WO2001072289A3 - Arzneimittel zur stimulierung der leukopoese, zur behandlung von tumor- und protozoenerkrankungen, von akarinosis, arthropodiasis und verfahren zu seiner herstellung - Google Patents

Arzneimittel zur stimulierung der leukopoese, zur behandlung von tumor- und protozoenerkrankungen, von akarinosis, arthropodiasis und verfahren zu seiner herstellung

Info

Publication number
WO2001072289A3
WO2001072289A3 PCT/EP2001/003609 EP0103609W WO0172289A3 WO 2001072289 A3 WO2001072289 A3 WO 2001072289A3 EP 0103609 W EP0103609 W EP 0103609W WO 0172289 A3 WO0172289 A3 WO 0172289A3
Authority
WO
WIPO (PCT)
Prior art keywords
mol
diseases
leucopoiesis
acarinosis
tumour
Prior art date
Application number
PCT/EP2001/003609
Other languages
English (en)
French (fr)
Other versions
WO2001072289A2 (de
Inventor
Hansjoerg Eibl
Original Assignee
Max Planck Gesellschaft
Hansjoerg Eibl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft, Hansjoerg Eibl filed Critical Max Planck Gesellschaft
Priority to IL15192601A priority Critical patent/IL151926A0/xx
Priority to AU2001263828A priority patent/AU2001263828A1/en
Priority to CA002404322A priority patent/CA2404322A1/en
Priority to EP01938070A priority patent/EP1267943A2/de
Priority to MXPA02009434A priority patent/MXPA02009434A/es
Priority to JP2001570250A priority patent/JP2003528134A/ja
Priority to US10/240,199 priority patent/US20030199476A1/en
Priority to BR0109799-7A priority patent/BR0109799A/pt
Publication of WO2001072289A2 publication Critical patent/WO2001072289A2/de
Publication of WO2001072289A3 publication Critical patent/WO2001072289A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Die Erfindung betrifft Arzneimittelformulierungen zur Stimulierung der Leukopoese und zur Behandlung von Tumor- und Protozoenerkrankungen, Acarinosis und von durch Arthropoden verursachte Erkrankungen, welche dadurch gekennzeichnet sind, dass sie ein wirksames Gemisch aus a) mindestens einer Phospholipidverbindung der Formel (I): worin R1 ein gesättigter oder ungesättigter Kohlenwasserstoffrest mit 16 bis 24 C-Atomen ist, R?2, R3 und R4¿ jeweils unabhängig H, eine C¿1?-C5-Alkylgruppe, eine C3-C6-Cycloalkylgruppe oder eine C1-C5-Hydroxyalkylgruppe sind, wobei zwei von R?2, R3 und R4¿ miteinander eine C¿2?-C5-Alkylengruppe bilden können, die gegebenenfalls mit einer -O-, -S- oder NR?5¿-Gruppe substituiert sein kann, worin R5 H, eine C¿1?-C5-Alkylgruppe, eine C3-C6-Cycloalkylgruppe oder C1-C5-Hydroxyalkylgruppe ist, n eine ganze Zahl von 2 bis 6 ist als Wirkstoff zu 30 bis 60 Mol-%, b) Cholesterin, und/oder Cholesterinderivat zu 25 bis 65 Mol-%, c) einem mindestens eine Oleylgruppe enthaltenden Phosphatidylmono- oder Phosphatidyloligoglycerin zu 5 bis 15 Mol-%, wobei a), b) und c) zusammen 100 Mol-% ergeben, und d) einem wassermischbaren, physiologisch annehmbaren Alkohol mit 2 bis 4 C-Atomen, der gegebenenfalls Wasser enthält, sowie gegebenenfalls übliche pharmazeutische Hilfsstoffe aufweist, wobei die Komponenten als in Wasser dispergierter Komplex vorliegen. Des Weiteren betrifft die Erfindung Verfahren zu deren Herstellung.
PCT/EP2001/003609 2000-03-30 2001-03-29 Arzneimittel zur stimulierung der leukopoese, zur behandlung von tumor- und protozoenerkrankungen, von akarinosis, arthropodiasis und verfahren zu seiner herstellung WO2001072289A2 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IL15192601A IL151926A0 (en) 2000-03-30 2001-03-29 Drug for stimulating leucopoiesis and for treating tumour diseases, protozoal diseases, acariasis and arthropodiasis, and process for producing it
AU2001263828A AU2001263828A1 (en) 2000-03-30 2001-03-29 Medicament for the stimulation of leucopoiesis and treatment of tumour and protozoan diseases acarinosis and arthropod-borne diseases and a method for production thereof
CA002404322A CA2404322A1 (en) 2000-03-30 2001-03-29 Medicament for the stimulation of leucopoiesis and treatment of tumour and protozoan diseases acarinosis and arthropod-borne diseases and a method for production thereof
EP01938070A EP1267943A2 (de) 2000-03-30 2001-03-29 Arzneimittel zur stimulierung der leukopoese, zur behandlung von tumor- und protozoenerkrankungen, von akarinosis, arthropodiasis und verfahren zu seiner herstellung
MXPA02009434A MXPA02009434A (es) 2000-03-30 2001-03-29 Formulacion medicinal para la estimulacion de la leucopoyesis para el tratamiento de enfermedades tumorales y de protozoos, de acarinosis, artropodiasis y un procedimiento para su preparacion.
JP2001570250A JP2003528134A (ja) 2000-03-30 2001-03-29 白血球産生の刺激用および腫瘍および原虫症の治療用およびダニ症、節足動物媒介感染の治療用医薬組成物およびその製法
US10/240,199 US20030199476A1 (en) 2000-03-30 2001-03-29 Medicament for the stimulation of leucopoiesis and treatment of tumour and protozoan diseases acarinosis and arthropod-borne diseases and a method for production thereof
BR0109799-7A BR0109799A (pt) 2000-03-30 2001-03-29 Medicamento para estimular a leucopoese, para tratamento de doenças tumorais e protozoárias, de acarinose, artropodìase e processo para produção do mesmo

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10015814A DE10015814A1 (de) 2000-03-30 2000-03-30 Arzneimittel zur Stimulierung der Leukopoese, zur Behandlung von Tumor- und Protozoenerkrankungen und Verfahren zu seiner Herstellung
DE10015814.5 2000-03-30

Publications (2)

Publication Number Publication Date
WO2001072289A2 WO2001072289A2 (de) 2001-10-04
WO2001072289A3 true WO2001072289A3 (de) 2002-04-18

Family

ID=7636966

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/003609 WO2001072289A2 (de) 2000-03-30 2001-03-29 Arzneimittel zur stimulierung der leukopoese, zur behandlung von tumor- und protozoenerkrankungen, von akarinosis, arthropodiasis und verfahren zu seiner herstellung

Country Status (11)

Country Link
US (1) US20030199476A1 (de)
EP (1) EP1267943A2 (de)
JP (1) JP2003528134A (de)
CN (1) CN1426311A (de)
AU (1) AU2001263828A1 (de)
BR (1) BR0109799A (de)
CA (1) CA2404322A1 (de)
DE (1) DE10015814A1 (de)
IL (1) IL151926A0 (de)
MX (1) MXPA02009434A (de)
WO (1) WO2001072289A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10148067A1 (de) * 2001-09-28 2003-04-17 Max Planck Gesellschaft Hitzesterilisierbare Alkylphosphocholin-Liposome
DE10148066A1 (de) * 2001-09-28 2003-04-24 Max Planck Gesellschaft Liposome enthaltend (Ether)-Lysolecithine
ES2184650B1 (es) * 2001-10-10 2004-09-16 Farmaleis, S.L. Utilizacion de colesterol y fosfolipidos en medicamentos para el tratamiento de la leishmaniasis en los canidos.
DK1827379T3 (da) * 2004-10-19 2011-04-04 Mpg Max Planck Ges Zur Foerderung Der Wissenschaften E V Formuleringer med alkylphosphocholiner under anvendelse af nye negative ladningsbærere
EP1745788A1 (de) 2005-07-22 2007-01-24 KTB Tumorforschungsgesellschaft mbH Acylglycerophospholipide zur Behandlung von Krebs und Tumorkachexie
CA2881958C (en) * 2012-08-13 2019-08-27 Adipharm Ead Pharmaceutical formulations containing 3-(4-cinnamyl-1-piperazinyl) amino derivatives of 3-formylrifamycin sv and 3-formylrifamycin s and a process of their preparation
EP3895709A1 (de) 2020-04-17 2021-10-20 Andreas Hettich GmbH & Co. KG Phospholipide und phospholipid-metaboliten zur behandlung von viralen und bakteriellen lungenentzündungen und sepsis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0319136A1 (de) * 1987-10-28 1989-06-07 K & V LICENCING OY Liposome und Verfahren zu deren Darstellung
DE19835611A1 (de) * 1998-08-06 2000-02-10 Max Planck Gesellschaft Neuartige Phospholipide mit synthetischen, ungesättigten Alkyl- und Acylketten

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
DE4111105A1 (de) * 1991-04-05 1992-10-08 Max Planck Gesellschaft Neue erucyl-, brassidyl- und nervonylderivate
DE4132344A1 (de) * 1991-09-27 1993-04-01 Max Planck Gesellschaft Verfahren zur herstellung eines arzneimittels zur oralen oder topischen verabreichung bei der behandlung von leishmaniasis
AU715208B2 (en) * 1996-02-16 2000-01-20 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Phosphatidyl oligoglycerols

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0319136A1 (de) * 1987-10-28 1989-06-07 K & V LICENCING OY Liposome und Verfahren zu deren Darstellung
DE19835611A1 (de) * 1998-08-06 2000-02-10 Max Planck Gesellschaft Neuartige Phospholipide mit synthetischen, ungesättigten Alkyl- und Acylketten

Also Published As

Publication number Publication date
WO2001072289A2 (de) 2001-10-04
CA2404322A1 (en) 2002-09-24
AU2001263828A1 (en) 2001-10-08
DE10015814A1 (de) 2001-10-11
US20030199476A1 (en) 2003-10-23
MXPA02009434A (es) 2003-09-22
CN1426311A (zh) 2003-06-25
JP2003528134A (ja) 2003-09-24
IL151926A0 (en) 2003-04-10
BR0109799A (pt) 2003-01-21
EP1267943A2 (de) 2003-01-02

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