WO2002085520A3 - Verfahren und vorrichtung zur manipulation kleiner flüssigkeitsmengen auf oberflächen - Google Patents

Verfahren und vorrichtung zur manipulation kleiner flüssigkeitsmengen auf oberflächen Download PDF

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Publication number
WO2002085520A3
WO2002085520A3 PCT/EP2002/004545 EP0204545W WO02085520A3 WO 2002085520 A3 WO2002085520 A3 WO 2002085520A3 EP 0204545 W EP0204545 W EP 0204545W WO 02085520 A3 WO02085520 A3 WO 02085520A3
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WO
WIPO (PCT)
Prior art keywords
liquid
small amounts
intermediate area
manipulating small
height
Prior art date
Application number
PCT/EP2002/004545
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English (en)
French (fr)
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WO2002085520A2 (de
Inventor
Achim Wixforth
Original Assignee
Advalytix Ag
Achim Wixforth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advalytix Ag, Achim Wixforth filed Critical Advalytix Ag
Priority to US10/475,957 priority Critical patent/US7198813B2/en
Priority to EP02732662A priority patent/EP1381467A2/de
Publication of WO2002085520A2 publication Critical patent/WO2002085520A2/de
Publication of WO2002085520A3 publication Critical patent/WO2002085520A3/de

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/023—Sending and receiving of information, e.g. using bluetooth
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0493—Specific techniques used
    • B01L2400/0496—Travelling waves, e.g. in combination with electrical or acoustic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/088—Passive control of flow resistance by specific surface properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24479—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Coating Apparatus (AREA)
  • Absorbent Articles And Supports Therefor (AREA)

Abstract

Die Erfindung betrifft Verfahren und Vorrichtungen zur Manipulation kleiner Flüssigkeitsmengen (1) auf Oberflächen, vorzugsweise auf Chipoberflächen. Erfindungsgemäss wird eine durch ihre Oberflächenspannung zusammengehaltene Flüssigkeitsmenge auf einen Bereich einer Oberfläche mit zumindest einem Zwischenbereich (3,4) gebracht, der zumindest in einer lateralen Raumrichtung an einen Führungsstreifen (5,6) angrenzt. Erfindungsgemäss haben entweder die Führungsstreifen (5,6) gegenüber dem Zwischenbereich (3,4) derartig unterschiedliche Oberflächenbeschaffenheit, dass sie von einer Flüssigkeit stärker benetzt werden, oder der Zwischenbereich (3,4) ist gegenüber der Führungsstreifen (5,6) erhaben, wobei die Höhe der Stufe klein gegenüber der Höhe der Flüssigkeitsmenge (1) ist.
PCT/EP2002/004545 2001-04-24 2002-04-24 Verfahren und vorrichtung zur manipulation kleiner flüssigkeitsmengen auf oberflächen WO2002085520A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/475,957 US7198813B2 (en) 2001-04-24 2002-04-24 Method and device for manipulating small amounts of liquid on surfaces
EP02732662A EP1381467A2 (de) 2001-04-24 2002-04-24 Verfahren und vorrichtung zur manipulation kleiner flüssigkeitsmengen auf oberflächen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10120035.8 2001-04-24
DE10120035A DE10120035B4 (de) 2001-04-24 2001-04-24 Verfahren und Vorrichtung zur Manipulation kleiner Flüssigkeitsmengen auf Oberflächen

Publications (2)

Publication Number Publication Date
WO2002085520A2 WO2002085520A2 (de) 2002-10-31
WO2002085520A3 true WO2002085520A3 (de) 2003-03-27

Family

ID=7682517

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/004545 WO2002085520A2 (de) 2001-04-24 2002-04-24 Verfahren und vorrichtung zur manipulation kleiner flüssigkeitsmengen auf oberflächen

Country Status (4)

Country Link
US (1) US7198813B2 (de)
EP (1) EP1381467A2 (de)
DE (1) DE10120035B4 (de)
WO (1) WO2002085520A2 (de)

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Publication number Priority date Publication date Assignee Title
DE10117772C2 (de) * 2001-04-09 2003-04-03 Advalytix Ag Mischvorrichtung und Mischverfahren für die Durchmischung kleiner Flüssigkeitsmengen
DE10164357B4 (de) * 2001-12-28 2005-11-10 Advalytix Ag Titrationsverfahren
EP1628906A1 (de) 2003-05-23 2006-03-01 Gyros Patent Ab Auf nichtbenetzbaren flächen basierende funktionen
DE10326607A1 (de) * 2003-06-13 2005-01-05 Steag Microparts Gmbh Vorrichtung zum Handhaben von Flüssigkeiten
DE102004037348A1 (de) * 2004-08-02 2006-03-16 Infineon Technologies Ag Fluid-Transport-Vorrichtung, Sensor-Anordnung, Fluid-Misch-Vorrichtung und Verfahren zum Herstellen einer Fluid-Transport-Vorrichtung
US20070062594A1 (en) * 2005-09-16 2007-03-22 Extrand Charles W Microfluidic device with anisotropic wetting surfaces
US20070065702A1 (en) * 2005-09-16 2007-03-22 Extrand Charles W Fuel cell with anisotropic wetting surfaces
US20070065637A1 (en) * 2005-09-16 2007-03-22 Extrand Charles W Carrier with anisotropic wetting surfaces
WO2007066478A1 (ja) * 2005-12-08 2007-06-14 Olympus Corporation 反応容器及び分析装置
JP2007232522A (ja) * 2006-02-28 2007-09-13 Olympus Corp 攪拌装置と分析装置
CN101516510B (zh) * 2006-08-03 2012-11-28 安捷伦科技有限公司 无通道流体样品运输介质
DE102007013688B3 (de) 2007-03-22 2008-11-06 Odelo Gmbh Optoelektronische Sensoreinrichtung und Verfahren zur Bestimmung der Transparenz einer Verschmutzungen ausgesetzten Oberfläche
FR2950544B1 (fr) 2009-09-29 2011-12-09 Ecole Polytech Circuit microfluidique
WO2015191534A2 (en) 2014-06-09 2015-12-17 Ascent Bio-Nano Technologies, Inc. System for manipulation and sorting of particles
US9645385B2 (en) * 2014-06-26 2017-05-09 Amazon Technologies, Inc. Methods and apparatuses for fabricating electrowetting displays

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EP0392678A2 (de) * 1989-03-20 1990-10-17 Xerox Corporation Verfahren und Vorrichtung zum Transport von Ionen in einem Trägergas
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US4233029A (en) * 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
EP0392678A2 (de) * 1989-03-20 1990-10-17 Xerox Corporation Verfahren und Vorrichtung zum Transport von Ionen in einem Trägergas
US5885527A (en) * 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
US5707799A (en) * 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
EP0905515A2 (de) * 1997-09-25 1999-03-31 Basf Aktiengesellschaft Analytisches Messverfahren und seine Verwendung
DE19748295A1 (de) * 1997-10-31 1999-05-06 Max Planck Gesellschaft Element mit extrem stark wasserabweisenden Trockenzonen an der Oberfläche
FR2783179A1 (fr) * 1998-09-16 2000-03-17 Commissariat Energie Atomique Dispositif d'analyse chimique ou biologique comprenant une pluralite de sites d'analyse sur un support, et son procede de fabrication
US20020031835A1 (en) * 2000-05-12 2002-03-14 University Of Delaware Laboratory-on-a-chip device using wetting forces and thermal marangoni pumping
WO2002030562A1 (en) * 2000-10-10 2002-04-18 Aviva Biosciences Corporation An integrated biochip system for sample preparation and analysis
WO2002076878A2 (en) * 2001-02-09 2002-10-03 Wisconsin Alumni Research Foundation Method and structure for microfluidic flow guiding
GB2374818A (en) * 2001-04-23 2002-10-30 Secr Defence Hydrophobic and hydrophilic surface, for promoting droplet formation

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Also Published As

Publication number Publication date
US20040180130A1 (en) 2004-09-16
WO2002085520A2 (de) 2002-10-31
DE10120035A1 (de) 2002-11-14
EP1381467A2 (de) 2004-01-21
DE10120035B4 (de) 2005-07-07
US7198813B2 (en) 2007-04-03

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