WO2002020509A3 - Arzneimittel gegen virale erkrankungen - Google Patents

Arzneimittel gegen virale erkrankungen Download PDF

Info

Publication number
WO2002020509A3
WO2002020509A3 PCT/EP2001/009772 EP0109772W WO0220509A3 WO 2002020509 A3 WO2002020509 A3 WO 2002020509A3 EP 0109772 W EP0109772 W EP 0109772W WO 0220509 A3 WO0220509 A3 WO 0220509A3
Authority
WO
WIPO (PCT)
Prior art keywords
hbv
viral infections
against viral
medicaments against
agents
Prior art date
Application number
PCT/EP2001/009772
Other languages
English (en)
French (fr)
Other versions
WO2002020509A2 (de
Inventor
Susanne Nikolic
Stephan Bartel
Michael Brands
Ulrich Niewoehner
Arnold Paessens
Erwin Graef
Karl-Heinz Schlemmer
Kerstin Henninger
Rainer Endermann
Olaf Weber
Diana Koletzki
Original Assignee
Bayer Ag
Susanne Nikolic
Stephan Bartel
Michael Brands
Ulrich Niewoehner
Arnold Paessens
Erwin Graef
Karl-Heinz Schlemmer
Kerstin Henninger
Rainer Endermann
Olaf Weber
Diana Koletzki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2000143791 external-priority patent/DE10043791A1/de
Priority claimed from DE2000154932 external-priority patent/DE10054932A1/de
Application filed by Bayer Ag, Susanne Nikolic, Stephan Bartel, Michael Brands, Ulrich Niewoehner, Arnold Paessens, Erwin Graef, Karl-Heinz Schlemmer, Kerstin Henninger, Rainer Endermann, Olaf Weber, Diana Koletzki filed Critical Bayer Ag
Priority to AU2001289831A priority Critical patent/AU2001289831A1/en
Publication of WO2002020509A2 publication Critical patent/WO2002020509A2/de
Publication of WO2002020509A3 publication Critical patent/WO2002020509A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Chromanonderivate sind hochwirksame antivirale Mittel. Kombinationen von Chromanonen und/oder Chromanolen mit HBV-Polymerase-Inhibitoren, HBV-DNA- bzw. HBV-core-Protein-Inhibitoren und/oder Isoxazolen und gegebenenfalls Interferon hemmen die Vermehrung von HBV-Viren besser als bislang bekannte Mittel.
PCT/EP2001/009772 2000-09-06 2001-08-24 Arzneimittel gegen virale erkrankungen WO2002020509A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001289831A AU2001289831A1 (en) 2000-09-06 2001-08-24 Medicaments against viral infections

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10043791.5 2000-09-06
DE2000143791 DE10043791A1 (de) 2000-09-06 2000-09-06 Arzneimittel gegen virale Erkrankungen
DE10054932.2 2000-11-06
DE2000154932 DE10054932A1 (de) 2000-11-06 2000-11-06 Arzneimittelkombinationen gegen virale Erkrankungen

Publications (2)

Publication Number Publication Date
WO2002020509A2 WO2002020509A2 (de) 2002-03-14
WO2002020509A3 true WO2002020509A3 (de) 2002-06-27

Family

ID=26006936

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/009772 WO2002020509A2 (de) 2000-09-06 2001-08-24 Arzneimittel gegen virale erkrankungen

Country Status (3)

Country Link
US (1) US20020082264A1 (de)
AU (1) AU2001289831A1 (de)
WO (1) WO2002020509A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2008013428A (es) * 2006-04-18 2008-11-04 Abbott Lab Antagonistas del receptor de vanilloides del subtipo (vr1) y usos de los mismos.
ATE552262T1 (de) * 2006-11-29 2012-04-15 Pfizer Prod Inc Spiroketone als inhibitoren von acetyl-coa- carboxylase
PE20081559A1 (es) 2007-01-12 2008-11-20 Merck & Co Inc DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA
AU2008205642B2 (en) * 2007-01-12 2013-06-06 Msd K.K. Spirochromanon derivatives
HUE028983T2 (en) 2010-05-06 2017-01-30 Vertex Pharma Heterocyclic chromene-spirocyclic piperidine amides as ion channel modulators
CN102558126B (zh) * 2010-12-16 2014-03-05 复旦大学 2-取代色原酮类化合物及其制备方法和用途
RS54785B1 (sr) 2011-02-02 2016-10-31 Vertex Pharma Pirolopirazin-spirociklični piperidin amidi kao modulatori jonskih kanala
JP5940562B2 (ja) 2011-02-18 2016-06-29 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ イオンチャネルのモジュレーターとしてのクロマン−スピロ環式ピペリジンアミド
ES2618929T3 (es) 2011-03-14 2017-06-22 Vertex Pharmaceuticals Incorporated Morfolina-Spiro piperidina amida cíclica como moduladores del canal iónico
EP3126360A1 (de) 2014-03-29 2017-02-08 Lupin Limited Sulfonamidverbindungen als spannungsabhängige natriumkanalmodulatoren
CN104262317B (zh) * 2014-09-04 2016-08-17 玉溪师范学院 一种二聚单萜类化合物及其制备方法与应用
CN107311973B (zh) * 2017-06-25 2021-04-06 石家庄学院 一种含硝酸酯基二氢杨梅素衍生物及其制备和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2611910A1 (de) * 1976-03-20 1977-09-22 Bayer Ag Chromanone-(4)
EP0004624A2 (de) * 1978-04-07 1979-10-17 Bayer Ag Neue Chromanon-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel und Wachstumsförderer
WO1995030642A1 (en) * 1994-05-06 1995-11-16 Pharmacopeia, Inc. Combinatorial dihydrobenzopyran library
EP0695547A1 (de) * 1993-04-09 1996-02-07 Toyama Chemical Co., Ltd. Immunomodulator, zelladhäsionsinhibitor und mittel zur behandlung und vorbeugung von autoimmunerkrankungen
US6005103A (en) * 1993-11-19 1999-12-21 Warner-Lambert Company Pyrone derivatives as protease inhibitors and antiviral agents
US6046355A (en) * 1996-11-01 2000-04-04 Warner-Lambert Company Dihydropyrones with improved antiviral activity

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2611910A1 (de) * 1976-03-20 1977-09-22 Bayer Ag Chromanone-(4)
EP0004624A2 (de) * 1978-04-07 1979-10-17 Bayer Ag Neue Chromanon-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel und Wachstumsförderer
EP0695547A1 (de) * 1993-04-09 1996-02-07 Toyama Chemical Co., Ltd. Immunomodulator, zelladhäsionsinhibitor und mittel zur behandlung und vorbeugung von autoimmunerkrankungen
US6005103A (en) * 1993-11-19 1999-12-21 Warner-Lambert Company Pyrone derivatives as protease inhibitors and antiviral agents
WO1995030642A1 (en) * 1994-05-06 1995-11-16 Pharmacopeia, Inc. Combinatorial dihydrobenzopyran library
US6046355A (en) * 1996-11-01 2000-04-04 Warner-Lambert Company Dihydropyrones with improved antiviral activity

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHIN-TENG CHANG ET AL.: "Coumarins and Anti-HBV constizuents from Zanthoxylum Schinifolium", PHYTOCHEMISTRY., vol. 45, no. 7, 1997, PERGAMON PRESS., GB, pages 1419 - 1422, XP004293278, ISSN: 0031-9422 *
STEVE R. TURNER ET AL.: "Tipranavir(PNU-140690) A potent, Orally Bioavailable Nonpeptidic HIV protease inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class", JOURNAL OF MEDICINAL CHEMISTRY., vol. 41, no. 18, 1998, AMERICAN CHEMICAL SOCIETY., US, pages 3467 - 3476, XP002194391, ISSN: 0022-2623 *
SUVIT THAISRIVONGS ET AL.: "Structure-based design of Hiv protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as effective, nonpeptidic Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY., vol. 39, no. 23, 1996, AMERICAN CHEMICAL SOCIETY., US, pages 4630 - 4642, XP002194392, ISSN: 0022-2623 *
ZE-QI XU ET AL.: "In Vitro Anti-Human Immunodeficiency Virus Activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, no. 8, 1998, OXFORD, GB, pages 2179 - 2184, XP004137242, ISSN: 0960-894X *

Also Published As

Publication number Publication date
AU2001289831A1 (en) 2002-03-22
US20020082264A1 (en) 2002-06-27
WO2002020509A2 (de) 2002-03-14

Similar Documents

Publication Publication Date Title
WO2001077091A3 (en) Ns5b hcv polymerase inhibitors
ATE269321T1 (de) Arzneimittel gegen virale erkrankungen
EP1653976A4 (de) Anti-virale nucleosid-analoga und verfahren zur behandlung von virusinfektionen, insbesondere hiv-infektionen
WO2004011478A3 (en) Anti-viral 7-deaza d-nucleosides and uses thereof
WO2002020509A3 (de) Arzneimittel gegen virale erkrankungen
IL215891A (en) Hepatitis C Serine Protease Inhibitors, Pharmaceutical Compounds Containing Them, and Their Use in Preparing Drugs to Treat Hepatitis C Infections
WO2002057287A3 (en) Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
WO2007001406A3 (en) Aryl-containing macrocyclic compounds
AU2002364730A1 (en) N4-acylcytosine-1,3-dioxolane nucleosides for treatment of viral infections
WO2007049265A3 (en) Anti mineralocorticoid therapy of infection
WO2006072625A8 (en) Anti-kir combination treatments and methods
WO2004007512A3 (en) Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
WO2004000858A3 (en) Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
WO2004003138A3 (en) Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
WO2008003149A3 (en) Substituted pteridines for the treatment and prevention of viral infections
WO2006101538A3 (en) Andrographolide derivatives to treat viral infections
WO2003055896A3 (en) Anti-viral 7-deaza l-nucleosides
AU2001232267A1 (en) Remedies for hepatitis c
WO2005013917A3 (en) Combination therapy for treating alphavirus infection and liver fibrosis
WO2001012228A3 (en) Compositions for treating viral infections, and methods therefor
WO2003025139A3 (en) Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof
WO2004052905A3 (en) Antiviral nucleoside derivatives
WO2002000613A3 (en) Inhibitors of hepatitis b virus infection
BR0108723A (pt) Medicamentos contra doenças viróticas
WO2001097749A3 (en) The use of synthetic, non-hormonal 21-aminosteroids and thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP