WO2002010351A3 - Autologe bindegewebe, verfahren zu ihrer herstellung und ihre verwendung - Google Patents

Autologe bindegewebe, verfahren zu ihrer herstellung und ihre verwendung Download PDF

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Publication number
WO2002010351A3
WO2002010351A3 PCT/DE2001/002899 DE0102899W WO0210351A3 WO 2002010351 A3 WO2002010351 A3 WO 2002010351A3 DE 0102899 W DE0102899 W DE 0102899W WO 0210351 A3 WO0210351 A3 WO 0210351A3
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WO
WIPO (PCT)
Prior art keywords
cells
production
tissue
methods
tissues
Prior art date
Application number
PCT/DE2001/002899
Other languages
English (en)
French (fr)
Other versions
WO2002010351A2 (de
Inventor
Michael Sittinger
Andreas Groeger
Frank Wanjura
Andreas Haisch
Original Assignee
Schmitt Waldburg Gbr
Michael Sittinger
Andreas Groeger
Frank Wanjura
Andreas Haisch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schmitt Waldburg Gbr, Michael Sittinger, Andreas Groeger, Frank Wanjura, Andreas Haisch filed Critical Schmitt Waldburg Gbr
Priority to EP01964866A priority Critical patent/EP1307543A2/de
Publication of WO2002010351A2 publication Critical patent/WO2002010351A2/de
Publication of WO2002010351A3 publication Critical patent/WO2002010351A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

Die Erfindung betrifft autologe Bindegewebe, Verfahren zu ihrer Herstellung, ihre Stabilisierung und ihre Verwendung als Transplantate. Die Herstellung der Gewebe erfolgt durch Isolation geeigneter Bindegewebszellen, wie Knorpel-, Perichondrium- und/oder Periostzellen sowie der entsprechenden Vorläuferzellen, ihre Vermehrung in vitro (Tissue engineering), Einbettung in eine dreidimensionale Matrix, Implantation und ihre Stimulation durch Corticosteroide. Die erfindungsgemässen Gewebe eignen sich zur Verwendung als Tissue engineering-Transplantate, insbesondere als Knorpel- und Knochengewebe.
PCT/DE2001/002899 2000-07-31 2001-07-30 Autologe bindegewebe, verfahren zu ihrer herstellung und ihre verwendung WO2002010351A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP01964866A EP1307543A2 (de) 2000-07-31 2001-07-30 Autologe bindegewebe, verfahren zu ihrer herstellung und ihre verwendung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10038700A DE10038700B4 (de) 2000-07-31 2000-07-31 Autologe Bindegewebe, Verfahren zu ihrer Herstellung und ihre Verwendung
DE10038700.4 2000-07-31

Publications (2)

Publication Number Publication Date
WO2002010351A2 WO2002010351A2 (de) 2002-02-07
WO2002010351A3 true WO2002010351A3 (de) 2002-09-12

Family

ID=7651736

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2001/002899 WO2002010351A2 (de) 2000-07-31 2001-07-30 Autologe bindegewebe, verfahren zu ihrer herstellung und ihre verwendung

Country Status (3)

Country Link
EP (1) EP1307543A2 (de)
DE (1) DE10038700B4 (de)
WO (1) WO2002010351A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10253066A1 (de) * 2002-11-07 2004-05-27 Co.Don Aktiengesellschaft Gewebeersatzstruktur, Verfahren zur Modifikation einer Gewebeläsion und Verwendung von vorgeformtem dreidimensionalem Gewebe als Lieferant von Botenstoffen und/oder Strukturbausteinen
US7744869B2 (en) 2003-08-20 2010-06-29 Ebi, Llc Methods of treatment using electromagnetic field stimulated mesenchymal stem cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997015655A2 (de) * 1995-10-20 1997-05-01 Michael Sittinger Neue künstliche gewebe, verfahren zu ihrer herstellung und ihre verwendung
DE19835368C1 (de) * 1998-08-05 2000-02-10 Juergen Steinmeyer Verfahren zur Herstellung einer Knorpelzellsuspension
EP1085084A1 (de) * 1999-09-16 2001-03-21 Universite Pierre Et Marie Curie Paris Vi Zusammensetzungen aus Chondrozyten, Herstellung und Verwendungen davon

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4431598C2 (de) * 1993-03-03 1997-03-20 Michael Sittinger Verfahren zum Herstellen eines Implantates aus Zellkulturen
WO1999009149A1 (en) * 1997-08-01 1999-02-25 Massachusetts Institute Of Technology Three-dimensional polymer matrices

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997015655A2 (de) * 1995-10-20 1997-05-01 Michael Sittinger Neue künstliche gewebe, verfahren zu ihrer herstellung und ihre verwendung
DE19835368C1 (de) * 1998-08-05 2000-02-10 Juergen Steinmeyer Verfahren zur Herstellung einer Knorpelzellsuspension
EP1085084A1 (de) * 1999-09-16 2001-03-21 Universite Pierre Et Marie Curie Paris Vi Zusammensetzungen aus Chondrozyten, Herstellung und Verwendungen davon

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HAISCH A ET AL: "Macroencapsulation of human cartilage implants: pilot study with polyelectrolyte complex membrane encapsulation", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 21, no. 15, August 2000 (2000-08-01), pages 1561 - 1566, XP004204630, ISSN: 0142-9612 *
See also references of EP1307543A2 *

Also Published As

Publication number Publication date
DE10038700B4 (de) 2006-09-07
WO2002010351A2 (de) 2002-02-07
DE10038700A1 (de) 2002-02-21
EP1307543A2 (de) 2003-05-07

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