WO2001079533A3 - Verfahren zur immobilisierung eines analyten an einer festen oberfläche - Google Patents

Verfahren zur immobilisierung eines analyten an einer festen oberfläche Download PDF

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Publication number
WO2001079533A3
WO2001079533A3 PCT/AT2001/000108 AT0100108W WO0179533A3 WO 2001079533 A3 WO2001079533 A3 WO 2001079533A3 AT 0100108 W AT0100108 W AT 0100108W WO 0179533 A3 WO0179533 A3 WO 0179533A3
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WIPO (PCT)
Prior art keywords
analyte
solid surface
bonded
immobilizing
cyclodextrin molecule
Prior art date
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PCT/AT2001/000108
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English (en)
French (fr)
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WO2001079533A2 (de
Inventor
Claudia Preininger
Original Assignee
Oesterr Forsch Seibersdorf
Claudia Preininger
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Application filed by Oesterr Forsch Seibersdorf, Claudia Preininger filed Critical Oesterr Forsch Seibersdorf
Priority to EP01923375A priority Critical patent/EP1272667A2/de
Priority to AU2001250146A priority patent/AU2001250146A1/en
Priority to CA002406091A priority patent/CA2406091A1/en
Publication of WO2001079533A2 publication Critical patent/WO2001079533A2/de
Publication of WO2001079533A3 publication Critical patent/WO2001079533A3/de
Priority to US10/269,395 priority patent/US20030040008A1/en

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00378Piezoelectric or ink jet dispensers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00427Means for dispensing and evacuation of reagents using masks
    • B01J2219/00432Photolithographic masks
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00527Sheets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572Chemical means
    • B01J2219/00574Chemical means radioactive
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572Chemical means
    • B01J2219/00576Chemical means fluorophore
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00585Parallel processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00596Solid-phase processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00639Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00644Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being present in discrete locations, e.g. gel pads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00677Ex-situ synthesis followed by deposition on the substrate
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709Type of synthesis
    • B01J2219/00711Light-directed synthesis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00722Nucleotides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00725Peptides
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Beschrieben wird ein Verfahren zur Immobilisierung eines Analyten an einer festen Oberfläche, welches gekennzeichnet ist durch die folgenden Schritte: Binden eines Cyclodextrin-Moleküls mit mindestens zwei funktionellen Gruppen an eine feste Oberfläche, so dass noch mindestens eine funktionelle Gruppe des Cyclodextrin-Moleküls mit einem Analyten kovalent gebunden werden kann, und kovalentes Binden des Analyten an das Oberflächen-gebundene Cyclodextrin-Molekül. Alternativ kann auch zunächst der Analyt kovalent an das Cyclodextrin-Molekül gebunden werden und danach das Cyclodextrin-Molekül mit der festen Oberfläche verbunden werden.
PCT/AT2001/000108 2000-04-14 2001-04-12 Verfahren zur immobilisierung eines analyten an einer festen oberfläche WO2001079533A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01923375A EP1272667A2 (de) 2000-04-14 2001-04-12 Verfahren zur immobilisierung eines analyten an einer festen oberfläche
AU2001250146A AU2001250146A1 (en) 2000-04-14 2001-04-12 Method for immobilizing an analyte on a solid surface
CA002406091A CA2406091A1 (en) 2000-04-14 2001-04-12 Method of immobilizing an analyte on a solid surface
US10/269,395 US20030040008A1 (en) 2000-04-14 2002-10-11 Method for lmmobilizing an analyte on a solid surface

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA656/2000 2000-04-14
AT0065600A AT408150B (de) 2000-04-14 2000-04-14 Verfahren zur immobilisierung eines analyten an einer festen oberfläche

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/269,395 Continuation US20030040008A1 (en) 2000-04-14 2002-10-11 Method for lmmobilizing an analyte on a solid surface

Publications (2)

Publication Number Publication Date
WO2001079533A2 WO2001079533A2 (de) 2001-10-25
WO2001079533A3 true WO2001079533A3 (de) 2002-04-04

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PCT/AT2001/000108 WO2001079533A2 (de) 2000-04-14 2001-04-12 Verfahren zur immobilisierung eines analyten an einer festen oberfläche

Country Status (6)

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US (1) US20030040008A1 (de)
EP (1) EP1272667A2 (de)
AT (1) AT408150B (de)
AU (1) AU2001250146A1 (de)
CA (1) CA2406091A1 (de)
WO (1) WO2001079533A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003056007A1 (en) * 2001-12-26 2003-07-10 Canon Kabushiki Kaisha Probe medium
US20050053954A1 (en) * 2002-11-01 2005-03-10 Brennan John D. Multicomponent protein microarrays
GB2414479A (en) * 2004-05-27 2005-11-30 Croda Int Plc Reactive cyclodextrins derivatised with proteins

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19520989A1 (de) * 1995-06-08 1996-12-12 Consortium Elektrochem Ind Cyclodextrinmodifizierte Polymere
US5661040A (en) * 1993-07-13 1997-08-26 Abbott Laboratories Fluorescent polymer labeled conjugates and intermediates
WO2000074828A1 (de) * 1999-06-03 2000-12-14 Gkss-Forschungszentrum Geesthacht Gmbh Hydrophile kompositmembran zur entwässerung organischer lösungen
WO2001004631A1 (en) * 1999-07-08 2001-01-18 Radiometer Medical A/S A sensor comprising a hydrophilic matrix material

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
US5068227A (en) * 1989-01-18 1991-11-26 Cyclex, Inc. Cyclodextrins as carriers
DE69434649T2 (de) * 1993-07-13 2007-02-22 Abbott Laboratories, Abbott Park Durch fluoreszierenden polymer markierte konjugate und zwischenprodukte
DE4401618A1 (de) * 1994-01-20 1995-07-27 Consortium Elektrochem Ind Verfahren zur Herstellung von aminofunktionellen Cyclodextrin Derivaten
DE4418513A1 (de) * 1994-05-27 1995-11-30 Bayer Ag Immuntest zum Nachweis hochmolekularer Antigene
DE4429229A1 (de) * 1994-08-18 1996-02-22 Consortium Elektrochem Ind Cyclodextrinderivate mit mindestens einem stickstoffhaltigen Heterozyklus, ihre Herstellung und Verwendung
BE1008978A5 (fr) * 1994-12-27 1996-10-01 Solvay Adjuvants pour vaccins.
US5877310A (en) * 1997-04-25 1999-03-02 Carnegie Mellon University Glycoconjugated fluorescent labeling reagents
US6582583B1 (en) * 1998-11-30 2003-06-24 The United States Of America As Represented By The Department Of Health And Human Services Amperometric biomimetic enzyme sensors based on modified cyclodextrin as electrocatalysts

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5661040A (en) * 1993-07-13 1997-08-26 Abbott Laboratories Fluorescent polymer labeled conjugates and intermediates
DE19520989A1 (de) * 1995-06-08 1996-12-12 Consortium Elektrochem Ind Cyclodextrinmodifizierte Polymere
WO2000074828A1 (de) * 1999-06-03 2000-12-14 Gkss-Forschungszentrum Geesthacht Gmbh Hydrophile kompositmembran zur entwässerung organischer lösungen
WO2001004631A1 (en) * 1999-07-08 2001-01-18 Radiometer Medical A/S A sensor comprising a hydrophilic matrix material

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DENTER, U. ET AL: "Surface modification of synthetic and natural fibers by fixation of cyclodextrin derivatives", J. INCLUSION PHENOM. MOL. RECOGNIT. CHEM. (1996), 25(1-3), 197-202, XP001016195 *
MARTEL, BERNARD ET AL: "Preparation and sorption properties of a.beta.- cyclodextrin -linked chitosan derivative", J. POLYM. SCI., PART A: POLYM. CHEM. (2000), VOLUME DATE 2001, 39(1), 169-176, XP001016030 *
MOLDENHAUER, J.-P. ET AL: "Textile finishing with MCT-.beta.- cyclodextrin", PROC. INT. SYMP. CYCLODEXTRINS, 9TH (1999), MEETING DATE 1998, 161-165. EDITOR(S): LABANDEIRA, J. J. TORRES;VILA-JATO, J. L. PUBLISHER: KLUWER ACADEMIC PUBLISHERS, DORDRECHT, NETH., XP001016181 *
PHAN, T. N. T. ET AL: "Synthesis and characterization of silica gels functionalized with monochlorotriazinyl.beta.- cyclodextrin and their sorption capacities towards organic compounds", J. INCLUSION PHENOM. MACROCYCLIC CHEM. (2000), 38(1-4), 345-359, XP001016243 *
REUSCHER, H. ET AL: "BETA W7 MCT -- New ways in surface modification", J. INCLUSION PHENOM. MOL. RECOGNIT. CHEM. (1996), 25(1-3), 191-196, XP001016194 *

Also Published As

Publication number Publication date
US20030040008A1 (en) 2003-02-27
AU2001250146A1 (en) 2001-10-30
CA2406091A1 (en) 2002-10-11
AT408150B (de) 2001-09-25
EP1272667A2 (de) 2003-01-08
ATA6562000A (de) 2001-01-15
WO2001079533A2 (de) 2001-10-25

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