WO2002086511A3 - VERFAHREN ZUR UNTERSUCHUNG VON PRION-PROTEIN ENTHALTENDEN PROBEN AUF DAS EVENTUELLE VORLIEGEN DER PrPSc-FORM - Google Patents

VERFAHREN ZUR UNTERSUCHUNG VON PRION-PROTEIN ENTHALTENDEN PROBEN AUF DAS EVENTUELLE VORLIEGEN DER PrPSc-FORM Download PDF

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Publication number
WO2002086511A3
WO2002086511A3 PCT/EP2002/004341 EP0204341W WO02086511A3 WO 2002086511 A3 WO2002086511 A3 WO 2002086511A3 EP 0204341 W EP0204341 W EP 0204341W WO 02086511 A3 WO02086511 A3 WO 02086511A3
Authority
WO
WIPO (PCT)
Prior art keywords
prion protein
protease
prpsc
sample
samples containing
Prior art date
Application number
PCT/EP2002/004341
Other languages
English (en)
French (fr)
Other versions
WO2002086511A2 (de
Inventor
Karin Biffiger
Markus Moser
Bruno Oesch
Original Assignee
Prionics Ag
Karin Biffiger
Markus Moser
Bruno Oesch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prionics Ag, Karin Biffiger, Markus Moser, Bruno Oesch filed Critical Prionics Ag
Priority to NZ527233A priority Critical patent/NZ527233A/en
Priority to US10/474,107 priority patent/US20040115752A1/en
Priority to JP2002583988A priority patent/JP2004528561A/ja
Priority to EP02737971A priority patent/EP1381868A2/de
Priority to CA002437880A priority patent/CA2437880A1/en
Publication of WO2002086511A2 publication Critical patent/WO2002086511A2/de
Publication of WO2002086511A3 publication Critical patent/WO2002086511A3/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Ein Verfahren zur Untersuchung von Prion-Protein enthaltenden Proben auf das eventuelle Vorliegen der PrPSc-Form, bei dem (Schritt a) die Probe mit Protease versetzt wird zur Verdauung Protease sensitiver Proteine bzw. Proteinbereiche, die Probe (Schritt b) nach Verdauung darauf überprüft wird, ob in ihr der Bereich PrP 27-30 des Prion-Proteins enthalten ist, der in der PrPSc-Form des Prion-Proteins Protease resistent ist und aus dem positiven Nachweis von PrP 27-30 auf das Vorliegen von PrPSc in der Probe geschlossen wird, ist dadurch gekennzeichnet, dass im Schritt b) die Probe zusätzlich darauf überprüft wird, ob eine vollständige Verdauung des Protease sensitiven Bereichs des Prion-Proteins stattgefunden hat.
PCT/EP2002/004341 2001-04-21 2002-04-19 VERFAHREN ZUR UNTERSUCHUNG VON PRION-PROTEIN ENTHALTENDEN PROBEN AUF DAS EVENTUELLE VORLIEGEN DER PrPSc-FORM WO2002086511A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
NZ527233A NZ527233A (en) 2001-04-21 2002-04-19 Method for testing samples containing prion protein for the possible presence of PrPSc 27-30
US10/474,107 US20040115752A1 (en) 2001-04-21 2002-04-19 Method for testing samples containing prion protein for the possible presence of the prpsc form
JP2002583988A JP2004528561A (ja) 2001-04-21 2002-04-19 プリオンタンパク質含有サンプルをＰｒＰＳｃ型の存在可能性について試験する方法
EP02737971A EP1381868A2 (de) 2001-04-21 2002-04-19 VERFAHREN ZUR UNTERSUCHUNG VON PRION-PROTEIN ENTHALTENDEN PROBEN AUF DAS EVENTUELLE VORLIEGEN DER PrP?Sc -FORM
CA002437880A CA2437880A1 (en) 2001-04-21 2002-04-19 Method for testing samples containing prion protein for the possible presence of the prpsc form

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10119713A DE10119713A1 (de) 2001-04-21 2001-04-21 Verfahren zur Untersuchung von Prion-Protein enthaltenden Proben auf das eventuelle Vorliegen der PrPSc-Form
DE10119713.6 2001-04-21

Publications (2)

Publication Number Publication Date
WO2002086511A2 WO2002086511A2 (de) 2002-10-31
WO2002086511A3 true WO2002086511A3 (de) 2003-07-24

Family

ID=7682316

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/004341 WO2002086511A2 (de) 2001-04-21 2002-04-19 VERFAHREN ZUR UNTERSUCHUNG VON PRION-PROTEIN ENTHALTENDEN PROBEN AUF DAS EVENTUELLE VORLIEGEN DER PrPSc-FORM

Country Status (7)

Country Link
US (1) US20040115752A1 (de)
EP (1) EP1381868A2 (de)
JP (1) JP2004528561A (de)
CA (1) CA2437880A1 (de)
DE (1) DE10119713A1 (de)
NZ (1) NZ527233A (de)
WO (1) WO2002086511A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2849204B1 (fr) 2002-12-20 2005-02-11 Afssa Procede de detection de la prpsc utilisant un antibiotique d de la famille des aminoglycosides pour l'elimination et la detection de la prpsc dans des echantillons biologiques
FR2849205B1 (fr) 2002-12-20 2005-02-11 Afssa Procede d'amplification de la detection de la prpsc et utilisation d'un ligand adjuvant macrocyclique pour une telle amplification
FR2865280B1 (fr) 2004-01-20 2007-01-12 Biomerieux Sa Procede de detection de la prp utilisant une molecule ayant au moins une charge positive et/ou au moins une liaison osidique et un ligand autre qu'un ligand proteique
EP1596199A1 (de) * 2004-05-14 2005-11-16 Prionics AG Verfahren zum Nachweis von pathogenen Prionenproteinen.
DE602005007458D1 (de) * 2004-11-15 2008-07-24 Roche Diagnostics Gmbh Hoch-Durchsatz Prion Tests
FR2888937B1 (fr) 2005-07-21 2012-10-26 Biomerieux Sa Procede de detection des fcpa utilisant un agent d'agregation des fcpa et un agent de capture des agregats formes
DE102007016324A1 (de) * 2007-04-04 2008-10-09 Priontype Gmbh & Co.Kg Verfahren zum Nachweis von pathologisch verändertem Prion-Protein (PrPSc)
WO2010084201A1 (en) * 2009-01-26 2010-07-29 Commissariat A L'energie Atomique Et Aux Energies Alternatives Novel derivative of erythromycin for the treatment and diagnosis of prion disease

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035236A2 (en) * 1997-02-06 1998-08-13 Enfer Technology Limited Immunological assay for spongiform encephalopathies
FR2774988A1 (fr) * 1998-02-16 1999-08-20 Commissariat Energie Atomique Procede de purification de la prpres a partir d'un echantillon biologique et ses applications
WO2000029850A1 (en) * 1998-11-17 2000-05-25 Wallac Oy An immunoassay for the determination of transmissible spongiform encephalopathies in bovine
WO2001023425A1 (en) * 1999-09-28 2001-04-05 Universität Zürich Factors having prion-binding activity in serum and plasma and agents to detect transmissible spongiform encephalopathitis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035236A2 (en) * 1997-02-06 1998-08-13 Enfer Technology Limited Immunological assay for spongiform encephalopathies
FR2774988A1 (fr) * 1998-02-16 1999-08-20 Commissariat Energie Atomique Procede de purification de la prpres a partir d'un echantillon biologique et ses applications
WO2000029850A1 (en) * 1998-11-17 2000-05-25 Wallac Oy An immunoassay for the determination of transmissible spongiform encephalopathies in bovine
WO2001023425A1 (en) * 1999-09-28 2001-04-05 Universität Zürich Factors having prion-binding activity in serum and plasma and agents to detect transmissible spongiform encephalopathitis

Also Published As

Publication number Publication date
JP2004528561A (ja) 2004-09-16
NZ527233A (en) 2005-07-29
DE10119713A1 (de) 2002-10-24
EP1381868A2 (de) 2004-01-21
CA2437880A1 (en) 2002-10-31
US20040115752A1 (en) 2004-06-17
WO2002086511A2 (de) 2002-10-31

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