WO2001079533A3 - Verfahren zur immobilisierung eines analyten an einer festen oberfläche - Google Patents

Verfahren zur immobilisierung eines analyten an einer festen oberfläche Download PDF

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Publication number
WO2001079533A3
WO2001079533A3 PCT/AT2001/000108 AT0100108W WO0179533A3 WO 2001079533 A3 WO2001079533 A3 WO 2001079533A3 AT 0100108 W AT0100108 W AT 0100108W WO 0179533 A3 WO0179533 A3 WO 0179533A3
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WO
WIPO (PCT)
Prior art keywords
analyte
solid surface
bonded
immobilizing
cyclodextrin molecule
Prior art date
Application number
PCT/AT2001/000108
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English (en)
French (fr)
Other versions
WO2001079533A2 (de
Inventor
Claudia Preininger
Original Assignee
Oesterr Forsch Seibersdorf
Claudia Preininger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oesterr Forsch Seibersdorf, Claudia Preininger filed Critical Oesterr Forsch Seibersdorf
Priority to EP01923375A priority Critical patent/EP1272667A2/de
Priority to AU2001250146A priority patent/AU2001250146A1/en
Priority to CA002406091A priority patent/CA2406091A1/en
Publication of WO2001079533A2 publication Critical patent/WO2001079533A2/de
Publication of WO2001079533A3 publication Critical patent/WO2001079533A3/de
Priority to US10/269,395 priority patent/US20030040008A1/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezoelectric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00427—Means for dispensing and evacuation of reagents using masks
    • B01J2219/00432—Photolithographic masks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00574—Chemical means radioactive
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00644—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being present in discrete locations, e.g. gel pads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00677—Ex-situ synthesis followed by deposition on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00711—Light-directed synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Beschrieben wird ein Verfahren zur Immobilisierung eines Analyten an einer festen Oberfläche, welches gekennzeichnet ist durch die folgenden Schritte: Binden eines Cyclodextrin-Moleküls mit mindestens zwei funktionellen Gruppen an eine feste Oberfläche, so dass noch mindestens eine funktionelle Gruppe des Cyclodextrin-Moleküls mit einem Analyten kovalent gebunden werden kann, und kovalentes Binden des Analyten an das Oberflächen-gebundene Cyclodextrin-Molekül. Alternativ kann auch zunächst der Analyt kovalent an das Cyclodextrin-Molekül gebunden werden und danach das Cyclodextrin-Molekül mit der festen Oberfläche verbunden werden.
PCT/AT2001/000108 2000-04-14 2001-04-12 Verfahren zur immobilisierung eines analyten an einer festen oberfläche WO2001079533A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01923375A EP1272667A2 (de) 2000-04-14 2001-04-12 Verfahren zur immobilisierung eines analyten an einer festen oberfläche
AU2001250146A AU2001250146A1 (en) 2000-04-14 2001-04-12 Method for immobilizing an analyte on a solid surface
CA002406091A CA2406091A1 (en) 2000-04-14 2001-04-12 Method of immobilizing an analyte on a solid surface
US10/269,395 US20030040008A1 (en) 2000-04-14 2002-10-11 Method for lmmobilizing an analyte on a solid surface

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA656/2000 2000-04-14
AT0065600A AT408150B (de) 2000-04-14 2000-04-14 Verfahren zur immobilisierung eines analyten an einer festen oberfläche

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/269,395 Continuation US20030040008A1 (en) 2000-04-14 2002-10-11 Method for lmmobilizing an analyte on a solid surface

Publications (2)

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WO2001079533A2 WO2001079533A2 (de) 2001-10-25
WO2001079533A3 true WO2001079533A3 (de) 2002-04-04

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PCT/AT2001/000108 WO2001079533A2 (de) 2000-04-14 2001-04-12 Verfahren zur immobilisierung eines analyten an einer festen oberfläche

Country Status (6)

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US (1) US20030040008A1 (de)
EP (1) EP1272667A2 (de)
AT (1) AT408150B (de)
AU (1) AU2001250146A1 (de)
CA (1) CA2406091A1 (de)
WO (1) WO2001079533A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003056007A1 (en) * 2001-12-26 2003-07-10 Canon Kabushiki Kaisha Probe medium
US20050053954A1 (en) * 2002-11-01 2005-03-10 Brennan John D. Multicomponent protein microarrays
GB2414479A (en) * 2004-05-27 2005-11-30 Croda Int Plc Reactive cyclodextrins derivatised with proteins

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19520989A1 (de) * 1995-06-08 1996-12-12 Consortium Elektrochem Ind Cyclodextrinmodifizierte Polymere
US5661040A (en) * 1993-07-13 1997-08-26 Abbott Laboratories Fluorescent polymer labeled conjugates and intermediates
WO2000074828A1 (de) * 1999-06-03 2000-12-14 Gkss-Forschungszentrum Geesthacht Gmbh Hydrophile kompositmembran zur entwässerung organischer lösungen
WO2001004631A1 (en) * 1999-07-08 2001-01-18 Radiometer Medical A/S A sensor comprising a hydrophilic matrix material

Family Cites Families (8)

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US5068227A (en) * 1989-01-18 1991-11-26 Cyclex, Inc. Cyclodextrins as carriers
DE69434649T2 (de) * 1993-07-13 2007-02-22 Abbott Laboratories, Abbott Park Durch fluoreszierenden polymer markierte konjugate und zwischenprodukte
DE4401618A1 (de) * 1994-01-20 1995-07-27 Consortium Elektrochem Ind Verfahren zur Herstellung von aminofunktionellen Cyclodextrin Derivaten
DE4418513A1 (de) * 1994-05-27 1995-11-30 Bayer Ag Immuntest zum Nachweis hochmolekularer Antigene
DE4429229A1 (de) * 1994-08-18 1996-02-22 Consortium Elektrochem Ind Cyclodextrinderivate mit mindestens einem stickstoffhaltigen Heterozyklus, ihre Herstellung und Verwendung
BE1008978A5 (fr) * 1994-12-27 1996-10-01 Solvay Adjuvants pour vaccins.
US5877310A (en) * 1997-04-25 1999-03-02 Carnegie Mellon University Glycoconjugated fluorescent labeling reagents
US6582583B1 (en) * 1998-11-30 2003-06-24 The United States Of America As Represented By The Department Of Health And Human Services Amperometric biomimetic enzyme sensors based on modified cyclodextrin as electrocatalysts

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US5661040A (en) * 1993-07-13 1997-08-26 Abbott Laboratories Fluorescent polymer labeled conjugates and intermediates
DE19520989A1 (de) * 1995-06-08 1996-12-12 Consortium Elektrochem Ind Cyclodextrinmodifizierte Polymere
WO2000074828A1 (de) * 1999-06-03 2000-12-14 Gkss-Forschungszentrum Geesthacht Gmbh Hydrophile kompositmembran zur entwässerung organischer lösungen
WO2001004631A1 (en) * 1999-07-08 2001-01-18 Radiometer Medical A/S A sensor comprising a hydrophilic matrix material

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DENTER, U. ET AL: "Surface modification of synthetic and natural fibers by fixation of cyclodextrin derivatives", J. INCLUSION PHENOM. MOL. RECOGNIT. CHEM. (1996), 25(1-3), 197-202, XP001016195 *
MARTEL, BERNARD ET AL: "Preparation and sorption properties of a.beta.- cyclodextrin -linked chitosan derivative", J. POLYM. SCI., PART A: POLYM. CHEM. (2000), VOLUME DATE 2001, 39(1), 169-176, XP001016030 *
MOLDENHAUER, J.-P. ET AL: "Textile finishing with MCT-.beta.- cyclodextrin", PROC. INT. SYMP. CYCLODEXTRINS, 9TH (1999), MEETING DATE 1998, 161-165. EDITOR(S): LABANDEIRA, J. J. TORRES;VILA-JATO, J. L. PUBLISHER: KLUWER ACADEMIC PUBLISHERS, DORDRECHT, NETH., XP001016181 *
PHAN, T. N. T. ET AL: "Synthesis and characterization of silica gels functionalized with monochlorotriazinyl.beta.- cyclodextrin and their sorption capacities towards organic compounds", J. INCLUSION PHENOM. MACROCYCLIC CHEM. (2000), 38(1-4), 345-359, XP001016243 *
REUSCHER, H. ET AL: "BETA W7 MCT -- New ways in surface modification", J. INCLUSION PHENOM. MOL. RECOGNIT. CHEM. (1996), 25(1-3), 191-196, XP001016194 *

Also Published As

Publication number Publication date
US20030040008A1 (en) 2003-02-27
AU2001250146A1 (en) 2001-10-30
CA2406091A1 (en) 2002-10-11
AT408150B (de) 2001-09-25
EP1272667A2 (de) 2003-01-08
ATA6562000A (de) 2001-01-15
WO2001079533A2 (de) 2001-10-25

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