WO2003008379A1 - Composes azasucre - Google Patents

Composes azasucre Download PDF

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Publication number
WO2003008379A1
WO2003008379A1 PCT/JP2002/005672 JP0205672W WO03008379A1 WO 2003008379 A1 WO2003008379 A1 WO 2003008379A1 JP 0205672 W JP0205672 W JP 0205672W WO 03008379 A1 WO03008379 A1 WO 03008379A1
Authority
WO
WIPO (PCT)
Prior art keywords
optionally substituted
alkyl
hydrogen
compounds
sugar chain
Prior art date
Application number
PCT/JP2002/005672
Other languages
English (en)
French (fr)
Inventor
Osamu Kanie
Chikako Saotome
Original Assignee
Mitsubishi Chemical Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chemical Corporation filed Critical Mitsubishi Chemical Corporation
Priority to JP2003513939A priority Critical patent/JP4363183B2/ja
Publication of WO2003008379A1 publication Critical patent/WO2003008379A1/ja
Priority to US10/726,550 priority patent/US7288565B2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
PCT/JP2002/005672 2001-06-08 2002-06-07 Composes azasucre WO2003008379A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2003513939A JP4363183B2 (ja) 2001-06-08 2002-06-07 アザ糖化合物
US10/726,550 US7288565B2 (en) 2001-06-08 2003-12-04 Azasugar compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001173855 2001-06-08
JP2001-173855 2001-06-08

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/726,550 Continuation-In-Part US7288565B2 (en) 2001-06-08 2003-12-04 Azasugar compound

Publications (1)

Publication Number Publication Date
WO2003008379A1 true WO2003008379A1 (fr) 2003-01-30

Family

ID=19015240

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/005672 WO2003008379A1 (fr) 2001-06-08 2002-06-07 Composes azasucre

Country Status (3)

Country Link
US (1) US7288565B2 (ja)
JP (1) JP4363183B2 (ja)
WO (1) WO2003008379A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7288565B2 (en) 2001-06-08 2007-10-30 Mitsubishi Chemical Corporation Azasugar compound
JP2012502884A (ja) * 2008-09-16 2012-02-02 サイモン フレイザー ユニバーシティ 選択的グリコシダーゼ阻害剤およびその使用
JP2013544841A (ja) * 2010-12-01 2013-12-19 ヤンセン ファーマシューティカ エヌ.ベー. Ccr2の4−置換シクロヘキシルアミノ−4−ピペリジニル−アセトアミドアンタゴニスト

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7456222B2 (en) * 2002-05-17 2008-11-25 Sequella, Inc. Anti tubercular drug: compositions and methods
US20040033986A1 (en) * 2002-05-17 2004-02-19 Protopopova Marina Nikolaevna Anti tubercular drug: compositions and methods
CN101404986B (zh) * 2002-05-17 2011-09-28 赛奎拉公司 用于诊断和治疗感染性疾病的组合物和制药方法
WO2005034857A2 (en) * 2003-09-05 2005-04-21 Sequella, Inc. Methods and compositions comprising diamines as new anti-tubercular therapeutics
US20050256168A1 (en) * 2004-04-28 2005-11-17 Block Timothy M Compositions for oral administration for the treatment of interferon-responsive disorders
EP1813119B1 (en) 2004-11-16 2019-01-09 Thomson Licensing Film grain sei message insertion for bit-accurate simulation in a video system
US20070088164A1 (en) * 2005-09-02 2007-04-19 Moriarity Robert M Combinatorial library approach to iminocyclitols with biological activity
FR2902097A1 (fr) * 2006-06-13 2007-12-14 Univ Joseph Fourier Etablissem Nouveau procede de preparation de nitrones et de n-hydroxylamines comportant au moins un groupe hydroxyle, et produits tels qu'obtenus
GB0614947D0 (en) * 2006-07-27 2006-09-06 Isis Innovation Epitope reduction therapy
US8957106B2 (en) * 2007-04-24 2015-02-17 The Chancellor, Masters And Scholars Of The University Of Oxford Iminosugar treatment of tumors
US20090281054A1 (en) * 2008-05-06 2009-11-12 Venkata Reddy Compositions and methods comprising capuramycin analogues
CN102131813B (zh) 2008-06-24 2014-07-30 科德克希思公司 用于制备基本上立体异构纯的稠合二环脯氨酸化合物的生物催化方法
WO2012083435A1 (en) 2010-12-23 2012-06-28 Alectos Therapeutics, Inc. Selective glycosidase inhibitors and uses thereof
EP2691407B1 (en) 2011-03-31 2017-02-22 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2013000086A1 (en) 2011-06-27 2013-01-03 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2014032185A1 (en) 2012-08-31 2014-03-06 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
EP2890675A4 (en) 2012-08-31 2016-01-13 Alectos Therapeutics Inc GLYCOSIDASE INHIBITORS AND USES THEREOF
WO2014067003A1 (en) 2012-10-31 2014-05-08 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04502619A (ja) * 1989-01-13 1992-05-14 ニユコメド・アクシエセルカペト 複素環式キレート化剤
WO1995024392A1 (en) * 1994-03-08 1995-09-14 G. D. Searle & Co. 2-chloro and 2-bromo derivatives of 1,5-iminosugars
WO2000068194A1 (en) * 1999-05-11 2000-11-16 The Scripps Research Institute Iminocyclitol inhibitors of hexoaminidase and glycosidase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003008379A1 (fr) 2001-06-08 2003-01-30 Mitsubishi Chemical Corporation Composes azasucre

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04502619A (ja) * 1989-01-13 1992-05-14 ニユコメド・アクシエセルカペト 複素環式キレート化剤
WO1995024392A1 (en) * 1994-03-08 1995-09-14 G. D. Searle & Co. 2-chloro and 2-bromo derivatives of 1,5-iminosugars
WO2000068194A1 (en) * 1999-05-11 2000-11-16 The Scripps Research Institute Iminocyclitol inhibitors of hexoaminidase and glycosidase

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
CAMPANINI, LAURENCE ET AL.: "Concise synthesis of new homoaza sugars. Fully substituted, functionally diverse pyrrolidines", TETRAHEDRON LETT., vol. 36, no. 44, 1995, pages 8015 - 8018, XP002955067 *
CAMPANINI, LAURENCE ET AL.: "One step synthesis of sulfur and nitrogen linked aza-disaccharide precursors from D-mannitol derived bis-aziridines", TETRAHEDRON LETT., vol. 37, no. 29, 1996, pages 5095 - 5098, XP004029598 *
FITREMANN, JULIETTE ET AL.: "2,5-Disubstituted pyrrolidines from D-mannitol-derived bis-aziridines", TETRAHEDRON LETT., vol. 35, no. 8, 1994, pages 1201 - 1204, XP002955070 *
FITREMANN, JULIETTE ET AL.: "Regioselective cyanide ring opening of C2 symmetric bis-aziridines by cyanide", SYNLETT, no. 3, 1995, pages 235 - 237, XP002955068 *
HERMETTER, ALBIN ET AL.: "Powerful probes for glycosidases novel, fluorescently tagged glycosidase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 10, 2001, pages 1339 - 1342, XP002955060 *
JANDA, KIM D. ET AL.: "Chemical selection for catalysis in combinatorial antibody libraries", SCIENCE, vol. 275, no. 5302, 1997, WASHINGTON, D.C., pages 945 - 948, XP001084162 *
KANG, SUNG HO ET AL.: "Intramolecular cyclization of C2 symmetric and meso-iodo amino alcohols: a synthetic approach to azasugars", TETRAHEDRON LETTERS, vol. 38, no. 4, 1997, pages 607 - 610, XP002955065 *
MCCORT, ISABELLE ET AL.: "Practical route to D-gluco aza sugars from C2 symmetric bis-aziridines", TETRAHEDRON LETTERS, vol. 37, no. 43, 1996, pages 7717 - 7720, XP002955066 *
MCCORT, ISABELLE ET AL.: "Synthesis and evaluation as glycosidase inhibitors of 2,5-imino-D-glucitol and 1,5-imino-D-mannitol related derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 8, no. 1, 2000, pages 135 - 143, XP002955062 *
MCCORT, ISABELLE ET AL.: "Synthesis of ester- and amide-linked pseudo-azadisaccharides via coupling of D-glucose with 6-amino-6-deoxy-2,5-imino-D-glucitol", TETRAHEDRON LETTERS, vol. 39, no. 25, 1998, pages 4463 - 4466, XP002955064 *
REYNOLDS, ROBERT C. ET AL.: "Ethambutol-sugar hybrids as potential inhibitors of mycobacterial cell-wall biosynthesis", CARBOHYDRATE RESEARCH, vol. 317, no. 1-4, 1999, pages 164 - 179, XP004180003 *
SCHUMACHER-WANDERSLEB, MICHAEL H.M.G. ET AL.: "Preparation of the N-acetylglucosaminidase inhibitor 1-acetamido-1,2,5-trideoxy-2,5-imino-D-glucitol from methyl .alpha.-D-mannopyranoside", LIEBIGS ANN. CHEM., no. 6, 1994, pages 555 - 561, XP002955069 *
WONG, CHI-HUEY ET AL.: "Synthesis and evaluation of homoaza sugars as glycosidase inhibitors", J. ORG. CHEM., vol. 60, no. 6, 1995, pages 1492 - 1501, XP002955063 *
WRODNIGG, T.M. ET AL.: "Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful .beta.-glucosidase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 8, 2001, pages 1063 - 1064, XP002955059 *
WRODNIGG, TANJA M. ET AL.: "Biologically active 1-aminodeoxy and 1-0-alkyl derivatives of the powerful D-glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol", JOURNAL OF CARBOHYDRATE CHEMISTRY, vol. 19, no. 8, 2000, pages 975 - 990, XP002955061 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7288565B2 (en) 2001-06-08 2007-10-30 Mitsubishi Chemical Corporation Azasugar compound
JP2012502884A (ja) * 2008-09-16 2012-02-02 サイモン フレイザー ユニバーシティ 選択的グリコシダーゼ阻害剤およびその使用
JP2013544841A (ja) * 2010-12-01 2013-12-19 ヤンセン ファーマシューティカ エヌ.ベー. Ccr2の4−置換シクロヘキシルアミノ−4−ピペリジニル−アセトアミドアンタゴニスト

Also Published As

Publication number Publication date
JPWO2003008379A1 (ja) 2004-11-04
JP4363183B2 (ja) 2009-11-11
US20040147591A1 (en) 2004-07-29
US7288565B2 (en) 2007-10-30

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