WO2002042755A2 - Electrode tubulaire - Google Patents

Electrode tubulaire Download PDF

Info

Publication number
WO2002042755A2
WO2002042755A2 PCT/EP2001/013839 EP0113839W WO0242755A2 WO 2002042755 A2 WO2002042755 A2 WO 2002042755A2 EP 0113839 W EP0113839 W EP 0113839W WO 0242755 A2 WO0242755 A2 WO 0242755A2
Authority
WO
WIPO (PCT)
Prior art keywords
sensor
jacket
electrically conductive
plastic
outside
Prior art date
Application number
PCT/EP2001/013839
Other languages
German (de)
English (en)
Other versions
WO2002042755A3 (fr
Inventor
Jochen Eshold
Guido Schwartenbeck
Michael Borchardt
Original Assignee
Institut für Chemo- und Biosensorik Münster E.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut für Chemo- und Biosensorik Münster E.V. filed Critical Institut für Chemo- und Biosensorik Münster E.V.
Priority to AU2002216061A priority Critical patent/AU2002216061A1/en
Publication of WO2002042755A2 publication Critical patent/WO2002042755A2/fr
Publication of WO2002042755A3 publication Critical patent/WO2002042755A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood

Definitions

  • the present invention relates to an electrode like this. for example in the field of sensors, in particular bio and chemical sensors.
  • the electrode consists of a porous tube with a diameter of approximately 100 ⁇ m, the pores of which are filled with an ion-selective cocktail.
  • the signal is picked up as a discharge contact by means of a wire that is wound around the electrode.
  • Tubularly arranged PVC membranes are also used in biosensors in "Biomedical Engineering” Volume 36, Issue 11/1991, pages 271-284. However, the membranes only serve as carriers, while the signals are obtained via a silver chloride-cement fixed section. ⁇ ⁇ ⁇ o c ⁇ o C ⁇ o c ⁇
  • the plastic tube itself can also be impregnated with material-selective material, so that it directly represents a material-selective electrode.
  • a silicone tube made electrically conductive by means of embedded metallic particles is suitable for such an electrode.
  • An advantage of the inventive hose-like jacket is that a co-extrusion with other membranes membrane which are to be applied to its outside or inside and are also made of plastic, is possible, so that a strong covalent bond between the membrane and the • tubular support material ' arises.
  • any connections of different hose pieces are possible using the hose-like jacket according to the invention.
  • the hoses can differ in terms of their diameter or length, among other things. This enables each piece of tubing to have its own function, for example as a reference electrode, for pre-oxidation or the like. A multi-sensor unit is therefore possible that has no dead volume, has short response times and does not interfere with the measurement depending on the flow behavior.
  • the time sequences such as reaction times, incubation times, measuring times and the like can be determined, recorded and controlled.
  • a microelectrode array consisting of pieces of tubing connected in series constitutes a "lab-in-tube".
  • the plastic of the jacket can be made electrically conductive and / or electrochemically active by means of electrically, conductive and / or electrochemically active additives, such as, for example, metallic particles and the like.
  • electrically, conductive and / or electrochemically active additives such as, for example, metallic particles and the like.
  • the incorporated electrically conductive and / or electrochemically active additives or particles each represent a type of microelectrode, so that there is a microelectrode effect with the better response behavior of the sensors known from this. If a further layer with a greatly reduced particle content is applied to the inside or outside of the jacket, this microelectrode effect can be further enhanced.
  • Silver particles are suitable, for example, for the solid derivation of ion-selective membranes applied from the outside or inside, while platinum as a carrier or pre-oxidation electrode for amperometric sensors or also as a carrier and working electrode for enzyme layers applied inside or outside with c ⁇ ⁇ t ⁇ c ⁇ o C ⁇ o C ⁇ o C ⁇ o C ⁇
  • the signal (tapping) on the transducer can therefore be dispensed with. It is possible, however, to enable the clamping, for example, a particularly extruded 'tab on the hose.
  • a microelectrode array can also be implemented using a plastic layer containing a few conductive particles in layer thickness.
  • a plastic hose that is normally made electrically conductive with particles then serves as a carrier and drain.
  • a combination of different electrodes, for example for sodium, potassium, pH, as reference electrode and the like, is also possible. These can be connected to one another via connecting pieces without dead volume or using adhesive technology.
  • Fig.- 1 the structure and use; a conventional ion selective electrode;
  • FIGS. 3 to 10 further electrodes according to the invention.
  • FIG. 1 shows a conventional ion-selective electrode 1, in which an ion-selective layer 3 and an immobilized layer are placed on a metallic electrode 2 Layer 4 containing enzymes is applied.
  • the analyte 5 contacts the enzyme layer 4, while the signal is derived from the metal electrode 2 via a conductor 6.
  • FIG. 2 shows an electrode 1 according to the invention.
  • the usual lateral layer sequence as shown in FIG. 1 is replaced by a hollow cylindrical structure.
  • the electrode 1 has a hose 2, on the inside of which an ion-sensitive layer 3 and an immobilized enzyme-containing layer 4 is applied.
  • the arrangement consequently forms a flow electrode. This is shown in FIG. 2A, while in FIG. 2B the individual layers 2, 3 and 4 are drawn separately from one another.
  • the jacket 2 consists of a silicone tube which is filled with silver particles in the plastic.
  • the innermost part is a silicone foam layer 4, which contains immobilized enzymes.
  • FIG. 4 shows a multi-electrode array in which a jacket 2a consists of a silicone tube which is coated with electrically conductive particles in the plastic. ⁇ o P 1 p>

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Oxygen Concentration In Cells (AREA)
  • Electrodes For Compound Or Non-Metal Manufacture (AREA)

Abstract

L'invention concerne un détecteur électrochimique comprenant au moins une électrode et une enveloppe tubulaire en matière plastique formant un volume intérieur. Cette enveloppe est électroconductrice au moins partiellement le long de sa périphérie et/ou du sens longitudinal du tube entre son côté intérieur délimitant le volume intérieur et son côté extérieur. L'électrode forme les zones électroconductrices du côté intérieur ou du côté extérieur.
PCT/EP2001/013839 2000-11-27 2001-11-27 Electrode tubulaire WO2002042755A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002216061A AU2002216061A1 (en) 2000-11-27 2001-11-27 Tubular electrode

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2000158746 DE10058746A1 (de) 2000-11-27 2000-11-27 Schlauchartige Elektrode
DE10058746.1 2000-11-27

Publications (2)

Publication Number Publication Date
WO2002042755A2 true WO2002042755A2 (fr) 2002-05-30
WO2002042755A3 WO2002042755A3 (fr) 2003-02-13

Family

ID=7664774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/013839 WO2002042755A2 (fr) 2000-11-27 2001-11-27 Electrode tubulaire

Country Status (3)

Country Link
AU (1) AU2002216061A1 (fr)
DE (1) DE10058746A1 (fr)
WO (1) WO2002042755A2 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2469202A1 (fr) * 1979-11-15 1981-05-22 Tacussel Jacques Cellules electrochimiques comportant des electrodes constituees par des materiaux composites
US4604182A (en) * 1983-08-15 1986-08-05 E. I. Du Pont De Nemours And Company Perfluorosulfonic acid polymer-coated indicator electrodes
DE3932247A1 (de) * 1989-09-27 1991-04-04 Biotechnolog Forschung Gmbh Elektrodenmaterial, elektroden, verfahren zur herstellung und verwendung der elektrode
EP0542140A2 (fr) * 1991-11-15 1993-05-19 Fresenius AG Agencement de tube utilisé dans un circuit sanguin
WO1993015393A1 (fr) * 1992-01-28 1993-08-05 Amagruss Limited Electrodes de reference
US5288388A (en) * 1987-12-09 1994-02-22 Societe Anonyme: Societe Lyonnaise D'electronique Appliquee Homogeneous potentiometer sensor
EP0757246A2 (fr) * 1995-08-04 1997-02-05 Universitat Rovira I Virgili - Servei de Tecnologia Quimica Pâte conductrice, électrodes, capteurs et réacteurs électrochimiques contenants cette pâte, et méthode pour leur fabrication

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4233136A (en) * 1978-07-17 1980-11-11 Nova Biomedical Corporation Liquid membrane electrode
US4565665A (en) * 1983-08-03 1986-01-21 Medtronic, Inc. Flow through ion selective electrode
US4565666A (en) * 1983-08-03 1986-01-21 Medtronic, Inc. Method of producing combination ion selective sensing electrode
DE3914662A1 (de) * 1989-05-03 1990-11-08 Alt Eckhard Vorrichtung zum uebertragen elektrischer signale zwischen einem implantierbaren medizinischen geraet und elektrisch erregbarem menschlichen gewebe

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2469202A1 (fr) * 1979-11-15 1981-05-22 Tacussel Jacques Cellules electrochimiques comportant des electrodes constituees par des materiaux composites
US4604182A (en) * 1983-08-15 1986-08-05 E. I. Du Pont De Nemours And Company Perfluorosulfonic acid polymer-coated indicator electrodes
US5288388A (en) * 1987-12-09 1994-02-22 Societe Anonyme: Societe Lyonnaise D'electronique Appliquee Homogeneous potentiometer sensor
DE3932247A1 (de) * 1989-09-27 1991-04-04 Biotechnolog Forschung Gmbh Elektrodenmaterial, elektroden, verfahren zur herstellung und verwendung der elektrode
EP0542140A2 (fr) * 1991-11-15 1993-05-19 Fresenius AG Agencement de tube utilisé dans un circuit sanguin
WO1993015393A1 (fr) * 1992-01-28 1993-08-05 Amagruss Limited Electrodes de reference
EP0757246A2 (fr) * 1995-08-04 1997-02-05 Universitat Rovira I Virgili - Servei de Tecnologia Quimica Pâte conductrice, électrodes, capteurs et réacteurs électrochimiques contenants cette pâte, et méthode pour leur fabrication

Also Published As

Publication number Publication date
AU2002216061A1 (en) 2002-06-03
WO2002042755A3 (fr) 2003-02-13
DE10058746A1 (de) 2002-06-06

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