WO2002074744A1 - Oxoammoniumsalze sowie deren verwendung - Google Patents
Oxoammoniumsalze sowie deren verwendung Download PDFInfo
- Publication number
- WO2002074744A1 WO2002074744A1 PCT/EP2002/002762 EP0202762W WO02074744A1 WO 2002074744 A1 WO2002074744 A1 WO 2002074744A1 EP 0202762 W EP0202762 W EP 0202762W WO 02074744 A1 WO02074744 A1 WO 02074744A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oxoammonium
- oxoammonium salt
- salt according
- group
- alcohols
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/50—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
Definitions
- the invention relates to new oxoammonium salts, their use and new oxidation processes.
- oxoammonium salts are known as reactive intermediates in oxidations using the 2,2,6,6-tetramethylpiperidinoxyl radical (TEMPO), which is also described as polymer-bound (review: Arjan EJ de Nooy, Arie C. Besemer, Hermann van Bekkum, Synthesis 1996, 1153).
- TEMPO 2,2,6,6-tetramethylpiperidinoxyl radical
- the TEMPO is first converted into the corresponding oxoammonium salt by a cooxidant (e.g. NaOCI), which then oxidizes the substrate to be oxidized in the same reaction batch.
- a cooxidant e.g. NaOCI
- a disadvantage that arises from the use of this radical especially in the case of the desired oxidation of alcohols to aldehydes, is the overoxidation of aldehydes to carboxylic acids.
- Another disadvantage that the use of TEMPO brings with it in oxidation reactions is the low reactivity towards non-benz
- TEMPO precursor 1-hydroxy-4-oxo-2,2,6,6-tetramethylpiperidine which is bound to silica gel
- this is first converted into TEMPO by a cooxidant, which then - presumably via an intermediate, non-isolated oxoammonium intermediate stage - oxidizes the substrate to be oxidized (Carsten Bolm, Thomas Fey, Chem. Commun., 1999, 1795-1796 ).
- Alcohols are oxidized, but the yields, especially in the oxidation of secondary alcohols, leave something to be desired.
- DMSO dimethyl sulfoxide
- Periodinans and various heavy metal reagents the latter mostly based on either chromium or ruthenium oxides.
- the object of the invention is therefore to provide new compounds which can be used as oxidizing agents and oxidation processes which overcome the disadvantages mentioned.
- the oxoammonium salt according to the invention has a positively charged reactive section Z + , which has one of the following structures:
- the counter ion which is denoted by X " , is an anion, in particular a halide ion, preferably a chloride ion.
- Z + is connected via a linker group L to an insoluble carrier material T as a solid phase.
- Z + has 4 or 5 radicals R, which are selected independently of one another from the group of alkyl, allyl, aryl and benzyl, C 1 -C 5 -alkyl being preferred. Particularly high yields of oxidized product are achieved when R 1 -R 4 or R 5 are methyl groups.
- the carrier material T which is insoluble in the solvents usually used for organic syntheses, can be a polymer, in particular 1% divinylbenzene polystyrene resin.
- T polycondensate of spherical polysilicic acids, also called silica gel.
- the linker group L preferably has an ether group. However, it is also possible for L to be one or more amide, amine or Has ester groups or the like. Alkyl groups without heteroatoms are also conceivable as linker groups.
- the oxoammonium salt consists of the above-mentioned positively charged 6-ring (a), a chloride ion, a CH 2 -0 linker group, the methylene group being linked to the insoluble carrier material T, and 1% divinylbenzene Polystyrene resin as an insoluble carrier material T.
- polymer-bound oxoammonium salts have hitherto only been known as reactive intermediates in oxidations using TEMPO.
- the compounds according to the invention are polymer-bound oxoammonium salts in isolated form. Such isolated salts are not known from the prior art.
- oxoammonium salts according to claims 1-9, oxidations of various substrates are possible.
- the salts described have proven to be particularly efficient in the oxidation of both aliphatic and benzylic alcohols. For example, a conversion of over 95% was achieved in the conversion of heptanol to heptanal.
- ketones to diketones, diols to lactones and phenols to quinones can also be oxidized.
- the inventive method for the oxidation of organic compounds according to claim 11 is characterized in that the compound to be oxidized is reacted with an oxoammonium salt according to the invention.
- the oxoammonium salt is used in pure, isolated form, the formation of by-products, in particular of Overoxidation products, largely avoided.
- product yields are achieved which are significantly higher than the yields achievable with the polymer-supported oxidizing agents known hitherto, such as the 1-hydroxy-4-oxo-2,2,6,6-tetramethylpiperidine from Carsten Bolm and Thomas Fey mentioned above.
- the compound according to the invention when used in the polymer-assisted solution synthesis carried out here, offers the possibility of taking advantage of solid-phase synthesis, which dominated combinatorial chemistry in its first decade (combinatorial chemistry synthesis, analysis, screening, (publisher: G. Jung) , Wiley-VCH, Weinheim, 1999; Combinatorial Paptide and Non-Peptide Libraris, (ed .: G. Jung), VCH, Weinheim, 1996), with the advantages of synthesis in solution.
- Polymeric reagents can be used in large excess and removed by filtration, whereas the products can easily be analyzed and further reacted in solution. Polymeric reagents are ideal for parallel combinatorial synthesis.
- Oxoammonium resin 2 was prepared in a three-step synthesis from chloromethylated polystyrene resin and was used in the oxidation of alcohols 3a to 22a. The oxidation of resin 1 was carried out with Br 2 , Cl 2 or NCS / HCl.
- Fig. 2 Collection of 20 chemically diverse alcohols 3a to 22a, which represent benzylic, allylic, primary aliphatic, secondary aliphatic alcohols and diols.
- Fig. 3 GC analysis of the reaction of alcohol 9a in DCM (1 mg / ml) for 1 h with 1, 2 and 3 equivalents of the polymeric oxoammonium salt 2 using a flame ionization detector (FID).
- FID flame ionization detector
- Fig. 4 Secondary oxidation products of alcohols 3a to 22a.
- Fig. 5 GC-FID of a mixture of 15 alcohols (top) and product mixture obtained after oxidation with resin 2 (bottom).
- the 4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl radical was coupled with sodium hydride as a base to 1% divinylbenzene-polystyrene resin (Fig. 1). Elemental analysis of resin 1 showed a loading of 0.93 mmolg "1 of the radical. ESR spectroscopy confirmed the presence of the free radical electron and showed the characteristic triplet signal which is produced by the coupling with the 14 N core. Accordingly, the spectrum was in the HR-MAS NMR A clear broadening of the lines can be observed, which can be explained by the increased relaxation of the nuclear magnetization due to the interaction with the persistent electron spins ..
- the resin was filtered off and washed thoroughly with water, water / DMF (1 : 1), DMF, THF, DCM (dichloromethane) and MeOH and dried in vacuo. Loading: 0.93 mmolg "1 chlorine content: 0.07%.
- 11a lld 83 150 (M + ); 135; 122; 107; 95; 91; 82; 77; 54; 39
- a compound collection consisting of 15 alcohols (3a-10a, 12a, 13a, 15a, 16a, 18a-20a) was used to investigate the implementation of complex mixtures of chemically diverse alcohols (Fig. 5).
- the mixture (1 mgml "1 per alcohol) was analyzed by both GC-FID and GC-MS. In the starting mixture, all alcohols could be separated and identified by their mass spectrum.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02730001A EP1368316A1 (de) | 2001-03-16 | 2002-03-13 | Oxoammoniumsalze sowie deren verwendung |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10113710.9 | 2001-03-16 | ||
DE2001113710 DE10113710A1 (de) | 2001-03-16 | 2001-03-16 | Oxoammoniumsalze sowie deren Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002074744A1 true WO2002074744A1 (de) | 2002-09-26 |
Family
ID=7678365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/002762 WO2002074744A1 (de) | 2001-03-16 | 2002-03-13 | Oxoammoniumsalze sowie deren verwendung |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1368316A1 (de) |
DE (1) | DE10113710A1 (de) |
WO (1) | WO2002074744A1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004031150A1 (en) * | 2002-10-07 | 2004-04-15 | Ciba Specialty Chemicals Holding Inc. | Oxoammonium salts of 1-oxy-2,2,6,6-tetramethyl-1-piperidine (tempo) and their use as oxidizing agents |
US9802937B2 (en) | 2011-04-21 | 2017-10-31 | Origenis Gmbh | Substituted pyrazolo{4,3-D}pyrimidines as kinase inhibitors |
-
2001
- 2001-03-16 DE DE2001113710 patent/DE10113710A1/de not_active Withdrawn
-
2002
- 2002-03-13 WO PCT/EP2002/002762 patent/WO2002074744A1/de not_active Application Discontinuation
- 2002-03-13 EP EP02730001A patent/EP1368316A1/de not_active Withdrawn
Non-Patent Citations (5)
Title |
---|
F. MACCORQUODALE ET AL.: "Synthesis and electrochemical characterisation of poly(TEMPO-acrylate)", TETRAHEDRON LETTERS, vol. 31, 1990, pages 771 - 774, XP002210213 * |
NOOY DE A E J ET AL: "ON THE USE OF STABLE ORGANIC NITROXYL RADICALS FOR THE OXIDATION OFPRIMARY AND SECONDARY ALCOHOLS", SYNTHESIS, GEORG THIEME VERLAG. STUTTGART, DE, 1 October 1996 (1996-10-01), pages 1153 - 1174, XP002072173, ISSN: 0039-7881 * |
S. WEIK ET AL.: "Oxoammonium resins as metal-free, highly reactive, versatile polymeric oxidation reagents", ANGEW. CHEM. INT. ED., vol. 40, 2001, pages 1436 - 1439, XP002210214 * |
T. MIYAZAWA ET AL.: "Selective oxidation of alcohols by oxoaminium salts (R2N=O+X-)", J. ORG. CHEM., vol. 50, 1985, pages 1332 - 1334, XP002210212 * |
T. MIYAZAWA, T. ENDO: "Oxidation of benzyl alcohol with Fe(III) using polymers containing the nitroxyl radical structure as a mediator", JOURNAL OF POLYMER SCIENCE: POLYMER CHEMISTRY EDITION, vol. 23, 1985, pages 2487 - 2494, XP002210211 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004031150A1 (en) * | 2002-10-07 | 2004-04-15 | Ciba Specialty Chemicals Holding Inc. | Oxoammonium salts of 1-oxy-2,2,6,6-tetramethyl-1-piperidine (tempo) and their use as oxidizing agents |
US9802937B2 (en) | 2011-04-21 | 2017-10-31 | Origenis Gmbh | Substituted pyrazolo{4,3-D}pyrimidines as kinase inhibitors |
Also Published As
Publication number | Publication date |
---|---|
DE10113710A1 (de) | 2002-09-26 |
EP1368316A1 (de) | 2003-12-10 |
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