WO2001091753A1 - Wirkstoffkombination enthaltend ein opioid mit fentanyl-artiger struktur und ketamin - Google Patents
Wirkstoffkombination enthaltend ein opioid mit fentanyl-artiger struktur und ketamin Download PDFInfo
- Publication number
- WO2001091753A1 WO2001091753A1 PCT/EP2001/005348 EP0105348W WO0191753A1 WO 2001091753 A1 WO2001091753 A1 WO 2001091753A1 EP 0105348 W EP0105348 W EP 0105348W WO 0191753 A1 WO0191753 A1 WO 0191753A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- active ingredient
- radical
- pharmaceutical formulation
- formulation according
- cellulose
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/452—Piperidinium derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001274021A AU2001274021A1 (en) | 2000-05-26 | 2001-05-10 | Active substance combination containing an opioid having a fentanyl-type structure and ketamine |
CA002406976A CA2406976A1 (en) | 2000-05-26 | 2001-05-10 | Active substance combination containing an opioid having a fentanyl-type structure and ketamine |
US10/296,098 US20040092531A1 (en) | 2000-05-26 | 2001-05-10 | Active substance combination containing an opioid having a fentanyl-type structure and ketamine |
MXPA02011610A MXPA02011610A (es) | 2000-05-26 | 2001-05-10 | Combinacion de sustancia activa que contiene un opioide que tiene una estructura tipo fentanilo y cetamina. |
HU0301972A HUP0301972A3 (en) | 2000-05-26 | 2001-05-10 | Active substance combination containing an opioid having a fentanyl-type structure and ketamine and pharmaceutical compositions containing it |
NZ521878A NZ521878A (en) | 2000-05-26 | 2001-05-10 | Active substance combination containing an opioid having a fentanyl-type structure and ketamine |
JP2001587768A JP2003534378A (ja) | 2000-05-26 | 2001-05-10 | フェンタニル型構造のオピオイドおよびケタミンを含有する有効成分の組合せ |
EP01940449A EP1289528A1 (de) | 2000-05-26 | 2001-05-10 | Wirkstoffkombination enthaltend ein opioid mit fentanyl-artiger struktur und ketamin |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10025946.4 | 2000-05-26 | ||
DE10025946A DE10025946A1 (de) | 2000-05-26 | 2000-05-26 | Wirkstoffkombination |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001091753A1 true WO2001091753A1 (de) | 2001-12-06 |
Family
ID=7643550
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/005348 WO2001091753A1 (de) | 2000-05-26 | 2001-05-10 | Wirkstoffkombination enthaltend ein opioid mit fentanyl-artiger struktur und ketamin |
Country Status (10)
Country | Link |
---|---|
US (1) | US20040092531A1 (de) |
EP (1) | EP1289528A1 (de) |
JP (1) | JP2003534378A (de) |
AU (1) | AU2001274021A1 (de) |
CA (1) | CA2406976A1 (de) |
DE (1) | DE10025946A1 (de) |
HU (1) | HUP0301972A3 (de) |
MX (1) | MXPA02011610A (de) |
NZ (1) | NZ521878A (de) |
WO (1) | WO2001091753A1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006502187A (ja) * | 2002-09-20 | 2006-01-19 | アンドルックス ラボズ リミテッド ライアビリティ カンパニー | ビグアニドおよびチアゾリジンジオン誘導体を含有する多段階製剤 |
WO2006024018A2 (en) * | 2004-08-24 | 2006-03-02 | Neuromolecular Pharmaceuticals, Inc. | Compositions for treating nociceptive pain |
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DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
US7959946B2 (en) * | 2002-09-20 | 2011-06-14 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
US7785627B2 (en) * | 2002-09-20 | 2010-08-31 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
US9060941B2 (en) * | 2002-09-20 | 2015-06-23 | Actavis, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
US8084058B2 (en) * | 2002-09-20 | 2011-12-27 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
CA2550023C (en) * | 2003-12-16 | 2011-04-12 | Cnsbio Pty Ltd | Treatment of neuropathic pain |
US20070104763A1 (en) * | 2005-11-10 | 2007-05-10 | Navinta Llc | Composition of fentanyl citrate oral solid transmucosal dosage form, excipient and binding material therefore, and methods of making |
US9066847B2 (en) * | 2007-01-05 | 2015-06-30 | Aceirx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
US8202535B2 (en) | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
CN101378732A (zh) * | 2006-01-06 | 2009-03-04 | 阿塞尔Rx制药有限公司 | 用于口腔经粘膜递送的生物粘附药物制剂 |
US8753308B2 (en) | 2006-01-06 | 2014-06-17 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US8252329B2 (en) | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
US9289583B2 (en) * | 2006-01-06 | 2016-03-22 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US8357114B2 (en) | 2006-01-06 | 2013-01-22 | Acelrx Pharmaceuticals, Inc. | Drug dispensing device with flexible push rod |
US8252328B2 (en) * | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
US20070260491A1 (en) * | 2006-05-08 | 2007-11-08 | Pamela Palmer | System for delivery and monitoring of administration of controlled substances |
US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
US8710070B2 (en) * | 2008-03-27 | 2014-04-29 | University Of Kentucky Research Foundation | Opioid-ketamine and norketamine codrug combinations for pain management |
MX347741B (es) * | 2008-09-16 | 2017-05-10 | Nektar Therapeutics | Opioides pegilados con bajo potencial de abuso. |
US8945592B2 (en) | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
US8481560B2 (en) * | 2010-04-02 | 2013-07-09 | Alltranz Inc. | Abuse deterrent transdermal formulations of opiate agonists and agonist-antagonists |
US9447026B2 (en) | 2013-03-14 | 2016-09-20 | Kalyra Pharmaceuticals, Inc. | Bicyclic analgesic compounds |
WO2015065547A1 (en) | 2013-10-31 | 2015-05-07 | Cima Labs Inc. | Immediate release abuse-deterrent granulated dosage forms |
US10189780B2 (en) | 2013-12-12 | 2019-01-29 | Zeno Royalties & Milestones, LLC | Bicyclic alkyl compounds and synthesis |
CN106232567B (zh) | 2014-03-07 | 2021-11-02 | 里科瑞尔姆Ip控股有限责任公司 | 螺桨烷衍生物及合成 |
EP3193855B1 (de) | 2014-09-17 | 2021-05-19 | Recurium IP Holdings, LLC | Bicyclische verbindungen |
NZ732808A (en) | 2014-12-23 | 2021-12-24 | Acelrx Pharmaceuticals Inc | Systems, devices and methods for dispensing oral transmucosal dosage forms |
WO2017160926A1 (en) * | 2016-03-16 | 2017-09-21 | Kalyra Pharmaceuticals, Inc. | Analgesic compounds |
US9650338B1 (en) * | 2016-07-29 | 2017-05-16 | VDM Biochemicals, Inc. | Opioid antagonist compounds and methods of making and using |
CA3063729A1 (en) | 2017-05-15 | 2018-11-22 | Recurium Ip Holdings, Llc | Analgesic compounds |
US11324707B2 (en) | 2019-05-07 | 2022-05-10 | Clexio Biosciences Ltd. | Abuse-deterrent dosage forms containing esketamine |
US11160799B2 (en) * | 2019-10-22 | 2021-11-02 | Cessatech A/S | Pediatric combination |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
WO2000003716A1 (en) * | 1998-07-16 | 2000-01-27 | Memorial Sloan-Kettering Cancer Center | Topical compositions comprising an opioid analgesic and an nmda antagonist |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3254124A (en) * | 1962-06-29 | 1966-05-31 | Parke Davis & Co | Aminoketones and methods for their production |
US5635204A (en) * | 1994-03-04 | 1997-06-03 | Montefiore Medical Center | Method for transdermal induction of anesthesia, analgesia or sedation |
CA2230690C (en) * | 1995-08-30 | 2008-12-23 | Stuart L. Weg | Administration of ketamine to manage pain and to reduce drug dependency |
-
2000
- 2000-05-26 DE DE10025946A patent/DE10025946A1/de not_active Withdrawn
-
2001
- 2001-05-10 CA CA002406976A patent/CA2406976A1/en not_active Abandoned
- 2001-05-10 NZ NZ521878A patent/NZ521878A/en unknown
- 2001-05-10 MX MXPA02011610A patent/MXPA02011610A/es unknown
- 2001-05-10 HU HU0301972A patent/HUP0301972A3/hu unknown
- 2001-05-10 JP JP2001587768A patent/JP2003534378A/ja active Pending
- 2001-05-10 WO PCT/EP2001/005348 patent/WO2001091753A1/de not_active Application Discontinuation
- 2001-05-10 AU AU2001274021A patent/AU2001274021A1/en not_active Abandoned
- 2001-05-10 EP EP01940449A patent/EP1289528A1/de not_active Withdrawn
- 2001-05-10 US US10/296,098 patent/US20040092531A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
WO2000003716A1 (en) * | 1998-07-16 | 2000-01-27 | Memorial Sloan-Kettering Cancer Center | Topical compositions comprising an opioid analgesic and an nmda antagonist |
Non-Patent Citations (12)
Title |
---|
BELL R.F.: "Low-dose subcutaneous ketamine infusion and morphine tolerance.", PAIN, (1999) 83/1 (101-103)., XP001012769 * |
CELERIER EVELYNE ET AL: "Long-lasting hyperalgesia induced by fentanyl in rats: Preventive effect of ketamine.", ANESTHESIOLOGY (HAGERSTOWN), vol. 92, no. 2, February 2000 (2000-02-01), pages 465 - 472, XP001012738, ISSN: 0003-3022 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1995, LUO YIFAN ET AL: "Comparison of Anesthesia Induced by Ketamine-Fentanyl Combination and Maintained by Propofol or Etomidate in New Zealand White Rabbits.", XP002180110, Database accession no. PREV199598381943 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; January 2000 (2000-01-01), XIA FANG ET AL: "Clinical observation of the influence of drug combination of Ketamine, Propofol, Fentanyl on cardiovascular side effects during intubation.", XP002180108, Database accession no. PREV200000337869 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; October 1998 (1998-10-01), YAMAGUCHI SHIGEKI ET AL: "Anesthetic management of a patient with hypertrophic cardiomyopathy using propofol, fentanyl and ketamine.", XP002180109, Database accession no. PREV199900127009 * |
FISHER A. ET AL: "Combined analgesic effect of morphine and ketamine [2].", ANAESTHESIA, (1995) 50/8 (746)., XP001012768 * |
HUBEI YIKEDAXUE XUEBAO, vol. 21, no. 1, January 2000 (2000-01-01), pages 65 - 66, ISSN: 1008-0724 * |
JAPANESE JOURNAL OF ANESTHESIOLOGY, vol. 47, no. 10, October 1998 (1998-10-01), pages 1240 - 1242, ISSN: 0021-4892 * |
LABORATORY ANIMAL SCIENCE, vol. 45, no. 3, 1995, pages 269 - 275, ISSN: 0023-6764 * |
MILDH L ET AL: "The effect of low-dose ketamine on fentanyl -induced respiratory depression.", ANAESTHESIA, (1998 OCT) 53 (10) 965-70., XP001012766 * |
PERSSON J ET AL: "Ketamine antagonises alfentanil-induced hypoventilation in healthy male volunteers.", ACTA ANAESTHESIOLOGICA SCANDINAVICA, vol. 43, no. 7, August 1999 (1999-08-01), pages 744 - 752, XP001012770, ISSN: 0001-5172 * |
SETHNA NAVIL F ET AL: "Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects.", ANESTHESIA & ANALGESIA, vol. 86, no. 6, June 1998 (1998-06-01), pages 1250 - 1256, XP001012771, ISSN: 0003-2999 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006502187A (ja) * | 2002-09-20 | 2006-01-19 | アンドルックス ラボズ リミテッド ライアビリティ カンパニー | ビグアニドおよびチアゾリジンジオン誘導体を含有する多段階製剤 |
JP4694841B2 (ja) * | 2002-09-20 | 2011-06-08 | アンドルックス ラボズ リミテッド ライアビリティ カンパニー | ビグアニドおよびチアゾリジンジオン誘導体を含有する多段階製剤 |
WO2006024018A2 (en) * | 2004-08-24 | 2006-03-02 | Neuromolecular Pharmaceuticals, Inc. | Compositions for treating nociceptive pain |
WO2006024018A3 (en) * | 2004-08-24 | 2006-07-20 | Neuromolecular Pharmaceuticals | Compositions for treating nociceptive pain |
Also Published As
Publication number | Publication date |
---|---|
DE10025946A1 (de) | 2001-11-29 |
MXPA02011610A (es) | 2003-05-14 |
CA2406976A1 (en) | 2002-10-22 |
HUP0301972A2 (hu) | 2003-11-28 |
US20040092531A1 (en) | 2004-05-13 |
HUP0301972A3 (en) | 2005-06-28 |
NZ521878A (en) | 2005-08-26 |
JP2003534378A (ja) | 2003-11-18 |
EP1289528A1 (de) | 2003-03-12 |
AU2001274021A1 (en) | 2001-12-11 |
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