WO2002047495A1 - Produit contenant de la tetrahydropalmatine pour le traitement de l'opiomanie et de l'heroinomanie et procede - Google Patents

Produit contenant de la tetrahydropalmatine pour le traitement de l'opiomanie et de l'heroinomanie et procede Download PDF

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Publication number
WO2002047495A1
WO2002047495A1 PCT/CN2001/001615 CN0101615W WO0247495A1 WO 2002047495 A1 WO2002047495 A1 WO 2002047495A1 CN 0101615 W CN0101615 W CN 0101615W WO 0247495 A1 WO0247495 A1 WO 0247495A1
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WO
WIPO (PCT)
Prior art keywords
tetrahydroxypalmatine
detoxification
cigarette
preventing relapse
relapse
Prior art date
Application number
PCT/CN2001/001615
Other languages
English (en)
Chinese (zh)
Inventor
Liuzhen Wu
Jun Xiao
Original Assignee
HUANG, Zhendong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HUANG, Zhendong filed Critical HUANG, Zhendong
Priority to CN01802359A priority Critical patent/CN1126473C/zh
Priority to AU2002215818A priority patent/AU2002215818A1/en
Publication of WO2002047495A1 publication Critical patent/WO2002047495A1/fr
Priority to HK02109364.7A priority patent/HK1048234B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives

Definitions

  • the present invention relates to the use of tetrahydroxypalmatine to prevent relapse after detoxification, and the prevention of relapse after detoxification containing tetrahydroxypalmatine.
  • the invention also relates to a smoking product and a preparation method thereof.
  • the present invention also relates to a cigarette, beverage and food containing tetrahydroxypalmatine for preventing relapse after detoxification, and a preparation method thereof, in particular to a morphine drug withdrawal symptom and Tetrahydroxypalmatine-containing cigarettes, beverages, and foods that prevent relapse of drug addiction after drug addiction prevention, and preparation methods thereof.
  • BACKGROUND Currently, internationally recognized detoxification is divided into two stages: detoxification and prevention of relapse. There are no ideal methods and technologies at home and abroad for the prevention of relapse.
  • An object of the present invention is to provide a tetrahydroxypalmatine-containing cigarette, beverage, and food for preventing relapse of existing drugs or preparations for preventing relapse among detox patients.
  • the cigarettes, beverages and foods containing tetrahydroxypalmatine for preventing relapse after detoxification according to the present invention can alleviate the withdrawal symptoms of morphine drugs and suppress drug addiction to drugs, non-toxic, non-addictive, and not form drug dependence. Convenient, reasonable cost and simple manufacturing process.
  • Another object of the present invention is to provide a method for preparing a tetrahydroxypalmatine-containing cigarette, beverage and food as described above for preventing relapse after detoxification.
  • the present invention provides a cigarette for preventing relapse after detoxification, which is characterized in that: the cigarette contains tetrahydroxypalmatine.
  • the invention also provides a method for preparing a cigarette for preventing relapse after detoxification, which comprises: preparing tetrahydroxypalmatine under light and at room temperature into a fine powder of 100 mesh or more; adding the fine powder under the condition of avoiding light An acidic water-soluble solvent is used to make a suspension, and the obtained aqueous suspension of tetrahydroxypalmatine is evenly sprayed on the cut tobacco; the cut tobacco containing tetrahydroxypalmatine is rolled and packaged according to a conventional method for preparing cigarettes.
  • the present invention also provides a food for preventing relapse after detoxification, which is characterized in that the food contains tetrahydroxypalmatine.
  • the present invention also provides a beverage for preventing relapse after detoxification, which is characterized in that the beverage contains tetrahydroxypalmatine.
  • tetrahydroxypalmatine is a commonly used drug recorded in the Chinese Pharmacopoeia. Tetrahydroxypalmatine has a sedative and hypnotic effect after oral or intramuscular injection.
  • the inventors of the present invention have conducted extensive screening and experiments on various drugs, and found that in addition to the sedative and hypnotic effects of tetrahydroxypalmatine, it also relieves the withdrawal symptoms of morphine drugs and inhibits drug addicts from treating drugs in the late stage of detoxification The role of psychological desire. Especially after mixing tetrahydroxypalmatine with cut tobacco for inhalation, detoxification and anti-heart addiction effects are more obvious. We know that smoking and drug use are very closely related. Most of the drug addicts can't give up smoking after quitting, and smoking has a very important psychological status for drug addicts.
  • Tetrahydroxypalmatine is used as an active ingredient to provide cigarettes to drug addicts, so that drug addicts can inhale relapse prevention drugs during conscious or unconscious smoking, and finally achieve the purpose of preventing relapse drugs. And it can be used for a long time.
  • the active ingredients of this kind of cigarette for preventing relapse after detoxification are non-toxic, non-addictive, do not form drug dependence, the manufacturing process is simple, and the price is reasonable.
  • the present invention provides a cigarette for preventing relapse after detoxification.
  • the feature is that the cigarette contains tetrahydroxypalmatine.
  • the amount of said tetrahydroxypalmatine is 6.25% based on the total weight of cut tobacco. -50%. .
  • the amount of said tetrahydroxypalmatine is preferably 12.5% o-43.55% based on the total weight of the shredded tobacco. .
  • the amount of tetrahydroxypalmatine based on the total weight of tobacco is preferably 18.75%. -37. 5% 0 .
  • the amount of said tetrahydroxypalmatine is preferably 25% based on the total weight of cut tobacco. -31. 25%. .
  • the present invention also provides a method for preparing a cigarette as described above for preventing relapse after detoxification, including:
  • Tetrahydroxypalmatine is made into a fine powder of 100 mesh or more under dark conditions at normal temperature; (2) The fine powder is added to an acidic water-soluble solvent to make a suspension under dark conditions, and The suspension is evenly sprayed on the shredded tobacco and mixed well;
  • step (3) The cigarette shreds obtained in step (2) are rolled and packaged according to a conventional cigarette preparation method.
  • the acidic water-soluble solvent is a mixture of water and at least one alcohol among C2-C5 alcohols, and the acid contained therein is ⁇ acid or hydrochloric acid.
  • the alcohol in the acidic water-soluble solvent is ethanol, propanol, propylene glycol, butanol, butylene glycol, pentyl alcohol, pentyl glycol, or a mixture thereof.
  • the present invention also provides a food for preventing relapse after detoxification, characterized in that the food contains tetrahydroxypalmatine.
  • the food may be various foods, preferably foods convenient for regular consumption, such as biscuits, candy or chewing gum.
  • the amount of said tetrahydroxypalmatine is 3% based on the total weight of the food. -25%. .
  • the present invention also provides a beverage for preventing relapse after detoxification, which is characterized in that the beverage contains tetrahydroxypalmatine.
  • the amount of said tetrahydroxypalmatine is 3% based on the total weight of the beverage. -25%. .
  • the beverage for preventing relapse after detoxification according to the present invention is characterized in that the beverage can be various soft drinks or nutritional oral solutions.
  • the preparation method of the tetrahydroxypalmatine-containing food for preventing relapse after detoxification according to the present invention is a conventional food preparation method, except that tetrahydroxypalmatine is ground into a fine powder having a particle size of greater than 100 mesh under dark and normal temperature It is then mixed with the raw materials for preparing food, and then it is made into food, such as candy or chewing gum, according to the conventional method for preparing food.
  • the tetrahydropalmatine-containing beverage for preventing relapse after detoxification according to the present invention is prepared by first preparing tetrahydroxypalmatine under light and normal temperature to make a fine powder of 100 mesh or more under normal conditions; The fine powder is added to the suspension with an acidic water-soluble solvent according to the method described above, and the suspension may be dispersed in the beverage.
  • Example 1 The present invention will be further described below with reference to non-limiting examples and test examples.
  • Example 1 The present invention will be further described below with reference to non-limiting examples and test examples.
  • Tetrahydroxypalmatine was ground into a 120-mesh fine powder at 25 ° C in the dark, and then mixed with water and an acidic (sulfuric acid) solution of propylene glycol to prepare a suspension. Under the condition of avoiding light, the prepared suspension was evenly sprayed on the shredded tobacco and mixed uniformly. The amount of cut tobacco and tetrahydroxypalmatine in each cigarette was 800 ⁇ g and 30 ⁇ g, respectively. The cut tobacco thus obtained is rolled and packaged according to a conventional manufacturing method in the field of cigarettes to obtain a cigarette for preventing relapse after detoxification according to the present invention.
  • Example 2
  • Tetrahydroxypalmatine was ground into a 100-mesh fine powder in the dark at 25 ° C, and then mixed with water and an acidic (sulfuric acid) solution of butanediol to prepare a suspension. Under the condition of avoiding light, the prepared suspension was evenly sprayed on the shredded tobacco and mixed uniformly. The amount of cut tobacco and tetrahydroxypalmatine in each cigarette was 800 mg and 15 mg, respectively. The cut tobacco thus obtained is rolled and packaged according to a conventional manufacturing method in the field of cigarettes to obtain a cigarette for preventing relapse after detoxification according to the present invention.
  • Cigarettes for preventing relapse after detoxification according to the present invention were prepared according to the same method as described in Example 1, except that the amount of cut tobacco and tetrahydroxypalmatine in each cigarette was 800 mg and 40 mg, respectively.
  • Example 4
  • Cigarettes for preventing relapse after detoxification according to the present invention were prepared according to the same method as described in Example 2, except that the amount of cut tobacco and tetrahydroxypalmatine in each cigarette was 800 mg and 35 mg, respectively.
  • Example 5 the amount of cut tobacco and tetrahydroxypalmatine in each cigarette was 800 mg and 35 mg, respectively.
  • Cigarettes for preventing relapse after detoxification of the present invention were prepared in the same manner as described in Example 2, except that the amount of cut tobacco and tetrahydroxypalmatine in each cigarette was 800 mg and 25 mg, respectively.
  • Cigarettes for preventing relapse after detoxification according to the present invention were prepared in the same manner as described in Example 1, except that the amount of cut tobacco and tetrahydroxypalmatine in each cigarette was 800 mg and 20 mg, respectively.
  • Example 7
  • Cigarettes for preventing relapse after detoxification of the present invention were prepared in the same manner as described in Example 1, except that the amount of cut tobacco and tetrahydroxypalmatine in each cigarette was 800 mg and 10 mg, respectively.
  • the method for preventing relapse after detoxification according to the present invention is prepared in the same manner as described in Example 2. Cigarettes, but the amount of cut tobacco and tetrahydroxypalmatine in each cigarette is 800 mg and 5 mg, respectively.
  • Example 9
  • Tetrahydroxypalmatine was ground into a 140-mesh fine powder at 25 ° C in the dark, and then mixed with water and an acidic (hydrochloric acid) solution of propanol to prepare a suspension. Under the condition of avoiding light, the prepared suspension was evenly sprayed on the shredded tobacco and mixed uniformly. The amount of cut tobacco and tetrahydroxypalmatine in each cigarette was 800 g and 3 mg, respectively.
  • the cigarette so obtained is rolled and packaged according to a conventional manufacturing method in the field of cigarettes to obtain the cigarette for preventing relapse after detoxification of the present invention.
  • Tetrahydroxypalmatine was ground into a 150-mesh fine powder at 25 ° C in the dark, and then mixed with water and an acidic (hydrochloric acid) solution of propylene glycol to prepare a suspension. . Under the condition of avoiding light, the prepared suspension was evenly sprayed on the shredded tobacco and mixed uniformly. The amount of cut tobacco and tetrahydroxypalmatine in each cigarette was 800 mg and 50 mg, respectively. The cut tobacco thus obtained is rolled and packaged according to a conventional method in the field of cigarettes to obtain a cigarette for preventing relapse after detoxification according to the present invention.
  • Tetrahydroxypalmatine was ground into a 150-mesh fine powder at 25 ° C in the dark, and then mixed with water and an acidic (sulfuric acid) solution of butanediol to prepare a suspension. .
  • the prepared suspension was sprayed on the shredded tobacco uniformly and mixed uniformly.
  • the amount of cut tobacco and tetrahydroxypalmatine in each cigarette was 800 mg and 10 mg, respectively.
  • the cut tobacco thus obtained is rolled and packaged according to a conventional manufacturing method in the field of cigarettes to obtain the cigarette of the present invention for preventing relapse after detoxification.
  • Tetrahydroxypalmatine was ground into a 120-mesh fine powder, which was then mixed with the raw material for the preparation of chewing gum to form a chewing gum containing tetrahydroxypalmatine according to a conventional method.
  • the amount of tetrahydroxypalmatine is 0.25 mg of tetrahydroxypalmatine per chewing gum. Examples 13-15
  • a tetrahydroxypalmatine-containing chewing gum was prepared in the same manner as in Example 12. However, the dosage of tetrahydroxypalmatine is 1 mg, 10 mg, and 20 mg of tetrahydroxypalmatine per chewing gum.
  • Tetrahydroxypalmatine was ground into a 120-mesh fine powder, which was then mixed with the raw materials for making confections to form a tetrahydroxypalmatine-containing confection according to a conventional method.
  • the amount of tetrahydroxypalmatine is 0.25 mg of tetrahydroxypalmatine per candy. Examples 17-19
  • a tetrahydroxypalmatine-containing chewing gum was prepared in the same manner as in Example 16. Just four The dosage of hydroxypalmatine is 1 mg, 10 mg and 20 mg of tetrahydroxypalmatine per candy.
  • Tetrahydroxypalmatine was ground into a 120-mesh fine powder, and then it was made into a suspension according to the method described in Example 1. Then the prepared suspension was added to the raw materials for preparing soft drinks and dispersed and mixed uniformly.
  • a conventional method makes a soft drink containing tetrahydroxypalmatine. The amount of tetrahydroxypalmatine is 0.25 mg of tetrahydroxypalmatine per 240 ml of soft drink. Examples 21-23
  • a tetrahydroxypalmatine-containing beverage was prepared in the same manner as in Example 20. However, the dosage of tetrahydroxypalmatine is 1 mg, 10 rag and 20 mg of tetrahydroxypalmatine per 240 liters of soft drink.
  • Example 24
  • Tetrahydroxypalmatine was ground into a fine powder of 120 mesh, and then it was made into a suspension according to the method described in Example 1. Then the prepared suspension was added to the raw materials for preparing a nutritional oral solution and mixed: Evenly, a soft drink containing tetrahydroxypalmatine was prepared according to a conventional method. The amount of tetrahydroxypalmatine was 0.25 mg of tetrahydroxypalmatine per oral solution. Examples 25-27
  • a tetrahydroxypalmatine-containing beverage was prepared in the same manner as in Example 24. However, the dosage of tetrahydroxypalmatine is 1 mg, 10 mg and 20 mg of tetrahydroxypalmatine per oral solution.
  • Test example 1 the dosage of tetrahydroxypalmatine is 1 mg, 10 mg and 20 mg of tetrahydroxypalmatine per oral solution.
  • the relapse prevention cigarettes prepared in accordance with the above method are provided to drug addicts for smoking, and the detoxification patients can take at least 3 cigarettes to prevent relapse after detoxification, which can be effective.
  • the invention also Will not produce any adverse reactions.
  • the percentage of anxiety and the percentage of heart addiction were obtained by the visual analog scale experimental method. As shown in the table above, compared with the control group, the cigarette for preventing relapse after detoxification according to the present invention can significantly improve various withdrawal symptoms after detoxification, such as occasional limb pain and discomfort, occasional cold sweat, and the like. Significantly reduce the mood anxiety and heart addiction after detoxification.
  • test example of the present invention was conducted using only the tetrahydroxypalmatine-containing cigarette of the present invention. It should be understood that other products of the present invention containing tetrahydroxypalmatine, such as the food and beverage of tetrahydroxypalmatine, have similar effects.
  • the present invention has been described above with reference to examples and test examples. It should be understood by those skilled in the art that various modifications and changes can be made to the present invention without departing from the spirit and essence of the present invention.

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Confectionery (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un produit contenant de la tétrahydropalmatine pour le traitement de l'opiomanie et de l'héroïnomanie, et le procédé associé. On peut produire des cigarettes, des aliments et des boissons avec un produit contenant 3 %o-50 %o de tétrahydropalmatine. Ledit produit est hautement efficace et sûr pour le traitement de l'opiomanie. Le procédé de production dudit produit consiste à moudre de la tétrahydropalmatine, à l'abri de la lumière et à une température normale, et à mélanger le mélange obtenu à des cigarettes, des aliments et des boissons. Un autre procédé de production consiste à produire une suspension à partir de la solution aqueuse acide de tétrahydropalmatine et à la mélanger à des cigarettes, des aliments et des boissons.
PCT/CN2001/001615 2000-12-11 2001-12-11 Produit contenant de la tetrahydropalmatine pour le traitement de l'opiomanie et de l'heroinomanie et procede WO2002047495A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN01802359A CN1126473C (zh) 2000-12-11 2001-12-11 一种预防戒毒后复吸的含有四羟巴马汀的制品及其制备方法
AU2002215818A AU2002215818A1 (en) 2000-12-11 2001-12-11 A product containing tetiahydiopalmatime for curing opium-addiction and heroinomania and the method thereof
HK02109364.7A HK1048234B (zh) 2000-12-11 2002-12-27 一種預防戒毒後復吸的含有四羥巴馬汀的製品及其製備方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN00134010.7 2000-12-11
CN00134010A CN1112136C (zh) 2000-12-11 2000-12-11 预防戒毒后复吸的香烟及其制法

Publications (1)

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WO2002047495A1 true WO2002047495A1 (fr) 2002-06-20

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PCT/CN2001/001615 WO2002047495A1 (fr) 2000-12-11 2001-12-11 Produit contenant de la tetrahydropalmatine pour le traitement de l'opiomanie et de l'heroinomanie et procede

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CN (2) CN1112136C (fr)
AU (1) AU2002215818A1 (fr)
HK (1) HK1048234B (fr)
WO (1) WO2002047495A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103284322B (zh) * 2013-04-02 2016-07-06 徐志强 一种能够抑制成瘾者对毒品渴求心瘾的香烟及其他制品及其制备方法
CN103301760B (zh) * 2013-06-19 2016-07-06 徐志强 一种溶解左旋四氢巴马汀的方法、左旋四氢巴马汀溶液及其应用
CN104839375A (zh) * 2015-06-10 2015-08-19 贵阳世纪珠玑科技有限公司 一种预防戒毒后复吸的茶叶及其制备方法
CN108208925A (zh) * 2016-12-09 2018-06-29 金朝晖 含有戒毒药物的戒毒药物吸食装置、香烟过滤嘴以及香烟
CN109077352A (zh) * 2018-07-06 2018-12-25 贵阳世纪珠玑科技有限公司 一种预防戒毒后复吸制品
CN113397163A (zh) * 2021-06-30 2021-09-17 魏道珍 一种含有延胡索乙素的制品及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1112425A (zh) * 1994-05-21 1995-11-29 曹均才 千金藤戒毒烟
CN1155432A (zh) * 1996-08-21 1997-07-30 卢和川 擒毒速汰灵

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1112425A (zh) * 1994-05-21 1995-11-29 曹均才 千金藤戒毒烟
CN1155432A (zh) * 1996-08-21 1997-07-30 卢和川 擒毒速汰灵

Also Published As

Publication number Publication date
CN1126473C (zh) 2003-11-05
CN1358463A (zh) 2002-07-17
CN1112136C (zh) 2003-06-25
AU2002215818A1 (en) 2002-06-24
HK1048234B (zh) 2004-08-13
CN1392777A (zh) 2003-01-22
HK1048234A1 (en) 2003-03-28

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