WO2003004629A3 - Regulation of human citron rho/rac-interacting kinase-short kinase - Google Patents

Regulation of human citron rho/rac-interacting kinase-short kinase Download PDF

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Publication number
WO2003004629A3
WO2003004629A3 PCT/EP2002/007229 EP0207229W WO03004629A3 WO 2003004629 A3 WO2003004629 A3 WO 2003004629A3 EP 0207229 W EP0207229 W EP 0207229W WO 03004629 A3 WO03004629 A3 WO 03004629A3
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WO
WIPO (PCT)
Prior art keywords
kinase
rac
regulation
short
interacting
Prior art date
Application number
PCT/EP2002/007229
Other languages
French (fr)
Other versions
WO2003004629A2 (en
Inventor
Zhimin Zhu
Original Assignee
Bayer Ag
Zhimin Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Zhimin Zhu filed Critical Bayer Ag
Priority to AU2002317860A priority Critical patent/AU2002317860A1/en
Publication of WO2003004629A2 publication Critical patent/WO2003004629A2/en
Publication of WO2003004629A3 publication Critical patent/WO2003004629A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reagents that regulate human CRIK-sk and reagents which bind to human CRIK-sk gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, obesity, diabetes, cancer or COPD.
PCT/EP2002/007229 2001-07-02 2002-07-01 Regulation of human citron rho/rac-interacting kinase-short kinase WO2003004629A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002317860A AU2002317860A1 (en) 2001-07-02 2002-07-01 Regulation of human citron rho/rac-interacting kinase-short kinase

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US30185301P 2001-07-02 2001-07-02
US60/301,853 2001-07-02
US33713001P 2001-12-10 2001-12-10
US60/337,130 2001-12-10
US37501502P 2002-04-25 2002-04-25
US60/375,015 2002-04-25

Publications (2)

Publication Number Publication Date
WO2003004629A2 WO2003004629A2 (en) 2003-01-16
WO2003004629A3 true WO2003004629A3 (en) 2003-10-30

Family

ID=27404841

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/007229 WO2003004629A2 (en) 2001-07-02 2002-07-01 Regulation of human citron rho/rac-interacting kinase-short kinase

Country Status (2)

Country Link
AU (1) AU2002317860A1 (en)
WO (1) WO2003004629A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638745B1 (en) * 2001-03-13 2003-10-28 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
EP1576099A4 (en) 2002-04-12 2007-07-11 Bristol Myers Squibb Co Novel polynucleotides encoding the human citron kinase polypeptide, bmsnkc 0020/0021
WO2006040047A2 (en) * 2004-10-15 2006-04-20 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with rho/rac-interacting citron kinase (cit)
CN100537769C (en) * 2006-11-10 2009-09-09 上海人类基因组研究中心 People Citron gene, its proteins encoded and application
CN103421887B (en) * 2012-05-21 2019-03-26 上海吉凯基因化学技术有限公司 The purposes and its related drugs of CIT gene

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001038503A2 (en) * 1999-11-24 2001-05-31 Sugen, Inc. Novel human protein kinases and protein kinase-like enzymes
WO2001096547A2 (en) * 2000-06-15 2001-12-20 Incyte Genomics, Inc. Human kinases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001038503A2 (en) * 1999-11-24 2001-05-31 Sugen, Inc. Novel human protein kinases and protein kinase-like enzymes
WO2001096547A2 (en) * 2000-06-15 2001-12-20 Incyte Genomics, Inc. Human kinases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DI CUNTO FERDINANDO ET AL: "Citron Rho-interacting kinase, a novel tissue-specific Ser/Thr kinase encompassing the Rho-Rac-binding protein citron", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 45, 6 November 1998 (1998-11-06), pages 29706 - 29711, XP002170360, ISSN: 0021-9258 *
MADAULE PASCAL ET AL: "Role of citron kinase as a target of the small GTPase Rho in cytokinesis.", NATURE (LONDON), vol. 394, no. 6692, 30 July 1998 (1998-07-30), pages 491 - 494, XP002240823, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
WO2003004629A2 (en) 2003-01-16
AU2002317860A1 (en) 2003-01-21

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