WO2002076925A3 - Composes d'aryl alkylamines non imidazole comme antagonistes des recepteurs h3 de l'histamine, preparation et applications therapeutiques - Google Patents

Composes d'aryl alkylamines non imidazole comme antagonistes des recepteurs h3 de l'histamine, preparation et applications therapeutiques Download PDF

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Publication number
WO2002076925A3
WO2002076925A3 PCT/US2002/006644 US0206644W WO02076925A3 WO 2002076925 A3 WO2002076925 A3 WO 2002076925A3 US 0206644 W US0206644 W US 0206644W WO 02076925 A3 WO02076925 A3 WO 02076925A3
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WIPO (PCT)
Prior art keywords
histamine
compounds
imidazole
preparation
receptor antagonists
Prior art date
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PCT/US2002/006644
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English (en)
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WO2002076925A2 (fr
Inventor
Lisa Selsam Beavers
Robert Alan Gadski
Philip Arthur Hipskind
Craig William Lindsley
Karen Lynn Lobb
James Arthur Nixon
Richard Todd Pickard
John Mehnert Schaus
Takako Takakuwa
Brian Morgan Watson
Original Assignee
Lilly Co Eli
Lisa Selsam Beavers
Robert Alan Gadski
Philip Arthur Hipskind
Craig William Lindsley
Karen Lynn Lobb
James Arthur Nixon
Richard Todd Pickard
John Mehnert Schaus
Takako Takakuwa
Brian Morgan Watson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Lilly Co Eli, Lisa Selsam Beavers, Robert Alan Gadski, Philip Arthur Hipskind, Craig William Lindsley, Karen Lynn Lobb, James Arthur Nixon, Richard Todd Pickard, John Mehnert Schaus, Takako Takakuwa, Brian Morgan Watson filed Critical Lilly Co Eli
Priority to JP2002576188A priority Critical patent/JP2004532834A/ja
Priority to EP02723329A priority patent/EP1379493A2/fr
Priority to CA002441080A priority patent/CA2441080A1/fr
Priority to AU2002254114A priority patent/AU2002254114A1/en
Priority to US10/472,675 priority patent/US7314937B2/en
Publication of WO2002076925A2 publication Critical patent/WO2002076925A2/fr
Publication of WO2002076925A3 publication Critical patent/WO2002076925A3/fr

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
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    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/73—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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Abstract

L'invention concerne de nouveaux composés d'aryl alkylamine substitués représentés par la formule (I), ou des sels pharmaceutiquement acceptables de ceux-ci, qui possèdent une activité sélective d'antagoniste des récepteurs H3 de l'histamine, ainsi que des procédés de préparation de ces composés. Dans une autre forme de réalisation, l'invention concerne des compositions pharmaceutiques contenant de telles amines cycliques, ainsi que des procédés d'utilisation de celles-ci pour traiter l'obésité et d'autres maladies associées aux récepteurs H3 de l'histamine.
PCT/US2002/006644 2001-03-23 2002-03-21 Composes d'aryl alkylamines non imidazole comme antagonistes des recepteurs h3 de l'histamine, preparation et applications therapeutiques WO2002076925A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2002576188A JP2004532834A (ja) 2001-03-23 2002-03-21 ヒスタミンｈ３受容体アンタゴニストである非イミダゾール系アリールアルキルアミン化合物、その製造および治療的使用
EP02723329A EP1379493A2 (fr) 2001-03-23 2002-03-21 Composes d'aryl alkylamines non imidazole comme antagonistes des recepteurs h3 de l'histamine, preparation et applications therapeutiques
CA002441080A CA2441080A1 (fr) 2001-03-23 2002-03-21 Composes d'aryl alkylamines non imidazole comme antagonistes des recepteurs h3 de l'histamine, preparation et applications therapeutiques
AU2002254114A AU2002254114A1 (en) 2001-03-23 2002-03-21 Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses
US10/472,675 US7314937B2 (en) 2002-03-21 2002-03-21 Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses

Applications Claiming Priority (2)

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US27823001P 2001-03-23 2001-03-23
US60/278,230 2001-03-23

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WO2002076925A2 WO2002076925A2 (fr) 2002-10-03
WO2002076925A3 true WO2002076925A3 (fr) 2003-09-18

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JP (1) JP2004532834A (fr)
AU (1) AU2002254114A1 (fr)
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WO (1) WO2002076925A2 (fr)

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