WO2002024164A3 - Procede de granulation par extrusion basse pression - Google Patents

Procede de granulation par extrusion basse pression Download PDF

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Publication number
WO2002024164A3
WO2002024164A3 PCT/FR2001/002948 FR0102948W WO0224164A3 WO 2002024164 A3 WO2002024164 A3 WO 2002024164A3 FR 0102948 W FR0102948 W FR 0102948W WO 0224164 A3 WO0224164 A3 WO 0224164A3
Authority
WO
WIPO (PCT)
Prior art keywords
granulation
low pressure
pressure extrusion
directly compressible
active substances
Prior art date
Application number
PCT/FR2001/002948
Other languages
English (en)
Other versions
WO2002024164A2 (fr
Inventor
Stephane Martin-Letellier
Thiesse Jean-Claude Le
Original Assignee
Rhodia Chimie Sa
Stephane Martin-Letellier
Thiesse Jean-Claude Le
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhodia Chimie Sa, Stephane Martin-Letellier, Thiesse Jean-Claude Le filed Critical Rhodia Chimie Sa
Priority to US10/380,954 priority Critical patent/US20040013735A1/en
Priority to AU2001293919A priority patent/AU2001293919A1/en
Priority to EP01974395A priority patent/EP1318789A2/fr
Publication of WO2002024164A2 publication Critical patent/WO2002024164A2/fr
Publication of WO2002024164A3 publication Critical patent/WO2002024164A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention a pour objet un procédé pour formuler une ou plusieurs matière(s) active(s) sous la forme de granulés directement compressibles comprenant la granulation par voie humide à l'aide d'une solution liante de ladite matière active et le cas échéant des excipients associés puis le séchage des granulés ainsi obtenus, caractérisé en ce que ladite granulation est effectuée par extrusion basse pression du mélange matière(s) active(s), solution liante et le cas échéant excipient(s).
PCT/FR2001/002948 2000-09-22 2001-09-21 Procede de granulation par extrusion basse pression WO2002024164A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/380,954 US20040013735A1 (en) 2000-09-22 2001-09-21 Method for granulation of active substances by low pressure extrusion to obtain directly compressible granules
AU2001293919A AU2001293919A1 (en) 2000-09-22 2001-09-21 Method for granulation of active substances by low pressure extrusion to obtain directly compressible granules
EP01974395A EP1318789A2 (fr) 2000-09-22 2001-09-21 Procede de granulation par extrusion basse pression

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0012112A FR2814366A1 (fr) 2000-09-22 2000-09-22 Procede de granulation de matieres actives par extrusion basse pression pour l'obtention de granules directement compressibles
FR00/12112 2000-09-22

Publications (2)

Publication Number Publication Date
WO2002024164A2 WO2002024164A2 (fr) 2002-03-28
WO2002024164A3 true WO2002024164A3 (fr) 2003-02-20

Family

ID=8854592

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2001/002948 WO2002024164A2 (fr) 2000-09-22 2001-09-21 Procede de granulation par extrusion basse pression

Country Status (6)

Country Link
US (1) US20040013735A1 (fr)
EP (1) EP1318789A2 (fr)
CN (1) CN1592606A (fr)
AU (1) AU2001293919A1 (fr)
FR (1) FR2814366A1 (fr)
WO (1) WO2002024164A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) * 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
RU2389480C2 (ru) * 2004-08-12 2010-05-20 РЕКИТТ БЕНКАЙЗЕР ХЕЛТКЭА (Ю Кей) ЛИМИТЕД Гранулы, содержащие нпвлс и сахарный спирт, изготовленные экструзией из расплава
WO2007053197A2 (fr) * 2005-06-03 2007-05-10 Elan Pharma International, Limited Preparations nanoparticulaires a base d'acetaminophene
NI200800073A (es) * 2005-09-09 2009-02-19 Formulación sólida de mezclas fungicidas
EP1952803A1 (fr) * 2007-01-23 2008-08-06 KTB-Tumorforschungs GmbH Composition pharmaceutique solide contenant des phospholipides hydrogénés
CN102823797A (zh) * 2012-08-31 2012-12-19 胡滨 一种制备淀粉颗粒的方法
CN104723597B (zh) * 2015-03-23 2017-04-05 辽宁天亿机械有限公司 一种间歇式压片机
CN106281567B (zh) * 2016-08-01 2019-07-30 内蒙古科技大学 一种流化床功能床料的制备装置及方法
CN114768677B (zh) * 2022-06-24 2022-08-23 山东百农思达生物科技有限公司 一种杀菌剂制备用造粒装置

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689235A (en) * 1984-01-31 1987-08-25 Scm Corporation Encapsulation matrix composition and encapsulate containing same
US5688510A (en) * 1993-11-18 1997-11-18 Nippon Shinyaku Co. Ltd. Process for producing stable medicinal composition, and pharmaceutical preparation
US5709885A (en) * 1992-10-09 1998-01-20 Hellen; Leena Process for the preparation of drug pellets
FR2761605A1 (fr) * 1997-04-07 1998-10-09 Prographarm Lab Forme pharmaceutique multiparticulaire, ses particules constitutives, procede et installation pour leur fabrication
US5968925A (en) * 1995-06-23 1999-10-19 Boeters & Bauer Process for continuous sintering of granules

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1583602A (en) * 1977-05-26 1981-01-28 Sterwin Ag N-acetyl-para-aminophenyl-n'-acetyl-amino-thioalkanoic acid ester derivatives
US5358717A (en) * 1989-12-22 1994-10-25 Syntex (U.S.A.) Inc. Directly-compressible naproxen or naproxen sodium compositions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689235A (en) * 1984-01-31 1987-08-25 Scm Corporation Encapsulation matrix composition and encapsulate containing same
US5709885A (en) * 1992-10-09 1998-01-20 Hellen; Leena Process for the preparation of drug pellets
US5688510A (en) * 1993-11-18 1997-11-18 Nippon Shinyaku Co. Ltd. Process for producing stable medicinal composition, and pharmaceutical preparation
US5968925A (en) * 1995-06-23 1999-10-19 Boeters & Bauer Process for continuous sintering of granules
FR2761605A1 (fr) * 1997-04-07 1998-10-09 Prographarm Lab Forme pharmaceutique multiparticulaire, ses particules constitutives, procede et installation pour leur fabrication

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Solids forming: extruding", LCI CORPORATION, XP002208368, Retrieved from the Internet <URL:http://www.lcicorp.com/index.html?bottom=/solids/extrude.html> [retrieved on 20020801] *
MEHTA K A ET AL: "Effect of formulation and process variables on porosity parameters and release rates from a multi unit erosion matrix of a poorly soluble drug", JOURNAL OF CONTROLLED RELEASE,NL,ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, vol. 63, no. 1-2, January 2000 (2000-01-01), pages 201 - 211, XP004185084, ISSN: 0168-3659 *
OTSUKA MAKOTO ET AL: "Effect of polymorphic forms of bulk powders on pharmaceutical properties of carbamazepine granules.", CHEMICAL & PHARMACEUTICAL BULLETIN (TOKYO), vol. 47, no. 6, June 1999 (1999-06-01), pages 852 - 856, XP002169229, ISSN: 0009-2363 *
OTSUKA, MAKOTO ET AL: "Comparative evaluation of tableting compression behaviors by methods of internal and external lubricant addition: Inhibition of enzymic activity of trypsin preparation by using external lubricant addition during the tableting compression process", PHARMSCI [ONLINE COMPUTER FILE] (2001), 3(3), NO PP. GIVEN, 11 July 2001 (2001-07-11), pages 1 - 7, XP002208518, Retrieved from the Internet <URL:http://www.pharmsci.org/scientificjournals/pharmsci/journal/01_20.html> [retrieved on 20020802] *
SONAGLIO D ET AL: "APPROACH TO THE DEVELOPMENT OF HIGH DOSE PARACETAMOL SPHERES BY EXTRUSION/SPHERONIZATION", PHARMAZIE,DD,VEB VERLAG VOLK UND GESUNDHEIT. BERLIN, vol. 52, no. 2, 1 February 1997 (1997-02-01), pages 129 - 134, XP000643321, ISSN: 0031-7144 *

Also Published As

Publication number Publication date
EP1318789A2 (fr) 2003-06-18
US20040013735A1 (en) 2004-01-22
FR2814366A1 (fr) 2002-03-29
AU2001293919A1 (en) 2002-04-02
WO2002024164A2 (fr) 2002-03-28
CN1592606A (zh) 2005-03-09

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