WO2003025174A3 - Regulation of human mrp1-like protein - Google Patents

Regulation of human mrp1-like protein Download PDF

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Publication number
WO2003025174A3
WO2003025174A3 PCT/EP2002/009773 EP0209773W WO03025174A3 WO 2003025174 A3 WO2003025174 A3 WO 2003025174A3 EP 0209773 W EP0209773 W EP 0209773W WO 03025174 A3 WO03025174 A3 WO 03025174A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
regulation
human mrp1
mrp1
reagents
Prior art date
Application number
PCT/EP2002/009773
Other languages
French (fr)
Other versions
WO2003025174A2 (en
Inventor
Alex Smolyar
Original Assignee
Bayer Healthcare Ag
Alex Smolyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Alex Smolyar filed Critical Bayer Healthcare Ag
Publication of WO2003025174A2 publication Critical patent/WO2003025174A2/en
Publication of WO2003025174A3 publication Critical patent/WO2003025174A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

Reagents that regulate human MRP1-like protein and reagents which bind to human MRP1-like protein gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, peripheral and central nervous system disorders or cardiovascular disorders.
PCT/EP2002/009773 2001-09-06 2002-09-02 Regulation of human mrp1-like protein WO2003025174A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31713401P 2001-09-06 2001-09-06
US60/317,134 2001-09-06

Publications (2)

Publication Number Publication Date
WO2003025174A2 WO2003025174A2 (en) 2003-03-27
WO2003025174A3 true WO2003025174A3 (en) 2003-12-31

Family

ID=23232262

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/009773 WO2003025174A2 (en) 2001-09-06 2002-09-02 Regulation of human mrp1-like protein

Country Status (1)

Country Link
WO (1) WO2003025174A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007251275A1 (en) 2006-05-12 2007-11-22 Solvo Biotechnology Cholesterol loaded insect cell membranes as test systems for ABC transporter proteins

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005943A1 (en) * 1986-03-28 1987-10-08 Board Of Trustees Of University Of Illinois Compositions and methods for clones containing dna sequences associated with multidrug resistance in human cells
WO2001009183A2 (en) * 1999-07-30 2001-02-08 Epidauros Polymorphisms in the human mdr-1 gene and applications thereof
WO2001094400A2 (en) * 2000-06-05 2001-12-13 The Brigham And Women's Hospital, Inc. A GENE ENCODING A MULTIDRUG RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7p15-21 AND USES THEREOF
WO2002040541A2 (en) * 2000-10-27 2002-05-23 Incyte Genomics, Inc. Transporters and ion channels
JP2002218984A (en) * 2001-01-26 2002-08-06 Takeda Chem Ind Ltd New protein and dna encoding the same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005943A1 (en) * 1986-03-28 1987-10-08 Board Of Trustees Of University Of Illinois Compositions and methods for clones containing dna sequences associated with multidrug resistance in human cells
WO2001009183A2 (en) * 1999-07-30 2001-02-08 Epidauros Polymorphisms in the human mdr-1 gene and applications thereof
WO2001094400A2 (en) * 2000-06-05 2001-12-13 The Brigham And Women's Hospital, Inc. A GENE ENCODING A MULTIDRUG RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7p15-21 AND USES THEREOF
WO2002040541A2 (en) * 2000-10-27 2002-05-23 Incyte Genomics, Inc. Transporters and ion channels
JP2002218984A (en) * 2001-01-26 2002-08-06 Takeda Chem Ind Ltd New protein and dna encoding the same

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BORST PIET ET AL: "The multidrug resistance protein family.", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1461, no. 2, 6 December 1999 (1999-12-06), pages 347 - 357, XP002243197, ISSN: 0006-3002 *
DATABASE EMBL, RELEASE 62 23 August 1997 (1997-08-23), KALICKI J. ET AL.: "Human BAC clone CTA-367O17 from 7p15-p21, complete sequence", XP002243345, Database accession no. AC002486 *
DEVAULT A ET AL: "TWO MEMBERS OF THE MOUSE MDR GENE FAMILY CONFER MULTIDRUG RESISTANCE WITH OVERLAPPING BUT DISTINCT DRUG SPECIFICITIES", MOLECULAR AND CELLULAR BIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 10, no. 4, 1 April 1990 (1990-04-01), pages 1652 - 1663, XP002015108, ISSN: 0270-7306 *
DEVINE S E ET AL: "FULL LENGTH AND ALTERNATIVELY SPLICED PGP-1 TRANSCRIPTS IN MULTIDRUG-RESISTANT CHINESE HAMSTER LUNG CELLS", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 7, 1991, pages 4545 - 4555, XP002243228, ISSN: 0021-9258 *
EDELMANN HELGA M L ET AL: "Cmdr1, a chicken P-glycoprotein, confers multidrug resistance and interacts with estradiol.", BIOLOGICAL CHEMISTRY, vol. 380, no. 2, February 1999 (1999-02-01), pages 231 - 241, XP002243200, ISSN: 1431-6730 *
LITMAN T ET AL: "From MDR to MXR: New understanding of multidrug resistance systems, their properties and clinical significance.", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 58, no. 7, June 2001 (2001-06-01), pages 931 - 959, XP002243198, ISSN: 1420-682X *
PATENT ABSTRACTS OF JAPAN vol. 2002, no. 12 12 December 2002 (2002-12-12) *
VAN DER BLIEK A M ET AL: "SEQUENCE OF MDR3 COMPLEMENTARY DNA ENCODING A HUMAN P-GLYCOPROTEIN", GENE (AMSTERDAM), vol. 71, no. 2, 1988, pages 401 - 412, XP001149101, ISSN: 0378-1119 *

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