WO2002070678A3 - Regulation of human serine/threonine protein kinase - Google Patents

Regulation of human serine/threonine protein kinase Download PDF

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Publication number
WO2002070678A3
WO2002070678A3 PCT/EP2002/001113 EP0201113W WO02070678A3 WO 2002070678 A3 WO2002070678 A3 WO 2002070678A3 EP 0201113 W EP0201113 W EP 0201113W WO 02070678 A3 WO02070678 A3 WO 02070678A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein kinase
threonine protein
human serine
regulation
reagents
Prior art date
Application number
PCT/EP2002/001113
Other languages
French (fr)
Other versions
WO2002070678A2 (en
Inventor
Alex Smolyar
Original Assignee
Bayer Ag
Alex Smolyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Alex Smolyar filed Critical Bayer Ag
Publication of WO2002070678A2 publication Critical patent/WO2002070678A2/en
Publication of WO2002070678A3 publication Critical patent/WO2002070678A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reagents that regulate human serine/threonine protein kinase and reagents which bind to human serine/threonine protein kinase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, COPD, cardiovascular disorders, urinary disorders, obesity, diabetes, and peripheral and central nervous system disorders.
PCT/EP2002/001113 2001-02-05 2002-02-04 Regulation of human serine/threonine protein kinase WO2002070678A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26590301P 2001-02-05 2001-02-05
US60/265,903 2001-02-05
US30810401P 2001-07-30 2001-07-30
US60/308,104 2001-07-30

Publications (2)

Publication Number Publication Date
WO2002070678A2 WO2002070678A2 (en) 2002-09-12
WO2002070678A3 true WO2002070678A3 (en) 2002-12-19

Family

ID=26951484

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/001113 WO2002070678A2 (en) 2001-02-05 2002-02-04 Regulation of human serine/threonine protein kinase

Country Status (1)

Country Link
WO (1) WO2002070678A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999050395A1 (en) * 1998-03-27 1999-10-07 Helix Research Institute Serine-threonine protein kinase expressed in kidney
WO2000073469A2 (en) * 1999-05-28 2000-12-07 Sugen, Inc. Protein kinases
WO2001090304A2 (en) * 2000-05-19 2001-11-29 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5080891A (en) 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
US4843155A (en) 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
NZ314630A (en) 1991-01-17 2000-11-24 Harvard College Use of trans-splicing ribozymes for genetic modification and cell ablation in a host cell
WO1993003151A1 (en) 1991-08-10 1993-02-18 Medical Research Council Treatment of cell populations
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5262311A (en) 1992-03-11 1993-11-16 Dana-Farber Cancer Institute, Inc. Methods to clone polyA mRNA
EP0672131B1 (en) 1992-10-30 2003-12-17 The General Hospital Corporation A novel cell cycle control protein
ATE199392T1 (en) 1992-12-04 2001-03-15 Medical Res Council MULTIVALENT AND MULTI-SPECIFIC BINDING PROTEINS, THEIR PRODUCTION AND USE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999050395A1 (en) * 1998-03-27 1999-10-07 Helix Research Institute Serine-threonine protein kinase expressed in kidney
WO2000073469A2 (en) * 1999-05-28 2000-12-07 Sugen, Inc. Protein kinases
WO2001090304A2 (en) * 2000-05-19 2001-11-29 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EBI [online] 18 April 1997 (1997-04-18), KERLAVAGE, AR: "EST96652 Testis I Homo sapiens cDNA 5' end similar to serine /threonine kinase p78", XP002210015, Database accession no. HSZZ88419 *
DATABASE EMBL [online] 17 June 2001 (2001-06-17), XP002210031, Database accession no. Q9C098 *

Also Published As

Publication number Publication date
WO2002070678A2 (en) 2002-09-12

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