blended as ingredients for Ameyomyei, for improving ocular diseases and maintaining eye function. Pharmaceutical composition for

7.A medicament for improving ocular diseases and maintaining ocular function, wherein the composition according to any one of claims 1 to 6 is combined with Shiragiku flower as a seizure liver fever and Mushroom as a hepatotropic agent. Composition

8 The composition according to any one of claims 1 to 7, further comprising Sanshu, Ginseng, Megusulinoki, Rice field, Chimpi powder, Eight-thick eel enriched powder, Kaikei ground yellow stem tea powder, Shiitake fungi extract powder , A pharmaceutical composition for improving ocular diseases and maintaining ocular function, characterized by combining the appropriate components of: ginseng leaf powder, edible chondroitin powder, and

9. The pharmaceutical composition according to any one of claims 1 to 8, wherein the carotenoid is encapsulated in a microcapsule and is blended. Wherein the carotenoid encapsulated in the microcapsules is astaxanthin or lycopene, and is a pharmaceutical composition for improving ocular diseases and maintaining ocular function. 11. The pharmaceutical composition according to claim 10, wherein the carotenoid is formulated into a powder form by adsorbing the carotenoid on a carrier, and the composition is used for improving ocular diseases and maintaining eye function.

12. The pharmaceutical composition according to claim 10, wherein the carotenoid is adsorbed on a carrier, converted into a powder form, and encapsulated in a microforce capsule. Composition

13.The pharmaceutical composition according to any one of claims 1 to 12, wherein the eye disease to be improved is macular degeneration.