WO2002013802A2 - Method of treating estrogen receptor positive carcinoma - Google Patents

Method of treating estrogen receptor positive carcinoma Download PDF

Info

Publication number
WO2002013802A2
WO2002013802A2 PCT/US2001/024615 US0124615W WO0213802A2 WO 2002013802 A2 WO2002013802 A2 WO 2002013802A2 US 0124615 W US0124615 W US 0124615W WO 0213802 A2 WO0213802 A2 WO 0213802A2
Authority
WO
WIPO (PCT)
Prior art keywords
rapamycin
carbon atoms
antiestrogen
hydroxy
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/024615
Other languages
English (en)
French (fr)
Other versions
WO2002013802A3 (en
Inventor
Yixian Zhang
Tammy Michelle Sadler
Philip Frost
Lee Martin Greenberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22840171&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2002013802(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to HK03109077.4A priority Critical patent/HK1056687B/en
Priority to DK01961914T priority patent/DK1318837T3/da
Priority to AU2001283139A priority patent/AU2001283139A1/en
Priority to EP01961914A priority patent/EP1318837B1/en
Priority to DE60106281T priority patent/DE60106281T2/de
Application filed by Wyeth LLC, American Home Products Corp filed Critical Wyeth LLC
Priority to JP2002518948A priority patent/JP2004507465A/ja
Priority to CA002416976A priority patent/CA2416976C/en
Priority to MXPA03001245A priority patent/MXPA03001245A/es
Priority to AT01961914T priority patent/ATE278421T1/de
Publication of WO2002013802A2 publication Critical patent/WO2002013802A2/en
Anticipated expiration legal-status Critical
Publication of WO2002013802A3 publication Critical patent/WO2002013802A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Definitions

  • Non-uterotrophic antiestrogens have been reported to have antitumor activity [see, US Patent 5,998,402].
  • Preferred antiestrogens include compounds such as triphenylene antiestrogens including tamoxifen and 4-hydroxytamoxifen; clomiphene; and non-uterotrophic antiesestrogens, such as those shown below in formulas I and II, raloxifene, droloxifene, idoxifine, nafoxidine, toremifene, TAT-59, levomeloxifene, LY-353381 , CP-336156, MDL-103323, EM-800, and ICI-182,780.
  • triphenylene antiestrogens including tamoxifen and 4-hydroxytamoxifen; clomiphene; and non-uterotrophic antiesestrogens, such as those shown below in formulas I and II, raloxifene, droloxifene, idoxifine, nafoxidine, toremifene, TAT-59, levomeloxifene,
  • the term "providing,” with respect to providing a compound or substance covered by this invention means either directly administering such a compound or substance, or administering a prodrug, derivative, or analog which will form the equivalent amount of the compound or substance within the body.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/US2001/024615 2000-08-11 2001-08-06 Method of treating estrogen receptor positive carcinoma Ceased WO2002013802A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AT01961914T ATE278421T1 (de) 2000-08-11 2001-08-06 Verfahren zur behandlung eines östrogenrezeptor positives karzinoms
CA002416976A CA2416976C (en) 2000-08-11 2001-08-06 Treatment of estrogen receptor positive carcinoma with a rapamycin and an antiestrogen
AU2001283139A AU2001283139A1 (en) 2000-08-11 2001-08-06 Method of treating estrogen receptor positive carcinoma
EP01961914A EP1318837B1 (en) 2000-08-11 2001-08-06 Method of treating estrogen receptor positive carcinoma
DE60106281T DE60106281T2 (de) 2000-08-11 2001-08-06 Verfahren zur Behandlung eines Östrogenrezeptor-positiven Karzinoms
HK03109077.4A HK1056687B (en) 2000-08-11 2001-08-06 Method of treating estrogen receptor positive carcinoma
JP2002518948A JP2004507465A (ja) 2000-08-11 2001-08-06 エストロゲン受容体陽性癌腫の治療方法
DK01961914T DK1318837T3 (da) 2000-08-11 2001-08-06 Fremgangsmåde til behandling af östrogenreceptorpositivt carcinom
MXPA03001245A MXPA03001245A (es) 2000-08-11 2001-08-06 Metodo para el tratamiento del carcionma positivo para receptores de estrogeno.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22432600P 2000-08-11 2000-08-11
US60/224,326 2000-08-11

Publications (2)

Publication Number Publication Date
WO2002013802A2 true WO2002013802A2 (en) 2002-02-21
WO2002013802A3 WO2002013802A3 (en) 2003-03-27

Family

ID=22840171

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024615 Ceased WO2002013802A2 (en) 2000-08-11 2001-08-06 Method of treating estrogen receptor positive carcinoma

Country Status (14)

Country Link
US (1) US6511986B2 (enExample)
EP (1) EP1318837B1 (enExample)
JP (1) JP2004507465A (enExample)
CN (1) CN100448487C (enExample)
AR (1) AR033555A1 (enExample)
AT (1) ATE278421T1 (enExample)
AU (1) AU2001283139A1 (enExample)
CA (1) CA2416976C (enExample)
DE (1) DE60106281T2 (enExample)
DK (1) DK1318837T3 (enExample)
ES (1) ES2228932T3 (enExample)
MX (1) MXPA03001245A (enExample)
PT (1) PT1318837E (enExample)
WO (1) WO2002013802A2 (enExample)

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US8703810B2 (en) 2010-06-10 2014-04-22 Seragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
AU2011226833B2 (en) * 2001-02-19 2014-05-22 Novartis Ag Cancer treatment
US9187460B2 (en) 2011-12-14 2015-11-17 Seragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
WO2017059139A1 (en) 2015-10-01 2017-04-06 Olema Pharmaceuticals, Inc. TETRAHYDRO-1H-PYRIDO[3,4-b]INDOLE ANTI-ESTROGENIC DRUGS
WO2017100712A1 (en) 2015-12-09 2017-06-15 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective estrogen receptor downregulators
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PT1318837E (pt) 2004-12-31
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DE60106281D1 (de) 2004-11-11
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ATE278421T1 (de) 2004-10-15
CN100448487C (zh) 2009-01-07
US20020045638A1 (en) 2002-04-18
DE60106281T2 (de) 2005-02-24
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CA2416976C (en) 2008-05-20
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