WO2002063302A1 - Technique permettant de reduire l'interference de l'heparine dans des essais diagnostic de la troponine cardiaque - Google Patents

Technique permettant de reduire l'interference de l'heparine dans des essais diagnostic de la troponine cardiaque Download PDF

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Publication number
WO2002063302A1
WO2002063302A1 PCT/US2002/003713 US0203713W WO02063302A1 WO 2002063302 A1 WO2002063302 A1 WO 2002063302A1 US 0203713 W US0203713 W US 0203713W WO 02063302 A1 WO02063302 A1 WO 02063302A1
Authority
WO
WIPO (PCT)
Prior art keywords
heparin
antagonist
antibody
moiety
troponin
Prior art date
Application number
PCT/US2002/003713
Other languages
English (en)
Inventor
Lance A. Liotta
Alan R. Day
Heather Schessler
Tabitha W. Harlacher
Original Assignee
Immunomatrix Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunomatrix Inc. filed Critical Immunomatrix Inc.
Publication of WO2002063302A1 publication Critical patent/WO2002063302A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein

Abstract

La présente invention concerne un processus permettant de réduire l'interférence de l'anticoagulant héparine se liant dans l'essai diagnostic anticorps-antigène, tel qu'un essai diagnostic de la troponine cardiaque. Ce processus utilise une fraction, telle qu'un peptide hautement chargé, qui est en concurrence avec l'éparine au niveau du site de liaison anticorps-antigène. Cette fraction est de préférence un antagoniste d'héparine tel qu'un sel de protamine ou qu'un bromure hexadiméthrine (polybrène).
PCT/US2002/003713 2001-02-07 2002-02-07 Technique permettant de reduire l'interference de l'heparine dans des essais diagnostic de la troponine cardiaque WO2002063302A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26689201P 2001-02-07 2001-02-07
US60/266,892 2001-02-07

Publications (1)

Publication Number Publication Date
WO2002063302A1 true WO2002063302A1 (fr) 2002-08-15

Family

ID=23016414

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/003713 WO2002063302A1 (fr) 2001-02-07 2002-02-07 Technique permettant de reduire l'interference de l'heparine dans des essais diagnostic de la troponine cardiaque

Country Status (1)

Country Link
WO (1) WO2002063302A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108254579A (zh) * 2018-01-31 2018-07-06 济南景正医疗器械有限公司 制备一种抗干扰能力强的高密度脂蛋白胆固醇检测试剂盒
JPWO2017179611A1 (ja) * 2016-04-13 2019-02-21 株式会社Ｌｓｉメディエンス 硫酸化多糖類を用いた免疫学的測定法
US10670611B2 (en) 2014-09-26 2020-06-02 Somalogic, Inc. Cardiovascular risk event prediction and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320812A (en) * 1993-10-04 1994-06-14 Becton, Dickinson And Company Clot activating polyelectrolyte complex and blood collection assembly containing same
US5677133A (en) * 1993-02-17 1997-10-14 Cardiovascular Diagnostics, Inc. Dry chemistry cascade immunoassay and affinity assay
WO1999040442A1 (fr) * 1998-02-05 1999-08-12 Bio-Rad Pasteur Dosage des troponines sans interferences dues a l'heparine
US6174686B1 (en) * 1995-04-18 2001-01-16 Biosite Diagnostics, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677133A (en) * 1993-02-17 1997-10-14 Cardiovascular Diagnostics, Inc. Dry chemistry cascade immunoassay and affinity assay
US5320812A (en) * 1993-10-04 1994-06-14 Becton, Dickinson And Company Clot activating polyelectrolyte complex and blood collection assembly containing same
US6174686B1 (en) * 1995-04-18 2001-01-16 Biosite Diagnostics, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
WO1999040442A1 (fr) * 1998-02-05 1999-08-12 Bio-Rad Pasteur Dosage des troponines sans interferences dues a l'heparine

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10670611B2 (en) 2014-09-26 2020-06-02 Somalogic, Inc. Cardiovascular risk event prediction and uses thereof
JPWO2017179611A1 (ja) * 2016-04-13 2019-02-21 株式会社Ｌｓｉメディエンス 硫酸化多糖類を用いた免疫学的測定法
EP3444612A4 (fr) * 2016-04-13 2019-12-11 LSI Medience Corporation Dosage immunologique utlisant un polysaccharide sulfaté
US11422128B2 (en) 2016-04-13 2022-08-23 Lsi Medience Corporation Immunoassay employing sulfated polysaccharide
CN108254579A (zh) * 2018-01-31 2018-07-06 济南景正医疗器械有限公司 制备一种抗干扰能力强的高密度脂蛋白胆固醇检测试剂盒

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