WO2002057461A3 - Regulation of human adam-ts-like zinc metalloprotease - Google Patents

Regulation of human adam-ts-like zinc metalloprotease Download PDF

Info

Publication number
WO2002057461A3
WO2002057461A3 PCT/EP2002/000129 EP0200129W WO02057461A3 WO 2002057461 A3 WO2002057461 A3 WO 2002057461A3 EP 0200129 W EP0200129 W EP 0200129W WO 02057461 A3 WO02057461 A3 WO 02057461A3
Authority
WO
WIPO (PCT)
Prior art keywords
zinc metalloprotease
human adam
regulation
reagents
adam
Prior art date
Application number
PCT/EP2002/000129
Other languages
French (fr)
Other versions
WO2002057461A2 (en
Inventor
Zhimin Zhu
Original Assignee
Bayer Ag
Zhimin Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Zhimin Zhu filed Critical Bayer Ag
Publication of WO2002057461A2 publication Critical patent/WO2002057461A2/en
Publication of WO2002057461A3 publication Critical patent/WO2002057461A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reagents that regulate human ADAM-TS-like zinc metalloprotease and reagents which bind to human ADAM-TS-like zinc metalloprotease gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, COPD, CNS disorders, and cardiovascular disorders.
PCT/EP2002/000129 2001-01-18 2002-01-09 Regulation of human adam-ts-like zinc metalloprotease WO2002057461A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26203401P 2001-01-18 2001-01-18
US60/262,034 2001-01-18

Publications (2)

Publication Number Publication Date
WO2002057461A2 WO2002057461A2 (en) 2002-07-25
WO2002057461A3 true WO2002057461A3 (en) 2002-12-27

Family

ID=22995900

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/000129 WO2002057461A2 (en) 2001-01-18 2002-01-09 Regulation of human adam-ts-like zinc metalloprotease

Country Status (1)

Country Link
WO (1) WO2002057461A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002033087A2 (en) * 2000-10-17 2002-04-25 Curagen Corporation Proteins and nucleic acids encoding same
DE10244842B4 (en) * 2002-09-22 2006-09-14 Stiftung Alfred-Wegener-Institut Für Polar- Und Meeresforschung For protein-cleaving enzymes in the form of specific proteases coding nucleic acid sequences, related polypeptides and use of all
WO2013166264A2 (en) * 2012-05-02 2013-11-07 University Of Georgia Research Foundation, Inc. Methods for altering virus replication

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998031818A2 (en) * 1997-01-21 1998-07-23 Human Genome Sciences, Inc. Tace-like and matrilysin-like polypeptides
WO2001083782A2 (en) * 2000-05-04 2001-11-08 Sugen, Inc. Novel proteases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998031818A2 (en) * 1997-01-21 1998-07-23 Human Genome Sciences, Inc. Tace-like and matrilysin-like polypeptides
WO2001083782A2 (en) * 2000-05-04 2001-11-08 Sugen, Inc. Novel proteases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HURSKAINEN TIINA L ET AL: "ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases: General features and genomic distribution of the Adam-TS family", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 36, 3 September 1999 (1999-09-03), pages 25555 - 25563, XP002158991, ISSN: 0021-9258 *
TANG B L ET AL: "ADAMTS: A novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 445, no. 2-3, 26 February 1999 (1999-02-26), pages 223 - 225, XP004259261, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
WO2002057461A2 (en) 2002-07-25

Similar Documents

Publication Publication Date Title
WO2002072824A3 (en) Human transient receptor potential channel protein.
WO2002057461A3 (en) Regulation of human adam-ts-like zinc metalloprotease
WO2002006453A3 (en) Regulation of human desc1-like serine protease
WO2003052088A3 (en) Regulation of human sialyltransferase
WO2003100087A3 (en) Regulation of novel human asparagine-hydroxylases
WO2002062974A3 (en) Regulation of human elongase hselo1-like protein
WO2002024927A3 (en) Regulation of human adam-ts 1 precursor-like protein
WO2002088363A3 (en) Regulation of novel human prolyl 4-hydroxylases
WO2002055681A3 (en) Regulation of human tau-tubulin kinase
WO2002053755A3 (en) Regulation of human otu-like cysteine protease
WO2002072825A3 (en) Human mrp5-like protein
WO2002062975A3 (en) Regulation of human elongase hselo1-like protein
WO2003033708A3 (en) Regulation of human serine/threonine protein kinase
WO2002055710A3 (en) Regulation of human purple acid phosphatase
WO2002061058A3 (en) Regulation of human phospholipase
WO2002092798A3 (en) Regulation of human phosphatidic acid phosphatase type 2c-like protein
WO2002032938A3 (en) Regulation of human pgc-1-like protein
WO2002053714A3 (en) Regulation of human phosphatidylinositol-4-phosphate 5-kinase
WO2002026999A3 (en) Regulation of human adam-ts-like protein
WO2003000903A3 (en) Regulation of human nek-like serine/threonine protein kinase
WO2003033709A3 (en) Regulation of human serine/threonine protein kinase
WO2002036781A3 (en) Regulation of human glutathione-s-transferase
WO2002090543A3 (en) Regulation of human phosphatidic acid phosphatase type 2c-like protein
WO2003018786A3 (en) Human serine/threonine kinase
WO2003035859A3 (en) Regulation of human serine/threonine kinase

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP