WO2002038085A1 - Dispositif et procede de reduction de la pression arterielle - Google Patents

Dispositif et procede de reduction de la pression arterielle Download PDF

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Publication number
WO2002038085A1
WO2002038085A1 PCT/US2001/048106 US0148106W WO0238085A1 WO 2002038085 A1 WO2002038085 A1 WO 2002038085A1 US 0148106 W US0148106 W US 0148106W WO 0238085 A1 WO0238085 A1 WO 0238085A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood flow
blood
flow diverting
renal artery
diverting means
Prior art date
Application number
PCT/US2001/048106
Other languages
English (en)
Inventor
Kenneth R. Kensey
Young Cho
Harold E. Clupper
Original Assignee
Kensey Kenneth R
Young Cho
Clupper Harold E
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kensey Kenneth R, Young Cho, Clupper Harold E filed Critical Kensey Kenneth R
Priority to AU2002229026A priority Critical patent/AU2002229026A1/en
Publication of WO2002038085A1 publication Critical patent/WO2002038085A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/848—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2002/061—Blood vessels provided with means for allowing access to secondary lumens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2002/068—Modifying the blood flow model, e.g. by diffuser or deflector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/0054—V-shaped

Definitions

  • This invention relates generally to medical devices and more particularly to devices including implantable devices for diverting and/or regulating blood flow to at least one renal artery.
  • High blood pressure is a serious health problem.
  • United States alone it is estimated that 60,130,000 patients have hypertension.
  • Conventional methods existing for reducing hypertension usually involve introducing into the body of a living being pharmaceutical compositions or compositions of naturally occurring ingredients to adjust the heart rate.
  • Angiotensin converting enzyme inhibitors are very popular and widely used in treating high blood pressure. These drugs are also often used in the treatment of diabetic kidney disease.
  • Other methods for reducing hypertension include cardiopulmonary bypass surgery.
  • kidneys control the various ways oxygen supply to the brain is increased. For example, through the release of certain hormones, the kidneys can elevate blood pressure throughout the body to increase the supply of oxygen to the brain. However, this elevation in blood pressure can also result in hypertension.
  • the manner in which the kidney determines what is happening in the rest of the body is by measuring the amount of blood it is getting. By diverting or increasing the amount of blood flow to the kidneys, one can "fool" the kidneys into thinking that a sufficient amount of oxygen is getting to the brain. Thus, the kidney will produce less hormones resulting in a reduction in hypertension.
  • United States Patent No. 5,617,878 discloses a method for treating aortic occlusive disease in or around the intersection of the aorta and attendant arteries such as the renal arteries using both a graft and a stent.
  • the graft is placed at the intersection of the two arteries using a balloon catheter.
  • a cauterizing device is used to make an opening in the graft at a point corresponding to the intersection of the aortic and renal arteries.
  • a stent is inserted into the graft and through the graft opening, the stent having an attachment mechanism to attach one end of the stent to the opening in the graft whereby the flow of blood at the intersection of the arteries is ensured. Any occluded area around the intersection of the aorta and renal artery is effectively repaired and strengthened.
  • United States Patent No. 4,501,263 discloses a device and method for diverting blood flow from one blood vessel to another, such as from the hepatic artery to the portal vein for reducing hypertension of the liver. This patent also includes a method for implanting this device.
  • United States Patent No. 4,204,525 discloses a method and device for continuously supplementing the flow pressure of venous blood to the liver which may be contained entirely internally of the patient so as to require no participation on his part or supplementary assistance.
  • the method comprises supplying venous blood to the liver at a pressure in excess of the back pressure created by the liver by introducing arterial blood into the flow path of the venous blood in the portal vein.
  • United States Patent No. 5,643,340 discloses a synthetic vascular prosthesis which is formed by a first tube member and a second tube member. Both tube members having inner flow paths for blood. An end of the second tube member is connected with an outer surface of the first tube member and the inner flow path of the second tube member communicates with the inner flow path of the first tube member.
  • the prosthesis is used to replace or bypass a lesioned portion of an in vivo blood vessel affected by an obstructive or distentive lesion.
  • An implantable intravascular device for diverting blood flow from the aorta into at least one renal artery of a living being to effect a reduction in the being's blood pressure.
  • the device comprises an anchoring means and a blood flow diverting means located on the anchoring means.
  • the blood flow diverting means is arranged for movement between a stowed position and an extended position to effect the controlled diversion of blood into the at least one renal artery.
  • the blood flow diverting means may be moved into any one of a plurality of intermediately deployed positions between said stowed and extended positions.
  • the position of said at least one blood flow diverting means is controllable.
  • the at least one blood flow diverting means comprises a cupped or depressed portion disposed at a first end thereof.
  • the anchoring means comprises a generally cylindrical stent having a central axis and the at least one blood flow diverting means comprises a plurality of blood flow diverting elements arranged equidistantly around the central axis of said stent.
  • the at least one blood flow diverting means comprises a pair of opposed blood flow diverting elements.
  • the anchoring means comprises a generally cylindrical stent having a central axis and wherein when the at least one blood flow diverting element is in the stowed position, the cupped or depressed portion is oriented substantially parallel to the central axis and wherein when the at least one blood flow diverting element is in one of the intermediate deployed positions or is in the fully extended position, the cupped or depressed portion points inwardly towards the central axis.
  • the device additionally comprises a threaded adjustment screw for controlling the position of the blood flow diverting means.
  • the cupped or depressed portion when the blood flow diverting means is moved to any one of the plurality of intermediately deployed positions or to the extended position, the cupped or depressed portion is oriented at an approximately 45 degree angle with respect to the axis.
  • the invention also describes a method of lowering blood pressure within a living being. The method comprises the step of introducing a device into the aorta of a living being adjacent at least one renal artery whereupon the device increases flow of blood to at least one renal artery to lower blood pressure within that living being.
  • the method comprises the additional step of controlling the amount of blood flow to the at least one renal artery.
  • the device comprises a blood flow diverting element and the method includes the step of controlling the amount of blood flow to the at least one renal artery by moving the blood flow diverting element from a stowed position to an extended position to increase the flow of blood into the at least one renal artery.
  • the method includes the sub-step of moving the blood flow diverting element into any one of a plurality of intermediate positions between the stowed position and the extended position.
  • Fig. 1 is a longitudinal sectional view of the aorta of a living being at its junction with the renal arteries and showing a first exemplary embodiment of the present invention positioned therein, with the blood flow diverting elements of the embodiment shown in one of their deployed positions;
  • Fig. 1A is a sectional view taken along line 1A-1A of Fig. 1;
  • Fig. 2 is an enlarged elevational view of one of the blood flow diverting elements of the present invention shown in its stowed position;
  • Fig. 3 is a sectional view taken along line 3-3 of Fig. 2;
  • Fig. 4 is a view similar to Fig. 2 but showing one of the blood flow diverting elements of the present invention in its deployed position;
  • Fig. 5 is a sectional view taken along line 5-5 of Fig. 4;
  • Fig. 6 is a plan view of a portion of a stent forming a portion of the present invention shown in its erected state to illustrate its construction; and, Fig. 7 is a view similar to Fig. 6, but showing the stent secured in place at juxtaposed apices according to the present invention.
  • Fig. 1 one exemplary embodiment of an intravascular device constructed in accordance with this invention for reducing blood pressure within a living being.
  • the device 20 of the present invention when installed within the body of the living being, the device 20 of the present invention is situated between the renal arteries 22 and the aortic-iliac bifurcation 27 just distal to the renal arteries 22.
  • this location is sometimes referred to as the target site.
  • the device 20 comprises two major components: a self-expanding stent, indicated at 25, and one or more blood diverting assemblies, each indicated at 30.
  • any such stent may be utilized.
  • any stent regardless of construction, geometry or operation, which is arranged to be deployed and erected or expanded in place can be used, although self-expanding stents offer the advantage of ease and simplicity of deployment.
  • the means for mounting the blood diverting assemblies 30 is not to be limited to stents. In fact, it is contemplated under this invention that a variety of structures and/or components other than stents could also serve well for locating the blood diverting assemblies 30 of the present invention within the aorta at its junction with the renal arteries.
  • the stent 25 is comprised of any suitable biocompatible material and is formed of any suitable construction.
  • the stent shown and discussed in this specification is merely exemplary.
  • the stent 25 could be formed of a material and constructed in accordance with the teachings set forth in U.S. Patent No. 6,051,020 (Goicoechea et al), the disclosure of which is incorporated herein by reference. As shown in Fig.
  • the stent 25 is made by winding a single strand 32 of a shape memory wire, e.g., nitinol wire, onto a mandrel (not shown) to form a plurality of hoops, each hoop having an apex 33.
  • the winding surface of the mandrel (not shown) is provided with a plurality of upstanding pins (not shown) to enable formation of the hoops and their corresponding apices 33.
  • the strand 32 is first wound to form a top tier indicated at 36a. Once the strand 32 is wound one full revolution around the mandrel, the top tier 36a is completed.
  • the strand 32 is looped upon itself, as indicated at 31a, and then dropped down to the next tier below, 36b.
  • the winding process is repeated. That is, once the strand 32 is wound one full revolution around the mandrel to complete the second tier 36b, as indicated at 31b, the strand 32 is dropped down to the next tier below, indicated at 36c. Thereafter, the strand 32 is wound as described above to form tiers 36c, 36d, 36e and 36f.
  • the wire 32 is annealed at any suitable temperature, e.g., 500° C for any suitable period of time, e.g., 60 minutes, and is then allowed to cool in air.
  • the purpose of the annealing is so that the wire "remembers" its configuration as wound on the mandrel (not shown). It should be appreciated that other temperatures and durations for the annealing are included within the present invention provided the wire "remembers" its wound configuration.
  • securing ties 40 could be polypropylene filaments.
  • Each apex 33 of each hoop is tied to the juxtaposed apex 33. It will be appreciated, however, that in other embodiments of the invention, only some of the juxtaposed apices 33 may be secured in this way.
  • the securing ties 40 may comprise a suture material, for example, to tie the juxtaposed apices 33 together.
  • the securing tie 40 may be a ring or staple formed of wire such as nitinol.
  • the stent 25 is cylindrical in shape and includes a central axis and an outer wall formed of the wound strand 32.
  • Each blood diverting assembly 30 comprises one or more blood diverting elements 34 that includes a deflecting portion 50 that is adjoined to a shank portion 55.
  • the deflecting portion 50 may be concave in shape. At this juncture, it is important to mention that the deflecting portion 50 is not limited to a concave shape, or for that matter to any particular construction or geometry.
  • the deflecting portion 50 may be shaped in a myriad of other ways, e.g., convex, bulbous, rounded, squared, flat, triangular, or any other geometric configuration that results in altering the amount of blood that is diverted from the aorta 27 into the renal arteries 22.
  • the deflecting portion 50 could include one or more through openings, perforations or apertures that would affect the amount of blood being diverted from the aorta into the renal arteries.
  • two blood diverting elements 34 are shown mounted to the stent 25 which are oriented face-to-face.
  • deflecting portion 50 and shank portion 55 are shown as being integral with each other, these components could also be distinct components joined to one another by any suitable means, e.g., welding.
  • the deflecting portion 50 and the shank portion 55 may be formed of any suitable biocompatible material, e.g., flexible stainless steel.
  • the shank portion 55 includes an upper slot 60 and a lower slot 65.
  • a front guide 70 and rear guide 75 are each provided with through openings 70a and 75a to enable passage of a wire 32 of the stent 25 therethrough to enable securement of the front and rear guides 70 and 75 to the stent 25.
  • the front and rear guides 70 and 75 may be formed of any suitable biocompatible material, e.g., stainless steel. As best shown in Figs.
  • the front guide 70 is situated within the upper slot 60 of the blood diverting assembly 30 and the rear guide 75 is situated within the lower slot 65 of the blood diverting assembly 30 to hold the blood diverting elements 34 captive and to enable translational movement of the blood diverting elements 34 from a stowed position, as best shown in Figs. 2 and 3, to a fully extended position and to any desirable deployed position therebetween.
  • Translational movement of the blood diverting element 34 from the stowed position to the fully extended position is along a path parallel to the central axis of the stent 25.
  • the blood diverting elements 34 are deployed to a position between said stowed position and said fully extended position.
  • the rear guide 75 also serves as a bearing for an externally threaded adjustment screw 80 and permits the adjustment screw 80 to rotate but not translate therein.
  • the adjustment screw 80 may be formed of any suitable biocompatible material, e.g., stainless steel, and is provided with a closed eye-loop 82 at one end to enable grasping and rotation of the adjustment screw 80 by any suitable biocompatible instrument, e.g., a flexible grasper (not shown) inserted into the body.
  • Such a flexible grasper is well known in the art and may be of any suitable construction so long as it is flexible in lateral directions so that it can be steered through the body's vasculature to the aorta 27 at its junction with the renal arteries 22 and is rotatable so that it can be rotated for deployment of the blood diverting elements 34.
  • An internally threaded block 85 formed of any suitable biocompatible material, e.g., stainless steel, is affixed to an end of the shank portion 55 opposite the deflecting portion 50.
  • the externally threaded adjustment screw 80 is engageable with the internally threaded block 85 such that upon rotation of the adjustment screw, the blood diverting element 34 moves or translates from the stowed position, as best shown in Figs. 2 and 3, to a fully extended position and to any one of a plurality of intermediate deployed positions therebetween.
  • Figs. 4 and 5 illustrate the blood diverting element 34 deployed from said stowed position to one of said intermediate deployed positions.
  • the front guide 70 has the additional function of retaining the deflecting portion 50 in an upright orientation and against the framework of the stent 25.
  • the stent may be compressed so that its diameter is reduced so that the device 20 may be placed within a suitable insertion catheter (not shown) to enable delivery of the device 20 at the target site.
  • the stent 25 may be deployed from the insertion catheter (not shown). Upon deployment, the stent 25, by its natural tendency, will self-expand from its compressed condition and will engage itself against the wall of the aorta at the desired location.
  • barbs may be provided to facilitate securement of the stent 25 within the aorta 27.
  • the grasping element (not shown), described above, may be introduced at the target site and used to engage the closed loops 82 of the adjustment screws 80 to deploy the blood diverting elements 34.
  • the deflecting portion 50 moves from an upright orientation to an inclined orientation pointing towards the central axis of the stent 25.
  • each blood flow diverting element is deployable.
  • one blood flow diverting element could be deployed while the other is retained in the stowed position to effect an increase of blood flow into one renal artery but not the other.
  • the ability to independently deploy any one of the blood diverting elements could be desirable where a kidney associated with one of the renal arteries has been removed and it is desirable to divert blood to one remaining kidney.
  • a significant portion of blood (indicated by arrows 39 ) flowing through the aorta 27 is diverted into the renal arteries 22.
  • This increased flow of blood to the kidneys through the renal arteries 22 has the effect of lowering blood pressure.
  • the position of the deflecting portions 50 may be adjusted by means previously discussed to adjust the amount of diverted flow of blood to the renal arteries.
  • a feedback mechanism or system could be employed in combination with the intravascular device 20 in a manner such that the system would monitor or detect blood pressure within the living being and in accordance with predetermined parameters defining a desired blood pressure level or goal, adjust the deployed position of the deflecting portions 50 to adjust upwardly or downwardly the level of blood pressure within the living being towards the desired blood pressure level.
  • the device 20 may be easily removed from the inner wall of the aorta 27, by introduction of the insertion catheter (not shown) at the target site.
  • the insertion catheter (not shown)
  • the insertion catheter Disposed within the insertion catheter are several grasping tools (not shown) each of which is arranged for grasping an apex 33 located on the bottom tier 36f to pull the device 20 of the present invention within the insertion device.
  • devices constructed in accordance with this invention increase the flow of blood through the renal arteries resulting in a reduction in blood pressure. While the disclosed embodiment is used for both renal arteries, if desired, it may be constructed and arranged for use with only one of the renal arteries. In any case, the subject invention accomplishes its end without necessitating the introduction of drugs, chemicals, etc., into the body to adjust the heart rate. Moreover, the device is simple in construction and easy to deploy and position within the aorta of a living being.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne un dispositif intravasculaire implantable permettant de dévier le flux sanguin provenant de l'aorte vers au moins une artère rénale d'un être vivant, de sorte à réduire la pression artérielle de cet être vivant. Ce dispositif comporte un moyen d'ancrage et un moyen de déviation du flux sanguin situé sur le moyen d'ancrage. L'élément de déviation du flux sanguin est disposé de sorte à pouvoir effectuer un mouvement entre une position d'arrimage et une position d'extension, afin d'effectuer une déviation régulée du sang dans l'artère rénale. L'invention concerne également un procédé d'abaissement de la pression artérielle d'un être vivant, ce procédé consistant à introduire un dispositif dans l'aorte d'un être vivant, à proximité d'au moins une artère rénale, le dispositif augmentant ensuite le flux sanguin vers l'artère rénale.
PCT/US2001/048106 2000-11-13 2001-11-08 Dispositif et procede de reduction de la pression arterielle WO2002038085A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002229026A AU2002229026A1 (en) 2000-11-13 2001-11-08 Device and method for reducing blood pressure

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71125100A 2000-11-13 2000-11-13
US09/711,251 2000-11-13

Publications (1)

Publication Number Publication Date
WO2002038085A1 true WO2002038085A1 (fr) 2002-05-16

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Cited By (23)

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WO2007127477A2 (fr) * 2006-04-27 2007-11-08 Synecor, Llc Augmentation du débit sanguin rénal pour traitement d'insuffisance cardiaque congestive
JP2008099995A (ja) * 2006-10-20 2008-05-01 Guroobu Kk ステント及びステントグラフト
WO2009118912A1 (fr) * 2008-03-28 2009-10-01 グローブ株式会社 Endoprothèse et endoprothèse couverte
CN104470579A (zh) * 2012-06-06 2015-03-25 洋红医疗有限公司 人工肾脏瓣膜
US20160113764A1 (en) * 2014-06-11 2016-04-28 Medtronic Vascular, Inc. Prosthetic Valve With Flow Director
US9592112B2 (en) 2011-11-16 2017-03-14 Bolton Medical, Inc. Device and method for aortic branched vessel repair
US9764113B2 (en) 2013-12-11 2017-09-19 Magenta Medical Ltd Curved catheter
US9913937B2 (en) 2013-03-13 2018-03-13 Magenta Medical Ltd. Renal pump
US10390932B2 (en) 2016-04-05 2019-08-27 Bolton Medical, Inc. Stent graft with internal tunnels and fenestrations and methods of use
US10524893B2 (en) 2014-09-23 2020-01-07 Bolton Medical, Inc. Vascular repair devices and methods of use
US10583231B2 (en) 2013-03-13 2020-03-10 Magenta Medical Ltd. Blood pump
US10881770B2 (en) 2018-01-10 2021-01-05 Magenta Medical Ltd. Impeller for blood pump
US10893927B2 (en) 2018-03-29 2021-01-19 Magenta Medical Ltd. Inferior vena cava blood-flow implant
US11033727B2 (en) 2016-11-23 2021-06-15 Magenta Medical Ltd. Blood pumps
US11039915B2 (en) 2016-09-29 2021-06-22 Magenta Medical Ltd. Blood vessel tube
US11191944B2 (en) 2019-01-24 2021-12-07 Magenta Medical Ltd. Distal tip element for a ventricular assist device
US11260212B2 (en) 2016-10-25 2022-03-01 Magenta Medical Ltd. Ventricular assist device
US11291824B2 (en) 2015-05-18 2022-04-05 Magenta Medical Ltd. Blood pump
US11291826B2 (en) 2018-01-10 2022-04-05 Magenta Medical Ltd. Axially-elongatable frame and impeller
US11395750B2 (en) 2016-05-25 2022-07-26 Bolton Medical, Inc. Stent grafts and methods of use for treating aneurysms
US11446167B2 (en) 2011-11-11 2022-09-20 Bolton Medical, Inc. Universal endovascular grafts
US11883030B2 (en) * 2022-04-29 2024-01-30 inQB8 Medical Technologies, LLC Systems, devices, and methods for controllably and selectively occluding, restricting, and diverting flow within a patient's vasculature
US11974751B2 (en) 2022-04-29 2024-05-07 inQB8 Medical Technologies, LLC Systems, devices, and methods for controllably and selectively occluding, restricting, and diverting flow within a patient's vasculature

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